Soonkyu Chung, PhD

  • 1793 Citations
  • 26 h-Index
20042020

Research output per year

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Research Output

  • 1793 Citations
  • 26 h-Index
  • 51 Article
  • 8 Review article
  • 1 Comment/debate
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Article
2020

Alpha-linolenic acid-enriched butter promotes fatty acid remodeling and thermogenic activation in the brown adipose tissue

You, M., Fan, R., Kim, J., Shin, S. H. & Chung, S., Jan 2020, In : Nutrients. 12, 1, 136.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Apigenin Reverses Interleukin-1β-Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes

Okla, M., Al Madani, J. O., Chung, S. & Alfayez, M., Jan 1 2020, In : Molecular Nutrition and Food Research. 64, 1, 1900925.

Research output: Contribution to journalArticle

1 Scopus citations

Red Raspberry Polyphenols Attenuate High-Fat Diet–Driven Activation of NLRP3 Inflammasome and its Paracrine Suppression of Adipogenesis via Histone Modifications

Fan, R., You, M., Toney, A. M., Kim, J., Giraud, D., Xian, Y., Ye, F., Gu, L., Ramer-Tait, A. E. & Chung, S., Aug 1 2020, In : Molecular Nutrition and Food Research. 64, 15, 1900995.

Research output: Contribution to journalArticle

α-Linolenic acid-enriched butter attenuated high fat diet-induced insulin resistance and inflammation by promoting bioconversion of n-3 PUFA and subsequent oxylipin formation

Fan, R., Kim, J., You, M., Giraud, D., Toney, A. M., Shin, S. H., Kim, S. Y., Borkowski, K., Newman, J. W. & Chung, S., Feb 2020, In : Journal of Nutritional Biochemistry. 76, 108285.

Research output: Contribution to journalArticle

3 Scopus citations
2019

Differentiating human pluripotent stem cells into vascular smooth muscle cells in three dimensional thermoreversible hydrogels

Lin, H., Du, Q., Li, Q., Wang, O., Wang, Z., Liu, K., Akert, L., Zhang, C., Chung, S., Duan, B. & Lei, Y., Jan 2019, In : Biomaterials Science. 7, 1, p. 347-361 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

Manufacturing human pluripotent stem cell derived endothelial cells in scalable and cell-friendly microenvironments

Lin, H., Du, Q., Li, Q., Wang, O., Wang, Z., Elowsky, C., Liu, K., Zhang, C., Chung, S., Duan, B. & Lei, Y., Jan 2019, In : Biomaterials Science. 7, 1, p. 373-388 16 p.

Research output: Contribution to journalArticle

Urolithin A, a Gut Metabolite, Improves Insulin Sensitivity Through Augmentation of Mitochondrial Function and Biogenesis

Toney, A. M., Fan, R., Xian, Y., Chaidez, V., Ramer-Tait, A. E. & Chung, S., Apr 2019, In : Obesity. 27, 4, p. 612-620 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

A Scalable and Efficient Bioprocess for Manufacturing Human Pluripotent Stem Cell-Derived Endothelial Cells

Lin, H., Du, Q., Li, Q., Wang, O., Wang, Z., Sahu, N., Elowsky, C., Liu, K., Zhang, C., Chung, S., Duan, B. & Lei, Y., Aug 14 2018, In : Stem Cell Reports. 11, 2, p. 454-469 16 p.

Research output: Contribution to journalArticle

8 Scopus citations

Effects of tunable, 3D-bioprinted hydrogels on human brown adipocyte behavior and metabolic function

Kuss, M., Kim, J., Qi, D., Wu, S., Lei, Y., Chung, S. & Duan, B., Apr 15 2018, In : Acta Biomaterialia. 71, p. 486-495 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages

Kim, Y., Gromovsky, A. D., Brown, J. M. & Chung, S., Aug 2018, In : Journal of Nutritional Biochemistry. 58, p. 169-177 9 p.

