• 1900 Citations
  • 24 h-Index
19982020

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Article
2020

Long-Term Follow-up of CALGB (Alliance) 100001: Autologous Followed by Nonmyeloablative Allogeneic Transplant for Multiple Myeloma

Holstein, S. A., Suman, V. J., Owzar, K., Santo, K., Benson, D. M., Shea, T. C., Martin, T., Silverman, M., Isola, L., Vij, R., Cheson, B. D., Linker, C., Anderson, K. C., Richardson, P. G. & McCarthy, P. L., 2020, (Accepted/In press) In : Biology of Blood and Marrow Transplantation.

Research output: Contribution to journalArticle

Open Access
2019

A patent review of bisphosphonates in treating bone disease

Holstein, S. A., May 4 2019, In : Expert Opinion on Therapeutic Patents. 29, 5, p. 315-325 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inhibition of geranylgeranyl diphosphate synthase is a novel therapeutic strategy for pancreatic ductal adenocarcinoma

Haney, S. L., Varney, M. L., Chhonker, Y. S., Shin, S., Mehla, K., Crawford, A. J., Smith, H. J., Smith, L. M., Murry, D. J., Hollingsworth, M. A. & Holstein, S. A., Jun 27 2019, In : Oncogene. 38, 26, p. 5308-5320 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
4 Scopus citations

Modeling the Effects of Multiple Myeloma on Kidney Function

Walk, J. C., Ayati, B. P. & Holstein, S. A., Dec 1 2019, In : Scientific reports. 9, 1, 1726.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation

Bhuiyan, N. H., Varney, M. L., Wiemer, D. F. & Holstein, S. A., Dec 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 24, 126757.

Research output: Contribution to journalArticle

Summary of the Second Annual BMT CTN Myeloma Intergroup Workshop on Minimal Residual Disease and Immune Profiling

Holstein, S. A., Ye, J. C., Howard, A., Bhutani, M., Gormley, N., Hahn, T., Hillengass, J., Krishnan, A., Landgren, C. O., Munshi, N. C., Oliva, S., Owen, R. G., Pasquini, M. C., Puig, N., Weinhold, N., Weisel, K. & McCarthy, P. L., Mar 2019, In : Biology of Blood and Marrow Transplantation. 25, 3, p. e89-e97

Research output: Contribution to journalArticle

4 Scopus citations

Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron

Haney, S. L., Varney, M. L., Safranek, H. R., Chhonker, Y. S., G-Dayanandan, N., Talmon, G., Murry, D. J., Wiemer, A. J., Wright, D. L. & Holstein, S. A., Feb 2019, In : Leukemia Research. 77, p. 17-27 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors

Bhuiyan, N. H., Varney, M. L., Bhattacharya, D. S., Payne, W. M., Mohs, A. M., Holstein, S. A. & Wiemer, D. F., Oct 1 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 19, 126633.

Research output: Contribution to journalArticle

2 Scopus citations
2018
1 Scopus citations

Maintenance Treatment and Survival in Patients with Myeloma: A Systematic Review and Network Meta-analysis

Gay, F., Jackson, G., Rosiñol, L., Holstein, S. A., Moreau, P., Spada, S., Davies, F., Lahuerta, J. J., Leleu, X., Bringhen, S., Evangelista, A., Hulin, C., Panzani, U., Cairns, D. A., Di Raimondo, F., Macro, M., Liberati, A. M., Pawlyn, C., Offidani, M., Spencer, A. & 11 others, Hájek, R., Terpos, E., Morgan, G. J., Bladé, J., Sonneveld, P., San-Miguel, J., McCarthy, P. L., Ludwig, H., Boccadoro, M., Mateos, M. V. & Attal, M., Oct 2018, In : JAMA Oncology. 4, 10, p. 1389-1397 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

Next-generation drugs targeting the cereblon ubiquitin ligase

Holstein, S. A., Hillengass, J. & McCarthy, P. L., Jul 10 2018, In : Journal of Clinical Oncology. 36, 20, p. 2101-2104 4 p.

