Subodh M Lele, MD

  • 3103 Citations
  • 34 h-Index
1992 …2020

Research output per year

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Research Output

  • 3103 Citations
  • 34 h-Index
  • 92 Article
  • 10 Review article
  • 3 Letter
  • 2 Comment/debate
2020

Bladder cancer, version 3.2020

Flaig, T. W., Spiess, P. E., Agarwal, N., Bangs, R., Boorjian, S. A., Buyyounouski, M. K., Chang, S., Downs, T. M., Efstathiou, J. A., Friedlander, T., Greenberg, R. E., Guru, K. A., Guzzo, T., Herr, H. W., Hoffman-Censits, J., Hoimes, C., Inman, B. A., Jimbo, M., Karim Kader, A., Lele, S. M. & 15 others, Michalski, J., Montgomery, J. S., Nandagopal, L., Pagliaro, L. C., Pal, S. K., Patterson, A., Plimack, E. R., Pohar, K. S., Preston, M. A., Sexton, W. J., Siefker-Radtke, A. O., Tward, J., Wright, J. L., Gurski, L. A. & Johnson-Chilla, A., 2020, In : JNCCN Journal of the National Comprehensive Cancer Network. 18, 2, p. 329-354 26 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structural optimization of HPMA copolymer-based dexamethasone prodrug for improved treatment of inflammatory arthritis

Jia, Z., Zhao, G., Wei, X., Kong, D., Sun, Y., Zhou, Y., Lele, S. M., Fehringer, E. V., Garvin, K. L., Goldring, S. R. & Wang, D., Aug 10 2020, In : Journal of Controlled Release. 324, p. 560-573 14 p.

Research output: Contribution to journalArticle

2019

A Macromolecular Janus Kinase (JAK) Inhibitor Prodrug Effectively Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

Zhao, G., Wei, X., Wu, J., Eichele, D. D., Lele, S. M., Yang, L., Zhang, F. & Wang, D., Apr 1 2019, In : Pharmaceutical Research. 36, 4, 64.

Research output: Contribution to journalArticle

A polymeric nanogel-based treatment regimen for enhanced efficacy and sequential administration of synergistic drug combination in pancreatic cancer

Soni, K. S., Thomas, D., Caffrey, T., Mehla, K., Lei, F., O'Connell, K. A., Sagar, S., Lele, S. M., Hollingsworth, M. A., Radhakrishnan, P. & Bronich, T. K., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 894-901 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
Open Access
1 Scopus citations

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Seshacharyulu, P., Rachagani, S., Muniyan, S., Siddiqui, J. A., Cruz, E., Sharma, S., Krishnan, R., Killips, B. J., Sheinin, Y., Lele, S. M., Smith, L. M., Talmon, G. A., Ponnusamy, M. P., Datta, K. & Batra, S. K., Jun 27 2019, In : Oncogene. 38, 26, p. 5265-5280 16 p.

Research output: Contribution to journalArticle

4 Scopus citations

First report of Sarcina ventriculi in a pyloric and duodenal brushing specimen

Rohr, J. M., Eidem, M. E. & Lele, S. M., 2019, In : Cytopathology. 30, 5, p. 563-564 2 p.

Research output: Contribution to journalLetter

Penile cancer with positive nodes: A case of HPV p16-positivity and its significance, implication of data from head and neck cancer

Nguyen, C., Leslie, S., Gross, J., Dietz, N., Lele, S. M. & Sirineni, G., Nov 2019, In : Urology Case Reports. 27, 101009.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Nimmakayala, R. K., Seshacharyulu, P., Lakshmanan, I., Rachagani, S., Chugh, S., Karmakar, S., Rauth, S., Vengoji, R., Atri, P., Talmon, G. A., Lele, S. M., Smith, L. M., Thapa, I., Bastola, D., Ouellette, M. M., Batra, S. K. & Ponnusamy, M. P., Sep 2018, In : Gastroenterology. 155, 3, p. 892-908.e6