Research output: Contribution to journalArticle

7 Scopus citations
3 Scopus citations

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

Okla, M., Zaher, W., Alfayez, M. & Chung, S., Mar 1 2018, In : Inflammation. 41, 2, p. 626-642 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Maternal n-3 PUFA supplementation promotes fetal brown adipose tissue development through epigenetic modifications in C57BL/6 mice

Fan, R., Toney, A. M., Jang, Y., Ro, S. H. & Chung, S., Dec 2018, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1863, 12, p. 1488-1497 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanically robust cryogels with injectability and bioprinting supportability for adipose tissue engineering

Qi, D., Wu, S., Kuss, M. A., Shi, W., Chung, S., Deegan, P. T., Kamenskiy, A., He, Y. & Duan, B., Jul 1 2018, In : Acta Biomaterialia. 74, p. 131-142 12 p.

Research output: Contribution to journalArticle

10 Scopus citations

Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity

Cuffe, H., Liu, M., Key, C. C. C., Boudyguina, E., Sawyer, J. K., Weckerle, A., Bashore, A., Fried, S. K., Chung, S. & Parks, J. S., Apr 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 4, p. 733-743 11 p.

Research output: Contribution to journalArticle

13 Scopus citations
2017

Annatto tocotrienol attenuates NLRP3 inflammasome activation in macrophages

Buckner, T., Fan, R., Kim, Y., Kim, J. & Chung, S., Jun 1 2017, In : Current Developments in Nutrition. 1, 6, e000760.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
3 Scopus citations

Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis

Key, C. C. C., Liu, M., Kurtz, C. L., Chung, S., Boudyguina, E., Dinh, T. A., Bashore, A., Phelan, P. E., Freedman, B. I., Osborne, T. F., Zhu, X., Ma, L., Sethupathy, P., Biddinger, S. B. & Parks, J. S., Jun 6 2017, In : Cell Reports. 19, 10, p. 2116-2129 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Eicosapentaenoic acid potentiates brown thermogenesis through FFAR4-dependent up-regulation of miR-30b and miR-378

Kim, J., Okla, M., Erickson, A., Carr, T., Natarajan, S. K. & Chung, S., Sep 23 2016, In : Journal of Biological Chemistry. 291, 39, p. 20551-20562 12 p.

Research output: Contribution to journalArticle

36 Scopus citations

Raspberry seed flour attenuates high-sucrose diet-mediated hepatic stress and adipose tissue inflammation

Kang, I., Espín, J. C., Carr, T. P., Tomás-Barberán, F. A. & Chung, S., Jun 1 2016, In : Journal of Nutritional Biochemistry. 32, p. 64-72 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Suppression of NLRP3 inflammasome by γ -tocotrienol ameliorates type 2 diabetes

Kim, Y., Wang, W., Okla, M., Kang, I., Moreau, R. & Chung, S., Jan 1 2016, In : Journal of Lipid Research. 57, 1, p. 66-76 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

Urolithin A, C, and D, but not iso-urolithin A and urolithin B, attenuate triglyceride accumulation in human cultures of adipocytes and hepatocytes

Kang, I., Kim, Y., Tomás-Barberán, F. A., Espín, J. C. & Chung, S., May 1 2016, In : Molecular Nutrition and Food Research. 60, 5, p. 1129-1138 10 p.

Research output: Contribution to journalArticle

37 Scopus citations
2015

Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress

Okla, M., Wang, W., Kang, I., Pashaj, A., Carr, T. & Chung, S., Oct 30 2015, In : Journal of Biological Chemistry. 290, 44, p. 26476-26490 15 p.

Research output: Contribution to journalArticle

41 Scopus citations

BMP7 drives human adipogenic stem cells into metabolically active beige adipocytes

Okla, M., Ha, J. H., Temel, R. E. & Chung, S., Dec 23 2015, In : Lipids. 50, 2, p. 111-120 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Ellagic acid modulates lipid accumulation in primary human adipocytes and human hepatoma Huh7 cells via discrete mechanisms

Okla, M., Kang, I., Kim, D. M., Gourineni, V., Shay, N., Gu, L. & Chung, S., 2015, In : Journal of Nutritional Biochemistry. 26, 1, p. 82-90 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment

Zhao, L., Kang, I., Fang, X., Wang, W., Lee, M. A., Hollins, R. R., Marshall, M. R. & Chung, S., Mar 12 2015, In : International Journal of Obesity. 39, 3, p. 438-446 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation

Zhao, L., Yagiz, Y., Xu, C., Lu, J., Chung, S. & Marshall, M. R., Jul 1 2015, In : Food and Function. 6, 7, p. 2293-2302 10 p.

