Raul G Barletta, PhD

  • 4466 Citations
  • 29 h-Index
1981 …2020

Research output per year

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Research Output

  • 4466 Citations
  • 29 h-Index
  • 62 Article
  • 8 Review article
  • 5 Chapter
2020

Elucidating the Regulon of a Fur-like Protein in Mycobacterium avium subsp. paratuberculosis (MAP)

Shoyama, F. M., Janetanakit, T., Bannantine, J. P., Barletta, R. G. & Sreevatsan, S., Apr 23 2020, In : Frontiers in Microbiology. 11, 598.

Research output: Contribution to journalArticle

Open Access
2019

Novel amphiphilic cyclobutene and cyclobutane cis-C18 fatty acid derivatives inhibit Mycobacterium avium subsp. paratuberculosis growth

Zinniel, D. K., Sittiwong, W., Marshall, D. D., Rathnaiah, G., Sakallioglu, I. T., Powers, R., Dussault, P. H. & Barletta, R. G., Jun 1 2019, In : Veterinary Sciences. 6, 2, 46.

Research output: Contribution to journalArticle

Open Access

Transposon Mutagenesis in Mycobacterium avium Subspecies Paratuberculosis

Bannantine, J. P., Zinniel, D. K. & Barletta, R. G., Jan 1 2019, Methods in Molecular Biology. Humana Press Inc., p. 117-125 9 p. (Methods in Molecular Biology; vol. 2016).

Research output: Chapter in Book/Report/Conference proceedingChapter

2018

The pathogenicity of Aspergillus fumigatus, drug resistance, and nanoparticle delivery

Szalewski, D. A., Hinrichs, V. S., Zinniel, D. K. & Barletta, R. G., Jan 1 2018, In : Canadian journal of microbiology. 64, 7, p. 439-453 15 p.

Research output: Contribution to journalReview article

4 Scopus citations
2017

Assessment of Metabolic Changes in Mycobacterium smegmatis Wild-Type and alr Mutant Strains: Evidence of a New Pathway of d -Alanine Biosynthesis

Marshall, D. D., Halouska, S., Zinniel, D. K., Fenton, R. J., Kenealy, K., Chahal, H. K., Rathnaiah, G., Barletta, R. G. & Powers, R., Mar 3 2017, In : Journal of proteome research. 16, 3, p. 1270-1279 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Pathogenesis, molecular genetics, and genomics of Mycobacterium avium subsp. paratuberculosis, the etiologic agent of Johne's disease

Rathnaiah, G., Zinniel, D. K., Bannantine, J. P., Stabel, J. R., Gröhn, Y. T., Collins, M. T. & Barletta, R. G., Nov 6 2017, In : Frontiers in Veterinary Science. 4, NOV, 187.

Research output: Contribution to journalReview article

17 Scopus citations
2016

Analysis of mycobacterium avium subsp. Paratuberculosis mutant libraries reveals loci-dependent transposition biases and strategies for novel mutant discovery

Rathnaiah, G., Bannantine, J. P., Bayles, D. O., Zinniel, D. K., Stabel, J. R., Gröhn, Y. T. & Barletta, R. G., Apr 2016, In : Microbiology (United Kingdom). 162, 4, p. 633-641 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Whole genomic sequence analysis of Bacillus infantis: Defining the genetic blueprint of strain NRRL B-14911, an emerging cardiopathogenic microbe

Massilamany, C., Mohammed, A., Loy, J. D., Purvis, T., Krishnan, B., Basavalingappa, R. H., Kelley, C. M., Guda, C., Barletta, R. G., Moriyama, E. N., Smith, T. P. L. & Reddy, J., Aug 22 2016, In : BMC genomics. 17, 511.

Research output: Contribution to journalArticle

5 Scopus citations
2014

Development of cyclobutene- and cyclobutane-functionalized fatty acids with inhibitory activity against mycobacterium tuberculosis

Sittiwong, W., Zinniel, D. K., Fenton, R. J., Marshall, D. D., Story, C. B., Kim, B., Lee, J. Y., Powers, R., Barletta, R. G. & Dussault, P. H., Aug 2014, In : ChemMedChem. 9, 8, p. 1838-1849 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Evaluation of eight live attenuated vaccine candidates for protection against challenge with virulent Mycobacterium avium subspecies paratuberculosis in mice

Bannantine, J. P., Everman, J. L., Rose, S. J., Babrak, L., Katani, R., Barletta, R. G., Talaat, A. M., Gröhn, Y. T., Chang, Y. F., Kapur, V. & Bermudez, L. E., Jan 1 2014, In : Frontiers in Cellular and Infection Microbiology. 4, JUL, 88.