Research output: Contribution to journalArticle

20 Scopus citations

Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium

Hsu, A. H., Lum, M. A., Shim, K. S., Frederick, P. J., Morrison, C. D., Chen, B., Lele, S. M., Sheinin, Y. M., Daikoku, T., Dey, S. K., Leone, G., Black, A. R. & Black, J. D., Jul 17 2018, In : Cell Reports. 24, 3, p. 655-669 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Development of a Janus Kinase Inhibitor Prodrug for the Treatment of Rheumatoid Arthritis

Wei, X., Wu, J., Zhao, G., Galdamez, J., Lele, S. M., Wang, X., Liu, Y., Soni, D. M., Purdue, P. E., Mikuls, T. R., Goldring, S. R. & Wang, D., Aug 6 2018, In : Molecular Pharmaceutics. 15, 8, p. 3456-3467 12 p.

Research output: Contribution to journalArticle

5 Scopus citations

Local Application of Pyrophosphorylated Simvastatin Prevents Experimental Periodontitis

Wang, X., Jia, Z., Almoshari, Y., Lele, S. M., Reinhardt, R. A. & Wang, D., Aug 1 2018, In : Pharmaceutical Research. 35, 8, 164.

Research output: Contribution to journalArticle

3 Scopus citations

MVP immunohistochemistry is a useful adjunct in distinguishing leiomyosarcoma from leiomyoma and leiomyoma with bizarre nuclei

Lintel, N. J., Luebker, S. A., Lele, S. M. & Koepsell, S. A., Mar 2018, In : Human Pathology. 73, p. 122-127 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

NCCN guidelines® insights bladder cancer, version 5.2018 featured updates to the NCCN guidelines

Flaig, T. W., Spiess, P. E., Agarwal, N., Bangs, R., Boorjian, S. A., Buyyounouski, M. K., Downs, T. M., Efstathiou, J. A., Friedlander, T., Greenberg, R. E., Guru, K. A., Hahn, N., Herr, H. W., Hoimes, C., Inman, B. A., Jimbo, M., Kader, A. K., Lele, S. M., Meeks, J. J., Michalski, J. & 16 others, Montgomery, J. S., Pagliaro, L. C., Pal, S. K., Patterson, A., Petrylak, D. P., Plimack, E. R., Pohar, K. S., Porter, M. P., Preston, M. A., Sexton, W. J., Siefker-Radtke, A. O., Tward, J., Wile, G., Johnson-Chilla, A., Dwyer, M. A. & Gurski, L. A., Sep 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 9, p. 1041-1053 13 p.

Research output: Contribution to journalReview article

49 Scopus citations

Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation

Zhou, J., Zeng, Y., Cui, L., Chen, X., Stauffer, S., Wang, Z., Yu, F., Lele, S. M., Talmon, G. A., Black, A. R., Chen, Y. & Dong, J., Jul 17 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 29, p. E6760-E6769

Research output: Contribution to journalArticle

8 Scopus citations
2017

Bladder cancer, version 5.2017: Clinical practice guidelines in oncology

Spiess, P. E., Agarwal, N., Bangs, R., Boorjian, S. A., Buyyounouski, M. K., Clark, P. E., Downs, T. M., Efstathiou, J. A., Flaig, T. W., Friedlander, T., Greenberg, R. E., Guru, K. A., Hahn, N., Herr, H. W., Hoimes, C., Inman, B. A., Jimbo, M., Kader, A. K., Lele, S. M., Meeks, J. J. & 16 others, Michalski, J., Montgomery, J. S., Pagliaro, L. C., Pal, S. K., Patterson, A., Plimack, E. R., Pohar, K. S., Porter, M. P., Preston, M. A., Sexton, W. J., Siefker-Radtke, A. O., Sonpavde, G., Tward, J., Wile, G., Dwyer, M. A. & Gurski, L. A., Oct 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 10, p. 1240-1267 28 p.

