• 6371 Citations
  • 44 h-Index
1983 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

A year-long extended release nanoformulated cabotegravir prodrug

Kulkarni, T. A., Bade, A. N., Sillman, B., Shetty, B. L. D., Wojtkiewicz, M. S., Gautam, N., Hilaire, J. R., Sravanam, S., Szlachetka, A., Lamberty, B. G., Morsey, B. M., Fox, H. S., Alnouti, Y., McMillan, J. E. M., Mosley, R. L., Meza, J., Domanico, P. L., Yue, T. Y., Moore, G., Edagwa, B. J. & 1 others, Gendelman, H. E., Aug 1 2020, In : Nature Materials. 19, 8, p. 910-920 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Neuroprotective Activities of Long-Acting Granulocyte–Macrophage Colony-Stimulating Factor (mPDM608) in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Intoxicated Mice

Olson, K. E., Namminga, K. L., Schwab, A. D., Thurston, M. J., Lu, Y., Woods, A., Lei, L., Shen, W., Wang, F., Joseph, S. B., Gendelman, H. E. & Mosley, R. L., 2020, (Accepted/In press) In : Neurotherapeutics.

Research output: Contribution to journalArticle

Rod-shape theranostic nanoparticles facilitate antiretroviral drug biodistribution and activity in human immunodeficiency virus susceptible cells and tissues

Kevadiya, B. D., Ottemann, B., Mukadam, I. Z., Castellanos, L., Sikora, K., Hilaire, J. R., Machhi, J., Herskovitz, J., Soni, D., Hasan, M., Zhang, W., Anandakumar, S., Garrison, J., McMillan, J. E., Edagwa, B., Mosley, R. L., Vachet, R. W. & Gendelman, H. E., 2020, In : Theranostics. 10, 2, p. 630-656 27 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2019

A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson’s Disease

Mosley, R. L., Lu, Y., Olson, K. E., Machhi, J., Yan, W., Namminga, K. L., Smith, J. R., Shandler, S. J. & Gendelman, H. E., Sep 18 2019, In : Frontiers in Cellular Neuroscience. 13, 421.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

Dash, P. K., Kaminski, R., Bella, R., Su, H., Mathews, S., Ahooyi, T. M., Chen, C., Mancuso, P., Sariyer, R., Ferrante, P., Donadoni, M., Robinson, J. A., Sillman, B., Lin, Z., Hilaire, J. R., Banoub, M., Elango, M., Gautam, N., Mosley, R. L., Poluektova, L. Y. & 12 others, McMillan, J. E., Bade, A. N., Gorantla, S., Sariyer, I. K., Burdo, T. H., Young, W. B., Amini, S., Gordon, J., Jacobson, J. M., Edagwa, B., Khalili, K. & Gendelman, H. E., Dec 1 2019, In : Nature communications. 10, 1, 2753.

Research output: Contribution to journalArticle

Open Access
44 Scopus citations
2018

Bioimaging predictors of rilpivirine biodistribution and antiretroviral activities

Ottemann, B. M., Helmink, A. J., Zhang, W., Mukadam, I., Woldstad, C., Hilaire, J. R., Liu, Y., McMillan, J. E. M., Edagwa, B. J., Mosley, R. L., Garrison, J. C., Kevadiya, B. D. & Gendelman, H. E., Dec 2018, In : Biomaterials. 185, p. 174-193 20 p.

Research output: Contribution to journalArticle

11 Scopus citations

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

Zhou, T., Su, H., Dash, P., Lin, Z., Dyavar Shetty, B. L., Kocher, T., Szlachetka, A., Lamberty, B., Fox, H. S., Poluektova, L., Gorantla, S., McMillan, J. E., Gautam, N., Mosley, R. L., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Jan 2018, In : Biomaterials. 151, p. 53-65 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Granulocyte-macrophage colony-stimulating factor neuroprotective activities in Alzheimer's disease mice

Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Yokoyama, I., Lee Mosley, R. & Gendelman, H. E., Jun 15 2018, In : Journal of Neuroimmunology. 319, p. 80-92 13 p.

Research output: Contribution to journalArticle

9 Scopus citations

Persistent EcoHIV infection induces nigral degeneration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

Olson, K. E., Bade, A. N., Namminga, K. L., Potash, M. J., Mosley, R. L., Poluektova, L. Y., Volsky, D. J. & Gendelman, H. E., Aug 1 2018, In : Journal of neurovirology. 24, 4, p. 398-410 13 p.