Research output: Contribution to journalArticle

17 Scopus citations

Evaluation of novel oral vaccine candidates and validation of a caprine model of Johne's disease

Hines, M. E., Turnquist, S. E., Ilha, M. R. S., Rajeev, S., Jones, A. L., Whittington, L., Bannantine, J. P., Barletta, R. G., Gröhn, Y. T., Katani, R., Talaat, A. M., Li, L. & Kapur, V., Jan 1 2014, In : Frontiers in Cellular and Infection Microbiology. 5, MAR, Article 26.

Research output: Contribution to journalArticle

30 Scopus citations

Generation and screening of a comprehensive Mycobacterium avium subsp. paratuberculosis transposon mutant bank

Rathnaiah, G., Lamont, E. A., Harris, N. B., Fenton, R. J., Zinniel, D. K., Liu, X., Sotos, J., Feng, Z., Livneh-Kol, A., Shpigel, N. Y., Czuprynski, C. J., Sreevatsan, S. & Barletta, R. G., Apr 2014, In : Frontiers in Cellular and Infection Microbiology. 4, 144.

Research output: Contribution to journalArticle

9 Scopus citations

Metabolomics analysis identifies d-alanine-d-alanine ligase as the primary lethal target of d-cycloserine in mycobacteria

Halouska, S., Fenton, R. J., Zinniel, D. K., Marshall, D. D., Barletta, R. G. & Powers, R., Feb 7 2014, In : Journal of proteome research. 13, 2, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pathogenesis of tuberculosis caused by Mycobacterium bovis

Thoen, C. O. & Barletta, R. G., May 5 2014, Zoonotic Tuberculosis: Mycobacterium bovis and Other Pathogenic Mycobacteria: 3rd Edition. Wiley-Blackwell, p. 51-62 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Rational framework for evaluating the next generation of vaccines against mycobacterium avium subspecies paratuberculosis

Bannantine, J. P., Hines, M. E., Bermudez, L. E., Talaat, A. M., Sreevatsan, S., Stabel, J. R., Chang, Y. F., Coussens, P. M., Barletta, R. G., Davis, W. C., Collins, D. M., Gro¨hn, Y. T. & Kapur, V., Jan 1 2014, In : Frontiers in Cellular and Infection Microbiology. 4, SEP, Article 126.

Research output: Contribution to journalReview article

21 Scopus citations
2013

Molecular analysis of the Mycobacterium tuberculosis lux-like mel2 operon

Janagama, H. K., Tounkang, S., Cirillo, S. L. G., Zinniel, D. K., Barletta, R. G. & Cirillo, J. D., Dec 1 2013, In : Tuberculosis. 93, SUPPL., p. S83-S87

Research output: Contribution to journalArticle

6 Scopus citations

Revisiting protocols for the NMR analysis of bacterial metabolomes

Halouska, S., Zhang, B., Gaupp, R., Lei, S., Snell, E., Fenton, R. J., Barletta, R. G., Somerville, G. A. & Powers, R., Dec 2013, In : Journal of Integrated OMICS. 3, 2, p. 120-137 18 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

Predicting the in vivo mechanism of action for drug leads using NMR metabolomics

Halouska, S., Fenton, R. J., Barletta, R. G. & Powers, R., Jan 20 2012, In : ACS chemical biology. 7, 1, p. 166-171 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Preparation of D-cycloserine and 13C-labeled D-cycloserine

Thacker, N. C., Molnár-Tóth, J., Miska, J. L., Barletta, R. G. & Takacs, J. M., Dec 1 2012, In : Heterocycles. 86, 2, p. 1575-1582 8 p.

Research output: Contribution to journalArticle

Sample preparation of mycobacterium tuberculosis extracts for nuclear magnetic resonance metabolomic studies

Zinniel, D. K., Fenton, R. J., Halouska, S., Powers, R. & Barletta, R. G., Sep 3 2012, In : Journal of Visualized Experiments. 67

Research output: Contribution to journalArticle

3 Scopus citations
2011

Characterization of the Mycobacterium avium subsp. paratuberculosis laminin-binding/histone-like protein (Lbp/Hlp) which reacts with sera from patients with Crohn's disease

Lefrançois, L. H., Pujol, C., Bodier, C. C., Teixeira-Gomez, A. P., Drobecq, H., Rosso, M. L., Raze, D., Dias, A. A., Hugot, J. P., Chacon, O., Barletta, R. G., Locht, C., Vidal Pessolani, M. C. & Biet, F., Jun 1 2011, In : Microbes and Infection. 13, 6, p. 585-594 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Immunogenicity and reactivity of novel Mycobacterium avium subsp. paratuberculosis PPE MAP1152 and conserved MAP1156 proteins with sera from experimentally and naturally infected animals