Research output: Contribution to journalArticle

3 Scopus citations

Preclinical investigation of a potent geranylgeranyl diphosphate synthase inhibitor

Haney, S. L., Chhonker, Y. S., Varney, M. L., Talmon, G., Murry, D. J. & Holstein, S. A., Oct 1 2018, In : Investigational New Drugs. 36, 5, p. 810-818 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Quantitative determination of a potent geranylgeranyl diphosphate synthase inhibitor using LC–MS/MS: Derivatization and application

Chhonker, Y. S., Haney, S. L., Matthiesen, R. A., Wiemer, D. F., Holstein, S. A. & Murry, D. J., May 10 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 153, p. 22-28 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Simultaneous quantitation of isoprenoid pyrophosphates in plasma and cancer cells using LC-MS/MS

Chhonker, Y. S., Haney, S. L., Bala, V., Holstein, S. A. & Murry, D. J., Dec 11 2018, In : Molecules. 23, 12, 3275.

Research output: Contribution to journalArticle

4 Scopus citations

α-Methylation enhances the potency of isoprenoid triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors

Matthiesen, R. A., Varney, M. L., Xu, P. C., Rier, A. S., Wiemer, D. F. & Holstein, S. A., Jan 15 2018, In : Bioorganic and Medicinal Chemistry. 26, 2, p. 376-385 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase

Wills, V. S., Metzger, J. I., Allen, C., Varney, M. L., Wiemer, D. F. & Holstein, S. A., 2017, In : Bioorganic and Medicinal Chemistry. 25, 8, p. 2437-2444 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Clinical practice guidelines in oncology

Kumar, S. K., Callander, N. S., Alsina, M., Atanackovic, D., Biermann, J. S., Chandler, J. C., Costello, C., Faiman, M., Fung, H. C., Gasparetto, C., Godby, K., Hofmeister, C., Holmberg, L., Holstein, S., Huff, C. A., Kassim, A., Liedtke, M., Martin, T., Omel, J., Raje, N. & 9 others, Reu, F. J., Singhal, S., Somlo, G., Stockerl-Goldstein, K., Treon, S. P., Weber, D., Yahalom, J., Shead, D. A. & Kumar, R., Feb 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 2, p. 230-269 40 p.

Research output: Contribution to journalArticle

Open Access
96 Scopus citations

Immune signatures associated with improved progression-free and overall survival for myeloma patients treated with AHSCT

Ho, C. M., McCarthy, P. L., Wallace, P. K., Zhang, Y., Fora, A., Mellors, P., Tario, J. D., McCarthy, B. L. S., Chen, G. L., Holstein, S. A., Balderman, S. R., Cao, X., Paiva, B. & Hahn, T., Jun 27 2017, In : Blood Advances. 1, 15, p. 1056-1066 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Lenalidomide maintenance after autologous stem-cell transplantation in newly diagnosed multiple myeloma: A meta-analysis

McCarthy, P. L., Holstein, S. A., Petrucci, M. T., Richardson, P. G., Hulin, C., Tosi, P., Bringhen, S., Musto, P., Anderson, K. C., Caillot, D., Gay, F., Moreau, P., Marit, G., Jung, S. H., Yu, Z., Winograd, B., Knight, R. D., Palumbo, A. & Attal, M., Oct 10 2017, In : Journal of Clinical Oncology. 35, 29, p. 3279-3289 11 p.

Research output: Contribution to journalArticle

190 Scopus citations

Novel tropolones induce the unfolded protein response pathway and apoptosis in multiple myeloma cells

Haney, S. L., Allen, C., Varney, M. L., Dykstra, K. M., Falcone, E. R., Colligan, S. H., Hu, Q., Aldridge, A. M., Wright, D. L., Wiemer, A. J. & Holstein, S. A., 2017, In : Oncotarget. 8, 44, p. 76085-76098 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Olefin isomers of a triazole bisphosphonate synergistically inhibit geranylgeranyl diphosphate synthase

