Punita Dhawan, PhD

  • 2867 Citations
  • 28 h-Index
19962020

Research output per year

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Research Output

  • 2867 Citations
  • 28 h-Index
  • 36 Article
  • 13 Review article
  • 1 Conference contribution
  • 1 Comment/debate
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Article
2020

Curcumin use in ulcerative colitis: Is it ready for prime time? A systematic review and meta-analysis of clinical trials

Chandan, S., Mohan, B. P., Chandan, O. C., Ahmad, R., Challa, A., Tummala, H., Singh, S., Dhawan, P., Ponnada, S., Singh, A. B. & Adler, D. G., 2020, In : Annals of Gastroenterology. 33, 1, p. 53-58 6 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Anti-Claudin-1 Conjugated to a Near-Infrared Fluorophore Targets Colon Cancer in PDOX Mouse Models

Hollandsworth, H. M., Lwin, T. M., Amirfakhri, S., Filemoni, F., Batra, S. K., Hoffman, R. M., Dhawan, P. & Bouvet, M., Oct 2019, In : Journal of Surgical Research. 242, p. 145-150 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cocaine Induces Inflammatory Gut Milieu by Compromising the Mucosal Barrier Integrity and Altering the Gut Microbiota Colonization

Chivero, E. T., Ahmad, R., Thangaraj, A., Periyasamy, P., Kumar, B., Kroeger, E., Feng, D., Guo, M. L., Roy, S., Dhawan, P., Singh, A. B. & Buch, S., Dec 1 2019, In : Scientific reports. 9, 1, 12187.

Research output: Contribution to journalArticle

Open Access

Smad4 loss in colorectal cancer patients correlates with recurrence, loss of immune infiltrate, and chemoresistance

Wasserman, I., Lee, L. H., Ogino, S., Marco, M. R., Wu, C., Chen, X., Datta, J., Sadot, E., Szeglin, B., Guillem, J. G., Paty, P. B., Weiser, M. R., Nash, G. M., Saltz, L., Barlas, A., Manova-Todorova, K., Uppada, S. P. B., Elghouayel, A. E., Ntiamoah, P., Glickman, J. N. & 15 others, Hamada, T., Kosumi, K., Inamura, K., Chan, A. T., Nishihara, R., Cercek, A., Ganesh, K., Kemeny, N. E., Dhawan, P., Yaeger, R., Sawyers, C. L., Garcia-Aguilar, J., Giannakis, M., Shia, J. & Joshua Smith, J., 2019, In : Clinical Cancer Research. 25, 6, p. 1948-1956 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner

Gowrikumar, S., Ahmad, R., Uppada, S. B., Washington, M. K., Shi, C., Singh, A. B. & Dhawan, P., Jun 27 2019, In : Oncogene. 38, 26, p. 5321-5337 17 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling

Uppada, S. B., Gowrikumar, S., Ahmad, R., Kumar, B., Szeglin, B., Chen, X., Smith, J. J., Batra, S. K., Singh, A. B. & Dhawan, P., Aug 1 2018, In : Molecular cancer. 17, 1, 111.

Research output: Contribution to journalArticle

16 Scopus citations
2017

HDAC-4 regulates claudin-2 expression in EGFR-ERK1/2 dependent manner to regulate colonic epithelial cell differentiation

Ahmad, R., Kumar, B., Pan, K., Dhawan, P. & Singh, A. B., 2017, In : Oncotarget. 8, 50, p. 87718-87736 19 p.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling

Ahmad, R., Kumar, B., Chen, Z., Chen, X., Müller, D., Lele, S. M., Washington, M. K., Batra, S. K., Dhawan, P. & Singh, A. B., Nov 23 2017, In : Oncogene. 36, 47, p. 6592-6604 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
16 Scopus citations
2016

Claudin-1 promotes TNF-α-induced epithelial-mesenchymal transition and migration in colorectal adenocarcinoma cells

Bhat, A. A., Ahmad, R., Uppada, S. P. B., Singh, A. B. & Dhawan, P., Nov 15 2016, In : Experimental Cell Research. 349, 1, p. 119-127 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the notch effector hath1 in colorectal cancer

Pai, P., Rachagani, S., Dhawan, P., Sheinin, Y. M., Macha, M. A., Qazi, A. K., Chugh, S., Ponnusamy, M. P., Mallya, K., Pothuraju, R. & Batra, S. K., May 2016, In : Genes and Cancer. 7, 5-6, p. 154-168 15 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Claudin-7 expression induces mesenchymal to epithelial transformation (MET) to inhibit colon tumorigenesis

Bhat, A. A., Pope, J. L., Smith, J. J., Ahmad, R., Chen, X., Washington, M. K., Beauchamp, R. D., Singh, A. B. & Dhawan, P., Aug 27 2015, In : Oncogene. 34, 35, p. 4570-4580 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2014

Claudin-1 overexpression in intestinal epithelial cells enhances susceptibility to adenamatous polyposis coli-mediated colon tumorigenesis

Pope, J. L., Ahmad, R., Bhat, A. A., Washington, M. K., Singh, A. B. & Dhawan, P., Jul 6 2014, In : Molecular cancer. 13, 1, 167.

Research output: Contribution to journalArticle

42 Scopus citations

Claudin-1 regulates intestinal epithelial homeostasis through the modulation of Notch-signalling

Pope, J. L., Bhat, A. A., Sharma, A., Ahmad, R., Krishnan, M., Washington, M. K., Beauchamp, R. D., Singh, A. B. & Dhawan, P., Apr 2014, In : Gut. 63, 4, p. 622-634 13 p.

Research output: Contribution to journalArticle

70 Scopus citations

Proteogenomic analysis reveals unanticipated adaptations of colorectal tumor cells to deficiencies in DNA mismatch repair

Halvey, P. J., Wang, X., Wang, J., Bhat, A. A., Dhawan, P., Li, M., Zhang, B., Liebler, D. C. & Slebos, R. J. C., Jan 1 2014, In : Cancer Research. 74, 1, p. 387-397 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis

Ahmad, R., Chaturvedi, R., Olivares-Villagómez, D., Habib, T., Asim, M., Shivesh, P., Polk, D. B., Wilson, K. T., Washington, M. K., Van Kaer, L., Dhawan, P. & Singh, A. B., Nov 25 2014, In : Mucosal Immunology. 7, 6, p. 1340-1353 14 p.

Research output: Contribution to journalArticle

51 Scopus citations
2013

Trichostatin-A modulates claudin-1 mRNA stability through the modulation of hu antigen R and tristetraprolin in colon cancer cells

Sharma, A., Bhat, A. A., Krishnan, M., Singh, A. B. & Dhawan, P., Nov 2013, In : Carcinogenesis. 34, 11, p. 2610-2621 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2012

Caudal homeobox protein Cdx-2 cooperates with Wnt pathway to regulate claudin-1 expression in colon cancer cells

Bhat, A. A., Sharma, A., Pope, J., Krishnan, M., Washington, M. K., Singh, A. B. & Dhawan, P., Jun 15 2012, In : PloS one. 7, 6, e37174.

Research output: Contribution to journalArticle

43 Scopus citations

Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner

Singh, A. B., Sharma, A. & Dhawan, P., Dec 2012, In : Carcinogenesis. 33, 12, p. 2538-2547 10 p., bgs275.

Research output: Contribution to journalArticle

39 Scopus citations
2011

Claudin-1 up-regulates the repressor ZEB-1 to inhibit E-cadherin expression in colon cancer cells

Singh, A. B., Sharma, A., Smith, J. J., Krishnan, M., Chen, X., Eschrich, S., Washington, M. K., Yeatman, T. J., Beauchamp, R. D. & Dhawan, P., Dec 2011, In : Gastroenterology. 141, 6, p. 2140-2153 14 p.

Research output: Contribution to journalArticle

91 Scopus citations

Claudin-2 expression increases tumorigenicity of colon cancer cells: Role of epidermal growth factor receptor activation

Dhawan, P., Ahmad, R., Chaturvedi, R., Smith, J. J., Midha, R., Mittal, M. K., Krishnan, M., Chen, X., Eschrich, S., Yeatman, T. J., Harris, R. C., Washington, M. K., Wilson, K. T., Beauchamp, R. D. & Singh, A. B., Jul 21 2011, In : Oncogene. 30, 29, p. 3234-3247 14 p.

Research output: Contribution to journalArticle

80 Scopus citations
2010

HDAC inhibitors regulate claudin-1 expression in colon cancer cells through modulation of mRNA stability

Krishnan, M., Singh, A. B., Smith, J. J., Sharma, A., Chen, X., Eschrich, S., Yeatman, T. J., Beauchamp, R. D. & Dhawan, P., Jan 2010, In : Oncogene. 29, 2, p. 305-312 8 p.