Research output: Contribution to journalReview article

125 Scopus citations

Carcinosarcoma of the Tunica Vaginalis Following Radiation Therapy for Localized Prostate Cancer

Viers, C. D., Lele, S. M., Kirkpatrick, T. & LaGrange, C. A., Jul 2017, In : Urology Case Reports. 13, p. 140-142 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling

Ahmad, R., Kumar, B., Chen, Z., Chen, X., Müller, D., Lele, S. M., Washington, M. K., Batra, S. K., Dhawan, P. & Singh, A. B., Nov 23 2017, In : Oncogene. 36, 47, p. 6592-6604 13 p.

Research output: Contribution to journalArticle

34 Scopus citations
8 Scopus citations

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Lakshmanan, I., Salfity, S., Seshacharyulu, P., Rachagani, S., Thomas, A., Das, S., Majhi, P. D., Nimmakayala, R. K., Vengoji, R., Lele, S. M., Ponnusamy, M. P., Batra, S. K. & Ganti, A. K., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2016

Adrenal oncoctyoma of uncertain malignant potential: A rare etiology of adrenal incidentaloma

Kedia, R. R., Muinov, L., Lele, S. M. & Shivaswamy, V., Mar 1 2016, In : Clinical Case Reports. 4, 3, p. 303-304 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Bladder Cancer, Version 2.2016 Featured Updates to the NCCN Guidelines

Clark, P. E., Spiess, P. E., Agarwal, N., Bangs, R., Boorjian, S. A., Buyyounouski, M. K., Efstathiou, J. A., Flaig, T. W., Friedlander, T., Greenberg, R. E., Guru, K. A., Hahn, N., Herr, H. W., Hoimes, C., Inman, B. A., Kader, A. K., Kibel, A. S., Kuzel, T. M., Lele, S. M., Meeks, J. J. & 16 others, Michalski, J., Montgomery, J. S., Pagliaro, L. C., Pal, S. K., Patterson, A., Petrylak, D., Plimack, E. R., Pohar, K. S., Porter, M. P., Sexton, W. J., Siefker-Radtke, A. O., Sonpavde, G., Tward, J., Wile, G., Dwyer, M. A. & Smith, C., Oct 1 2016, In : JNCCN Journal of the National Comprehensive Cancer Network. 14, 10, p. 1213-1224 12 p.

Research output: Contribution to journalArticle

63 Scopus citations

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Vaz, A. P., Deb, S., Rachagani, S., Dey, P., Muniyan, S., Lakshmanan, I., Karmakar, S., Smith, L., Johansson, S., Lele, S., Ouellette, M., Ponnusamy, M. P. & Batra, S. K., 2016, In : Oncotarget. 7, 3, p. 3317-3331 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription

Hua, G., He, C., Lv, X., Fan, L., Wang, C., Remmenga, S. W., Rodabaugh, K. J., Yang, L., Lele, S. M., Yang, P., Karpf, A. R., Davis, J. S. & Wang, C., 2016, In : Cell Death and Disease. 7, 7, e2297.

Research output: Contribution to journalArticle

16 Scopus citations

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells

Hua, G., Lv, X., He, C., Remmenga, S. W., Rodabough, K. J., Dong, J., Yang, L., Lele, S. M., Yang, P., Zhou, J., Karst, A., Drapkin, R. I., Davis, J. S. & Wang, C., Apr 28 2016, In : Oncogene. 35, 17, p. 2247-2265 19 p.

Research output: Contribution to journalArticle

33 Scopus citations
2015

Desmoid tumor: An unusual case of gross hematuria

Isharwal, S., Desai, V., Horn, A., Lele, S. M. & Lagrange, C. A., Feb 2015, In : Therapeutic Advances in Urology. 7, 1, p. 49-51 3 p.

Research output: Contribution to journalLetter

1 Scopus citations

Erratum: MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway (Oncogene (2015) 34:2814 DOI:10.1038/onc.2015.116)

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Farghaly, H., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., May 21 2015, In : Oncogene. 34, 21, 1 p.

