• 7616 Citations
  • 43 h-Index
1989 …2020

Research output per year

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Research Output

2020

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Awaji, M., Saxena, S., Wu, L., Prajapati, D. R., Purohit, A., Varney, M. L., Kumar, S., Rachagani, S., Ly, Q. P., Jain, M., Batra, S. K. & Singh, R. K., Jul 1 2020, In : FASEB Journal. 34, 7, p. 9405-9418 14 p.

Research output: Contribution to journalArticle

IL-17–CXC Chemokine Receptor 2 Axis Facilitates Breast Cancer Progression by Up-Regulating Neutrophil Recruitment

Wu, L., Awaji, M., Saxena, S., Varney, M. L., Sharma, B. & Singh, R. K., Jan 2020, In : American Journal of Pathology. 190, 1, p. 222-233 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Neutrophils in the Tumor Microenvironment

Wu, L., Saxena, S. & Singh, R. K., 2020, Advances in Experimental Medicine and Biology. Springer, p. 1-20 20 p. (Advances in Experimental Medicine and Biology; vol. 1224).

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy

Xie, Y., Hang, Y., Wang, Y., Sleightholm, R., Prajapati, D. R., Bader, J., Yu, A., Tang, W., Jaramillo, L., Li, J., Singh, R. K. & Oupický, D., Jan 28 2020, In : ACS Nano. 14, 1, p. 255-271 17 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8

Awaji, M., Futakuchi, M., Heavican, T., Iqbal, J. & Singh, R. K., Apr 1 2019, In : Cancer Microenvironment. 12, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cancer-associated fibroblasts’ functional heterogeneity in pancreatic ductal adenocarcinoma

Awaji, M. & Singh, R. K., Mar 2019, In : Cancers. 11, 3, 290.

Research output: Contribution to journalReview article

Open Access
9 Scopus citations

CXCR2: A novel mediator of mammary tumor bone metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 2019, In : International journal of molecular sciences. 20, 5, 1237.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tumor‐associated neutrophils in cancer: Going pro

Wu, L., Saxena, S., Awaji, M. & Singh, R. K., Apr 2019, In : Cancers. 11, 4, 564.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
2018

Macrophage-derived neuropilin-2 exhibits novel tumor-promoting functions

Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., Singh, R. K., Talmadge, J. E., Muders, M. H., Batra, S. K. & Datta, K., Oct 1 2018, In : Cancer Research. 78, 19, p. 5600-5617 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis

Saxena, S., Hayashi, Y., Wu, L., Awaji, M., Atri, P., Varney, M. L., Purohit, A., Rachagani, S., Batra, S. K. & Singh, R. K., 2018, In : Oncotarget. 9, 5, p. 5931-5943 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells

Saxena, S., Purohit, A., Varney, M. L., Hayashi, Y. & Singh, R. K., Dec 22 2018, In : BMC cancer. 18, 1, 1283.

Research output: Contribution to journalArticle

6 Scopus citations
2017

CXCR1/2 chemokine network regulates melanoma resistance to chemotherapies mediated by NF-κB

Wu, S., Saxena, S., Varney, M. L. & Singh, R. K., Jul 1 2017, In : Current Molecular Medicine. 17, 6, p. 436-449 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy

Sleightholm, R. L., Neilsen, B. K., Li, J., Steele, M. M., Singh, R. K., Hollingsworth, M. A. & Oupicky, D., Nov 2017, In : Pharmacology and Therapeutics. 179, p. 158-170 13 p.

Research output: Contribution to journalReview article

37 Scopus citations

Micellar delivery of miR-34a modulator rubone and paclitaxel in resistant prostate cancer

Wen, D., Peng, Y., Lin, F., Singh, R. K. & Mahato, R. I., Jun 15 2017, In : Cancer Research. 77, 12, p. 3244-3254 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Multifaceted role of neuropilins in the immune system: Potential targets for immunotherapy

Roy, S., Bag, A. K., Singh, R. K., Talmadge, J. E., Batra, S. K. & Datta, K., Oct 10 2017, In : Frontiers in immunology. 8, OCT, 1228.