Research output: Contribution to journalArticle

17 Scopus citations
2014

Activation of autophagy and AMPK by gamma-tocotrienol suppresses the adipogenesis in human adipose derived stem cells

Zhao, L., Ha, J. H., Okla, M. & Chung, S., Mar 2014, In : Molecular Nutrition and Food Research. 58, 3, p. 569-579 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys

Chung, S., Cuffe, H., Marshall, S. M., McDaniel, A. L., Ha, J. H., Kavanagh, K., Hong, C., Tontonoz, P., Temel, R. E. & Parks, J. S., Sep 2014, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 34, 9, p. 1880-1887 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
24 Scopus citations

Ocular inflammation and endoplasmic reticulum stress are attenuated by supplementation with grape polyphenols in human retinal pigmented epithelium cells and in C57BL/6 mice

Ha, J. H., Shil, P. K., Zhu, P., Gu, L., Li, Q. & Chung, S., Jun 2014, In : Journal of Nutrition. 144, 6, p. 799-806 8 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apob100-only low density lipoprotein (LDL) receptor knockout mice

Forrest, L. M., Lough, C. M., Chung, S., Boudyguina, E. Y., Gebre, A. K., Smith, T. L., Colvin, P. L. & Parks, J. S., Jul 12 2013, In : Nutrients. 5, 7, p. 2629-2645 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF diet-induced or genetically obese mouse models

Zhu, X., Chung, S., Bi, X., Chuang, C. C., Brown, A. L., Liu, M., Seo, J., Cuffe, H., Gebre, A. K., Boudyguina, E. & Parks, J. S., Oct 2013, In : Journal of Lipid Research. 54, 10, p. 2708-2717 10 p.

Research output: Contribution to journalArticle

7 Scopus citations
2012

CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action

Lord, C. C., Betters, J. L., Ivanova, P. T., Milne, S. B., Myers, D. S., Madenspacher, J., Thomas, G., Chung, S., Liu, M., Davis, M. A., Lee, R. G., Crooke, R. M., Graham, M. J., Parks, J. S., Brasaemle, D. L., Fessler, M. B., Brown, H. A. & Brown, J. M., Feb 2012, In : Diabetes. 61, 2, p. 355-363 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice

Chuang, C. C., Shen, W., Chen, H., Xie, G., Jia, W., Chung, S. & McIntosh, M. K., Dec 26 2012, In : Journal of Agricultural and Food Chemistry. 60, 51, p. 12458-12468 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Muscadine grape (Vitis rotundifolia) and wine phytochemicals prevented obesity-associated metabolic complications in C57BL/6J Mice

Gourineni, V., Shay, N. F., Chung, S., Sandhu, A. K. & Gu, L., Aug 8 2012, In : Journal of Agricultural and Food Chemistry. 60, 31, p. 7674-7681 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Trans-10, cis-12 conjugated linoleic acid decreases de novo lipid synthesis in human adipocytes

Obsen, T., Faergeman, N. J., Chung, S., Martinez, K., Gobern, S., Loreau, O., Wabitsch, M., Mandrup, S. & McIntosh, M., Jun 2012, In : Journal of Nutritional Biochemistry. 23, 6, p. 580-590 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2011

Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo

Chung, S., Sawyer, J. K., Gebre, A. K., Maeda, N. & Parks, J. S., Oct 11 2011, In : Circulation. 124, 15, p. 1663-1672 10 p.

Research output: Contribution to journalArticle

58 Scopus citations
2010

A novel role for ABCA1-generated large pre-β migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion

Chung, S., Gebre, A. K., Seo, J., Shelness, G. S. & Parks, J. S., Apr 1 2010, In : Journal of Lipid Research. 51, 4, p. 729-742 14 p.

Research output: Contribution to journalArticle

28 Scopus citations

Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis

Brown, J. M., Chung, S., Sawyer, J. K., Degirolamo, C., Alger, H. M., Nguyen, T. M., Zhu, X., Duong, M. N., Brown, A. L., Lord, C., Shah, R., Davis, M. A., Kelley, K., Wilson, M. D., Madenspacher, J., Fessler, M. B., Parks, J. S. & Rudel, L. L., Jan 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 1, p. 24-30 7 p.