Research output: Contribution to journalArticle

62 Scopus citations
2009

Soluble HB-EGF induces epithelial-to-mesenchymal transition in inner medullary collecting duct cells by upregulating Snail-2

Smith, J. P., Pozzi, A., Dhawan, P., Singh, A. B. & Harris, R. C., May 2009, In : American Journal of Physiology - Renal Physiology. 296, 5, p. F957-F965

Research output: Contribution to journalArticle

22 Scopus citations
2008

The lymphotoxin-β receptor is an upstream activator of NF-κB-mediated transcription in melanoma cells

Dhawan, P., Su, Y., Yee, M. T., Yu, Y., Baugher, P., Ellis, D. L., Sobolik-Delmaire, T., Kelley, M., Cheung, T. C., Ware, C. F. & Richmond, A., May 30 2008, In : Journal of Biological Chemistry. 283, 22, p. 15399-15408 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
2007

Juxtacrine activation of EGFR regulates claudin expression and increases transepithelial resistance

Singh, A. B., Sugimoto, K., Dhawan, P. & Harris, R. C., Nov 2007, In : American Journal of Physiology - Cell Physiology. 293, 5, p. C1660-C1668

Research output: Contribution to journalArticle

37 Scopus citations

Smad4 regulates claudin-1 expression in a transforming growth factor-β-independent manner in colon cancer cells

Shiou, S. R., Singh, A. B., Moorthy, K., Datta, P. K., Washington, M. K., Beauchamp, R. D. & Dhawan, P., Feb 15 2007, In : Cancer Research. 67, 4, p. 1571-1579 9 p.

Research output: Contribution to journalArticle

70 Scopus citations
2006

Smad4-dependent regulation of urokinase plasminogen activator secretion and RNA stability associated with invasiveness by autocrine and paracrine transforming growth factor-β

Shiou, S. R., Datta, P. K., Dhawan, P., Law, B. K., Yingling, J. M., Dixon, D. A. & Beauchamp, R. D., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 33971-33981 11 p.

Research output: Contribution to journalArticle

39 Scopus citations
2005

Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer

Dhawan, P., Singh, A. B., Deane, N. G., No, Y. R., Shiou, S. R., Schmidt, C., Neff, J., Washington, M. K. & Beauchamp, R. D., Jul 2005, In : Journal of Clinical Investigation. 115, 7, p. 1765-1776 12 p.

Research output: Contribution to journalArticle

377 Scopus citations
2002

A novel NF-κB-inducing kinase-MAPK signaling pathway up-regulates NF-κB activity in melanoma cells

Dhawan, P. & Richmond, A., Mar 8 2002, In : Journal of Biological Chemistry. 277, 10, p. 7920-7928 9 p.

Research output: Contribution to journalArticle

215 Scopus citations

Constitutive activation of Akt/protein kinase B in melanoma leads to up-regulation of nuclear factor-κB and tumor progression

Dhawan, P., Singh, A. B., Ellis, D. L. & Richmond, A., Dec 15 2002, In : Cancer Research. 62, 24, p. 7335-7342 8 p.

Research output: Contribution to journalArticle

224 Scopus citations
2001

The Role of CDP in the Negative Regulation of CXCL1 Gene Expression

Nirodi, C., Hart, J., Dhawan, P., Moon, N. S., Nepveu, A. & Richmond, A., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 26122-26131 10 p.

Research output: Contribution to journalArticle

31 Scopus citations
1999
36 Scopus citations

One-way cross-talk between p38(MAPK) and p42/44(MAPK): Inhibition of p38(MAPK) induces low density lipoprotein receptor expression through activation of the p42/44(MAPK) cascade

Singh, R. P., Dhawan, P., Golden, C., Kapoor, G. S. & Mehta, K. D., Jul 9 1999, In : Journal of Biological Chemistry. 274, 28, p. 19593-19600 8 p.

Research output: Contribution to journalArticle

148 Scopus citations
1998

Genetic complexity of the human geranylgeranyltransferase I β-subunit gene: A multigene family of pseudogenes derived from mis-spliced transcripts

Dhawan, P., Yang, E., Kumar, A. & Mehta, K. D., Mar 27 1998, In : Gene. 210, 1, p. 9-15 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
1997

Identification of essential nucleotides of the FP1 element responsible for enhancement of low density lipoprotein receptor gene transcription

Dhawan, P., Chang, R. & Mehta, K. D., Oct 15 1997, In : Nucleic acids research. 25, 20, p. 4132-4138 7 p.

Research output: Contribution to journalArticle

11 Scopus citations
1996

α-subunit of farnesyltransferase is phosphorylated in vivo: Effect of protein phosphatase-1 on enzymatic activity

Kumar, A., Beresini, M. H., Dhawan, P. & Mehta, K. D., May 15 1996, In : Biochemical and Biophysical Research Communications. 222, 2, p. 445-452 8 p.

Research output: Contribution to journalArticle

16 Scopus citations