• 2616 Citations
  • 29 h-Index
1980 …2020

Research output per year

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Research Output

  • 2616 Citations
  • 29 h-Index
  • 71 Article
  • 5 Review article
  • 3 Comment/debate
  • 1 Letter
2020

High-throughput identification of protein functional similarities using a gene-expression-based siRNA screen

Neilsen, B. K., Kelly, D. L., Chakraborty, B., Kim, H. S., White, M. A., Lewis, R. E. & Fisher, K. W., Dec 1 2020, In : Scientific Data. 7, 1, 27.

Research output: Contribution to journalArticle

Open Access
2019

A Genome-wide Functional Signature Ontology Map and Applications to Natural Product Mechanism of Action Discovery

McMillan, E. A., Kwon, G., Clemenceau, J. R., Fisher, K. W., Vaden, R. M., Shaikh, A. F., Neilsen, B. K., Kelly, D., Potts, M. B., Sung, Y. J., Mendiratta, S., Hight, S. K., Lee, Y., MacMillan, J. B., Lewis, R. E., Kim, H. S. & White, M. A., Oct 17 2019, In : Cell Chemical Biology. 26, 10, p. 1380-1392.e6

Research output: Contribution to journalArticle

2 Scopus citations

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Neilsen, B. K., Frodyma, D. E., McCall, J. L., Fisher, K. W. & Lewis, R. E., Jan 2019, In : PloS one. 14, 1, e0209224.

Research output: Contribution to journalArticle

3 Scopus citations

Erratum: O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3 (Immunity (2019) 50(3) (576–590.e6), (S1074761319300305), (10.1016/j.immuni.2019.01.007))

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Apr 16 2019, In : Immunity. 50, 4, 1 p.

Research output: Contribution to journalComment/debate

O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3

Li, X., Gong, W., Wang, H., Li, T., Attri, K. S., Lewis, R. E., Kalil, A. C., Bhinderwala, F., Powers, R., Yin, G., Herring, L. E., Asara, J. M., Lei, Y. L., Yang, X., Rodriguez, D. A., Yang, M., Green, D. R., Singh, P. K. & Wen, H., Mar 19 2019, In : Immunity. 50, 3, p. 576-590.e6

Research output: Contribution to journalArticle

13 Scopus citations

The miR-17~92 cluster activates mTORC1 in mantle cell lymphoma by targeting multiple regulators in the STK11/AMPK/TSC/mTOR pathway

Jiang, C., Bi, C., Jiang, X., Tian, T., Huang, X., Wang, C., Fernandez, M. R., Iqbal, J., Chan, W. C., McKeithan, T. W., Lewis, R. E. & Fu, K., May 2019, In : British Journal of Haematology. 185, 3, p. 616-620 5 p.

Research output: Contribution to journalLetter

1 Scopus citations
2018

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

Das, B., Neilsen, B. K., Fisher, K. W., Gehring, D., Hu, Y., Volle, D. J., Kim, H. S., McCall, J. L., Kelly, D. L., MacMillan, J. B., White, M. A. & Lewis, R. E., Dec 1 2018, In : Scientific reports. 8, 1, 3770.

Research output: Contribution to journalArticle

7 Scopus citations

Correction: KSR1 is required for cell cycle reinitiation following DNA damage.(Journal of Biological Chemistry (2018)284 (6705– 6715))

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Dec 7 2018, In : Journal of Biological Chemistry. 293, 49, 1 p.

Research output: Contribution to journalComment/debate

WDR5 supports colon cancer cells by promoting methylation of H3K4 and suppressing DNA damage

Neilsen, B. K., Chakraborty, B., McCall, J. L., Frodyma, D. E., Sleightholm, R. L., Fisher, K. W. & Lewis, R. E., Jun 20 2018, In : BMC cancer. 18, 1, 673.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Coordinating ERK signaling via the molecular scaffold Kinase Suppressor of Ras

Lewis, R., Frodyma, D., Neilsen, B., Costanzo-Garvey, D. & Fisher, K., 2017, In : F1000Research. 6, 1621.

Research output: Contribution to journalReview article

10 Scopus citations

Kinase Suppressor of Ras 2 (KSR2) expression in the brain regulates energy balance and glucose homeostasis

Guo, L., Costanzo-Garvey, D. L., Smith, D. R., Neilsen, B. K., MacDonald, R. G. & Lewis, R. E., Feb 1 2017, In : Molecular Metabolism. 6, 2, p. 194-205 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

KSR as a therapeutic target for Ras-dependent cancers

Neilsen, B. K., Frodyma, D. E., Lewis, R. E. & Fisher, K. W., May 4 2017, In : Expert Opinion on Therapeutic Targets. 21, 5, p. 499-509 11 p.

