Richard A Reinhardt, DDS, PhD

  • 4001 Citations
  • 35 h-Index
1977 …2020

Research output per year

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Research Output

  • 4001 Citations
  • 35 h-Index
  • 127 Article
  • 6 Review article
  • 2 Conference contribution
  • 1 Conference article
2020

Dual Delivery of Alendronate and E7-BMP-2 Peptide via Calcium Chelation to Mineralized Nanofiber Fragments for Alveolar Bone Regeneration

Boda, S. K., Wang, H., John, J. V., Reinhardt, R. A. & Xie, J., Apr 13 2020, In : ACS Biomaterials Science and Engineering. 6, 4, p. 2368-2375 8 p.

Research output: Contribution to journalArticle

Engineering Biomimetic Nanofiber Microspheres with Tailored Size, Predesigned Structure, and Desired Composition via Gas Bubble–Mediated Coaxial Electrospray

John, J. V., McCarthy, A., Wang, H., Chen, S., Su, Y., Davis, E., Li, X., Park, J. S., Reinhardt, R. A. & Xie, J., May 1 2020, In : Small. 16, 19, 1907393.

Research output: Contribution to journalArticle

1 Scopus citations

GSK3 inhibitor-loaded osteotropic Pluronic hydrogel effectively mitigates periodontal tissue damage associated with experimental periodontitis

Almoshari, Y., Ren, R., Zhang, H., Jia, Z., Wei, X., Chen, N., Li, G., Ryu, S., Lele, S. M., Reinhardt, R. A. & Wang, D., Dec 2020, In : Biomaterials. 261, 120293.

Research output: Contribution to journalArticle

2019

Impact of modifiable risk factors on bone loss during periodontal maintenance

Cui, X., Monacelli, E., Killeen, A. C., Samson, K. & Reinhardt, R. A., 2019, In : Operative dentistry. 44, 3, p. 254-261 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mineralized nanofiber segments coupled with calcium-binding BMP-2 peptides for alveolar bone regeneration

Boda, S. K., Almoshari, Y., Wang, H., Wang, X., Reinhardt, R. A., Duan, B., Wang, D. & Xie, J., Feb 2019, In : Acta Biomaterialia. 85, p. 282-293 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Mineralized short nanofibers coupled with BMP-2 peptides for alveolar bone regeneration

Xie, J., Boda, S. K., Wang, H., Wang, D. & Reinhardt, R. A., 2019, Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting. Society for Biomaterials, p. 485 1 p. (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; vol. 40).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Tethering peptides onto biomimetic and injectable nanofiber microspheres to direct cellular response

John, J. V., Choksi, M., Chen, S., Boda, S. K., Su, Y., McCarthy, A., Teusink, M. J., Reinhardt, R. A. & Xie, J., Nov 2019, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 22, 102081.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis

Wang, X., Jia, Z., Almoshari, Y., Lele, S. M., Reinhardt, R. A. & Wang, D., Aug 1 2018, In : Pharmaceutical Research. 35, 8, 164.

Research output: Contribution to journalArticle

4 Scopus citations

Two-Year Randomized Clinical Trial of Adjunctive Minocycline Microspheres in Periodontal Maintenance

Killeen, A. C., Harn, J. A., Jensen, J., Yu, F., Custer, S. & Reinhardt, R. A., Aug 1 2018, In : Journal of dental hygiene : JDH. 92, 4, p. 51-58 8 p.

Research output: Contribution to journalArticle

2 Scopus citations
2017

Standardized rat model testing effects of inflammation and grafting on extraction healing

Willett, E. S., Liu, J., Berke, M., Giannini, P. J., Schmid, M., Jia, Z., Wang, X., Wang, X., Samson, K., Yu, F., Wang, D., Nawshad, A. & Reinhardt, R. A., Aug 2017, In : Journal of periodontology. 88, 8, p. 799-807 9 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Effect of simvastatin prodrug on experimental periodontitis

Bradley, A. D., Zhang, Y., Jia, Z., Zhao, G., Wang, X., Pranke, L., Schmid, M. J., Wang, D. & Reinhardt, R. A., May 2016, In : Journal of periodontology. 87, 5, p. 577-582 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Local minocycline effect on inflammation and clinical attachment during periodontal maintenance: Randomized clinical trial