Research output: Contribution to journalComment/debate

Malignant paraganglioma of the bladder: A case report and review of the literature

Quist, E. E., Javadzadeh, B. M., Johannesen, E., Johansson, S. L., Lele, S. M. & Kozel, J. A., Feb 1 2015, In : Pathology Research and Practice. 211, 2, p. 183-188 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., Mar 26 2015, In : Oncogene. 34, 13, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

p66Shc longevity protein regulates the proliferation of human ovarian cancer cells

Muniyan, S., Chou, Y. W., Tsai, T. J., Thomes, P., Veeramani, S., Benigno, B. B., Walker, L. D., Mcdonald, J. F., Khan, S. A., Lin, F. F., Lele, S. M. & Lin, M. F., Aug 1 2015, In : Molecular Carcinogenesis. 54, 8, p. 618-631 14 p.

Research output: Contribution to journalArticle

7 Scopus citations

Sixty-five thousand shades of gray: Importance of color in surgical pathology diagnoses

Campbell, W. S., Talmon, G. A., Foster, K. W., Lele, S. M., Kozel, J. A. & West, W. W., Dec 2015, In : Human Pathology. 46, 12, p. 1945-1950 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells

Zhang, L., Yang, S., Chen, X., Stauffer, S., Yu, F., Lele, S. M., Fu, K., Datta, K., Palermo, N., Chen, Y. & Dong, J., 2015, In : Molecular and cellular biology. 35, 8, p. 1350-1362 13 p.

Research output: Contribution to journalArticle

71 Scopus citations

YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression

He, C., Lv, X., Hua, G., Lele, S. M., Remmenga, S., Dong, J., Davis, J. S. & Wang, C., Dec 10 2015, In : Oncogene. 34, 50, p. 6040-6054 15 p.

Research output: Contribution to journalArticle

48 Scopus citations
2014

Altered expression of transmembrane mucins, MUC1 and MUC4, in bladder cancer: Pathological implications in diagnosis

Kaur, S., Momi, N., Chakraborty, S., Wagner, D. G., Horn, A. J., Lele, S. M., Theodorescu, D. & Batra, S. K., Mar 26 2014, In : PloS one. 9, 3, e92742.

Research output: Contribution to journalArticle

23 Scopus citations

Chronic lymphocytic leukemia of the bladder: An atypical etiology of gross hematuria

Desai, V., Isharwal, S., Pooli, A., Lele, S. & Feloney, M., Oct 2014, In : Therapeutic Advances in Urology. 6, 5, p. 198-200 3 p.

Research output: Contribution to journalReview article

2 Scopus citations

MUC4-mediated regulation of acute phase protein lipocalin 2 through HER2/AKT/NF-κB signaling in pancreatic cancer

Kaur, S., Sharma, N., Krishn, S. R., Lakshmanan, I., Rachagani, S., Baine, M. J., Smith, L. M., Lele, S. M., Sasson, A. R., Guha, S., Mallya, K., Anderson, J. M., Hollingsworth, M. A. & Batra, S. K., 2014, In : Clinical Cancer Research. 20, 3, p. 688-700 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Nanomedicines for inflammatory arthritis: Head-to-head comparison of glucocorticoid-containing polymers, micelles, and liposomes

Quan, L., Zhang, Y., Crielaard, B. J., Dusad, A., Lele, S. M., Rijcken, C. J. F., Metselaar, J. M., Kostková, H., Etrych, T., Ulbrich, K., Kiessling, F., Mikuls, T. R., Hennink, W. E., Storm, G., Lammers, T. & Wang, D., Jan 28 2014, In : ACS Nano. 8, 1, p. 458-466 9 p.

Research output: Contribution to journalArticle

74 Scopus citations
27 Scopus citations

YAP regulates cell proliferation, migration, and steroidogenesis in adult granulosa cell tumors

Fu, D., Lv, X., Hua, G., He, C., Dong, J., Lele, S. M., Li, D. W. C., Zhai, Q., Davis, J. S. & Wang, C., Apr 2014, In : Endocrine-Related Cancer. 21, 2, p. 297-310 14 p.

Research output: Contribution to journalArticle

51 Scopus citations
2013

A dexamethasone prodrug reduces the renal macrophage response and provides enhanced resolution of established murine lupus nephritis

Yuan, F., Tabor, D. E., Nelson, R. K., Yuan, H., Zhang, Y., Nuxoll, J., Bynoté, K. K., Lele, S. M., Wang, D. & Gould, K. A., Nov 28 2013, In : PloS one. 8, 11, e81483.