Research output: Contribution to journalReview article

27 Scopus citations
2016

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Pandey, P., Sliker, B., Peters, H. L., Tuli, A., Herskovitz, J., Smits, K., Purohit, A., Singh, R. K., Dong, J., Batra, S. K., Coulter, D. W. & Solheim, J. C., Apr 12 2016, In : Oncotarget. 7, 15, p. 19430-19444 15 p.

Research output: Contribution to journalReview article

36 Scopus citations

Bioinformatics analysis to identify cell adhesion molecules in cancer

Sadanandam, A., Gibb, W. J. & Singh, R. K., Apr 19 2016, Adhesion Molecules. CRC Press, p. 309-325 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Purohit, A., Varney, M., Rachagani, S., Ouellette, M. M., Batra, S. K. & Singh, R. K., 2016, In : Oncotarget. 7, 6, p. 7280-7296 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells

Sharma, B., Varney, M. L., Saxena, S., Wu, L. & Singh, R. K., Mar 28 2016, In : Cancer Letters. 372, 2, p. 192-200 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle cell lymphoma independent of p53 status

Hassan, H. M., Varney, M. L., Chaturvedi, N. K., Joshi, S. S., Weisenburger, D. D., Singh, R. K. & Dave, B. J., Dec 1 2016, In : Leukemia and Lymphoma. 57, 12, p. 2874-2889 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells

Dodmane, P. R., Arnold, L. L., Pennington, K. L., Singh, R. K., Cardoso, A. P. F. & Cohen, S. M., May 1 2015, In : Toxicology Reports. 2, p. 833-837 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Host Cxcr2-dependent regulation of mammary tumor growth and metastasis

Sharma, B., Nannuru, K. C., Varney, M. L. & Singh, R. K., Jan 28 2015, In : Clinical and Experimental Metastasis. 32, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
14 Scopus citations

Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer

Zhu, Y., Li, J., Kanvinde, S., Lin, Z., Hazeldine, S., Singh, R. K. & Oupický, D., Feb 2 2015, In : Molecular Pharmaceutics. 12, 2, p. 332-341 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tumor microenvironment: Blood vascular system in cancer metastasis

Senapati, S., Singh, R. K. & Batra, S. K., Jan 1 2015, Systems Biology of Cancer. Cambridge University Press, p. 309-322 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2014

Disruption of chromosomal locus 1p36 differentially modulates TAp73 and Δnp73 expression in follicular lymphoma

Hassan, H. M., Varney, M. L., Jain, S., Weisenburger, D. D., Singh, R. K. & Dave, B. J., Dec 1 2014, In : Leukemia and Lymphoma. 55, 12, p. 2924-2931 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness

Jami, M. S., Hou, J., Liu, M., Varney, M. L., Hassan, H., Dong, J., Geng, L., Wang, J., Yu, F., Huang, X., Peng, H., Fu, K., Li, Y., Singh, R. K. & Ding, S. J., Mar 15 2014, In : BMC cancer. 14, 1, 194.

Research output: Contribution to journalArticle

44 Scopus citations

Semaphorin 5A mediated cellular navigation: Connecting nervous system and cancer

Purohit, A., Sadanandam, A., Myneni, P. & Singh, R. K., Dec 1 2014, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1846, 2, p. 485-493 9 p.

Research output: Contribution to journalReview article

10 Scopus citations

TP73, an under-appreciated player in non-hodgkin lymphoma pathogenesis and management

Hassan, H. M., Dave, B. J. & Singh, R. K., 2014, In : Current Molecular Medicine. 14, 4, p. 432-439 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Animal model for mammary tumor growth in the bone microenvironment

Futakuchi, M. & Singh, R. K., Jul 2013, In : Breast Cancer. 20, 3, p. 195-203 9 p.