Research output: Contribution to journalReview article

8 Scopus citations
2016

Cell non-autonomous regulation of hepatic IGF-1 and neonatal growth by Kinase Suppressor of Ras 2 (KSR2)

Guo, L., Costanzo-Garvey, D. L., Smith, D. R., Zavorka, M. E., Venable-Kang, M., Macdonald, R. G. & Lewis, R. E., Aug 26 2016, In : Scientific reports. 6, 32093.

Research output: Contribution to journalArticle

9 Scopus citations

KSR1 and EPHB4 regulate Myc and PGC1β to promote survival of human colon tumors

McCall, J. L., Gehring, D., Clymer, B. K., Fisher, K. W., Das, B., Kelly, D. L., Kim, H., White, M. A. & Lewis, R. E., 2016, In : Molecular and cellular biology. 36, 17, p. 2246-2261 16 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

AMPK promotes aberrant PGC1ß expression to support human colon tumor cell survival

Fisher, K. W., Das, B., Kim, H. S., Clymer, B. K., Gehring, D., Smith, D. R., Costanzo-Garvey, D. L., Fernandez, M. R., Brattain, M. G., Kelly, D. L., MacMillan, J., White, M. A. & Lewis, R. E., 2015, In : Molecular and cellular biology. 35, 22, p. 3866-3879 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Metalloprotease OMA1 Fine-tunes Mitochondrial Bioenergetic Function and Respiratory Supercomplex Stability

Bohovych, I., Fernandez, M. R., Rahn, J. J., Stackley, K. D., Bestman, J. E., Anandhan, A., Franco, R., Claypool, S. M., Lewis, R. E., Chan, S. S. L. & Khalimonchuk, O., Sep 14 2015, In : Scientific reports. 5, 13989.

Research output: Contribution to journalArticle

24 Scopus citations
2014

Caveolin-1 is required for kinase suppressor of Ras 1 (KSR1)-mediated extracellular signal-regulated kinase 1/2 activation, H-RasV12-induced Senescence, and transformation

Kortum, R. L., Fernandez, M. R., Costanzo-Garvey, D. L., Johnson, H. J., Fisher, K. W., Volle, D. J. & Lewis, R. E., 2014, In : Molecular and cellular biology. 34, 18, p. 3461-3472 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Identification of a truncated kinase suppressor of Ras 2 mRNA in sperm

Guo, L., Volle, D. J. & Lewis, R. E., 2014, In : FEBS Open Bio. 4, p. 420-425 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Obesity-dependent dysregulation of glucose homeostasis in kinase suppressor of ras 2-/- mice

Henry, M. D., Costanzo-Garvey, D. L., Klutho, P. J. & Lewis, R. E., 2014, In : Physiological Reports. 2, 7, e12053.

Research output: Contribution to journalArticle

9 Scopus citations
2013

Essential role for dnmt1 in the prevention and maintenance of MYC-Induced T-Cell lmphomas

Peters, S. L., Hlady, R. A., Opavska, J., Klinkebiel, D., Novakova, S., Smith, L. M., Lewis, R. E., Karpf, A. R., Simpson, M. A., Wu, L. & Opavsky, R., 2013, In : Molecular and cellular biology. 33, 21, p. 4321-4333 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

Using functional signature ontology (FUSION) to identify mechanisms of action for Natural products

Potts, M. B., Kim, H. S., Fisher, K. W., Hu, Y., Carrasco, Y. P., Bulut, G. B., Ou, Y. H., Herrera-Herrera, M. L., Cubillos, F., Mendiratta, S., Xiao, G., Hofree, M., Ideker, T., Xie, Y., Huang, L. J. S., Lewis, R. E., MacMillan, J. B. & White, M. A., Oct 15 2013, In : Science signaling. 6, 297, ra90.

Research output: Contribution to journalArticle

41 Scopus citations
2012

Kinase suppressor of Ras 2 (KSR2) regulates tumor cell transformation via AMPK

Fernandez, M. R., Henry, M. L. D. & Lewis, R. E., Sep 2012, In : Molecular and cellular biology. 32, 18, p. 3718-3731 14 p.

Research output: Contribution to journalArticle

36 Scopus citations
2011

KIBRA protein phosphorylation is regulated by mitotic kinase Aurora and protein phosphatase 1

Xiao, L., Chen, Y., Ji, M., Volle, D. J., Lewis, R. E., Tsai, M. Y. & Dong, J., Oct 21 2011, In : Journal of Biological Chemistry. 286, 42, p. 36304-36315 12 p.

