Shilpa J Buch - Projects - Research Nebraska

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Phone402-559-3465

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Research activity per year

18 Finished
31 Not started

49 results

Not started

Morphine and the Neuropathogenesis of SIV in Macaques
Buch, S. J. (CoPI) & Buch, S. J. (PI)
Project: Research project
Combinatorial effects of HIV, cART, & morphine on neuroinflammation: implications for HAND
Buch, S. J. (PI), Guo, M. (CoPI), Guo, M. (CoPI) & Buch, S. J. (CoPI)
Project: Research project
Mechanism and Therapy of HIV Encephalitis
Buch, S. J. (PI) & Buch, S. J. (CoPI)
Project: Research project
HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
Buch, S. J. (PI) & Buch, S. J. (CoPI)
Project: Research project
Molecular mechanisms underlying HIV & Cocaine-mediated microglial activation: Targeting NLRP3 inflammasome
Buch, S. J. (PI), Guo, M. (CoPI) & Guo, M. (CoPI)
Project: Research project
PLGA/Antisense IL-10: Gene Therapy for Cocaine Abusers with HAD
Buch, S. J. (PI) & Buch, S. J. (CoPI)
Project: Research project
Chronic HIV Infection and Aging in NeuroAIDS (CHAIN) Center
Buch, S. J. (CoPI), Buch, S. J. (PI), Boska, M. D. (CoPI), Ciborowski, P. S. (CoPI), Fox, H. S. (CoPI), Gendelman, H. E. (CoPI), Gorantla, S. (CoPI), Sajja, B. R. (CoPI), Swindells, S. (CoPI), Sarvetnick, N. E. (CoPI), Wilson, T. W. (CoPI), Fox, H. S. (CoPI) & Wood, C. (CoPI)
Project: Research project
PDGF-BB Reverses Impaired Neurogenesis Mediated by Tat and Cocaine
Hu, G. (PI) & Buch, S. J. (CoPI)
Project: Research project
Cell/Tissue/Animal Core (Page 182)
Buch, S. J. (PI)
Project: Research project
Novel Approaches for the Control of Microbial Pathogens
Buch, S. J. (CoPI)
Project: Research project
Molecular Mechanisms & Therapy for Cocaine Abuse in HAND
Buch, S. J. (PI)
Project: Research project
Mechanisms underlying dysregulated neuroimmune signaling and neuronal dysfunction in HIV (+) individuals with cART and cocaine
Buch, S. J. (CoPI) & Guo, M. (PI)
Project: Research project
Opiate induced SIV-Neuropathogenesis: Role of miRNA-29b in the Periphery-CNS Cro
Buch, S. J. (PI)
Project: Research project
PDGF-CC Mediated Reversal of Synaptodendritic Injury in HAND
Buch, S. J. (PI)
Project: Research project
Title: Pharmacokinetic, pharmacodynamic , and toxicological interactions among Opioids and Cabotegravir
Fletcher, C. V. (CoPI) & Buch, S. J. (CoPI)
Project: Research project
HIV Tat & Morphine induce mircroglial migration & activation via release of miR-9 & 138
Fox, H. S. (CoPI) & Buch, S. J. (PI)
Project: Research project
Mechanisms underlying dysregulated neuroimmune signaling and neuronal dysfunction in HIV (+) individuals with cART and cocaine
Buch, S. J. (PI), Guo, M. (CoPI) & Guo, M. (CoPI)
Project: Research project
DEVELOPMENT OF GENE THERAPY FOR LENTIVIRAL ENCEPHALITIS
Buch, S. J. (PI)
Project: Research project
Molecular mechanisms underlying HIV & Cocaine-mediated microglial activation: Targeting NLRP3 inflammasome
Buch, S. J. (PI) & Guo, M. (CoPI)
Project: Research project
Cocaine & HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
Buch, S. J. (PI)
Project: Research project
HIV Tat and Opiate-mediated aberrations in glial-neuronal crosstalk: Implications for the role of extracellular RNA in HAND
Buch, S. J. (PI)
Project: Research project
HIV-1 mediated synaptodendritic injury and microglial activation: Role of extracellular vesicle miRNAs
Buch, S. J. (PI) & Hu, G. (CoPI)
Project: Research project
Uncovering HIV/opioid effects in the brain at the single cell level: transcription, chromatin accessibility, and reservoir analysis in the SIV/cART/morphine/rhesus monkey model
Fox, H. S. (PI) & Buch, S. J. (CoPI)
Project: Research project
Single cell determinants of brain in the context of viral persistence in SIV/cART/cocaine non-human primates
Buch, S. J. (CoPI)
Project: Research project
Development of Neuronal gene therapy for HIV-dementia
Buch, S. J. (PI)
Project: Research project
HIV Tat & Cocaine-Mediated induction of Astrogliosis: Role of ER Stress in HAND
Guo, M. (PI) & Buch, S. J. (CoPI)
Project: Research project
Combinatorial effects of HIV, cART, & morphine on neuroinflammation: implications for HAND
Buch, S. J. (CoPI) & Guo, M. (PI)
Project: Research project
HIV-1 mediated synaptodendritic injury and microglial activation: Role of extracellular vesicle miRNAs
Hu, G. (CoPI) & Buch, S. J. (PI)
Project: Research project
HIV Tat & cocaine-mediated alterations in microglial migration & activation involve epigenetic reulation of miRNAs
