Shi-Hua Xiang, PhD

  • 2858 Citations
  • 25 h-Index
1993 …2020

Research output per year

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Research Output

  • 2858 Citations
  • 25 h-Index
  • 56 Article
  • 1 Comment/debate
  • 1 Review article
2020

Identification of immunogenic epitopes that permit the detection of antigen-specific T cell responses in multiple serotypes of group B coxsackievirus infections

Lasrado, N., Gangaplara, A., Arumugam, R., Massilamany, C., Pokal, S., Zhou, Y., Xiang, S. H., Steffen, D. & Reddy, J., 2020, In : Viruses. 12, 3, 347.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that localize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection

Basavalingappa, R. H., Arumugam, R., Lasrado, N., Yalaka, B., Massilamany, C., Gangaplara, A., Riethoven, J. J., Xiang, S. H., Steffen, D. & Reddy, J., Aug 2020, In : Molecular Immunology. 124, p. 218-228 11 p.

Research output: Contribution to journalArticle

2019

Blocking HIV-1 infection by chromosomal integrative expression of human CD4 on the surface of lactobacillus acidophilus ATCC 4356

Wei, W., Wiggins, J., Hu, D., Vrbanac, V., Bowder, D., Mellon, M., Tager, A., Sodroski, J. & Xiang, S. H., 2019, In : Journal of virology. 93, 8, Y.

Research output: Contribution to journalArticle

3 Scopus citations

Nucleolin is a functional binding protein for salinomycin in neuroblastoma stem cells

Wang, F., Zhou, S., Qi, D., Xiang, S. H., Wong, E. T., Wang, X., Fonkem, E., Hsieh, T. C., Yang, J., Kirmani, B., Shabb, J. B., Wu, J. M., Wu, M., Huang, J. H., Yu, W. H. & Wu, E., Feb 27 2019, In : Journal of the American Chemical Society. 141, 8, p. 3613-3622 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

The polar region of the HIV-1 envelope protein determines viral fusion and infectivity by stabilizing the gp120-gp41 association

Lu, W., Chen, S., Yu, J., Behrens, R., Wiggins, J., Sherer, N., Liu, S. L., Xiong, Y., Xiang, S. H. & Wu, L., 2019, In : Journal of virology. 93, 7, e02128.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Characterization of twin-cysteine motif in the V2-loop region of gp120 in primate lentiviruses

Bowder, D., Thompson, J., Durst, K., Hollingsead, H., Hu, D., Wei, W. & Xiang, S. H., Jun 2018, In : Virology. 519, p. 180-189 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses

Bowder, D., Hollingsead, H., Durst, K., Hu, D., Wei, W., Wiggins, J., Medjahed, H., Finzi, A., Sodroski, J. & Xiang, S. H., Aug 2018, In : Virology. 521, p. 158-168 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Discovery of a non-nucleoside RNA polymerase inhibitor for blocking Zika virus replication through in silico screening

Pattnaik, A., Palermo, N., Sahoo, B. R., Yuan, Z., Hu, D., Annamalai, A. S., Vu, H. L., Correas, I., Prathipati, P. K., Destache, C. J., Li, Q., Osorio, F. A., Pattnaik, A. K. & Xiang, S-H., Mar 2018, In : Antiviral Research. 151, p. 78-86 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Persistence of SIV in the brain of SIV-infected Chinese rhesus macaques with or without antiretroviral therapy

Perez, S., Johnson, A. M., Xiang, S. H., Li, J., Foley, B. T., Doyle-Meyers, L., Panganiban, A., Kaur, A., Veazey, R. S., Wu, Y. & Ling, B., Feb 1 2018, In : Journal of neurovirology. 24, 1, p. 62-74 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function

Wang, B., Wang, Y., Frabutt, D. A., Zhang, X., Yao, X., Hu, D., Zhang, Z., Liu, C., Zheng, S., Xiang, S. H. & Zheng, Y. H., Apr 7 2017, In : Journal of Biological Chemistry. 292, 14, p. 5860-5870 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Tryptophan 375 stabilizes the outer-domain core of gp120 for HIV vaccine immunogen design

Hu, D., Bowder, D., Wei, W., Thompson, J., Wilson, M. A. & Xiang, S. H., May 25 2017, In : Vaccine. 35, 23, p. 3067-3075 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

Zika virus encoding nonglycosylated envelope protein is attenuated and defective in neuroinvasion

Annamalai, A. S., Pattnaik, A., Sahoo, B. R., Muthukrishnan, E., Natarajan, S. K., Steffen, D., Vu, H. L. X., Delhon, G., Osorio, F. A., Petro, T. M., Xiang, S. H. & Pattnaik, A. K., Dec 1 2017, In : Journal of virology. 91, 23, e01348-17.

Research output: Contribution to journalArticle

36 Scopus citations
2016

A highly conserved gp120 inner domain residue modulates Env conformation and trimer stability

Ding, S., Tolbert, W. D., Prévost, J., Pacheco, B., Coutu, M., Debbeche, O., Xiang, S. H., Pazgier, M. & Finzi, A., 2016, In : Journal of virology. 90, 19, p. 8395-8409 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular determinants of its high selectivity for α3β2 nAChR

Lin, B., Xu, M., Zhu, X., Wu, Y., Liu, X., Zhangsun, D., Hu, Y., Xiang, S. H., Kasheverov, I. E., Tsetlin, V. I., Wang, X. & Luo, S., Mar 1 2016, In : Scientific reports. 6, 22349.

Research output: Contribution to journalArticle

22 Scopus citations

Genome-wide search for host association factors during ovine progressive pneumonia virus infection

Thompson, J., Ma, F., Quinn, M. & Xiang, S. H., Mar 2016, In : PloS one. 11, 3, e0150344.

Research output: Contribution to journalArticle

4 Scopus citations

Lineage-specific differences between the gp120 inner domain layer 3 of human immunodeficiency virus and that of simian immunodeficiency virus

Ding, S., Medjahed, H., Prévost, J., Coutu, M., Xiang, S. H. & Finzi, A., 2016, In : Journal of virology. 90, 22, p. 10065-10073 9 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Residues responsible for the selectivity of α-conotoxins for Ac-AChBP or nAChRs

Lin, B., Xiang, S. & Li, M., Oct 1 2016, In : Marine Drugs. 14, 10, 173.

Research output: Contribution to journalReview article

11 Scopus citations

Sulfotyrosine dipeptide: Synthesis and evaluation as HIV-entry inhibitor

Ju, T., Hu, D., Xiang, S. H. & Guo, J., Oct 1 2016, In : Bioorganic Chemistry. 68, p. 105-111 7 p.

Research output: Contribution to journalArticle

3 Scopus citations
2015

Escherichia coli surface display of single-chain antibody VRC01 against HIV-1 infection

Wang, L. X., Mellon, M., Bowder, D., Quinn, M., Shea, D., Wood, C. & Xiang, S. H., Jan 5 2015, In : Virology. 475, p. 179-186 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2014

Sumoylation differentially regulates Sp1 to control cell differentiation

Gong, L., Ji, W. K., Hu, X. H., Hu, W. F., Tang, X. C., Huang, Z. X., Li, L., Liu, M., Xiang, S. H., Wu, E., Woodward, Z., Liu, Y. Z., Nguyen, Q. D. & Li, D. W. C., Apr 15 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 15, p. 5574-5579 6 p.

Research output: Contribution to journalArticle

52 Scopus citations
2013

A Twin-Cysteine Motif in the V2 Region of gp120 Is Associated with SIV Envelope Trimer Stabilization

Bohl, C., Bowder, D., Thompson, J., Abrahamyan, L., Gonzalez-Ramirez, S., Mao, Y., Sodroski, J., Wood, C. & Xiang, S. H., Jul 23 2013, In : PloS one. 8, 7, e69406.

Research output: Contribution to journalArticle

15 Scopus citations

Characterization of a dual-tropic Human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2

Xiang, S. H., Pacheco, B., Bowder, D., Yuan, W. & Sodroski, J., 2013, In : Virology. 438, 1, p. 5-13 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer

Mao, Y., Wang, L., Gu, C., Herschhorn, A., Désormeaux, A., Finzi, A., Xiang, S. H. & Sodroski, J. G., Jul 23 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 30, p. 12438-12443 6 p.

Research output: Contribution to journalArticle

76 Scopus citations
3 Scopus citations

The highly conserved layer-3 component of the hiv-1 gp120 inner domain is critical for CD4-required conformational transitions

Désormeaux, A., Coutu, M., Medjahed, H., Pacheco, B., Herschhorn, A., Gu, C., Xiang, S. H., Mao, Y., Sodroski, J. & Finzi, A., Mar 2013, In : Journal of virology. 87, 5, p. 2549-2562 14 p.

Research output: Contribution to journalArticle

36 Scopus citations
2012

Critical role of leucine-valine change in distinct low pH requirements for membrane fusion between two related retrovirus envelopes

Côté, M., Zheng, Y. M., Li, K., Xiang, S. H., Albritton, L. M. & Liu, S. L., Mar 2 2012, In : Journal of Biological Chemistry. 287, 10, p. 7640-7651 12 p.

Research output: Contribution to journalArticle

6 Scopus citations

Identification of molecular determinants from Moloney leukemia virus 10 homolog (MOV10) protein for virion packaging and anti-HIV-1 activity

Abudu, A., Wang, X., Dang, Y., Zhou, T., Xiang, S. H. & Zheng, Y. H., Jan 6 2012, In : Journal of Biological Chemistry. 287, 2, p. 1220-1228 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding

Finzi, A., Pacheco, B., Xiang, S. H., Pancera, M., Herschhorn, A., Wang, L., Zeng, X., Desormeaux, A., Kwong, P. D. & Sodroski, J., Sep 2012, In : Journal of virology. 86, 17, p. 8974-8986 13 p.

Research output: Contribution to journalArticle

23 Scopus citations

Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer

Mao, Y., Wang, L., Gu, C., Herschhorn, A., Xiang, S. H., Haim, H., Yang, X. & Sodroski, J., Sep 2012, In : Nature Structural and Molecular Biology. 19, 9, p. 893-899 7 p.

Research output: Contribution to journalArticle

119 Scopus citations
2010

A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer

Xiang, S. H., Finzi, A., Pacheco, B., Alexander, K., Yuan, W., Rizzuto, C., Huang, C. C., Kwong, P. D. & Sodroski, J., Apr 2010, In : Journal of virology. 84, 7, p. 3147-3161 15 p.

Research output: Contribution to journalArticle

56 Scopus citations

Topological Layers in the HIV-1 gp120 Inner Domain Regulate gp41 Interaction and CD4-Triggered Conformational Transitions

Finzi, A., Xiang, S. H., Pacheco, B., Wang, L., Haight, J., Kassa, A., Danek, B., Pancera, M., Kwong, P. D. & Sodroski, J., Mar 12 2010, In : Molecular Cell. 37, 5, p. 656-667 12 p.

Research output: Contribution to journalArticle

137 Scopus citations
2009

Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain

Kassa, A., Madani, N., Schön, A., Haim, H., Finzi, A., Xiang, S. H., Wang, L., Princiotto, A., Pancera, M., Courter, J., Smith, A. B., Freire, E., Kwong, P. D. & Sodroski, J., 2009, In : Journal of virology. 83, 17, p. 8364-8378 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens

Hovav, A. H., Santosuosso, M., Bivas-Benita, M., Plair, A., Cheng, A., Elnekave, M., Righi, E., Chen, T., Kashiwagi, S., Panas, M. W., Xiang, S. H., Furmanov, K., Letvin, N. L. & Poznansky, M. C., Nov 2009, In : Journal of virology. 83, 21, p. 10941-10950 10 p.

Research output: Contribution to journalArticle

9 Scopus citations
2008

Adaptation of the human immunodeficiency virus type 1 envelope glycoproteins to New World monkey receptors

Pacheco, B., Basmaciogullari, S., Labonte, J. A., Xiang, S. H. & Sodroski, J., Jan 2008, In : Journal of virology. 82, 1, p. 346-357 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Small-Molecule CD4 Mimics Interact with a Highly Conserved Pocket on HIV-1 gp120

Madani, N., Schön, A., Princiotto, A. M., LaLonde, J. M., Courter, J. R., Soeta, T., Ng, D., Wang, L., Brower, E. T., Xiang, S. H., Do Kwon, Y., Huang, C. C., Wyatt, R., Kwong, P. D., Freire, E., Smith, A. B. & Sodroski, J., Nov 12 2008, In : Structure. 16, 11, p. 1689-1701 13 p.

Research output: Contribution to journalArticle

133 Scopus citations
2007

Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: Antigenicity, biophysics, and immunogenicity

Dey, B., Pancera, M., Svehla, K., Shu, Y., Xiang, S. H., Vainshtein, J., Li, Y., Sodroski, J., Kwong, P. D., Mascola, J. R. & Wyatt, R., Jun 2007, In : Journal of virology. 81, 11, p. 5579-5593 15 p.

Research output: Contribution to journalArticle

92 Scopus citations

Functional interplay between the B-box 2 and the B30.2(SPRY) domains of TRIM5α

Li, X., Song, B., Xiang, S. H. & Sodroski, J., Sep 30 2007, In : Virology. 366, 2, p. 234-244 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Modulation of retroviral restriction and proteasome inhibitor-resistant turnover by changes in the TRIM5α B-box 2 domain

Diaz-Griffero, F., Kar, A., Perron, M., Xiang, S. H., Javanbakht, H., Li, X. & Sodroski, J., Oct 2007, In : Journal of virology. 81, 19, p. 10362-10378 17 p.

Research output: Contribution to journalArticle

61 Scopus citations

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Zhou, T., Xu, L., Dey, B., Hessell, A. J., Van Ryk, D., Xiang, S. H., Yang, X., Zhang, M. Y., Zwick, M. B., Arthos, J., Burton, D. R., Dimitrov, D. S., Sodroski, J., Wyatt, R., Nabel, G. J. & Kwong, P. D., Feb 15 2007, In : Nature. 445, 7129, p. 732-737 6 p.

Research output: Contribution to journalArticle

627 Scopus citations

Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4

Huang, C. C., Lam, S. N., Acharya, P., Tang, M., Xiang, S. H., Shahzad-Ul-Hussan, S., Stanfield, R. L., Robinson, J., Sodroski, J., Wilson, I. A., Wyatt, R., Bewley, C. A. & Kwong, P. D., Sep 28 2007, In : Science. 317, 5846, p. 1930-1934 5 p.

Research output: Contribution to journalArticle

325 Scopus citations
2006

DNA vaccination with CCL2 DNA modified by the addition of an adjuvant epitope protects against "nonimmune" toxic renal injury

Zheng, G., Wang, Y., Xiang, S. H., Tay, Y. C., Wu, H., Watson, D., Coombes, J., Rangan, G. K., Alexander, S. I. & Harris, D. C. H., Feb 2006, In : Journal of the American Society of Nephrology. 17, 2, p. 465-474 10 p.

Research output: Contribution to journalArticle

28 Scopus citations
2005

Functional mimicry of a human immunodeficiency virus type 1 coreceptor by a neutralizing monoclonal antibody

Xiang, S. H., Farzan, M., Si, Z., Madani, N., Wang, L., Rosenberg, E., Robinson, J. & Sodroski, J., May 2005, In : Journal of virology. 79, 10, p. 6068-6077 10 p.

Research output: Contribution to journalArticle

32 Scopus citations
2003

Conformational changes in env oligomer induced by an antibody dependent on the V3 loop base

Cavacini, L., Duval, M., Song, L., Sangster, R., Xiang, S. H., Sodroski, J. & Posner, M., Mar 28 2003, In : AIDS. 17, 5, p. 685-689 5 p.

Research output: Contribution to journalArticle

47 Scopus citations

Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains

Xiang, S. H., Wang, L., Abreu, M., Huang, C. C., Kwong, P. D., Rosenberg, E., Robinson, J. E. & Sodroski, J., Oct 10 2003, In : Virology. 315, 1, p. 124-134 11 p.

Research output: Contribution to journalArticle

69 Scopus citations

Role of activator protein-1 in the down-regulation of the human CYP2J2 gene in hypoxia

Marden, N. Y., Fiala-Beer, E., Xiang, S. H. & Murray, M., Aug 1 2003, In : Biochemical Journal. 373, 3, p. 669-680 12 p.

Research output: Contribution to journalArticle

43 Scopus citations
2002

Characterization of CD4-induced epitopes on the HIV type 1 gp120 envelope glycoprotein recognized by neutralizing human monoclonal antibodies

Xiang, S. H., Doka, N., Choudhary, R. K., Sodroski, J. & Robinson, J. E., 2002, In : AIDS Research and Human Retroviruses. 18, 16, p. 1207-1217 11 p.

Research output: Contribution to journalArticle

130 Scopus citations

Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein

Xiang, S. H., Kwong, P. D., Gupta, R., Rizzuto, C. D., Casper, D. J., Wyatt, R., Wang, L., Hendrickson, W. A., Doyle, M. L. & Sodroski, J., Oct 2002, In : Journal of virology. 76, 19, p. 9888-9899 12 p.

Research output: Contribution to journalArticle

155 Scopus citations
1998

Identification of a novel transcriptional silencer in the protein-coding region of the human CYP2 C9 gene

Xiang, S. H., Parsons, H. K. & Murray, M., Mar 16 1998, In : Gene. 209, 1-2, p. 123-129 7 p.

Research output: Contribution to journalArticle

10 Scopus citations
1997

Coinfection and Genetic Recombination between HIV-1 Strains: Possible Biological Implications in Australia and South East Asia

Saksena, N. K., Wang, B., Ge, Y. C., Xiang, S. H., Dwyer, D. E. & Cunningham, A. L., Jan 1997, In : Annals of the Academy of Medicine Singapore. 26, 1, p. 121-127 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Molecular analyses of human immunodeficiency virus type 1 V3 region quasispecies derived from plasma and peripheral blood mononuclear cells of the first long-term-nonprogressing mother and child pair

Wang, B., Ge, Y. C., Jozwiak, R., Bolton, W., Palasanthiran, P., Ziegler, J., Chang, J., Xiang, S. H., Cunningham, A. L. & Saksena, N. K., 1997, In : Journal of Infectious Diseases. 175, 6, p. 1510-1515 6 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations