Steven Claude Sansom, PhD

  • 2715 Citations
  • 35 h-Index
1976 …2019

Research output per year

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Research Output

2019

Furosemide reduces BK-αβ4-mediated K+ secretion in mice on an alkaline high-K+ diet

Wang, B., Wang-France, J., Li, H. & Sansom, S. C., Feb 2019, In : American Journal of Physiology - Renal Physiology. 316, 2, p. F341-F350

Research output: Contribution to journalArticle

2 Scopus citations

Potassium-sparing effects of furosemide in mice on high-potassium diets

Wang, B. & Sansom, S. C., May 2019, In : American Journal of Physiology - Renal Physiology. 316, 5, p. F970-F973

Research output: Contribution to journalReview article

2017

Net K+ secretion in the thick ascending limb of mice on a low-Na, high-K diet

Wang, B., Wen, D., Li, H., Wang-France, J. & Sansom, S. C., Oct 2017, In : Kidney International. 92, 4, p. 864-875 12 p.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Maintaining K+ balance on the low-Na+, high-K+ diet

Cornelius, R. J., Wang, B., Wang-France, J. & Sansom, S. C., Apr 1 2016, In : American Journal of Physiology - Renal Physiology. 310, 7, p. F581-F595

Research output: Contribution to journalReview article

7 Scopus citations
2015

Deficient acid handling with distal RTA in the NBCe2 knockout mouse

Wen, D., Yuan, Y., Cornelius, R. J., Li, H., Warner, P. C., Wang, B., Wang-France, J., Boettger, T. & Sansom, S. C., Sep 15 2015, In : American Journal of Physiology - Renal Physiology. 309, 6, p. F523-F530

Research output: Contribution to journalArticle

6 Scopus citations

Increased epithelial sodium channel activity contributes to hypertension caused by Na+-HCO3- cotransporter electrogenic 2 deficiency

Wen, D., Yuan, Y., Warner, P. C., Wang, B., Cornelius, R. J., Wang-France, J., Li, H., Boettger, T. & Sansom, S. C., Jul 4 2015, In : Hypertension. 66, 1, p. 68-74 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Low Na, high K diet and the role of aldosterone in BK-mediated K excretion

Cornelius, R. J., Wen, D., Li, H., Yuan, Y., Wang-France, J., Warner, P. C. & Sansom, S. C., Jan 21 2015, In : PloS one. 10, 1, e0115515.

Research output: Contribution to journalArticle

19 Scopus citations

Physiological role of NBCe2 in the regulation of electrolyte transport in the distal nephron

Wen, D. & Sansom, S. C., Sep 15 2015, In : American Journal of Physiology - Renal Physiology. 309, 6, p. F489-F491

Research output: Contribution to journalReview article

3 Scopus citations
2014

Interacting influence of diuretics and diet on BK channel-regulated K homeostasis

Wen, D., Cornelius, R. J. & Sansom, S. C., Apr 1 2014, In : Current Opinion in Pharmacology. 15, 1, p. 28-32 5 p.

Research output: Contribution to journalReview article

15 Scopus citations

Relation between BK-α/β4-mediated potassium secretion and ENaC-mediated sodium reabsorption

Wen, D., Cornelius, R. J., Rivero-Hernandez, D., Yuan, Y., Li, H., Weinstein, A. M. & Sansom, S. C., Jul 2014, In : Kidney International. 86, 1, p. 139-145 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2013

Regulation of BK-α expression in the distal nephron by aldosterone and urine pH

Wen, D., Cornelius, R. J., Yuan, Y. & Sansom, S. C., May 8 2013, In : American Journal of Physiology - Renal Physiology. 305, 4, p. F463-F476

Research output: Contribution to journalArticle

29 Scopus citations
2012

Bicarbonate promotes BK-α/β4-mediated K excretion in the renal distal nephron

Cornelius, R. J., Wen, D., Hatcher, L. I. & Sansom, S. C., Dec 1 2012, In : American Journal of Physiology - Renal Physiology. 303, 11, p. F1563-F1571

Research output: Contribution to journalArticle

18 Scopus citations

Flow-sensitive K+-coupled ATP secretion modulates activity of the epithelial Na+ channel in the distal nephron

Bugaj, V., Sansom, S. C., Wen, D., Hatcher, L. I., Stockand, J. D. & Mironova, E., Nov 9 2012, In : Journal of Biological Chemistry. 287, 46, p. 38552-38558 7 p.