Research output: Contribution to journalArticle

38 Scopus citations

Kinase suppressor of ras 1 (KSR1) regulates PGC1α and estrogen-related receptor α to promote oncogenic ras-dependent anchorage-independent growth

Fisher, K. W., Das, B., Kortum, R. L., Chaika, O. V. & Lewis, R. E., Jun 2011, In : Molecular and cellular biology. 31, 12, p. 2453-2461 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels

Llobet, D., Eritja, N., Domingo, M., Bergada, L., Mirantes, C., Santacana, M., Pallares, J., Macià, A., Yeramian, A., Encinas, M., Moreno-Bueno, G., Palacios, J., Lewis, R. E., Matias-Guiu, X. & Dolcet, X., Apr 2011, In : American Journal of Pathology. 178, 4, p. 1529-1543 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of glucose homeostasis by KSR1 and MARK2

Klutho, P. J., Costanzo-Garvey, D. L. & Lewis, R. E., Dec 19 2011, In : PloS one. 6, 12, e29304.

Research output: Contribution to journalArticle

8 Scopus citations
2009

KSR1 is required for cell cycle reinitiation following DNA Damage

Razidlo, G. L., Johnson, H. J., Stoeger, S. M., Cowan, K. H., Bessho, T. & Lewis, R. E., Mar 13 2009, In : Journal of Biological Chemistry. 284, 11, p. 6705-6715 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

Costanzo-Garvey, D. L., Pfluger, P. T., Dougherty, M. K., Stock, J. L., Boehm, M., Chaika, O., Fernandez, M. R., Fisher, K., Kortum, R. L., Hong, E. G., Jun, J. Y., Ko, H. J., Schreiner, A., Volle, D. J., Treece, T., Swift, A. L., Winer, M., Chen, D., Wu, M., Leon, L. R. & 6 others, Shaw, A. S., McNeish, J., Kim, J. K., Morrison, D. K., Tschöp, M. H. & Lewis, R. E., Nov 4 2009, In : Cell Metabolism. 10, 5, p. 366-378 13 p.

Research output: Contribution to journalArticle

92 Scopus citations

Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins

Casar, B., Arozarena, I., Sanz-Moreno, V., Pinto, A., Agudo-Ibáñez, L., Marais, R., Lewis, R. E., Berciano, M. T. & Crespo, P., Mar 2009, In : Molecular and cellular biology. 29, 5, p. 1338-1353 16 p.

Research output: Contribution to journalArticle

81 Scopus citations

The mitogen-activated protein kinase scaffold KSR1 is required for recruitment of extracellular signal-regulated kinase to the immunological synapse

Giurisato, E., Lin, J., Harding, A., Cerutti, E., Cella, M., Lewis, R. E., Colonna, M. & Shaw, A. S., Mar 2009, In : Molecular and cellular biology. 29, 6, p. 1554-1564 11 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds

Chen, C., Lewis, R. E. & White, M. A., May 9 2008, In : Journal of Biological Chemistry. 283, 19, p. 12789-12796 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

Extracellular signal-regulated kinase regulates clathrin-independent endosomal trafficking

Robertson, S. E., Setty, S. R. G., Sitaram, A., Marks, M. S., Lewis, R. E. & Chou, M. M., Feb 2006, In : Molecular biology of the cell. 17, 2, p. 645-657 13 p.

Research output: Contribution to journalArticle

45 Scopus citations

The MAPK scaffold kinase suppressor of Ras is involved in ERK activation by stress and proinflammatory cytokines and induction of arthritis

Fuselo, A. M., Mandik-Nayak, L., Shih, F., Lewis, R. E., Allen, P. M. & Shaw, A. S., Nov 1 2006, In : Journal of Immunology. 177, 9, p. 6152-6158 7 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

The molecular scaffold kinase suppressor of Ras 1 is a modifier of Ras V12-induced and replicative senescence

Kortum, R. L., Johnson, H. J., Costanzo, D. L., Volle, D. J., Razidlo, G. L., Fusello, A. M., Shaw, A. S. & Lewis, R. E., Mar 2006, In : Molecular and cellular biology. 26, 6, p. 2202-2214 13 p.

Research output: Contribution to journalArticle

31 Scopus citations
2005

Expression of kinase suppressor of Ras1 enhances cisplatin-induced extracellular signal-regulated kinase activation and cisplatin sensitivity

Kim, M., Yan, Y., Kortum, R. L., Stoeger, S. M., Sgagias, M. K., Lee, K., Lewis, R. E. & Cowan, K. H., May 15 2005, In : Cancer Research. 65, 10, p. 3986-3992 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

The molecular scaffold kinase suppressor of Ras 1 (KSR1) regulates adipogenesis

Kortum, R. L., Costanzo, D. L., Haferbier, J., Schreiner, S. J., Razidlo, G. L., Wu, M. H., Volle, D. J., Mori, T., Sakaue, H., Chaika, N. V., Chaika, O. V. & Lewis, R. E., Sep 2005, In : Molecular and cellular biology. 25, 17, p. 7592-7604 13 p.

Research output: Contribution to journalArticle

55 Scopus citations
2004

Phosphorylation regulates KSR1 stability, ERK activation, and cell proliferation

Razidlo, G. L., Kortum, R. L., Haferbier, J. L. & Lewis, R. E., Nov 12 2004, In : Journal of Biological Chemistry. 279, 46, p. 47808-47814 7 p.

Research output: Contribution to journalArticle

50 Scopus citations

Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

Matheny, S. A., Chen, C., Kortum, R. L., Razidlo, G. L., Lewis, R. E. & White, M. A., Jan 15 2004, In : Nature. 427, 6971, p. 256-260 5 p.

Research output: Contribution to journalArticle

148 Scopus citations

The molecular scaffold KSR1 regulates the proliferative and oncogenic potential of cells

Kortum, R. L. & Lewis, R. E., May 2004, In : Molecular and cellular biology. 24, 10, p. 4407-4416 10 p.

Research output: Contribution to journalArticle

108 Scopus citations
2003

B-myb repressor function is regulated by cyclin a phosphorylation and sequences within the c-terminal domain

Petrovas, C., Jeay, S., Lewis, R. E. & Sonenshein, G. E., Apr 3 2003, In : Oncogene. 22, 13, p. 2011-2020 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

The formin-homology-domain-containing protein FHOD1 enhances cell migration

Koka, S., Neudauer, C. L., Li, X., Lewis, R. E., McCarthy, J. B. & Westendorf, J. J., May 1 2003, In : Journal of cell science. 116, 9, p. 1745-1755 11 p.

Research output: Contribution to journalArticle

59 Scopus citations
2002

Effects of B-Myb on gene transcription: Phosphorylation-dependent activity and acetylation by p300

Johnson, L. R., Johnson, T. K., Desler, M., Luster, T. A., Nowling, T., Lewis, R. E. & Rizzino, A. A., Feb 8 2002, In : Journal of Biological Chemistry. 277, 6, p. 4088-4097 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo

Nguyen, A. C., Burack, W. R., Stock, J. L., Kortum, R., Chaika, O. V., Afkarian, M., Muller, W. J., Murphy, K. M., Morrison, D. K., Lewis, R. E., McNeish, J. & Shaw, A. S., 2002, In : Molecular and cellular biology. 22, 9, p. 3035-3045 11 p.

Research output: Contribution to journalArticle

210 Scopus citations

Phosphorylation of Vpr regulates HIV type 1 nuclear import and macrophage infection

Agostini, I., Popov, S., Hao, T., Li, J. H., Dubrovsky, L., Chaika, O., Chaika, N., Lewis, R. & Bukrinsky, M., 2002, In : AIDS Research and Human Retroviruses. 18, 4, p. 283-288 6 p.

Research output: Contribution to journalArticle

34 Scopus citations

Phosphorylation regulates the nucleocytoplasmic distribution of kinase suppressor of Ras

Brennan, J. A., Volle, D. J., Chaika, O. V. & Lewis, R. E., Feb 15 2002, In : Journal of Biological Chemistry. 277, 7, p. 5369-5377 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2001

Histamine utilizes JAK-STAT pathway in regulating cytokine production

Osna, N., Elliott, K., Chaika, O., Patterson, E., Lewis, R. E. & Khan, M. M., 2001, In : International Immunopharmacology. 1, 4, p. 759-762 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

PARP co-activates B-MYB through enhanced phosphorylation at cyclin/cdk2 sites

Santilli, G., Cervellera, M. N., Johnson, T. K., Lewis, R. E., Iacobelli, S. & Sala, A., 2001, In : Oncogene. 20, 57, p. 8167-8174 8 p.

Research output: Contribution to journalArticle

18 Scopus citations
2000

Therapeutic manipulation of the insulin receptor kinase - A review

Lewis, R. E. & Chaika, O. V., 2000, In : Expert Opinion on Therapeutic Patents. 10, 2, p. 191-198 8 p.

Research output: Contribution to journalReview article

1999

Analysis of potential phosphorylation sites in human T cell leukemia virus type 1 Tax

Boehm, A. K., Stawhecker, J. A., Semmes, O. J., Jankowski, P. E., Lewis, R. & Hinrichs, S. H., 1999, In : Journal of Biomedical Science. 6, 3, p. 206-212 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

B-MYB transactivates its own promoter through SP1-binding sites

Sala, A., Saitta, B., De Luca, P., Cervellera, M. N., Casella, I., Lewis, R. E., Watson, R. & Peschle, C., Feb 11 1999, In : Oncogene. 18, 6, p. 1333-1339 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations