• 1935 Citations
  • 25 h-Index
1990 …2020

Research output per year

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Research Output

  • 1935 Citations
  • 25 h-Index
  • 38 Article
  • 6 Review article
  • 3 Conference contribution
  • 1 Chapter
2020

A selective PPARγ modulator reduces hepatic fibrosis

McVicker, B. L., Hamel, F. G., Simpson, R. L. & Bennett, R. G., Jul 2020, In : Biology. 9, 7, p. 1-9 9 p., 151.

Research output: Contribution to journalArticle

Open Access
2019

Relaxin and extracellular matrix remodeling: Mechanisms and signaling pathways

Ng, H. H., Shen, M., Samuel, C. S., Schlossmann, J. & Bennett, R. G., May 1 2019, In : Molecular and Cellular Endocrinology. 487, p. 59-65 7 p.

Research output: Contribution to journalReview article

4 Scopus citations

Relaxin and fibrosis: Emerging targets, challenges, and future directions

Kanai, A. J., Konieczko, E. M., Bennett, R. G., Samuel, C. S. & Royce, S. G., May 1 2019, In : Molecular and Cellular Endocrinology. 487, p. 66-74 9 p.

Research output: Contribution to journalReview article

4 Scopus citations
2017

Anti-fibrotic actions of relaxin

Samuel, C. S., Royce, S. G., Hewitson, T. D., Denton, K. M., Cooney, T. E. & Bennett, R. G., 2017, In : British Journal of Pharmacology. 174, 10, p. 962-976 15 p.

Research output: Contribution to journalArticle

45 Scopus citations

Novel anti-fibrotic therapies

McVicker, B. L. & Bennett, R. G., May 31 2017, In : Frontiers in Pharmacology. 8, MAY, 318.

Research output: Contribution to journalReview article

25 Scopus citations

Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis

Bennett, R. G., Simpson, R. L. & Hamel, F. G., Jun 14 2017, In : World Journal of Gastroenterology. 23, 22, p. 3999-4006 8 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

Relaxin activates peroxisome proliferator-activated receptor γ(PPAR γ)through a pathway involving PPAR γ coactivator 1α (PGC1α)

Singh, S., Simpson, R. L. & Bennett, R. G., Jan 9 2015, In : Journal of Biological Chemistry. 290, 2, p. 950-959 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2014

Relaxin decreases the severity of established hepatic fibrosis in mice

Bennett, R. G., Heimann, D. G., Singh, S., Simpson, R. L. & Tuma, D. J., Mar 2014, In : Liver International. 34, 3, p. 416-426 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Tacrolimus and sirolimus have distinct effects on insulin signaling in male and female rats

Shivaswamy, V., Bennett, R. G., Clure, C. C., Ottemann, B., Davis, J. S., Larsen, J. L. & Hamel, F. G., Mar 2014, In : Translational Research. 163, 3, p. 221-231 11 p.

Research output: Contribution to journalArticle

20 Scopus citations
2013

Dominant-negative and knockdown approaches to studying PPAR activity

Singh, S. & Bennett, R. G., 2013, Peroxisome Proliferator-Activated Receptors (PPARs): Methods and Protocols. Badr, M. & Youssef, J. (eds.). p. 87-98 12 p. (Methods in Molecular Biology; vol. 952).

Research output: Chapter in Book/Report/Conference proceedingChapter

Metformin improves immunosuppressant induced hyperglycemia and exocrine apoptosis in rats

Shivaswamy, V., Bennett, R. G., Clure, C. C., Larsen, J. L. & Hamel, F. G., Jan 27 2013, In : Transplantation. 95, 2, p. 280-284 5 p.

Research output: Contribution to journalArticle

16 Scopus citations
2012

Gene expression of vitamin d metabolic enzymes at baseline and in response to vitamin d treatment in thyroid cancer cell lines

Bennett, R. G., Wakeley, S. E., Hamel, F. G., High, R. R., Korch, C. & Goldner, W. S., Sep 2012, In : Oncology (Switzerland). 83, 5, p. 264-272 9 p.

Research output: Contribution to journalArticle

10 Scopus citations
2011

Redox regulation of insulin degradation by insulin-degrading enzyme

Cordes, C. M., Bennett, R. G., Siford, G. L. & Hamel, F. G., 2011, In : PloS one. 6, 3, e18138.