Allen, C., Kortagere, S., Tong, H., Matthiesen, R. A., Metzger, J. I., Wiemer, D. F. & Holstein, S. A., Mar 2017, In : Molecular pharmacology. 91, 3, p. 229-236 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Phase 2 study of tabalumab, a human anti-B-cell activating factor antibody, with bortezomib and dexamethasone in patients with previously treated multiple myeloma

Raje, N. S., Moreau, P., Terpos, E., Benboubker, L., Grząśko, N., Holstein, S. A., Oriol, A., Huang, S. Y., Beksac, M., Kuliczkowski, K., Tai, D. F., Wooldridge, J. E., Conti, I., Kaiser, C. J., Nguyen, T. S., Cronier, D. M. & Palumbo, A., Mar 1 2017, In : British Journal of Haematology. 176, 5, p. 783-795 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial

Holstein, S. A., Jung, S. H., Richardson, P. G., Hofmeister, C. C., Hurd, D. D., Hassoun, H., Giralt, S., Stadtmauer, E. A., Weisdorf, D. J., Vij, R., Moreb, J. S., Callander, N. S., van Besien, K., Gentile, T. G., Isola, L., Maziarz, R. T., Bashey, A., Landau, H., Martin, T., Qazilbash, M. H. & 18 others, Rodriguez, C., McClune, B., Schlossman, R. L., Smith, S. E., Hars, V., Owzar, K., Jiang, C., Boyd, M., Schultz, C., Wilson, M., Hari, P., Pasquini, M. C., Horowitz, M. M., Shea, T. C., Devine, S. M., Linker, C., Anderson, K. C. & McCarthy, P. L., Sep 2017, In : The Lancet Haematology. 4, 9, p. e431-e442

Research output: Contribution to journalArticle

51 Scopus citations
2016

Anaplastic Multiple Myeloma: An Aggressive Variant With a Poor Response to Novel Therapies

Ammannagari, N., Celotto, K., Neppalli, V., Lee, K. & Holstein, S. A., Sep 1 2016, In : Clinical Lymphoma, Myeloma and Leukemia. 16, 9, p. e129-e131

Research output: Contribution to journalArticle

3 Scopus citations

A new motif for inhibitors of geranylgeranyl diphosphate synthase

Foust, B. J., Allen, C., Holstein, S. A. & Wiemer, D. F., 2016, In : Bioorganic and Medicinal Chemistry. 24, 16, p. 3734-3741 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

NCCN guidelines® insights multiple myeloma, version 3.2016 featured updates to the NCCN guidelines

Anderson, K. C., Alsina, M., Atanackovic, D., Biermann, J. S., Chandler, J. C., Costello, C., Djulbegovic, B., Fung, H. C., Gasparetto, C., Godby, K., Hofmeister, C., Holmberg, L., Holstein, S., Huff, C. A., Kassim, A., Krishnan, A. Y., Kumar, S. K., Liedtke, M., Lunning, M., Raje, N. & 9 others, Reu, F. J., Singhal, S., Somlo, G., Stockerl-Goldstein, K., Treon, S. P., Weber, D., Yahalom, J., Shead, D. A. & Kumar, R., Apr 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 4, p. 389-400 12 p.

Research output: Contribution to journalArticle

Open Access
41 Scopus citations

Novel α-substituted tropolones promote potent and selective caspase-dependent leukemia cell apoptosis

Li, J., Falcone, E. R., Holstein, S. A., Anderson, A. C., Wright, D. L. & Wiemer, A. J., Nov 1 2016, In : Pharmacological Research. 113, p. 438-448 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Role of stem cell transplant and maintenance therapy in plasma cell disorders

McCarthy, P. L. & Holstein, S. A., 2016, In : Hematology. 2016, 1, p. 504-511 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Stereocontrolled regeneration of olefins from epoxides

Wills, V. S., Zhou, X., Allen, C., Holstein, S. A. & Wiemer, D. F., Mar 23 2016, In : Tetrahedron Letters. 57, 12, p. 1335-1337 3 p.