Killeen, A. C., Harn, J. A., Erickson, L. M., Yu, F. & Reinhardt, R. A., Oct 2016, In : Journal of periodontology. 87, 10, p. 1149-1157 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015

Adjunctive non-surgical therapy of inflamed periodontal pockets during maintenance therapy using diode laser: A randomized clinical trial

Nguyen, N. T., Byarlay, M. R., Reinhardt, R. A., Marx, D. B., Meinberg, T. A. & Kaldahl, W. B., Oct 1 2015, In : Journal of periodontology. 86, 10, p. 1133-1140 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Do Mobility and Occlusal Trauma Impact Periodontal Longevity?

Reinhardt, R. A. & Killeen, A. C., Oct 1 2015, In : Dental clinics of North America. 59, 4, p. 873-883 11 p.

Research output: Contribution to journalReview article

5 Scopus citations

Effect of dexamethasone prodrug on inflamed temporomandibular joints in juvenile rats

Knudsen, M., Bury, M., Holwegner, C., Reinhardt, A. L., Yuan, F., Zhang, Y., Giannini, P., Marx, D. B., Wang, D. & Reinhardt, R. A., Sep 24 2015, In : Arthritis Research and Therapy. 17, 1, 267.

Research output: Contribution to journalArticle

3 Scopus citations
9 Scopus citations
2014

Statins, bone metabolism and treatment of bone catabolic diseases

Zhang, Y., Bradley, A. D., Wang, D. & Reinhardt, R. A., Aug 19 2014, In : Pharmacological Research. 88, p. 53-61 9 p.

Research output: Contribution to journalReview article

44 Scopus citations

The development of drug-free therapy for prevention of dental caries

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2014, In : Pharmaceutical Research. 31, 11, p. 3031-3037 7 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Effect of simvastatin injections on temporomandibular joint inflammation in growing rats

George, M. D., Owen, C. M., Reinhardt, A. L., Giannini, P. J., Marx, D. B. & Reinhardt, R. A., May 2013, In : Journal of Oral and Maxillofacial Surgery. 71, 5, p. 846-853 8 p.

Research output: Contribution to journalArticle

13 Scopus citations

Effects of local simvastatin-alendronate conjugate in preventing periodontitis bone loss

Price, U., Le, H. O. T., Powell, S. E., Schmid, M. J., Marx, D. B., Zhang, Y., Wang, D., Narayana, N. & Reinhardt, R. A., Oct 2013, In : Journal of Periodontal Research. 48, 5, p. 541-548 8 p.

Research output: Contribution to journalArticle

24 Scopus citations

The development of dentotropic micelles with biodegradable tooth-binding moieties

Chen, F., Jia, Z., Rice, K. C., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2013, In : Pharmaceutical Research. 30, 11, p. 2808-2817 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Impact of local and systemic alendronate on simvastatin-induced new bone around periodontal defects

Killeen, A. C., Rakes, P. A., Schmid, M. J., Zhang, Y., Narayana, N., Marx, D. B., Payne, J. B., Wang, D. & Reinhardt, R. A., Dec 2012, In : Journal of periodontology. 83, 12, p. 1463-1471 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011

Efficacy of structurally diverse aldose reductase inhibitors on experimental periodontitis in rats

Kador, P. F., O'Meara, J. D., Blessing, K., Marx, D. B. & Reinhardt, R. A., Jun 2011, In : Journal of periodontology. 82, 6, p. 926-933 8 p.

Research output: Contribution to journalArticle

22 Scopus citations

Role of prostaglandin pathway and alendronate-based carriers to enhance statin-induced bone

Lee, Y., Liu, X., Nawshad, A., Marx, D. B., Wang, D. & Reinhardt, R. A., Aug 1 2011, In : Molecular Pharmaceutics. 8, 4, p. 1035-1042 8 p.