Guo, M. (CoPI), Hu, G. (CoPI) & Buch, S. J. (PI)
Project: Research project
The brain as a SIV reservoir under suppressive cART potentiation by drugs of abuse
Fox, H. S. (PI), Buch, S. J. (CoPI) & Byrareddy, S. (CoPI)
Project: Research project
The combinatorial effects of Opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogensis and latency
Buch, S. J. (PI) & Byrareddy, S. (CoPI)
Project: Research project
Finished
The brain as a SIV reservoir under suppressive cART potentiation by drugs of abuse
Fox, H. S. (PI), Buch, S. J. (CoPI) & Byrareddy, S. (CoPI)
National Institutes of Health
9/15/16 → 8/31/21
Project: Research project
HIV Tat & cocaine-mediated alterations in microglial migration & activation involve epigenetic reulation of miRNAs
Buch, S. J. (PI), Guo, M. (CoPI) & Hu, G. (CoPI)
National Institutes of Health
9/1/16 → 5/31/21
Project: Research project
The combinatorial effects of Opiates and the emerging promoter-variant strains of HIV-1 subtype C on HIV neuropathogensis and latency
Buch, S. J. (PI) & Byrareddy, S. (CoPI)
National Institutes of Health
8/15/16 → 7/31/21
Project: Research project
HIV Tat & Morphine induce mircroglial migration & activation via release of miR-9 & 138
Buch, S. J. (PI) & Fox, H. S. (CoPI)
National Institutes of Health
8/1/15 → 5/31/20
Project: Research project
PDGF-CC Mediated Reversal of Synaptodendritic Injury in HAND
Buch, S. J. (PI)
National Institutes of Health
7/3/15 → 5/31/20
Project: Research project
HIV Tat & Cocaine-Mediated induction of Astrogliosis: Role of ER Stress in HAND
Buch, S. J. (PI) & Guo, M. (PI)
National Institutes of Health
7/1/13 → 3/31/18
Project: Research project
Opiate induced SIV-Neuropathogenesis: Role of miRNA-29b in the Periphery-CNS Cro
Buch, S. J. (PI)
National Institutes of Health
2/1/13 → 1/31/18
Project: Research project
PDGF-BB Reverses Impaired Neurogenesis Mediated by Tat and Cocaine
Buch, S. J. (PI), Honghong, Y. (PI) & Hu, G. (PI)
National Institutes of Health
1/15/12 → 12/31/16
Project: Research project
Molecular Mechanisms &Therapy for Cocaine Abuse in HAND
Buch, S. J. (PI)
National Institutes of Health
9/30/11 → 7/31/14
Project: Research project
Cocaine &HIV: Role of PDGF/PDGF-Receptor Axis in Blood Brain Barrier Disruption
Buch, S. J. (PI) & Kim, K. (PI)
National Institutes of Health
9/15/09 → 5/31/15
Project: Research project
PLGA/Antisense IL-10: Gene Therapy for Cocaine Abusers with HAD
Buch, S. J. (PI)
National Institutes of Health
2/1/09 → 1/31/12
Project: Research project
Morphine and the Neuropathogenesis of SIV in Macaques
Buch, S. J. (PI)
National Institutes of Health
9/30/07 → 8/31/13
Project: Research project
HIV-Encephalitis and Cocaine Abuse: Mechanism of Synergy and Therapy
Buch, S. J. (PI)
National Institutes of Health
5/1/06 → 4/30/12
Project: Research project
Development of Neuronal gene therapy for HIV-dementia
Buch, S. J. (PI)
National Institutes of Health
12/20/04 → 11/30/07
Project: Research project
Mechanism and Therapy of SHIV Encephalitis in Macaques
Buch, S. J. (PI)
National Institutes of Health
4/1/03 → 3/31/14
Project: Research project
NOVEL APPROACHES FOR CONTROL OF MICROBIAL PATHOGENS
Buch, S. J. (PI), Tang, X. (PI), Schonbrunn, E. (PI), Passarelli, A. L. (PI), Sundaramoorthy, M. (PI), Mukherjee, A. (PI), Cue, D. (PI), Lutkenhaus, J. (PI), Lamb, A. (PI), MacKay, G. (PI), Hagedorn, C. (PI), Nicot, C. (PI), Dutta, A. (PI), Singh, D. (PI), Moro, M. (PI), Ladokhin, A. (PI), Holyoak, T. (PI), Hancock, L. (PI), Yankee, T. M. (PI), Vines, C. (PI), Tang, L. (PI), Fields, P. (PI), Kim, K. (PI), Slusser, J. G. (PI), Arrode, G. (PI), Berkland, C. (PI), Chang, K. (PI), Montello, M. (PI), Jianming, Q. (PI), Hardwidge, P. R. (PI), Gudima, S. (PI), Stephens, E. B. (PI), Mohammad Ayoub, M. (PI), Narayan, O. (PI), Chebloune, Y. (PI) & Biswas, I. (PI)
National Institutes of Health
9/30/01 → 6/30/12
Project: Research project
DEVELOPMENT OF GENE THERAPY FOR LENTIVIRAL ENCEPHALITIS
Buch, S. J. (PI)
National Institutes of Health
1/1/01 → 12/31/03
Project: Research project
SCRIPPS NEUROAIDS PRECLINICAL STUDIES (SNAPS)
Ciborowski, P. S. (PI), Boska, M. D. (PI), Gendelman, H. E. (PI), Wood, C. (PI), Swindells, S. (PI), Sarvetnick, N. E. (PI), Fox, H. S. (PI), Ideker, T. (PI), Buch, S. (PI), Taffe, M. (PI), Elder, J. (PI), Dawson, P. (PI), Henriksen, S. (PI), Campbell, I. L. (PI), Buch, S. J. (PI), Gorantla, S. (PI), Fox, H. S. (CoPI) & Wilson, T. W. (PI)
National Institutes of Health
9/30/00 → 2/28/17
Project: Research project

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