Bannantine, J. P., Paulson, A. L., Chacon, O., Fenton, R. J., Zinniel, D. K., McVey, D. S., Smith, D. R., Czuprynski, C. J. & Barletta, R. G., Jan 1 2011, In : Clinical and Vaccine Immunology. 18, 1, p. 105-112 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine

Bruning, J. B., Murillo, A. C., Chacon, O., Barletta, R. G. & Sacchettini, J. C., Jan 1 2011, In : Antimicrobial Agents and Chemotherapy. 55, 1, p. 291-301 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
2010

Molecular genetics of mycobacterium avium subsp. paratuberculosis

Chacon, O. & Barletta, R. G., Jan 29 2010, Paratuberculosis: Organism, Disease, Control. CABI Publishing, p. 83-93 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Mycobacterium

Olsen, I., Barletta, R. G. & Thoen, C. O., May 12 2010, Pathogenesis of Bacterial Infections in Animals: Fourth Edition. Wiley-Blackwell, p. 113-132 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations
33 Scopus citations
2009

A kinetic study of in vitro lysis of mycobacterium smegmatis

Valente, W. J., Pienaar, E., Fast, A., Fluitt, A., Whitney, S. E., Fenton, R. J., Barletta, R. G., Chacon, O. & Viljoen, H. J., May 1 2009, In : Chemical Engineering Science. 64, 9, p. 1944-1952 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
5 Scopus citations

Impairment of D-Alanine biosynthesis in Mycobacterium smegmatis determines decreased intracellular survival in human macrophages

Chacon, O., Bermudez, L. E., Zinniel, D. K., Chahal, H. K., Fenton, R. J., Feng, Z., Hanford, K., Adams, L. G. & Barletta, R. G., Aug 10 2009, In : Microbiology. 155, 5, p. 1440-1450 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

Demonstration of allelic exchange in the slow-growing bacterium Mycobacterium avium subsp. paratuberculosis, and generation of mutants with deletions at the pknG, relA, and lsr2 loci

Kun, T. P., Dahl, J. L., Bannantine, J. P., Barletta, R. G., Ahn, J., Allen, A. J., Hamilton, M. J. & Davis, W. C., Mar 1 2008, In : Applied and environmental microbiology. 74, 6, p. 1687-1695 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genetic resistance of mice to Mycobacterium paratuberculosis is influenced by Slc11a1 at the early but not at the late stage of infection

Roupie, V., Rosseels, V., Piersoel, V., Zinniel, D. K., Barletta, R. G. & Huygen, K., May 1 2008, In : Infection and immunity. 76, 5, p. 2099-2105 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Pathogenesis of Mycobacterium Bovis

Thoen, C. O. & Barletta, R. G., Jan 28 2008, Mycobacterium Bovis Infection in Animals and Humans: Second Edition. Blackwell Publishing Ltd, p. 18-33 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Plasmid transformation and expression of the firefly luciferase in Microbacterium testaceum type and endophytic colonizing field strains

Zinniel, D. K., Feng, Z., Blum, P. H., Barletta, R. G. & Vidaver, A. K., Nov 1 2008, In : Canadian journal of microbiology. 54, 11, p. 964-970 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2007

Extracellular ATP is cytotoxic to mononuclear phagocytes but does not induce killing of intracellular Mycobacterium avium subsp. paratuberculosis

Woo, S. R., Barletta, R. G. & Czuprynski, C. J., Sep 1 2007, In : Clinical and Vaccine Immunology. 14, 9, p. 1078-1083 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Life and death in bovine monocytes: The fate of Mycobacterium avium subsp. paratuberculosis

Woo, S. R., Heintz, J. A., Albrecht, R., Barletta, R. G. & Czuprynski, C. J., Aug 1 2007, In : Microbial Pathogenesis. 43, 2, p. 106-113 8 p.

Research output: Contribution to journalArticle

28 Scopus citations

Use of NMR metabolomics to analyze the targets of D-cycloserine in mycobacteria: Role of D-alanine racemase

Halouska, S., Chacon, O., Fenton, R. J., Zinniel, D. K., Barletta, R. G. & Powers, R., Dec 1 2007, In : Journal of proteome research. 6, 12, p. 4608-4614 7 p.

Research output: Contribution to journalArticle

58 Scopus citations
2006

Bovine monocytes and a macrophage cell line differ in their ability to phagocytose and support the intracellular survival of Mycobacterium avium subsp. paratuberculosis

Woo, S. R., Sotos, J., Hart, A. P., Barletta, R. G. & Czuprynski, C. J., Mar 15 2006, In : Veterinary Immunology and Immunopathology. 110, 1-2, p. 109-120 12 p.