Research output: Contribution to journalReview article

15 Scopus citations

Biomedical Applications of "Click"-Modified Cyclodextrins

Jia, Z., Singh, R. K. & Wang, D., Feb 6 2013, Click Chemistry in Glycoscience: New Developments and Strategies. John Wiley and Sons, p. 271-292 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Targeting CXCR2 enhances chemotherapeutic response, inhibits mammary tumor growth, angiogenesis, and lung metastasis

Sharma, B., Nawandar, D. M., Nannuru, K. C., Varney, M. L. & Singh, R. K., May 2013, In : Molecular cancer therapeutics. 12, 5, p. 799-808 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

The efficacy of nuclease-resistant Chol-siRNA in primary breast tumors following complexation with PLL-PEG(5K)

Ambardekar, V. V., Wakaskar, R. R., Sharma, B., Bowman, J., Vayaboury, W., Singh, R. K. & Vetro, J. A., Jul 2013, In : Biomaterials. 34, 20, p. 4839-4848 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Modulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion, and metastasis

Wu, S., Singh, S., Varney, M. L., Kindle, S. & Singh, R. K., Dec 2012, In : Cancer Medicine. 1, 3, p. 306-317 12 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

Sadanandam, A., Sidhu, S. S., Wullschleger, S., Singh, S., Varney, M. L., Yang, C. S., Ashour, A. E., Batra, S. K. & Singh, R. K., Jul 24 2012, In : British journal of cancer. 107, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
2011

A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling

Sadanandam, A., Futakuchi, M., Lyssiotis, C. A., Gibb, W. J. & Singh, R. K., Jul 20 2011, In : BMC cancer. 11, 304.

Research output: Contribution to journalArticle

10 Scopus citations

Corrigendum to "Effects of the PPAR? agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse" [Toxicol. Appl. Pharmacol. (2009) 83-90]

Kakiuchi-Kiyota, S., Vetro, J. A., Suzuki, S., Varney, M. L., Han, H. Y., Nascimento, M., Pennington, K. L., Arnold, L. L., Singh, R. K. & Cohen, S. M., Jun 15 2011, In : Toxicology and Applied Pharmacology. 253, 3, 1 p.

Research output: Contribution to journalComment/debate

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation

Singh, S., Wu, S., Varney, M., Singh, A. P. & Singh, R. K., Nov 2011, In : Microvascular Research. 82, 3, p. 318-325 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

CXCR2-dependent endothelial progenitor cell mobilization in pancreatic cancer growth

Li, A., Cheng, X. J., Moro, A., Singh, R. K., Hines, O. J. & Eibl, G., Feb 2011, In : Translational Oncology. 4, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Emerging candidates in breast cancer stem cell maintenance, therapy resistance and relapse

Sharma, B. & Singh, R., 2011, In : Journal of Carcinogenesis. 10, 36.

Research output: Contribution to journalReview article

8 Scopus citations
21 Scopus citations

Role of chemokine receptor CXCR2 expression in mammary tumor growth, angiogenesis and metastasis

Nannuru, K., Sharma, B., Varney, M. & Singh, R., 2011, In : Journal of Carcinogenesis. 10, 40.

Research output: Contribution to journalArticle

36 Scopus citations

Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases

Varney, M. L., Singh, S., Li, A., Mayer-Ezell, R., Bond, R. & Singh, R. K., Jan 28 2011, In : Cancer Letters. 300, 2, p. 180-188 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

The modification of siRNA with 3' cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes

Ambardekar, V. V., Han, H. Y., Varney, M. L., Vinogradov, S. V., Singh, R. K. & Vetro, J. A., Feb 2011, In : Biomaterials. 32, 5, p. 1404-1411 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
36 Scopus citations
2010

Cathepsin G-mediated enhanced TGF-β signaling promotes angiogenesis via upregulation of VEGF and MCP-1

Wilson, T. J., Nannuru, K. C., Futakuchi, M. & Singh, R. K., Feb 28 2010, In : Cancer Letters. 288, 2, p. 162-169 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

CXCL8 and its cognate receptors in melanoma progression and metastasis

Singh, S., Singh, A. P., Sharma, B., Owen, L. B. & Singh, R. K., 2010, In : Future Oncology. 6, 1, p. 111-116 6 p.

Research output: Contribution to journalReview article

66 Scopus citations