• 7616 Citations
  • 43 h-Index
1989 …2020

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2020

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Awaji, M., Saxena, S., Wu, L., Prajapati, D. R., Purohit, A., Varney, M. L., Kumar, S., Rachagani, S., Ly, Q. P., Jain, M., Batra, S. K. & Singh, R. K., Jul 1 2020, In : FASEB Journal. 34, 7, p. 9405-9418 14 p.

Research output: Contribution to journalArticle

IL-17–CXC Chemokine Receptor 2 Axis Facilitates Breast Cancer Progression by Up-Regulating Neutrophil Recruitment

Wu, L., Awaji, M., Saxena, S., Varney, M. L., Sharma, B. & Singh, R. K., Jan 2020, In : American Journal of Pathology. 190, 1, p. 222-233 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy

Xie, Y., Hang, Y., Wang, Y., Sleightholm, R., Prajapati, D. R., Bader, J., Yu, A., Tang, W., Jaramillo, L., Li, J., Singh, R. K. & Oupický, D., Jan 28 2020, In : ACS Nano. 14, 1, p. 255-271 17 p.

Research output: Contribution to journalArticle

4 Scopus citations
2019

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

Liu, T., Romanova, S., Wang, S., Hyun, M. A., Zhang, C., Cohen, S. M., Singh, R. K. & Bronich, T. K., Jan 1 2019, In : Molecular Pharmaceutics.

Research output: Contribution to journalArticle

Cancer-Associated Fibroblasts Enhance Survival and Progression of the Aggressive Pancreatic Tumor Via FGF-2 and CXCL8

Awaji, M., Futakuchi, M., Heavican, T., Iqbal, J. & Singh, R. K., Apr 1 2019, In : Cancer Microenvironment. 12, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

CXCR2: A novel mediator of mammary tumor bone metastasis

Sharma, B., Nannuru, K. C., Saxena, S., Varney, M. L. & Singh, R. K., Mar 2019, In : International journal of molecular sciences. 20, 5, 1237.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Tumor‐associated neutrophils in cancer: Going pro

Wu, L., Saxena, S., Awaji, M. & Singh, R. K., Apr 2019, In : Cancers. 11, 4, 564.

Research output: Contribution to journalArticle

Open Access
26 Scopus citations
2018

Macrophage-derived neuropilin-2 exhibits novel tumor-promoting functions

Roy, S., Bag, A. K., Dutta, S., Polavaram, N. S., Islam, R., Schellenburg, S., Banwait, J., Guda, C., Ran, S., Hollingsworth, M. A., Singh, R. K., Talmadge, J. E., Muders, M. H., Batra, S. K. & Datta, K., Oct 1 2018, In : Cancer Research. 78, 19, p. 5600-5617 18 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis

Saxena, S., Hayashi, Y., Wu, L., Awaji, M., Atri, P., Varney, M. L., Purohit, A., Rachagani, S., Batra, S. K. & Singh, R. K., 2018, In : Oncotarget. 9, 5, p. 5931-5943 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Semaphorin-5A maintains epithelial phenotype of malignant pancreatic cancer cells

Saxena, S., Purohit, A., Varney, M. L., Hayashi, Y. & Singh, R. K., Dec 22 2018, In : BMC cancer. 18, 1, 1283.

Research output: Contribution to journalArticle

6 Scopus citations
2017

CXCR1/2 chemokine network regulates melanoma resistance to chemotherapies mediated by NF-κB

Wu, S., Saxena, S., Varney, M. L. & Singh, R. K., Jul 1 2017, In : Current Molecular Medicine. 17, 6, p. 436-449 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Micellar delivery of miR-34a modulator rubone and paclitaxel in resistant prostate cancer

Wen, D., Peng, Y., Lin, F., Singh, R. K. & Mahato, R. I., Jun 15 2017, In : Cancer Research. 77, 12, p. 3244-3254 11 p.

Research output: Contribution to journalArticle

28 Scopus citations
2016

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Purohit, A., Varney, M., Rachagani, S., Ouellette, M. M., Batra, S. K. & Singh, R. K., 2016, In : Oncotarget. 7, 6, p. 7280-7296 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

Induction of CXCR2 ligands, stem cell-like phenotype, and metastasis in chemotherapy-resistant breast cancer cells

Sharma, B., Varney, M. L., Saxena, S., Wu, L. & Singh, R. K., Mar 28 2016, In : Cancer Letters. 372, 2, p. 192-200 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle cell lymphoma independent of p53 status

Hassan, H. M., Varney, M. L., Chaturvedi, N. K., Joshi, S. S., Weisenburger, D. D., Singh, R. K. & Dave, B. J., Dec 1 2016, In : Leukemia and Lymphoma. 57, 12, p. 2874-2889 16 p.

Research output: Contribution to journalArticle

1 Scopus citations
2015

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells

Dodmane, P. R., Arnold, L. L., Pennington, K. L., Singh, R. K., Cardoso, A. P. F. & Cohen, S. M., May 1 2015, In : Toxicology Reports. 2, p. 833-837 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Host Cxcr2-dependent regulation of mammary tumor growth and metastasis

Sharma, B., Nannuru, K. C., Varney, M. L. & Singh, R. K., Jan 28 2015, In : Clinical and Experimental Metastasis. 32, 1, p. 65-72 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
14 Scopus citations

Self-immolative polycations as gene delivery vectors and prodrugs targeting polyamine metabolism in cancer

Zhu, Y., Li, J., Kanvinde, S., Lin, Z., Hazeldine, S., Singh, R. K. & Oupický, D., Feb 2 2015, In : Molecular Pharmaceutics. 12, 2, p. 332-341 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Disruption of chromosomal locus 1p36 differentially modulates TAp73 and Δnp73 expression in follicular lymphoma

Hassan, H. M., Varney, M. L., Jain, S., Weisenburger, D. D., Singh, R. K. & Dave, B. J., Dec 1 2014, In : Leukemia and Lymphoma. 55, 12, p. 2924-2931 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness

Jami, M. S., Hou, J., Liu, M., Varney, M. L., Hassan, H., Dong, J., Geng, L., Wang, J., Yu, F., Huang, X., Peng, H., Fu, K., Li, Y., Singh, R. K. & Ding, S. J., Mar 15 2014, In : BMC cancer. 14, 1, 194.

Research output: Contribution to journalArticle

44 Scopus citations

TP73, an under-appreciated player in non-hodgkin lymphoma pathogenesis and management

Hassan, H. M., Dave, B. J. & Singh, R. K., 2014, In : Current Molecular Medicine. 14, 4, p. 432-439 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Targeting CXCR2 enhances chemotherapeutic response, inhibits mammary tumor growth, angiogenesis, and lung metastasis

Sharma, B., Nawandar, D. M., Nannuru, K. C., Varney, M. L. & Singh, R. K., May 2013, In : Molecular cancer therapeutics. 12, 5, p. 799-808 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

The efficacy of nuclease-resistant Chol-siRNA in primary breast tumors following complexation with PLL-PEG(5K)

Ambardekar, V. V., Wakaskar, R. R., Sharma, B., Bowman, J., Vayaboury, W., Singh, R. K. & Vetro, J. A., Jul 2013, In : Biomaterials. 34, 20, p. 4839-4848 10 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

Modulation of CXCL-8 expression in human melanoma cells regulates tumor growth, angiogenesis, invasion, and metastasis

Wu, S., Singh, S., Varney, M. L., Kindle, S. & Singh, R. K., Dec 2012, In : Cancer Medicine. 1, 3, p. 306-317 12 p.

Research output: Contribution to journalArticle

Open Access
31 Scopus citations

Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation

Sadanandam, A., Sidhu, S. S., Wullschleger, S., Singh, S., Varney, M. L., Yang, C. S., Ashour, A. E., Batra, S. K. & Singh, R. K., Jul 24 2012, In : British journal of cancer. 107, 3, p. 501-507 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
2011

A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling

Sadanandam, A., Futakuchi, M., Lyssiotis, C. A., Gibb, W. J. & Singh, R. K., Jul 20 2011, In : BMC cancer. 11, 304.

Research output: Contribution to journalArticle

10 Scopus citations

CXCR1 and CXCR2 silencing modulates CXCL8-dependent endothelial cell proliferation, migration and capillary-like structure formation

Singh, S., Wu, S., Varney, M., Singh, A. P. & Singh, R. K., Nov 2011, In : Microvascular Research. 82, 3, p. 318-325 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

CXCR2-dependent endothelial progenitor cell mobilization in pancreatic cancer growth

Li, A., Cheng, X. J., Moro, A., Singh, R. K., Hines, O. J. & Eibl, G., Feb 2011, In : Translational Oncology. 4, 1, p. 20-28 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
21 Scopus citations

Role of chemokine receptor CXCR2 expression in mammary tumor growth, angiogenesis and metastasis

Nannuru, K., Sharma, B., Varney, M. & Singh, R., 2011, In : Journal of Carcinogenesis. 10, 40.

Research output: Contribution to journalArticle

36 Scopus citations

Small molecule antagonists for CXCR2 and CXCR1 inhibit human colon cancer liver metastases

Varney, M. L., Singh, S., Li, A., Mayer-Ezell, R., Bond, R. & Singh, R. K., Jan 28 2011, In : Cancer Letters. 300, 2, p. 180-188 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

The modification of siRNA with 3' cholesterol to increase nuclease protection and suppression of native mRNA by select siRNA polyplexes

Ambardekar, V. V., Han, H. Y., Varney, M. L., Vinogradov, S. V., Singh, R. K. & Vetro, J. A., Feb 2011, In : Biomaterials. 32, 5, p. 1404-1411 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
36 Scopus citations
2010

Cathepsin G-mediated enhanced TGF-β signaling promotes angiogenesis via upregulation of VEGF and MCP-1

Wilson, T. J., Nannuru, K. C., Futakuchi, M. & Singh, R. K., Feb 28 2010, In : Cancer Letters. 288, 2, p. 162-169 8 p.

Research output: Contribution to journalArticle

47 Scopus citations

Generation of high-affinity fully human anti-interleukin-8 antibodies from its cDNA by two-hybrid screening and affinity maturation in yeast

Ding, L., Azam, M., Lin, Y. H., Sheridan, J., Wei, S., Gupta, G., Singh, R. K., Pauling, M. H., Chu, W., Tran, A., Yu, N. X., Hu, J., Wang, W., Long, H., Xiang, D., Zhu, L. & Hua, S. B., Oct 2010, In : Protein Science. 19, 10, p. 1957-1966 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis

Sadanandam, A., Varney, M. L., Singh, S., Ashour, A. E., Moniaux, N., Deb, S., Lele, S. M., Batra, S. K. & Singh, R. K., Sep 1 2010, In : International Journal of Cancer. 127, 6, p. 1373-1383 11 p.

Research output: Contribution to journalArticle

45 Scopus citations

Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and transforming growth factor-β signaling at the tumor-bone interface

Nannuru, K. C., Futakuchi, M., Varney, M. L., Vincent, T. M., Marcusson, E. G. & Singh, R. K., May 1 2010, In : Cancer Research. 70, 9, p. 3494-3504 11 p.

Research output: Contribution to journalArticle

79 Scopus citations

Multifunctional peptide-PEG intercalating conjugates: Programmatic of gene delivery to the blood-brain barrier

Zhang, H., Gerson, T., Varney, M. L., Singh, R. K. & Vinogradov, S. V., Dec 2010, In : Pharmaceutical Research. 27, 12, p. 2528-2543 16 p.

Research output: Contribution to journalArticle

21 Scopus citations

Myeloid-derived suppressor cells in mammary tumor progression in FVB Neu transgenic mice

Abe, F., Dafferner, A. J., Donkor, M., Westphal, S. N., Scholar, E. M., Solheim, J. C., Singh, R. K., Hoke, T. A. & Talmadge, J. E., Jan 2010, In : Cancer Immunology, Immunotherapy. 59, 1, p. 47-62 16 p.

Research output: Contribution to journalArticle

41 Scopus citations

Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway

Senapati, S., Rachagani, S., Chaudhary, K., Johansson, S. L., Singh, R. K. & Batra, S. K., Mar 2010, In : Oncogene. 29, 9, p. 1293-1302 10 p.

Research output: Contribution to journalArticle

84 Scopus citations

Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis

Sadanandam, A., Rosenbaugh, E. G., Singh, S., Varney, M. & Singh, R. K., Jan 2010, In : Microvascular Research. 79, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

59 Scopus citations

Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion

Singh, S., Sadanandam, A., Varney, M. L., Nannuru, K. C. & Singh, R. K., Jan 15 2010, In : International Journal of Cancer. 126, 2, p. 328-336 9 p.

Research output: Contribution to journalArticle

42 Scopus citations
2009
39 Scopus citations

Cathepsin G recruits osteoclast precursors via proteolytic activation of protease-activated receptor-1

Wilson, T. J., Nannuru, K. C. & Singh, R. K., Apr 1 2009, In : Cancer Research. 69, 7, p. 3188-3195 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion

Singh, S., Nannuru, K. C., Sadanandam, A., Varney, M. L. & Singh, R. K., May 19 2009, In : British journal of cancer. 100, 10, p. 1638-1646 9 p.

Research output: Contribution to journalArticle

80 Scopus citations

Effects of the PPARγ agonist troglitazone on endothelial cells in vivo and in vitro: Differences between human and mouse

Kakiuchi-Kiyota, S., Vetro, J. A., Suzuki, S., Varney, M. L., Han, H. Y., Nascimento, M., Pennington, K. L., Arnold, L. L., Singh, R. K. & Cohen, S. M., May 15 2009, In : Toxicology and Applied Pharmacology. 237, 1, p. 83-90 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Enhanced expression and shedding of receptor activator of NF-κB ligand during tumor-bone interaction potentiates mammary tumor-induced osteolysis

Nannuru, K. C., Futakuchi, M., Sadanandam, A., Wilson, T. J., Varney, M. L., Myers, K. J., Li, X., Marcusson, E. G. & Singh, R. K., Oct 2009, In : Clinical and Experimental Metastasis. 26, 7, p. 797-808 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis

Singh, S., Varney, M. & Singh, R. K., Jan 15 2009, In : Cancer Research. 69, 2, p. 411-415 5 p.

Research output: Contribution to journalArticle

90 Scopus citations