Research output: Contribution to journalArticle

45 Scopus citations

Inflammation and insulin resistance induced by trans-10, cis-12 conjugated linoleic acid depend on intracellular calcium levels in primary cultures of human adipocytes

Kennedy, A., Martinez, K., Chung, S., LaPoint, K., Hopkins, R., Schmidt, S. F., Andersen, K., Mandrup, S. & McIntosh, M., Jul 1 2010, In : Journal of Lipid Research. 51, 7, p. 1906-1917 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Niemann-pick C1-like 1 deletion in mice prevents high-fat diet-induced fatty liver by reducing lipogenesis

Jia, L., Ma, Y., Rong, S., Betters, J. L., Xie, P., Chung, S., Wang, N., Tang, W. & Yu, L., Nov 2010, In : Journal of Lipid Research. 51, 11, p. 3135-3144 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism

Chung, S., Timmins, J. M., Duong, M. N., Degirolamo, C., Rong, S., Sawyer, J. K., Singaraja, R. R., Hayden, M. R., Maeda, N., Rudel, L. L., Shelness, G. S. & Parks, J. S., Apr 16 2010, In : Journal of Biological Chemistry. 285, 16, p. 12197-12209 13 p.

Research output: Contribution to journalArticle

46 Scopus citations
2008

Inhibition of Stearoyl-Coenzyme A Desaturase 1 Dissociates Insulin Resistance and Obesity from Atherosclerosis

Brown, J. M., Chung, S., Sawyer, J. K., Degirolamo, C., Alger, H. M., Nguyen, T., Zhu, X., Duong, M. N., Wibley, A. L., Shah, R., Davis, M. A., Kelley, K., Wilson, M. D., Kent, C., Parks, J. S. & Rudel, L. L., Sep 30 2008, In : Circulation. 118, 14, p. 1467-1475 9 p.

Research output: Contribution to journalArticle

114 Scopus citations

Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL

Mulya, A., Lee, J. Y., Gebre, A. K., Boudyguina, E. Y., Chung, S. K., Smith, T. L., Colvin, P. L., Jiang, X. C. & Parks, J. S., 2008, In : Journal of Lipid Research. 49, 11, p. 2390-2401 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARγ activity in primary cultures of human adipocytes

Kennedy, A., Chung, S., LaPoint, K., Fabiyi, O. & McIntosh, M. K., Mar 2008, In : Journal of Nutrition. 138, 3, p. 455-461 7 p.

Research output: Contribution to journalArticle

Open Access
61 Scopus citations
2007

CGI-58 facilitates the mobilization of cytoplasmic triglyceride for lipoprotein secretion in hepatoma cells

Brown, J. M., Chung, S., Das, A., Shelness, G. S., Rudel, L. L. & Yu, L., Oct 2007, In : Journal of Lipid Research. 48, 10, p. 2295-2305 11 p.

Research output: Contribution to journalArticle

36 Scopus citations
2006

Preadipocytes mediate lipopolysaccharide-induced inflammation and insulin resistance in primary cultures of newly differentiated human adipocytes

Chung, S., LaPoint, K., Martinez, K., Kennedy, A., Sandberg, M. B. & McIntosh, M. K., 2006, In : Endocrinology. 147, 11, p. 5340-5351 12 p.

Research output: Contribution to journalArticle

180 Scopus citations
2005

Conjugated linoleic acid promotes human adipocyte insulin resistance through NFκB-dependent cytokine production

Chung, S., Brown, J. M., Provo, J. N., Hopkins, R. & McIntosh, M. K., 2005, In : Journal of Biological Chemistry. 280, 46, p. 38445-38456 12 p.

Research output: Contribution to journalArticle

137 Scopus citations

Trans-10, cis-12 CLA increases adipocyte lipolysis and alters lipid droplet-associated proteins: Role of mTOR and ERK signaling

Chung, S., Brown, J. M., Sandberg, M. B. & McIntosh, M., 2005, In : Journal of Lipid Research. 46, 5, p. 885-895 11 p.

Research output: Contribution to journalArticle

72 Scopus citations