Research output: Contribution to journalArticle

19 Scopus citations
2010

Exposure of precision-cut rat liver slices to ethanol accelerates fibrogenesis

Schaffert, C. S., Duryee, M. J., Bennett, R. G., DeVeney, A. L., Tuma, D. J., Olinga, P., Easterling, K. C., Thiele, G. M. & Klassen, L. W., Sep 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 3, p. G661-G668

Research output: Contribution to journalArticle

19 Scopus citations

Hyperglycemia induced by tacrolimus and sirolimus is reversible in normal sprague-dawley rats

Shivaswamy, V., McClure, M., Passer, J., Frahm, C., Ochsner, L., Erickson, J., Bennett, R. G., Hamel, F. G. & Larsen, J. L., Jun 2010, In : Endocrine. 37, 3, p. 489-496 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Insulin degrading enzyme induces a conformational change in varicella-zoster virus gE, and enhances virus infectivity and stability

Li, Q., Ali, M. A., Wang, K., Sayre, D., Hamel, F. G., Fischer, E. R., Bennett, R. G. & Cohen, J. I., 2010, In : PloS one. 5, 6, e11327.

Research output: Contribution to journalArticle

12 Scopus citations

Relaxin signaling activates peroxisome proliferator-activated receptor gamma

Singh, S. & Bennett, R. G., Feb 5 2010, In : Molecular and Cellular Endocrinology. 315, 1-2, p. 239-245 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
2009

Degradation of relaxin family peptides by insulin-degrading enzyme

Bennett, R. G., Heimann, D. G. & Hamel, F. G., Apr 2009, Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., p. 38-41 4 p. (Annals of the New York Academy of Sciences; vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Scopus citations

Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation

Cordes, C. M., Bennett, R. G., Siford, G. L. & Hamel, F. G., Mar 15 2009, In : Biochemical Pharmacology. 77, 6, p. 1064-1073 10 p.

Research output: Contribution to journalArticle

43 Scopus citations

Relaxin and its role in the development and treatment of fibrosis

Bennett, R. G., Jul 2009, In : Translational Research. 154, 1, p. 1-6 6 p.

Research output: Contribution to journalReview article

54 Scopus citations

Relaxin family peptide receptor 1 activation stimulates peroxisome proliferator-activated receptor gamma

Singh, S. & Bennett, R. G., Apr 2009, Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., p. 112-116 5 p. (Annals of the New York Academy of Sciences; vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis

Bennett, R. G., Heimann, D. G. & Tuma, D. J., Apr 2009, Relaxin and Related Peptides Fifth International Conference. Blackwell Publishing Inc., p. 348-349 2 p. (Annals of the New York Academy of Sciences; vol. 1160).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

14 Scopus citations
2007

Relaxin receptors in hepatic stellate cells and cirrhotic liver

Bennett, R. G., Dalton, S. R., Mahan, K. J., Gentry-Nielsen, M. J., Hamel, F. G. & Tuma, D. J., Apr 1 2007, In : Biochemical Pharmacology. 73, 7, p. 1033-1040 8 p.

Research output: Contribution to journalArticle

25 Scopus citations
2006

Effect of nelfinavir on insulin metabolism, proteasome activity and protein degradation in HepG2 cells

Hamel, F. G., Fawcett, J., Tsui, B. T., Bennett, R. G. & Duckworth, W. C., Nov 2006, In : Diabetes, Obesity and Metabolism. 8, 6, p. 661-668 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Tacrolimus and sirolimus cause insulin resistance in normal Sprague Dawley rats

Larsen, J. L., Bennett, R. G., Burkman, T., Ramirez, A. L., Yamamoto, S., Gulizia, J., Radio, S. & Hamel, F. G., Aug 2006, In : Transplantation. 82, 4, p. 466-470 5 p.

Research output: Contribution to journalArticle

62 Scopus citations
2005

Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue

Bennett, R. G., Mahan, K. J., Gentry-Nielsen, M. J. & Tuma, D. J., 2005, In : Annals of the New York Academy of Sciences. 1041, p. 185-189 5 p.

Research output: Contribution to journalArticle

11 Scopus citations
2004

Biological activity of a fragment of insulin

Duckworth, W. C., Fawcett, J., Tsui, B. T., Bennett, R. G. & Hamel, F. G., Jun 11 2004, In : Biochemical and Biophysical Research Communications. 318, 4, p. 1019-1024 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Control of proteolysis: Hormones, nutrients, and the changing role of the proteasome

Hamel, F. G., Fawcett, J., Bennett, R. G. & Duckworth, W. C., May 2004, In : Current Opinion in Clinical Nutrition and Metabolic Care. 7, 3, p. 255-258 4 p.

Research output: Contribution to journalReview article

17 Scopus citations
2003
78 Scopus citations

Inhibition of markers of hepatic stellate cell activation by the hormone relaxin

Bennett, R. G., Kharbanda, K. K. & Tuma, D. J., Sep 1 2003, In : Biochemical Pharmacology. 66, 5, p. 867-874 8 p.

Research output: Contribution to journalArticle

60 Scopus citations

Insulin inhibition of protein degradation in cells expressing wild-type and mutant insulin receptors

Hamel, F. G., Fawcett, J., Andersen, C. I., Berhanu, P., Bennett, R. G. & Duckworth, W. C., Nov 2003, In : Journal of Endocrinological Investigation. 26, 11, p. 1088-1094 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Insulin inhibition of the proteasome is dependent on degradation of insulin by insulin-degrading enzyme

Bennett, R. G., Fawcett, J., Kruer, M. C., Duckworth, W. C. & Hamel, F. G., Jun 1 2003, In : Journal of Endocrinology. 177, 3, p. 399-405 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

In vitro inhibition of insulin-degrading enzyme by long-chain fatty acids and their coenzyme A thioesters

Hamel, F. G., Upward, J. L. & Bennett, R. G., Jun 1 2003, In : Endocrinology. 144, 6, p. 2404-2408 5 p.

Research output: Contribution to journalArticle

54 Scopus citations
2002

Relaxin stimulates bronchial epithelial cell PKA activation, migration, and ciliary beating

Wyatt, T. A., Sisson, J. H., Forgèt, M. A., Bennett, R. G., Hamel, F. G. & Spurzem, J. R., Dec 2002, In : Experimental Biology and Medicine. 227, 11, p. 1047-1053 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2001

Insulin and analogue effects on protein degradation in different cell types. Dissociation between binding and activity

Fawcett, J., Hamel, F. G., Bennett, R. G., Vajo, Z. & Duckworth, W. C., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 11552-11558 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Insulin inhibits peroxisomal fatty acid oxidation in isolated rat hepatocytes

Hamel, F. G., Bennett, R. G., Upward, J. L. & Duckworth, W. C., 2001, In : Endocrinology. 142, 6, p. 2702-2706 5 p.

Research output: Contribution to journalArticle

Open Access
34 Scopus citations
2000

Degradation of amylin by insulin-degrading enzyme

Bennett, R. G., Duckworth, W. C. & Hamel, F. G., Nov 24 2000, In : Journal of Biological Chemistry. 275, 47, p. 36621-36625 5 p.

Research output: Contribution to journalArticle

116 Scopus citations

Insulin inhibits the ubiquitin-dependent degrading activity of the 26S proteasome

Bennett, R. G., Hamel, F. G. & Duckworth, W. C., 2000, In : Endocrinology. 141, 7, p. 2508-2517 10 p.

Research output: Contribution to journalArticle

Open Access
45 Scopus citations
1998

Insulin acts intracellularly on proteasomes through insulin-degrading enzyme

Duckworth, W. C., Bennett, R. G. & Hamel, F. G., Mar 17 1998, In : Biochemical and Biophysical Research Communications. 244, 2, p. 390-394 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Insulin degradation: Progress and potential

Duckworth, W. C., Bennett, R. G. & Hamel, F. G., 1998, In : Endocrine reviews. 19, 5, p. 608-624 17 p.

Research output: Contribution to journalReview article

592 Scopus citations

Regulation of multicatalytic enzyme activity by insulin and the insulin- degrading enzyme

Hamel, F. G., Bennett, R. G. & Duckworth, W. C., 1998, In : Endocrinology. 139, 10, p. 4061-4066 6 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations
1997

Characterization of the insulin inhibition of the peptidolytic activities of the insulin-degrading enzyme-proteasome complex

Bennett, R. G., Hamel, F. G. & Duckworth, W. C., Feb 1997, In : Diabetes. 46, 2, p. 197-203 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Insulin inhibition of proteasome activity in intact cells

Hamel, F. G., Bennett, R. G., Harmon, K. S. & Duckworth, W. C., May 29 1997, In : Biochemical and Biophysical Research Communications. 234, 3, p. 671-674 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

The Significance of Intracellular Insulin to Insulin Action

Duckworth, W. C., Bennett, R. G. & Hamel, F. G., Feb 1997, In : Journal of Investigative Medicine. 45, 2, p. 20-27 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
1994
53 Scopus citations
27 Scopus citations
1991

Identification of the metal associated with the insulin degrading enzyme

Ebrahim, A., Hamel, F. G., Bennett, R. G. & Duckworth, W. C., Dec 31 1991, In : Biochemical and Biophysical Research Communications. 181, 3, p. 1398-1406 9 p.

Research output: Contribution to journalArticle

29 Scopus citations
1990
31 Scopus citations