Research output: Contribution to journalArticle

27 Scopus citations

Development of luminescent Mycobacterium avium subsp. paratuberculosis for rapid screening of vaccine candidates in mice

Rosseeis, V., Roupie, V., Zinniel, D., Barletta, R. G. & Huygen, K., Jun 1 2006, In : Infection and immunity. 74, 6, p. 3684-3686 3 p.

Research output: Contribution to journalArticle

21 Scopus citations
2004

Application of the genome sequence to address concerns that Mycobacterium avium subspecies paratuberculosis might be a foodborne pathogen.

Bannantine, J. P., Barletta, R. G., Stabel, J. R., Paustian, M. L. & Kapur, V., Jan 1 2004, In : Foodborne pathogens and disease. 1, 1, p. 3-15 13 p.

Research output: Contribution to journalReview article

18 Scopus citations

Immune response of pigs inoculated with Mycobacterium bovis BCG expressing a truncated form of GP5 and M protein of porcine reproductive and respiratory syndrome virus

Bastos, R. G., Dellagostin, O. A., Barletta, R. G., Doster, A. R., Nelson, E., Zuckermann, F. & Osorio, F. A., Jan 2 2004, In : Vaccine. 22, 3-4, p. 467-474 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Inactivación de genes de Mycobacterium tuberculosis y su potencial utilidad en la prevención y el control de la tuberculosis.

Translated title of the contribution: Gene inactivation in Mycobacterium tuberculosis and its use in tuberculosis control and preventionChacón, O., Realpe, T., Barletta, R. G. & Robledo, J., Jun 2004, In : Biomédica : revista del Instituto Nacional de Salud. 24 Supp 1, p. 165-187 23 p.

Research output: Contribution to journalReview article

Johne's disease, inflammatory bowel disease, and Mycobacterium paratuberculosis

Chacon, O., Bermudez, L. E. & Barletta, R. G., Dec 7 2004, In : Annual Review of Microbiology. 58, p. 329-363 35 p.

Research output: Contribution to journalReview article

194 Scopus citations
2003

B-Cell Epitopes in the Immunodominant p34 Antigen of Mycobacterium avium ssp. paratuberculosis Recognized by Antibodies from Infected Cattle

Ostrowski, M., Mundo, S. L., Harris, N. B., Barletta, R. G. & Lopez, O. J., Nov 1 2003, In : Scandinavian Journal of Immunology. 58, 5, p. 511-521 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
100 Scopus citations
2002

Antigenicity of Mycobacterium paratuberculosis superoxide dismutase in mice

Mullerad, J., Hovav, A. H., Fishman, Y., Barletta, R. G. & Bercovier, H., Sep 6 2002, In : FEMS Immunology and Medical Microbiology. 34, 1, p. 81-88 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cell sorting of formalin treated pathogenic Mycobacterium paratuberculosis expressing GFP

Harris, N. B., Zinniel, D. K., Hsieh, M. K., Cirillo, J. D. & Barletta, R. G., Mar 20 2002, In : BioTechniques. 32, 3, p. 522-527 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Construction and immunogenicity of recombinant Mycobacterium bovis BCG expressing GP5 and M protein of porcine reproductive respiratory syndrome virus

Bastos, R. G., Dellagostin, O. A., Barletta, R. G., Doster, A. R., Nelson, E. & Osorio, F. A., Nov 22 2002, In : Vaccine. 21, 1-2, p. 21-29 9 p.

Research output: Contribution to journalArticle

56 Scopus citations

Isolation and characterization of endophytic colonizing bacteria from agronomic crops and prairie plants

Zinniel, D. K., Lambrecht, P., Harris, N. B., Feng, Z., Kuczmarski, D., Higley, P., Ishimaru, C. A., Arunakumari, A., Barletta, R. G. & Vidaver, A. K., May 18 2002, In : Applied and environmental microbiology. 68, 5, p. 2198-2208 11 p.

Research output: Contribution to journalArticle

307 Scopus citations

Killing of Mycobacterium avium and Mycobacterium tuberculosis by a mycobacteriophage delivered by a nonvirulent Mycobacterium: A model for phage therapy of intracellular bacterial pathogens

Broxmeyer, L., Sosnowska, D., Miltner, E., Chacoón, O., Wagner, D., Mc Garvey, J., Barletta, R. G. & Bermudez, L. E., Oct 15 2002, In : Journal of Infectious Diseases. 186, 8, p. 1155-1160 6 p.

Research output: Contribution to journalArticle

87 Scopus citations

Molecular cloning, sequencing, and characterization of bovine transporter associated with antigen processing 2 (BoTAP2)

Ambagala, A. P. N., Feng, Z., Barletta, R. G. & Srikumaran, S., May 20 2002, In : Immunogenetics. 54, 1, p. 30-38 9 p.

Research output: Contribution to journalArticle

7 Scopus citations