Satyanarayana Rachagani, PhD

  • 2686 Citations
  • 26 h-Index
20062020

Research output per year

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Research Output

  • 2686 Citations
  • 26 h-Index
  • 65 Article
  • 11 Review article
  • 3 Comment/debate
  • 1 Short survey
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Article
2020

CXCR2 signaling promotes secretory cancer-associated fibroblasts in pancreatic ductal adenocarcinoma

Awaji, M., Saxena, S., Wu, L., Prajapati, D. R., Purohit, A., Varney, M. L., Kumar, S., Rachagani, S., Ly, Q. P., Jain, M., Batra, S. K. & Singh, R. K., Jul 1 2020, In : FASEB Journal. 34, 7, p. 9405-9418 14 p.

Research output: Contribution to journalArticle

Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesis

Gupta, R., Leon, F., Thompson, C. M., Nimmakayala, R., Karmakar, S., Nallasamy, P., Chugh, S., Prajapati, D. R., Rachagani, S., Kumar, S. & Ponnusamy, M. P., May 26 2020, In : British journal of cancer. 122, 11, p. 1661-1672 12 p.

Research output: Contribution to journalArticle

Irreversible and sustained upregulation of endothelin axis during oncogene-associated pancreatic inflammation and cancer

Gupta, S., Prajapati, A., Gulati, M., Gautam, S. K., Kumar, S., Dalal, V., Talmon, G. A., Rachagani, S. & Jain, M., Feb 2020, In : Neoplasia (United States). 22, 2, p. 98-110 13 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

Pothuraju, R., Rachagani, S., Krishn, S. R., Chaudhary, S., Nimmakayala, R. K., Siddiqui, J. A., Ganguly, K., Lakshmanan, I., Cox, J. L., Mallya, K., Kaur, S. & Batra, S. K., Feb 25 2020, In : Molecular cancer. 19, 1, 37.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019

Afatinib and Temozolomide combination inhibits tumorigenesis by targeting EGFRvIII-cMet signaling in glioblastoma cells

Vengoji, R., Macha, M. A., Nimmakayala, R. K., Rachagani, S., Siddiqui, J. A., Mallya, K., Gorantla, S., Jain, M., Ponnusamy, M. P., Batra, S. K. & Shonka, N., Jun 18 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 266.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations
Open Access
1 Scopus citations

Dual delivery nanoscale device for miR-345 and gemcitabine co-delivery to treat pancreatic cancer

Uz, M., Kalaga, M., Pothuraju, R., Ju, J., Junker, W. M., Batra, S. K., Mallapragada, S. & Rachagani, S., Jan 28 2019, In : Journal of Controlled Release. 294, p. 237-246 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition

Abdalla, M. Y., Ahmad, I. M., Rachagani, S., Banerjee, K., Thompson, C. M., Maurer, H. C., Olive, K. P., Bailey, K. L., Britigan, B. E. & Kumar, S., May 2019, In : Translational Research. 207, p. 56-69 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

Trefoil factor(s) and CA19.9: A promising panel for early detection of pancreatic cancer

Jahan, R., Ganguly, K., Smith, L. M., Atri, P., Carmicheal, J., Sheinin, Y., Rachagani, S., Natarajan, G., Brand, R. E., Macha, M. A., Grandgenett, P. M., Kaur, S. & Batra, S. K., Apr 2019, In : EBioMedicine. 42, p. 375-385 11 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
2018

Axed MUC4 (MUC4/X) aggravates pancreatic malignant phenotype by activating integrin-β1/FAK/ERK pathway

Jahan, R., Macha, M. A., Rachagani, S., Das, S., Smith, L. M., Kaur, S. & Batra, S. K., Aug 2018, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1864, 8, p. 2538-2549 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

20 Scopus citations

Disruption of C1galt1 Gene Promotes Development and Metastasis of Pancreatic Adenocarcinomas in Mice

Chugh, S., Barkeer, S., Rachagani, S., Nimmakayala, R. K., Perumal, N., Pothuraju, R., Atri, P., Mahapatra, S., Thapa, I., Talmon, G. A., Smith, L. M., Yu, X., Neelamegham, S., Fu, J., Xia, L., Palanimuthu Ponnusamy, M. & Batra, S. K., Nov 2018, In : Gastroenterology. 155, 5, p. 1608-1624 17 p.

