Peter F Kador, PhD

  • 6313 Citations
  • 42 h-Index
1975 …2020

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2020

Novel oral multifunctional antioxidant prevents noise-induced hearing loss and hair cell loss

Chen, G. D., Daszynski, D. M., Ding, D., Jiang, H., Woolman, T., Blessing, K., Kador, P. F. & Salvi, R., Mar 15 2020, In : Hearing Research. 388, 107880.

Research output: Contribution to journalArticle

1 Scopus citations
2019

Failure of Oxysterols Such as Lanosterol to Restore Lens Clarity from Cataracts

Daszynski, D. M., Santhoshkumar, P., Phadte, A. S., Sharma, K. K., Zhong, H. A., Lou, M. F. & Kador, P. F., Dec 1 2019, In : Scientific reports. 9, 1, 8459.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
2015

Effects of multifunctional antioxidants on mitochondrial dysfunction and amyloid-β metal dyshomeostasis

Kawada, H., Blessing, K., Kiyota, T., Woolman, T., Winchester, L. & Kador, P. F., Jan 1 2015, In : Journal of Alzheimer's Disease. 44, 1, p. 297-307 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
10 Scopus citations
2014

Novel transgenic mouse models develop retinal changes associated with early diabetic retinopathy similar to those observed in rats with diabetes mellitus

Guo, C., Zhang, Z., Zhang, P., Makita, J., Kawada, H., Blessing, K. & Kador, P. F., Feb 1 2014, In : Experimental Eye Research. 119, p. 77-87 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Polyol effects on growth factors and MAPK signaling in rat retinal capillary cells

Zhang, P., Zhang, Z. & Kador, P. F., Feb 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 1, p. 4-11 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Topical nutraceutical optixcare eh ameliorates experimental ocular oxidative stress in rats

Kador, P. F., Guo, C., Kawada, H., Randazzo, J. & Blessing, K., Sep 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 7, p. 593-602 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

Novel Diabetic Mouse Models as Tools for Investigating Diabetic Retinopathy

Kador, P. F., Zhang, P., Makita, J., Zhang, Z., Guo, C., Randazzo, J., Kawada, H., Haider, N. & Blessing, K., Dec 12 2012, In : PloS one. 7, 12, e49422.

Research output: Contribution to journalArticle

9 Scopus citations

Osmotic stress, not aldose reductase activity, directly induces growth factors and MAPK signaling changes during sugar cataract formation

Zhang, P., Xing, K., Randazzo, J., Blessing, K., Lou, M. F. & Kador, P. F., Aug 1 2012, In : Experimental Eye Research. 101, p. 36-43 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2011

Aldose reductase/polyol inhibitors for diabetic retinopathy

Obrosova, I. G. & Kador, P. F., Feb 10 2011, In : Current Pharmaceutical Biotechnology. 12, 3, p. 373-385 13 p.

Research output: Contribution to journalArticle

62 Scopus citations

Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats

Kador, P. F., O'Meara, J. D., Blessing, K., Marx, D. B. & Reinhardt, R. A., Jun 1 2011, In : Journal of periodontology. 82, 6, p. 926-933 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Orally active multi-functional antioxidants are neuroprotective in a rat model of light-induced retinal damage

Randazzo, J., Zhang, Z., Hoff, M., Kawada, H., Sachs, A., Yuan, Y., Haider, N. & Kador, P., Jul 19 2011, In : PloS one. 6, 7, e21926.

Research output: Contribution to journalArticle

12 Scopus citations

Orally active multi-functional antioxidants delay cataract formation in streptozotocin (type 1) diabetic and gamma-irradiated rats

Randazzo, J., Zhang, P., Makita, J., Blessing, K. & Kador, P. F., May 9 2011, In : PloS one. 6, 4, e18980.

Research output: Contribution to journalArticle

25 Scopus citations

Response of rat retinal capillary pericytes and endothelial cells to glucose

Makita, J., Hosoya, K. I., Zhang, P. & Kador, P. F., Feb 1 2011, In : Journal of Ocular Pharmacology and Therapeutics. 27, 1, p. 7-15 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Up-regulation of NDRG2 in senescent lens epithelial cells contributes to age-related cataract in human

Zhang, Z. F., Zhang, J., Hui, Y. N., Zheng, M. H., Liu, X. P., Kador, P. F., Wang, Y. S., Yao, L. B. & Zhou, J., Oct 17 2011, In : PloS one. 6, 10, e26102.

Research output: Contribution to journalArticle

17 Scopus citations
2010

Autoimmunity in membranous nephropathy targets aldose reductase and SOD2

Prunotto, M., Carnevali, M. L., Candiano, G., Murtas, C., Bruschi, M., Corradini, E., Trivelli, A., Magnasco, A., Petretto, A., Santucci, L., Mattei, S., Gatti, R., Scolari, F., Kador, P., Allegri, L. & Ghiggeri, G. M., Mar 1 2010, In : Journal of the American Society of Nephrology. 21, 3, p. 507-519 13 p.