Research output: Contribution to journalArticle

8 Scopus citations
2011

Coupled ATP and potassium efflux from intercalated cells

David Holtzclaw, J., Cornelius, R. J., Hatcher, L. I. & Sansom, S. C., Jun 1 2011, In : American Journal of Physiology - Renal Physiology. 300, 6, p. F1319-F1326

Research output: Contribution to journalArticle

33 Scopus citations

Role of BK channels in hypertension and potassium secretion

Holtzclaw, J. D., Grimm, P. R. & Sansom, S. C., Sep 1 2011, In : Current opinion in nephrology and hypertension. 20, 5, p. 512-517 6 p.

Research output: Contribution to journalReview article

43 Scopus citations
2010

BK channels and a new form of hypertension

Grimm, P. R. & Sansom, S. C., Nov 1 2010, In : Kidney International. 78, 10, p. 956-962 7 p.

Research output: Contribution to journalShort survey

31 Scopus citations

Intercalated cell BK-α/β4 channels modulate sodium and potassium handling during potassium adaptation

Holtzclaw, J. D., Grimm, P. R. & Sansom, S. C., Apr 1 2010, In : Journal of the American Society of Nephrology. 21, 4, p. 634-645 12 p.

Research output: Contribution to journalArticle

43 Scopus citations

Shear stress-induced volume decrease in C11-MDCK cells by BK-α/β4

Holtzclaw, J. D., Liu, L., Grimm, P. R. & Sansom, S. C., Sep 1 2010, In : American Journal of Physiology - Renal Physiology. 299, 3, p. F507-F516

Research output: Contribution to journalArticle

19 Scopus citations
2009

Biomechanical strain causes maladaptive gene regulation, contributing to alport glomerular disease

Meehan, D. T., Delimont, D., Cheung, L., Zallocchi, M., Sansom, S. C., Holzclaw, J. D., Rao, V. & Cosgrove, D., Nov 1 2009, In : Kidney International. 76, 9, p. 968-976 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism

Grimm, P. R., Irsik, D. L., Settles, D. C., Holtzclaw, J. D. & Sansom, S. C., Jul 14 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 28, p. 11800-11805 6 p.

Research output: Contribution to journalArticle

77 Scopus citations

Role of BKβ1 in Na+ reabsorption by cortical collecting ducts of Na+-deprived mice

Grimm, P. R., Irsik, D. L., Liu, L., Holtzclaw, J. D. & Sansom, S. C., Aug 1 2009, In : American Journal of Physiology - Renal Physiology. 297, 2, p. F420-F428

Research output: Contribution to journalArticle

23 Scopus citations

Simvastatin reverses podocyte injury but not mesangial expansion in early stage type 2 diabetes mellitus

Wei, P., Grimm, P. R., Settles, D. C., Balwanz, C. R., Padanilam, B. J. & Sansom, S. C., Dec 30 2009, In : Renal Failure. 31, 6, p. 503-513 11 p.