Research output: Contribution to journalArticle

3 Scopus citations

Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function

Iseka, F. M., Goetz, B. T., Mushtaq, I., An, W., Cypher, L. R., Bielecki, T. A., Tom, E. C., Arya, P., Bhattacharyya, S., Storck, M. D., Semerad, C. L., Talmadge, J. E., Mosley, R. L., Band, V. & Band, H., Jan 15 2018, In : Journal of Immunology. 200, 2, p. 483-499 17 p.

Research output: Contribution to journalArticle

3 Scopus citations
12 Scopus citations

URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer's disease

Kiyota, T., Machhi, J., Lu, Y., Dyavarshetty, B., Nemati, M., Zhang, G., Lee Mosley, R., Gelbard, H. A. & Gendelman, H. E., May 5 2018, In : Journal of Neuroinflammation. 15, 1, 137.

Research output: Contribution to journalArticle

10 Scopus citations
2017
47 Scopus citations

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

Gnanadhas, D. P., Dash, P. K., Sillman, B., Bade, A. N., Lin, Z., Palandri, D. L., Gautam, N., Alnouti, Y., Gelbard, H. A., McMillan, J. M., Mosley, R. L., Edagwa, B. J., Gendelman, H. E. & Gorantla, S., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 857-873 17 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Adaptive Immunity in Neurodegenerative and Neuropsychological Disorders

Lee Mosley, R., Dec 1 2015, In : Journal of Neuroimmune Pharmacology. 10, 4, p. 522-527 6 p.

Research output: Contribution to journalArticle

5 Scopus citations
21 Scopus citations

Cellular responses and tissue depots for nanoformulated antiretroviral therapy

Martinez-Skinner, A. L., Araínga, M. A., Puligujja, P., Palandri, D. L., Baldridge, H. M., Edagwa, B. J., McMillan, J. E. M., Mosley, R. L. & Gendelman, H. E., Dec 1 2015, In : PloS one. 10, 12, e0145966.

Research output: Contribution to journalArticle

12 Scopus citations

Granulocyte-Macrophage colony stimulating factor exerts protective and immunomodulatory effects in cortical trauma

Kelso, M. L., Elliott, B. R., Haverland, N. A., Mosley, R. L. & Gendelman, H. E., Jan 15 2015, In : Journal of Neuroimmunology. 278, p. 162-173 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pharmacodynamics of folic acid receptor targeted antiretroviral nanotherapy in HIV-1-infected humanized mice

Puligujja, P., Araínga, M., Dash, P., Palandri, D., Mosley, R. L., Gorantla, S., Poluektova, L., McMillan, J. E. & Gendelman, H. E., 2015, In : Antiviral Research. 120, 1, p. 85-88 4 p.

Research output: Contribution to journalArticle

16 Scopus citations
3 Scopus citations

Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion

Tian, C., Li, Y., Huang, Y., Wang, Y., Chen, D., Liu, J., Deng, X., Sun, L., Anderson, K., Qi, X., Li, Y., Lee Mosley, R., Chen, X., Huang, J. & Zheng, J. C., Jul 30 2015, In : Scientific reports. 5, 12622.

Research output: Contribution to journalArticle

26 Scopus citations

Selective VIP receptor agonists facilitate immune transformation for dopaminergic neuroprotection in MPTP-intoxicated mice

Olson, K. E., Kosloski-Bilek, L. M., Anderson, K. M., Diggs, B. J., Clark, B. E., Gledhill, J. M., Shandler, S. J., Mosley, R. L. & Gendelman, H. E., Dec 16 2015, In : Journal of Neuroscience. 35, 50, p. 16463-16478 16 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014

Macrophages offer a paradigm switch for CNS delivery of therapeutic proteins

Klyachko, N. L., Haney, M. J., Zhao, Y., Manickam, D. S., Mahajan, V., Suresh, P., Hingtgen, S. D., Mosley, R. L., Gendelman, H. E., Kabanov, A. V. & Batrakova, E. V., Jul 1 2014, In : Nanomedicine. 9, 9, p. 1403-1422 20 p.

Research output: Contribution to journalArticle

41 Scopus citations

Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson's disease

Heinrichs-Graham, E., Wilson, T. W., Santamaria, P. M., Heithoff, S. K., Torres-Russotto, D., Hutter-Saunders, J. A. L., Estes, K. A., Meza, J. L., Mosley, R. L. & Gendelman, H. E., 2014, In : Cerebral Cortex. 24, 10, p. 2669-2678 10 p.