Research output: Contribution to journalReview article

10 Scopus citations

Serum bone biomarkers and oral/systemic bone loss in humans

Payne, J. B., Stoner, J. A., Lee, H. M., Nummikoski, P. V., Reinhardt, R. A. & Golub, L. M., Jun 2011, In : Journal of Dental Research. 90, 6, p. 747-751 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Simvastatin application to augment facial jaw bone in a dog model: Pilot study

Rutledge, J., Schieber, M. D., Chamberlain, J. M., Byarlay, M., Killeen, A. C., Giannini, P. J., Marx, D. B. & Reinhardt, R. A., Apr 2011, In : Journal of periodontology. 82, 4, p. 597-605 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

The effect of subantimicrobial-dosedoxycycline periodontal therapy on serum biomarkers of systemic inflammation: A randomized, double-masked, placebo-controlled clinical trial

Payne, J. B., Golub, L. M., Stoner, J. A., Lee, H. M., Reinhardt, R. A., Sorsa, T. & Slepian, M. J., Mar 2011, In : Journal of the American Dental Association. 142, 3, p. 262-273 12 p.

Research output: Contribution to journalArticle

54 Scopus citations
2010

Association of gingival crevicular fluid biomarkers during periodontal maintenance with subsequent progressive periodontitis

Reinhardt, R. A., Stoner, J. A., Golub, L. M., Lee, H. M., Nummikoski, P. V., Sorsa, T. & Payne, J. B., Feb 2010, In : Journal of periodontology. 81, 2, p. 251-259 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Doxycycline effects on serum bone biomarkers in post-menopausal women

Golub, L. M., Lee, H. M., Stoner, J. A., Reinhardt, R. A., Sorsa, T., Goren, A. D. & Payne, J. B., Jun 2010, In : Journal of Dental Research. 89, 6, p. 644-649 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Effect of an aldose reductase inhibitor on alveolar bone loss associated with periodontitis in diabetic rats

Kador, P. F., Hamada, T., Reinhardt, R. A. & Blessing, K., May 2010, In : Postgraduate Medicine. 122, 3, p. 138-144 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Triclosan-loaded tooth-binding micelles for prevention and treatment of dental biofilm

Chen, F., Rice, K. C., Liu, X. M., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2010, In : Pharmaceutical Research. 27, 11, p. 2356-2364 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009
184 Scopus citations

Tooth-binding micelles for dental caries prevention

Chen, F., Liu, X. M., Rice, K. C., Li, X., Yu, F., Reinhardt, R. A., Bayles, K. W. & Wang, D., Nov 2009, In : Antimicrobial Agents and Chemotherapy. 53, 11, p. 4898-4902 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2008
23 Scopus citations

Injectable simvastatin in periodontal defects and alveolar ridges: Pilot studies

Morris, M. S., Lee, Y., Lavin, M. T., Giannini, P. J., Schmid, M. J., Marx, D. B. & Reinhardt, R. A., Aug 2008, In : Journal of periodontology. 79, 8, p. 1465-1473 9 p.

Research output: Contribution to journalArticle

35 Scopus citations

Osteotropic β-cyclodextrin for local bone regeneration

Liu, X. M., Wiswall, A. T., Rutledge, J. E., Akhter, M. P., Cullen, D. M., Reinhardt, R. A. & Wang, D., Apr 2008, In : Biomaterials. 29, 11, p. 1686-1692 7 p.

Research output: Contribution to journalArticle

38 Scopus citations

Subantimicrobial-dose doxycycline modulates gingival crevicular fluid biomarkers of periodontitis in postmenopausal osteopenic women

Golub, L. M., Hsi, M. L., Stoner, J. A., Sorsa, T., Reinhardt, R. A., Wolff, M. S., Ryan, M. E., Nummikoski, P. V. & Payne, J. B., Aug 2008, In : Journal of periodontology. 79, 8, p. 1409-1418 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

The effect of local simvastatin delivery strategies on mandibular bone formation in vivo

Lee, Y., Schmid, M. J., Marx, D. B., Beatty, M. W., Cullen, D. M., Collins, M. E. & Reinhardt, R. A., Apr 2008, In : Biomaterials. 29, 12, p. 1940-1949 10 p.

Research output: Contribution to journalArticle

79 Scopus citations
2007

Cyclooxygenase-2 inhibitor reduces simvastatin-induced bone morphogenetic protein-2 and bone formation in vivo

Bradley, J. D., Cleverly, D. G., Burns, A. M., Helm, N. B., Schmid, M. J., Marx, D. B., Cullen, D. M. & Reinhardt, R. A., Jun 2007, In : Journal of Periodontal Research. 42, 3, p. 267-273 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Efficacy of sub-antimicrobial dose doxycycline in post-menopausal women: Clinical outcomes

Reinhardt, R. A., Stoner, J. A., Golub, L. M., Wolff, M. S., Lee, H. M., Meinberg, T. A., Lynch, J. C., Ryan, M. E., Sorsa, T. & Payne, J. B., Sep 2007, In : Journal of Clinical Periodontology. 34, 9, p. 768-775 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

Inflammatory mediator release following bone grafting in humans: A pilot study

Preston, R. D., Meinberg, T. A., Payne, J. B., Schmid, M. J., Lee, H. M., Golub, L. M., Marx, D. B. & Reinhardt, R. A., Sep 2007, In : Journal of Clinical Periodontology. 34, 9, p. 797-804 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity

Liu, X. M., Lee, H. T., Reinhardt, R. A., Marky, L. A. & Wang, D., Sep 11 2007, In : Journal of Controlled Release. 122, 1, p. 54-62 9 p.

Research output: Contribution to journalArticle

38 Scopus citations

Subantimicrobial dose doxycycline effects on alveolar bone loss in post-menopausal women

Payne, J. B., Stoner, J. A., Nummikoski, P. V., Reinhardt, R. A., Goren, A. D., Wolff, M. S., Lee, H. M., Lynch, J. C., Valente, R. & Golub, L. M., Sep 2007, In : Journal of Clinical Periodontology. 34, 9, p. 776-787 12 p.

Research output: Contribution to journalArticle

37 Scopus citations

Subantimicrobial dose doxycycline effects on osteopenic bone loss: Microbiologic results

Walker, C., Puumala, S., Golub, L. M., Stoner, J. A., Reinhardt, R. A., Lee, H. M. & Payne, J. B., Aug 2007, In : Journal of periodontology. 78, 8, p. 1590-1601 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2006

Can systemic diseases co-induce (not just exacerbate) periodontitis? A hypothetical "two-hit" model

Golub, L. M., Payne, J. B., Reinhardt, R. A. & Nieman, G., Feb 2006, In : Journal of Dental Research. 85, 2, p. 102-105 4 p.

Research output: Contribution to journalReview article

91 Scopus citations

Drug delivery strategies for common orofacial diseases

Liu, X. M., Reinhardt, R. A. & Wang, D., Sep 2006, In : Journal of Drug Targeting. 14, 8, p. 583-597 15 p.

Research output: Contribution to journalReview article

7 Scopus citations
2005

Comparison of irrigation to floss as an adjunct to tooth brushing: Effect on bleeding, gingivitis, and supragingival plaque

Barnes, C. M., Russell, C. M., Reinhardt, R. A., Payne, J. B. & Lyle, D. M., 2005, In : Journal of Clinical Dentistry. 16, 3, p. 71-77 7 p.

Research output: Contribution to journalArticle

40 Scopus citations

Local simvastatin effects on mandibular bone growth and inflammation

Stein, D., Lee, Y., Schmid, M. J., Killpack, B., Genrich, M. A., Narayana, N., Marx, D. B., Cullen, D. M. & Reinhardt, R. A., Nov 2005, In : Journal of periodontology. 76, 11, p. 1861-1870 10 p.

Research output: Contribution to journalArticle

127 Scopus citations

Relationship between gelatinases and bone turnover in the healing bone defect

Reinhardt, R. A., Lee, H. M., Schmid, M., Payne, J. B. & Golub, L., Oct 2005, In : Journal of Oral and Maxillofacial Surgery. 63, 10, p. 1455-1460 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
2004

Local biochemical markers of bone turnover: Relationship to subsequent density of healing alveolar bone defects

Reinhardt, R. A., Sanderfer, V. J., Meinberg, T. A., Nummikoski, P., Lee, H. M. & Marx, D. B., Mar 2004, In : Journal of Clinical Periodontology. 31, 3, p. 223-228 6 p.

Research output: Contribution to journalArticle

10 Scopus citations