Research output: Contribution to journalArticle

11 Scopus citations

Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells

Barkeer, S., Chugh, S., Karmakar, S., Kaushik, G., Rauth, S., Rachagani, S., Batra, S. K. & Ponnusamy, M. P., Nov 22 2018, In : BMC cancer. 18, 1, 1157.

Research output: Contribution to journalArticle

8 Scopus citations

Pathological and functional significance of Semaphorin-5A in pancreatic cancer progression and metastasis

Saxena, S., Hayashi, Y., Wu, L., Awaji, M., Atri, P., Varney, M. L., Purohit, A., Rachagani, S., Batra, S. K. & Singh, R. K., 2018, In : Oncotarget. 9, 5, p. 5931-5943 13 p.

Research output: Contribution to journalArticle

10 Scopus citations
2017

Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Macha, M. A., Rachagani, S., Qazi, A. K., Jahan, R., Gupta, S., Patel, A. A., Seshacharyulu, P., Lin, C., Li, S., Wang, S., Verma, V., Kishida, S., Kishida, M., Nakamura, N., Kibe, T., Lydiatt, W. M., Smith, R. B., Ganti, A. K., Jones, D. T., Batra, S. K. & 1 others, Jain, M., 2017, In : Oncotarget. 8, 13, p. 20961-20973 13 p.

Research output: Contribution to journalArticle

18 Scopus citations

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Lakshmanan, I., Salfity, S., Seshacharyulu, P., Rachagani, S., Thomas, A., Das, S., Majhi, P. D., Nimmakayala, R. K., Vengoji, R., Lele, S. M., Ponnusamy, M. P., Batra, S. K. & Ganti, A. K., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

Joshi, S., Cruz, E., Rachagani, S., Guha, S., Brand, R. E., Ponnusamy, M. P., Kumar, S. & Batra, S. K., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1063-1077 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Purohit, A., Varney, M., Rachagani, S., Ouellette, M. M., Batra, S. K. & Singh, R. K., 2016, In : Oncotarget. 7, 6, p. 7280-7296 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

Das, S., Rachagani, S., Sheinin, Y., Smith, L. M., Gurumurthy, C. B., Roy, H. K. & Batra, S. K., May 19 2016, In : Oncogene. 35, 20, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism

Muniyan, S., Haridas, D., Chugh, S., Rachagani, S., Lakshmanan, I., Gupta, S., Seshacharyulu, P., Smith, L. M., Ponnusamy, M. P. & Batra, S. K., Mar 2016, In : Genes and Cancer. 7, 3-4, p. 110-124 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the notch effector hath1 in colorectal cancer

Pai, P., Rachagani, S., Dhawan, P., Sheinin, Y. M., Macha, M. A., Qazi, A. K., Chugh, S., Ponnusamy, M. P., Mallya, K., Pothuraju, R. & Batra, S. K., May 2016, In : Genes and Cancer. 7, 5-6, p. 154-168 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

Lakshmanan, I., Rachagani, S., Hauke, R., Krishn, S. R., Paknikar, S., Seshacharyulu, P., Karmakar, S., Nimmakayala, R. K., Kaushik, G., Johansson, S. L., Carey, G. B., Ponnusamy, M. P., Kaur, S., Batra, S. K. & Ganti, A. K., Aug 4 2016, In : Oncogene. 35, 31, p. 4112-4121 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Vaz, A. P., Deb, S., Rachagani, S., Dey, P., Muniyan, S., Lakshmanan, I., Karmakar, S., Smith, L., Johansson, S., Lele, S., Ouellette, M., Ponnusamy, M. P. & Batra, S. K., 2016, In : Oncotarget. 7, 3, p. 3317-3331 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Wang, Y., Kumar, S., Rachagani, S., Sajja, B. R., Xie, Y., Hang, Y., Jain, M., Li, J., Boska, M. D., Batra, S. K. & Oupický, D., Sep 1 2016, In : Biomaterials. 101, p. 108-120 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Ponnusamy, M. P., Mumby, M. C., Batra, S. K. & Yan, Y., Apr 15 2016, In : Cancer Research. 76, 8, p. 2243-2253 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma

Pai, P., Rachagani, S., Lakshmanan, I., Macha, M. A., Sheinin, Y., Smith, L. M., Ponnusamy, M. P. & Batra, S. K., Feb 1 2016, In : Molecular Oncology. 10, 2, p. 224-239 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

Pandey, P., Rachagani, S., Das, S., Seshacharyulu, P., Sheinin, Y., Naslavsky, N., Pan, Z., Smith, B. L., Peters, H. L., Radhakrishnan, P., McKenna, N. R., Panapakkam Giridharan, S. S., Haridas, D., Kaur, S., Hollingsworth, M. A., MacDonald, R. G., Meza, J. L., Caplan, S., Batra, S. K. & Solheim, J. C., 2015, In : Oncotarget. 6, 4, p. 2064-2075 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

Das, S., Rachagani, S., Torres-Gonzalez, M. P., Lakshmanan, I., Majhi, P. D., Smith, L. M., Wagner, K. U. & Batra, S. K., 2015, In : Oncotarget. 6, 8, p. 5772-5787 16 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model

Rachagani, S., Macha, M. A., Menning, M. S., Dey, P., Pai, P., Smith, L. M., Mo, Y. Y. & Batra, S. K., 2015, In : Oncotarget. 6, 37, p. 40295-40309 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Codelivery of small molecule hedgehog inhibitor and miRNA for treating pancreatic cancer

Kumar, V., Mondal, G., Slavik, P., Rachagani, S., Batra, S. K. & Mahato, R. I., Apr 6 2015, In : Molecular Pharmaceutics. 12, 4, p. 1289-1298 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Mimeault, M., Rachagani, S., Muniyan, S., Seshacharyulu, P., Johansson, S. L., Datta, K., Lin, M. F. & Batra, S. K., 2015, In : Oncotarget. 6, 6, p. 3887-3903 17 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments

Das, S., Majhi, P. D., Al-Mugotir, M. H., Rachagani, S., Sorgen, P. & Batra, S. K., Jun 5 2015, In : Scientific reports. 5, 9759.

Research output: Contribution to journalArticle

21 Scopus citations

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., Mar 26 2015, In : Oncogene. 34, 13, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
14 Scopus citations

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K., Ponnusamy, M. P. & Batra, S. K., 2015, In : Oncotarget. 6, 25, p. 21085-21099 15 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Seshacharyulu, P., Ponnusamy, M. P., Rachagani, S., Lakshmanan, I., Haridas, D., Yan, Y., Ganti, A. K. & Batra, S. K., 2015, In : Oncotarget. 6, 7, p. 5164-5181 18 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations
2014

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers

Macha, M. A., Seshacharyulu, P., Krishn, S. R., Pai, P., Rachagani, S., Jain, M. & Batra, S. K., 2014, In : Current Pharmaceutical Design. 20, 33, p. 5287-5297 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer

Kaur, S., Sharma, N., Krishn, S. R., Lakshmanan, I., Rachagani, S., Baine, M. J., Smith, L. M., Lele, S. M., Sasson, A. R., Guha, S., Mallya, K., Anderson, J. M., Hollingsworth, M. A. & Batra, S. K., 2014, In : Clinical Cancer Research. 20, 3, p. 688-700 13 p.

Research output: Contribution to journalArticle

22 Scopus citations
21 Scopus citations

PD2/Paf1 depletion in pancreatic acinar cells promotes acinarto-ductal metaplasia

Dey, P., Rachagani, S., Vaz, A. P., Ponnusamy, M. P. & Batra, S. K., 2014, In : Oncotarget. 5, 12, p. 4480-4491 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophages

Kumar, S., Torres, M. P., Kaur, S., Rachagani, S., Joshi, S., Johansson, S. L., Momi, N., Baine, M. J., Gilling, C. E., Smith, L. M., Wyatt, T. A., Jain, M., Joshi, S. S. & Batra, S. K., Jun 9 2014, In : Oncogene. 34, 16, p. 2052-2060 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Unbiased analysis of pancreatic cancer radiation resistance reveals cholesterol biosynthesis as a novel target for radiosensitisation.

Souchek, J. J., Baine, M. J., Lin, C., Rachagani, S., Gupta, S., Kaur, S., Lester, K., Zheng, D., Chen, S., Smith, L. M., Lazenby, A. J., Johansson, S. L., Jain, M. & Batra, S. K., Sep 9 2014, In : British journal of cancer. 111, 6, p. 1139-1149 11 p.

Research output: Contribution to journalArticle

33 Scopus citations
2013

Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects

Cheng, Y., Rachagani, S., Cánovas, A., Mayes, M. S., Tait, R. G., Dekkers, J. C. M. & Reecy, J. M., Oct 29 2013, In : BMC Genetics. 14, 103.

Research output: Contribution to journalArticle

5 Scopus citations

Guggulsterone decreases proliferation and metastatic behavior of pancreatic cancer cells by modulating JAK/STAT and Src/FAK signaling

Macha, M. A., Rachagani, S., Gupta, S., Pai, P., Ponnusamy, M. P., Batra, S. K. & Jain, M., Dec 1 2013, In : Cancer Letters. 341, 2, p. 166-177 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Holy Basil leaf extract decreases tumorigenicity and metastasis of aggressive human pancreatic cancer cells in vitro and in vivo: Potential role in therapy

Shimizu, T., Torres, M. P., Chakraborty, S., Souchek, J. J., Rachagani, S., Kaur, S., Macha, M. A., Ganti, A. K., Hauke, R. J. & Batra, S. K., Aug 19 2013, In : Cancer Letters. 336, 2, p. 270-280 11 p.

Research output: Contribution to journalArticle

25 Scopus citations

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

Pandey, P., Seshacharyulu, P., Das, S., Rachagani, S., Ponnusamy, M. P., Yan, Y., Johansson, S. L., Datta, K., Lin, M. F. & Batra, S. K., Jun 25 2013, In : British journal of cancer. 108, 12, p. 2590-2600 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Nicotine/cigarette smoke promotes metastasis of pancreatic cancer through α7nAChR-mediated MUC4 upregulation

Momi, N., Ponnusamy, M. P., Kaur, S., Rachagani, S., Kunigal, S. S., Chellappan, S., Ouellette, M. M. & Batra, S. K., Mar 14 2013, In : Oncogene. 32, 11, p. 1384-1395 12 p.

Research output: Contribution to journalArticle

77 Scopus citations

Novel pancreatic cancer cell lines derived from genetically engineered mouse models of spontaneous pancreatic adenocarcinoma: Applications in diagnosis and therapy

Torres, M. P., Rachagani, S., Souchek, J. J., Mallya, K., Johansson, S. L. & Batra, S. K., Nov 20 2013, In : PloS one. 8, 11, e80580.

Research output: Contribution to journalArticle

51 Scopus citations
2012

Graviola: A novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism

Torres, M. P., Rachagani, S., Purohit, V., Pandey, P., Joshi, S., Moore, E. D., Johansson, S. L., Singh, P. K., Ganti, A. K. & Batra, S. K., Oct 1 2012, In : Cancer Letters. 323, 1, p. 29-40 12 p.

Research output: Contribution to journalArticle

84 Scopus citations