Research output: Contribution to journalArticle

9 Scopus citations

Bladder cancer: Clinical practice guidelines in oncology

Clark, P. E., Agarwal, N., Biagioli, M. C., Eisenberger, M. A., Greenberg, R. E., Herr, H. W., Inman, B. A., Kuban, D. A., Kuzel, T. M., Lele, S. M., Michalski, J., Pagliaro, L. C., Pal, S. K., Patterson, A., Plimack, E. R., Pohar, K. S., Porter, M. P., Richie, J. P., Sexton, W. J., Shipley, W. U. & 7 others, Small, E. J., Spiess, P. E., Trump, D. L., Wile, G., Wilson, T. G., Dwyer, M. & Ho, M., 2013, In : JNCCN Journal of the National Comprehensive Cancer Network. 11, 4, p. 446-475 30 p.

Research output: Contribution to journalArticle

Open Access
253 Scopus citations

Immunocytochemistry for MUC4 and MUC16 is a useful adjunct in the diagnosis of pancreatic adenocarcinoma on fine-needle aspiration cytology

Horn, A., Chakraborty, S., Dey, P., Haridas, D., Souchek, J., Batra, S. K. & Lele, S. M., Apr 2013, In : Archives of Pathology and Laboratory Medicine. 137, 4, p. 546-551 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

MUC4 Overexpression Augments Cell Migration and Metastasis through EGFR Family Proteins in Triple Negative Breast Cancer Cells

Mukhopadhyay, P., Lakshmanan, I., Ponnusamy, M. P., Chakraborty, S., Jain, M., Pai, P., Smith, L. M., Lele, S. M. & Batra, S. K., Feb 11 2013, In : PloS one. 8, 2, e54455.

Research output: Contribution to journalArticle

41 Scopus citations

Novel mechanism of apoptosis resistance in cancer mediated by extracellular PAR-4

Burikhanov, R., Shrestha-Bhattarai, T., Qiu, S., Shukla, N., Hebbar, N., Lele, S. M., Horbinski, C. & Rangnekar, V. M., Jan 15 2013, In : Cancer Research. 73, 2, p. 1011-1019 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Penile cancer

Clark, P. E., Spiess, P. E., Agarwal, N., Biagioli, M. C., Eisenberger, M. A., Greenberg, R. E., Herr, H. W., Inman, B. A., Kuban, D. A., Kuzel, T. M., Lele, S. M., Michalski, J., Pagliaro, L., Pal, S. K., Patterson, A., Plimack, E. R., Pohar, K. S., Porter, M. P., Richie, J. P., Sexton, W. J. & 7 others, Shipley, W. U., Small, E. J., Trump, D. L., Wile, G., Wilson, T. G., Dwyer, M. & Ho, M., 2013, In : JNCCN Journal of the National Comprehensive Cancer Network. 11, 5, p. 594-615 22 p.

Research output: Contribution to journalArticle

Open Access
88 Scopus citations

Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

Radhakrishnan, P., Bryant, V. C., Blowers, E. C., Rajule, R. N., Gautam, N., Anwar, M. M., Mohr, A. M., Grandgenett, P. M., Bunt, S. K., Arnst, J. L., Lele, S. M., Alnouti, Y., Hollingsworth, M. A. & Natarajan, A., Apr 15 2013, In : Clinical Cancer Research. 19, 8, p. 2025-2035 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Urothelial cell intracytoplasmic inclusions after treatment of promyelocytic leukemia with arsenic trioxide

Wedel, W. R., Muirhead, D. E., Arnold, L. L., Dodmane, P. R., Lele, S. M., Maness-Harris, L., Hoyt, R. & Cohen, S. M., Aug 2013, In : Toxicological Sciences. 134, 2, p. 271-275 5 p.

Research output: Contribution to journalArticle

8 Scopus citations
2012
51 Scopus citations