Research output: Contribution to journalArticle

4 Scopus citations

Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates

Matthiesen, R. A., Wills, V. S., Metzger, J. I., Holstein, S. A. & Wiemer, D. F., Oct 7 2016, In : Journal of Organic Chemistry. 81, 19, p. 9438-9442 5 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

Mechanisms for autophagy modulation by isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Dykstra, K. M., Allen, C., Born, E. J., Tong, H. & Holstein, S. A., 2015, In : Oncotarget. 6, 39, p. 41535-41549 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

N-oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation

Zhou, X., Born, E. J., Allen, C., Holstein, S. A. & Wiemer, D. F., Jun 1 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 11, p. 2331-2334 4 p., 22604.

Research output: Contribution to journalArticle

6 Scopus citations

Phase I and pharmacokinetic study of the novel anthracycline derivative 5-imino-13-deoxydoxorubicin (GPX-150) in patients with advanced solid tumors

Holstein, S. A., Bigelow, J. C., Olson, R. D., Vestal, R. E., Walsh, G. M. & Hohl, R. J., Jun 22 2015, In : Investigational New Drugs. 33, 3, p. 594-602 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase

Wills, V. S., Allen, C., Holstein, S. A. & Wiemer, D. F., Dec 10 2015, In : ACS Medicinal Chemistry Letters. 6, 12, p. 1195-1198 4 p.

Research output: Contribution to journalArticle

22 Scopus citations
2014

Geranyl and neryl triazole bisphosphonates as inhibitors of geranylgeranyl diphosphate synthase

Zhou, X., Ferree, S. D., Wills, V. S., Born, E. J., Tong, H., Wiemer, D. F. & Holstein, S. A., May 1 2014, In : Bioorganic and Medicinal Chemistry. 22, 9, p. 2791-2798 8 p.

Research output: Contribution to journalArticle

26 Scopus citations

The evolving tale of immunomodulatory drugs and cereblon

Holstein, S. A., Sep 17 2014, In : Clinical Pharmacology and Therapeutics. 96, 5, p. 538-541 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013
12 Scopus citations

The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model

Graham, J. M., Ayati, B. P., Holstein, S. A. & Martin, J. A., May 22 2013, In : PloS one. 8, 5, e63884.

Research output: Contribution to journalArticle

30 Scopus citations

Triazole-based inhibitors of geranylgeranyltransferase II

Zhou, X., Hartman, S. V., Born, E. J., Smits, J. P., Holstein, S. A. & Wiemer, D. F., Feb 1 2013, In : Bioorganic and Medicinal Chemistry Letters. 23, 3, p. 764-766 3 p.

Research output: Contribution to journalArticle

21 Scopus citations
2011
28 Scopus citations

Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis

Holstein, S. A., Kuder, C. H., Tong, H. & Hohl, R. J., Oct 2011, In : Lipids. 46, 10, p. 907-921 15 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Differential activities of thalidomide and isoprenoid biosynthetic pathway inhibitors in multiple myeloma cells

Holstein, S. A., Tong, H. & Hohl, R. J., Mar 2010, In : Leukemia Research. 34, 3, p. 344-351 8 p.

Research output: Contribution to journalArticle

15 Scopus citations
2009

Quantitative determination of geranyl diphosphate levels in cultured human cells

Holstein, S. A., Tong, H., Kuder, C. H. & Hohl, R. J., Nov 2009, In : Lipids. 44, 11, p. 1055-1062 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Renal failure and recovery associated with second-generation Bcr-Abl kinase inhibitors in imatinib-resistant chronic myelogenous leukemia

Holstein, S. A., Stokes, J. B. & Hohl, R. J., Feb 2009, In : Leukemia Research. 33, 2, p. 344-347 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Severe lead poisoning caused by use of health supplements presenting as acute abdominal pain during pregnancy

Shamshirsaz, A. A., Yankowitz, J., Rijhsinghani, A., Greiner, A., Holstein, S. A. & Niebyl, J. R., Aug 2009, In : Obstetrics and gynecology. 114, 2 PART 2 SUPPL., p. 448-450 3 p.

Research output: Contribution to journalArticle

6 Scopus citations