Research output: Contribution to journalArticle

16 Scopus citations
2008

Insulin increases the activity of mesangial BK channels through MAPK signaling

Foutz, R. M., Grimm, P. R. & Sansom, S. C., Jun 1 2008, In : American Journal of Physiology - Renal Physiology. 294, 6, p. F1465-F1472

Research output: Contribution to journalArticle

13 Scopus citations
2007

Association of VASP with TRPC4 in PKG-mediated inhibition of the store-operated calcium response in mesangial cells

Wang, X., Pluznick, J. L., Settles, D. C. & Sansom, S. C., Dec 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 6, p. F1768-F1776

Research output: Contribution to journalArticle

26 Scopus citations

BK channels in the kidney

Grimm, P. R. & Sansom, S. C., Sep 1 2007, In : Current opinion in nephrology and hypertension. 16, 5, p. 430-436 7 p.

Research output: Contribution to journalReview article

32 Scopus citations

Identification and localization of BK-β subunits in the distal nephron of the mouse kidney

Grimm, P. R., Foutz, R. M., Brenner, R. & Sansom, S. C., Jul 1 2007, In : American Journal of Physiology - Renal Physiology. 293, 1, p. F350-F359

Research output: Contribution to journalArticle

54 Scopus citations

Reemergence of the maxi K+ as a K+ secretory channel [1]

Sansom, S. C., Jun 1 2007, In : Kidney International. 71, 12, p. 1322-1324 3 p.

Research output: Contribution to journalLetter

3 Scopus citations

Two channels for one job

Sansom, S. C. & Welling, P. A., Sep 2007, In : Kidney International. 72, 5, p. 529-530 2 p.

Research output: Contribution to journalComment/debate

36 Scopus citations
2006

BK channels in the kidney: Role in K+ secretion and localization of molecular components

Pluznick, J. L. & Sansom, S. C., Sep 13 2006, In : American Journal of Physiology - Renal Physiology. 291, 3, p. F517-F529

Research output: Contribution to journalReview article

68 Scopus citations
2005

BK-β1 subunit: Immunolocalization in the mammalian connecting tubule and its role in the kaliuretic response to volume expansion

Pluznick, J. L., Wei, P., Grimm, P. R. & Sansom, S. C., Apr 1 2005, In : American Journal of Physiology - Renal Physiology. 288, 4 57-4, p. F846-F854

Research output: Contribution to journalArticle

80 Scopus citations

Ion channels in mesangial cells: Function, malfunction, or fiction

Ma, R., Pluznick, J. L. & Sansom, S. C., Apr 2005, In : Physiology. 20, 2, p. 102-111 10 p.

Research output: Contribution to journalReview article

31 Scopus citations
2004
29 Scopus citations

Glomerular structural and functional changes in a high-fat diet mouse model of early-stage Type 2 diabetes

Wei, P., Lane, P. H., Lane, J. T., Padanilam, B. J. & Sansom, S. C., Sep 1 2004, In : Diabetologia. 47, 9, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

TRPC4 forms store-operated Ca2+ channels in mouse mesangial cells

Wang, X., Pluznick, J. L., Wei, P., Padanilam, B. J. & Sansom, S. C., Aug 1 2004, In : American Journal of Physiology - Cell Physiology. 287, 2 56-2, p. C357-C364

Research output: Contribution to journalArticle

70 Scopus citations
2003

Renal fluid and electrolyte handling in BKCa-β1-/- mice

Pluznick, J. L., Wei, P., Carmines, P. K. & Sansom, S. C., Jun 1 2003, In : American Journal of Physiology - Renal Physiology. 284, 6 53-6, p. F1274-F1279

Research output: Contribution to journalArticle

64 Scopus citations

Role of hβ1 in activation of human mesangial BK channels by cGMP kinase

Kudlacek, P. E., Pluznick, J. L., Ma, R., Padanilam, B. & Sansom, S. C., Aug 1 2003, In : American Journal of Physiology - Renal Physiology. 285, 2 54-2, p. F289-F294

Research output: Contribution to journalArticle

28 Scopus citations
2002

Protein kinase Cα participates in activation of store-operated Ca2+ channels in human glomerular mesangial cells