Research output: Contribution to journalArticle

70 Scopus citations
2013

GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice

Kosloski, L. M., Kosmacek, E. A., Olson, K. E., Mosley, R. L. & Gendelman, H. E., Dec 15 2013, In : Journal of Neuroimmunology. 265, 1-2, p. 1-10 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Specific Transfection of Inflamed Brain by Macrophages: A New Therapeutic Strategy for Neurodegenerative Diseases

Haney, M. J., Zhao, Y., Harrison, E. B., Mahajan, V., Ahmed, S., He, Z., Suresh, P., Hingtgen, S. D., Klyachko, N. L., Mosley, R. L., Gendelman, H. E., Kabanov, A. V. & Batrakova, E. V., Apr 19 2013, In : PloS one. 8, 4, e61852.

Research output: Contribution to journalArticle

67 Scopus citations
2012

A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease

Stone, D. K., Kiyota, T., Mosley, R. L. & Gendelman, H. E., Aug 15 2012, In : Neuroscience Letters. 523, 2, p. 167-173 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Blood-borne macrophage-neural cell interactions hitchhike on endosome networks for cell-based nanozyme brain delivery

Haney, M. J., Suresh, P., Zhao, Y., Kanmogne, G. D., Kadiu, I., Sokolsky-Papkov, M., Klyachko, N. L., Mosley, R. L., Kabanov, A. V., Gendelman, H. E. & Batrakova, E. V., Jun 2012, In : Nanomedicine. 7, 6, p. 815-833 19 p.

Research output: Contribution to journalArticle

29 Scopus citations

CD4+ regulatory and effector/memory T cell subsets profile motor dysfunction in Parkinson's disease

Saunders, J. A. H., Estes, K. A., Kosloski, L. M., Allen, H. E., Dempsey, K. M., Torres-Russotto, D. R., Meza, J. L., Santamaria, P. M., Bertoni, J. M., Murman, D. L., Ali, H. H., Standaert, D. G., Mosley, R. L. & Gendelman, H. E., Dec 2012, In : Journal of Neuroimmune Pharmacology. 7, 4, p. 927-938 12 p.

Research output: Contribution to journalArticle

114 Scopus citations

Immunization strategies for Parkinson's disease

Ha, D., Stone, D. K., Mosley, R. L. & Gendelman, H. E., Jan 2012, In : Parkinsonism and Related Disorders. 18, SUPPL. 1, p. S218-S221

Research output: Contribution to journalArticle

20 Scopus citations

Inflammation and adaptive immunity in Parkinson's disease

Mosley, R. L., Hutter-Saunders, J. A., Stone, D. K. & Gendelman, H. E., Jan 2012, In : Cold Spring Harbor Perspectives in Medicine. 2, 1

Research output: Contribution to journalArticle

132 Scopus citations

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

Dash, P. K., Gendelman, H. E., Roy, U., Balkundi, S., Alnouti, Y., Mosley, R. L., Gelbard, H. A., McMillan, J., Gorantla, S. & Poluektova, L. Y., Nov 13 2012, In : AIDS. 26, 17, p. 2135-2144 10 p.

Research output: Contribution to journalArticle

81 Scopus citations
19 Scopus citations
49 Scopus citations
2011

Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages

Nowacek, A. S., Balkundi, S., McMillan, J., Roy, U., Martinez-Skinner, A., Mosley, R. L., Kanmogne, G., Kabanov, A. V., Bronich, T. & Gendelman, H. E., Mar 10 2011, In : Journal of Controlled Release. 150, 2, p. 204-211 8 p.

Research output: Contribution to journalArticle

83 Scopus citations

BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice

Hutter-Saunders, J. A. L., Kosloski, L. M., McMillan, J. M., Yotam, N., Rinat, T., Mosley, R. L. & Gendelman, H. E., Apr 28 2011, In : Neuroscience. 180, p. 293-304 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis

Gong, N., Liu, J., Reynolds, A. D., Gorantla, S., Mosley, R. L. & Gendelman, H. E., Jan 2011, In : Journal of Neuroimmunology. 230, 1-2, p. 33-41 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells

Haney, M. J., Zhao, Y., Li, S., Higginbotham, S. M., Booth, S. L., Han, H. Y., Vetro, J. A., Mosley, R. L., Kabanov, A. V., Gendelman, H. E. & Batrakova, E. V., Sep 2011, In : Nanomedicine. 6, 7, p. 1215-1230 16 p.

Research output: Contribution to journalArticle

39 Scopus citations

Comparative manufacture and cell-based delivery of antiretroviral nanoformulations.

Balkundi, S., Nowacek, A. S., Veerubhotla, R. S., Chen, H., Martinez-Skinner, A., Roy, U., Mosley, R. L., Kanmogne, G., Liu, X., Kabanov, A. V., Bronich, T., McMillan, J. E. & Gendelman, H. E., 2011, In : International journal of nanomedicine. 6, p. 3393-3404 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles

Zhao, Y., Haney, M. J., Klyachko, N. L., Li, S., Booth, S. L., Higginbotham, S. M., Jones, J., Zimmerman, M. C., Mosley, R. L., Kabanov, A. V., Gendelman, H. E. & Batrakova, E. V., Jan 2011, In : Nanomedicine. 6, 1, p. 25-42 18 p.

Research output: Contribution to journalArticle

38 Scopus citations
2010

Effects of pluronic and doxorubicin on drug uptake, cellular metabolism, apoptosis and tumor inhibition in animal models of MDR cancers

Batrakova, E. V., Li, S., Brynskikh, A. M., Sharma, A. K., Li, Y., Boska, M., Gong, N., Mosley, R. L., Alakhov, V. Y., Gendelman, H. E. & Kabanov, A. V., May 2010, In : Journal of Controlled Release. 143, 3, p. 290-301 12 p.

Research output: Contribution to journalArticle

117 Scopus citations

Macrophage delivery of therapeutic nanozymes in a murine model of Parkinsons disease

Brynskikh, A. M., Zhao, Y., Mosley, R. L., Li, S., Boska, M. D., Klyachko, N. L., Kabanov, A. V., Gendelman, H. E. & Batrakova, E. V., Apr 2010, In : Nanomedicine. 5, 3, p. 379-396 18 p.

Research output: Contribution to journalArticle

95 Scopus citations

Neuroprotective Activities of CD4+CD25+ Regulatory T Cells

Reynolds, A. D., Stone, D. K., Mosley, R. L. & Gendelman, H. E., Jan 1 2010, In : NeuroImmune Biology. 9, C, p. 197-210 14 p.

Research output: Contribution to journalArticle

Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease

Reynolds, A. D., Stone, D. K., Hutter, J. A. L., Benner, E. J., Mosley, R. L. & Gendelman, H. E., Mar 1 2010, In : Journal of Immunology. 184, 5, p. 2261-2271 11 p.

Research output: Contribution to journalArticle

215 Scopus citations
2009

Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles

Beduneau, A., Ma, Z., Grotepas, C. B., Kabanov, A., Rabinow, B. E., Gong, N., Mosley, R. L., Dou, H., Boska, M. D. & Gendelman, H. E., Feb 2 2009, In : PloS one. 4, 2, e4343.

Research output: Contribution to journalArticle

107 Scopus citations

Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration

Gendelman, H. E., Ding, S., Gong, N., Liu, J., Ramirez, S. H., Persidsky, Y., Lee Mosley, R., Wang, T., Volsky, D. J. & Xiong, H., Mar 2009, In : Journal of Neuroimmune Pharmacology. 4, 1, p. 47-59 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

NanoART synthesis, characterization, uptake, release and toxicology for human monocyte-macrophage drug delivery

Nowacek, A. S., Miller, R. L., McMillan, J. E., Kanmogne, G., Kanmogne, M., Mosley, R. L., Ma, Z., Graham, S., Chaubal, M., Werling, J., Rabinow, B., Dou, H. & Gendelman, H. E., Dec 2009, In : Nanomedicine. 4, 8, p. 903-917 15 p.

Research output: Contribution to journalArticle

88 Scopus citations

Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration

Liu, J., Gong, N., Huang, X., Reynolds, A. D., Mosley, R. L. & Gendelman, H. E., Mar 15 2009, In : Journal of Immunology. 182, 6, p. 3855-3865 11 p.

Research output: Contribution to journalArticle

66 Scopus citations

Nitrated α-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets

Reynolds, A. D., Stone, D. K., Mosley, R. L. & Gendelman, H. E., Apr 1 2009, In : Journal of Immunology. 182, 7, p. 4137-4149 13 p.

Research output: Contribution to journalArticle

124 Scopus citations

Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells

Reynolds, A. D., Stone, D. K., Mosley, R. L. & Gendelman, H. E., Jul 6 2009, In : Journal of proteome research. 8, 7, p. 3497-3511 15 p.

Research output: Contribution to journalArticle

60 Scopus citations