Research output: Contribution to journalArticle

152 Scopus citations

Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats

Kador, P. F., Hamada, T., Reinhardt, R. A. & Blessing, K., May 1 2010, In : Postgraduate Medicine. 122, 3, p. 138-144 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Multifunctional antioxidants for the treatment of age-related diseases

Jin, H., Randazzo, J., Zhang, P. & Kador, P. F., Mar 1 2010, In : Journal of Medicinal Chemistry. 53, 3, p. 1117-1127 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Topical KINOSTAT ameliorates the clinical development and progression of cataracts in dogs with diabetes mellitus

Kador, P. F., Webb, T. R., Bras, D., Ketring, K. & Wyman, M., Nov 1 2010, In : Veterinary Ophthalmology. 13, 6, p. 363-368 6 p.

Research output: Contribution to journalArticle

22 Scopus citations
2009

Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats

Drel, V. R., Xu, W., Zhang, J., Kador, P. F., Ali, T. K., Shin, J., Julius, U., Slusher, B., El-Remessy, A. B. & Obrosova, I. G., Apr 1 2009, In : Investigative Ophthalmology and Visual Science. 50, 4, p. 1778-1790 13 p.

Research output: Contribution to journalArticle

54 Scopus citations

Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)

Kador, P. F., Randazzo, J., Blessing, K., Makita, J., Zhang, P., Yu, K., Hosoya, K. I. & Terasaki, T., Aug 1 2009, In : Journal of Ocular Pharmacology and Therapeutics. 25, 4, p. 299-307 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Asteroid hyalosis: Pathogenesis and prospects for prevention

Kador, P. F. & Wyman, M., Jan 1 2008, In : Eye. 22, 10, p. 1278-1285 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2007

Age-dependent retinal capillary pericyte degeneration in galactose-fed dogs

Kador, P. F., Takahashi, Y., Akagi, Y., Blessing, K., Randazzo, J. & Wyman, M., Feb 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 1, p. 63-69 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats

Mulhern, M. L., Madson, C. J., Kador, P. F., Randazzo, J. & Shinohara, T., Aug 10 2007, In : Molecular Vision. 13, p. 1397-1405 9 p.

Research output: Contribution to journalArticle

43 Scopus citations

Evaluation of the vascular targeting agent combretastatin A-4 prodrug on retinal neovascularization in the galactose-fed dog

Kador, P. F., Blessing, K., Randazzo, J., Makita, J. & Wyman, M., Apr 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 2, p. 132-142 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Topical aldose reductase inhibitor formulations for effective lens drug delivery in a rat model for sugar cataracts

Kador, P. F., Randazzo, J., Babb, T., Koushik, K., Takamura, Y., Zhu, W., Blessing, K. & Kompella, U. B., Apr 1 2007, In : Journal of Ocular Pharmacology and Therapeutics. 23, 2, p. 116-123 8 p.

Research output: Contribution to journalArticle

16 Scopus citations
2006

Aqueous flow in galactose-fed dogs

Toris, C. B., Lane, J. T., Akagi, Y., Blessing, K. A. & Kador, P. F., Oct 1 2006, In : Experimental Eye Research. 83, 4, p. 865-870 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Effects of topical administration of an aldose reductase inhibitor on cataract formation in dogs fed a diet high in galactose

Kador, P. F., Betts, D., Wyman, M., Blessing, K. & Randazzo, J., Oct 26 2006, In : American journal of veterinary research. 67, 10, p. 1783-1787 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation

Ikesugi, K., Mulhern, M. L., Madson, C. J., Hosoya, K. I., Terasaki, T., Kador, P. F. & Shinohara, T., Nov 1 2006, In : Current Eye Research. 31, 11, p. 947-953 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Structure of asteroid bodies in the vitreous of galactose-fed dogs

Wang, M., Kador, P. F. & Wyman, M., Apr 4 2006, In : Molecular Vision. 12, p. 283-289 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

The unfolded protein response in lens epithelial cells from galactosemic rat lenses

Mulhern, M. L., Madson, C. J., Danford, A., Ikesugi, K., Kador, P. F. & Shinohara, T., Sep 1 2006, In : Investigative Ophthalmology and Visual Science. 47, 9, p. 3951-3959 9 p.

Research output: Contribution to journalArticle

93 Scopus citations
2005
2 Scopus citations
2004

Anticataract activity of analogs of a sorbitol dehydrogenase inhibitor

Kador, P. F., Inoue, J. & Blessing, K., Aug 1 2004, In : Journal of Ocular Pharmacology and Therapeutics. 20, 4, p. 333-344 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dr Abraham Spector International Symposium

Kador, P. F. & Reddy, V., Dec 1 2004, In : Experimental Eye Research. 79, 6, p. 737-739 3 p.

Research output: Contribution to journalArticle

Long-term treatment with cyclosporine decreases aquaporins and urea transporters in the rat kidney

Lim, S. W., Li, C., Sun, B. K., Han, K. H., Kim, W. Y., Oh, Y. W., Lee, J. U., Kador, P. F., Knepper, M. A., Sands, J. M., Kim, J. & Yang, C. W., Jul 1 2004, In : American Journal of Physiology - Renal Physiology. 287, 1 56-1, p. F139-F151

Research output: Contribution to journalArticle

53 Scopus citations

Method for isolating tight-binding inhibitors of rat lens aldose reductase

Sun, G., Ma, Y., Gao, X., König, S., Fales, H. M. & Kador, P. F., Dec 1 2004, In : Experimental Eye Research. 79, 6, p. 919-926 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
2003

Diabetes can alter the signal transduction pathways in the lens of rats

Zatechka, D. S., Kador, P. F., Garcia-Castiñeiras, S. & Lou, M. F., Apr 1 2003, In : Diabetes. 52, 4, p. 1014-1022 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Effects of Aldose Reductase Inhibitors and Galactose Withdrawal on Fluorescein Angiographic Lesions in Galactose-Fed Dogs

Cusick, M., Chew, E. Y., Ferris, F., Cox, T. A., Chan, C. C. & Kador, P. F., Dec 1 2003, In : Archives of Ophthalmology. 121, 12, p. 1745-1751 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Hydrogen bonding interactions between aldose reductase complexed with NADP(H) and inhibitor tolrestat studied by molecular dynamics simulations and binding assay

Lee, Y. S., Hodoscek, M., Kador, P. F. & Sugiyama, K., Feb 1 2003, In : Chemico-Biological Interactions. 143-144, p. 307-316 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2002

Aldose reductase: An aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia

Kawamura, M., Eisenhofer, G., Kopin, I. J., Kador, P. F., Lee, Y. S., Fujisawa, S. & Sato, S., Mar 18 2002, In : Autonomic Neuroscience: Basic and Clinical. 96, 2, p. 131-139 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Effect of galactose diet removal on the progression of retinal vessel changes in galactose-fed dogs

Kador, P. F., Takahashi, Y., Akagi, Y., Neuenschwander, H., Greentree, W., Lackner, P., Blessing, K. & Wyman, M., Jun 13 2002, In : Investigative Ophthalmology and Visual Science. 43, 6, p. 1916-1921 6 p.

Research output: Contribution to journalArticle

23 Scopus citations

Selective pericyte degeneration in the retinal capillaries of galactose-fed dogs results from apoptosis linked to aldose reductase-catalyzed galactitol accumulation

Murata, M., Ohta, N., Fujisawa, S., Tsai, J. Y., Sato, S., Akagi, Y., Takahashi, Y., Neuenschwander, H. & Kador, P. F., Jan 1 2002, In : Journal of Diabetes and Its Complications. 16, 5, p. 363-370 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
2001

Determination of aldose reductase activity in the eye by localized magnetic resonance spectroscopy

Lizak, M. J., Mori, K. & Kador, P. F., Jan 1 2001, In : Journal of Ocular Pharmacology and Therapeutics. 17, 5, p. 475-483 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Effect of bovine small intestine thioredoxin on aldose reductase activity

Mizoguchi, T., Maeda, I., Yagi, K. & F. Kador, P., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 609-615 7 p.

Research output: Contribution to journalArticle

Intrinsic inhibition of aldose reductase

Kador, P. F., Sun, G., Rait, V. K., Rodriguez, L., Ma, Y. & Sugiyama, K., Aug 1 2001, In : Journal of Ocular Pharmacology and Therapeutics. 17, 4, p. 373-381 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis of potential aldose reductase inhibitors based on minimal pharmacophore requirements

Schlitzer, M., Rodriguez, L. & Kador, P. F., Jun 23 2001, In : Journal of Pharmacy and Pharmacology. 53, 6, p. 831-839 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

The role of aldose reductase in sugar cataract formation: Aldose reductase plays a key role in lens epithelial cell death (apoptosis)

Murata, M., Ohta, N., Sakurai, S., Alam, S., Tsai, J. Y., Kador, P. F. & Sato, S., Jan 30 2001, In : Chemico-Biological Interactions. 130-132, p. 617-625 9 p.

Research output: Contribution to journalArticle

54 Scopus citations
2000

Isolation of a non-covalent aldose reductase-nucleotide-inhibitor complex

Sugiyama, K., Chen, Z., Lee, Y. S. & Kador, P. F., Feb 15 2000, In : Biochemical Pharmacology. 59, 4, p. 329-336 8 p.

Research output: Contribution to journalArticle

11 Scopus citations

MRI of the human eye using magnetization transfer contrast enhancement

Lizak, M. J., Datiles, M. B., Aletras, A. H., Kador, P. F. & Balaban, R. S., Nov 16 2000, In : Investigative Ophthalmology and Visual Science. 41, 12, p. 3878-3881 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats

Kador, P. F., Lee, J. W., Fujisawa, S., Blessing, K. & Lou, M. F., Apr 2000, In : Journal of Ocular Pharmacology and Therapeutics. 16, 2, p. 149-160 12 p.

Research output: Contribution to journalArticle

33 Scopus citations