Ma, R., Kudlacek, P. E. & Sansom, S. C., Nov 2002, In : American Journal of Physiology - Cell Physiology. 283, 5 52-5, p. C1390-C1398

Research output: Contribution to journalArticle

39 Scopus citations
2001
36 Scopus citations

Influence of Ca2+-activated K+ channels on rat renal arteriolar responses to depolarizing agonists

Fallet, R. W., Bast, J. P., Fujiwara, K., Ishii, N., Sansom, S. C. & Carmines, P. K., Apr 1 2001, In : American Journal of Physiology - Renal Physiology. 280, 4 49-4, p. F583-F591

Research output: Contribution to journalArticle

43 Scopus citations

Protein Kinase C Activates Store-operated Ca2+ Channels in Human Glomerular Mesangial Cells

Ma, R., Pluznick, J., Kudlacek, P. & Sansom, S. C., Jul 13 2001, In : Journal of Biological Chemistry. 276, 28, p. 25759-25765 7 p.

Research output: Contribution to journalArticle

47 Scopus citations
2000

Dihydropyridine-sensitive Ca2+ channels in human glomerular mesangial cells

Hall, D. A., Carmines, P. K. & Sansom, S. C., Jan 2000, In : American Journal of Physiology - Renal Physiology. 278, 1 47-1, p. F97-F103

Research output: Contribution to journalArticle

30 Scopus citations

Regulation of Ca2+-activated K+ channels by multifunctional Ca2+/calmodulin-dependent protein kinase

Sansom, S. C., Ma, R., Carmines, P. K. & Hall, D. A., Sep 18 2000, In : American Journal of Physiology - Renal Physiology. 279, 2 48-2, p. F283-F288

Research output: Contribution to journalArticle

23 Scopus citations

Store-operated Ca2+ channels in human glomerular mesangial cells

Ma, R., Smith, S., Child, A., Carmines, P. K. & Sansom, S. C., Jun 1 2000, In : American Journal of Physiology - Renal Physiology. 278, 6 47-6, p. F954-F961

Research output: Contribution to journalArticle

45 Scopus citations
1999
3 Scopus citations
1998

Arachidonic acid potentiates the feedback response of mesangial BKCa channels to angiotensin II

Stockand, J. D., Silverman, M., Hall, D., Derr, T., Kubacak, B. & Sansom, S. C., Apr 1998, In : American Journal of Physiology - Renal Physiology. 274, 4 43-4, p. F658-F664

Research output: Contribution to journalArticle

16 Scopus citations

Glomerular mesangial cells: Electrophysiology and regulation of contraction

Stockand, J. D. & Sansom, S. C., Jul 1998, In : Physiological Reviews. 78, 3, p. 723-744 22 p.

Research output: Contribution to journalReview article

159 Scopus citations
1997

Regulation of filtration rate by glomerular mesangial cells in health and diabetic renal disease

Stockand, J. D. & Sansom, S. C., Jun 1997, In : American Journal of Kidney Diseases. 29, 6, p. 971-981 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Regulation of large calcium-activated potassium channels by protein phosphatase 2A

Sansom, S. C., Stockand, J. D., Hall, D. & Williams, B., Apr 11 1997, In : Journal of Biological Chemistry. 272, 15, p. 9902-9906 5 p.

Research output: Contribution to journalArticle

48 Scopus citations

Regulation of mesangial large Ca-activated K channels by protein phosphatase 2A

Sansom, S. C., Stockand, J. D., Hall, D. A. & Williams, B. R., Dec 1 1997, In : FASEB Journal. 11, 3, p. A87

Research output: Contribution to journalArticle

1996

Activation by high ambient glucose of large ca2+-activated k+ channels ibk(Ci) in human mesangial cells

Silverman, M., Stockand, J. D. & Sansom, S. C., Dec 1 1996, In : FASEB Journal. 10, 3, p. A545

Research output: Contribution to journalArticle

2 Scopus citations