Surinder Kumar Batra, PhD

  • 20980 Citations
  • 74 h-Index
1985 …2020

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2017

Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells

Burchett, K. M., Etekpo, A., Batra, S. K., Yan, Y. & Ouellette, M. M., 2017, In : Oncotarget. 8, 48, p. 83754-83767 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Loss of claudin-3 expression induces IL6/gp130/Stat3 signaling to promote colon cancer malignancy by hyperactivating Wnt/β-catenin signaling

Ahmad, R., Kumar, B., Chen, Z., Chen, X., Müller, D., Lele, S. M., Washington, M. K., Batra, S. K., Dhawan, P. & Singh, A. B., Nov 23 2017, In : Oncogene. 36, 47, p. 6592-6604 13 p.

Research output: Contribution to journalArticle

34 Scopus citations

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Lakshmanan, I., Salfity, S., Seshacharyulu, P., Rachagani, S., Thomas, A., Das, S., Majhi, P. D., Nimmakayala, R. K., Vengoji, R., Lele, S. M., Ponnusamy, M. P., Batra, S. K. & Ganti, A. K., Jul 15 2017, In : Clinical Cancer Research. 23, 14, p. 3906-3917 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

Mucins and associated O-glycans based immunoprofile for stratification of colorectal polyps: Clinical implication for improved colon surveillance

Krishn, S. R., Kaur, S., Sheinin, Y. M., Smith, L. M., Gautam, S. K., Patel, A., Jain, M., Juvvigunta, V., Pai, P., Lazenby, A. J., Roy, H. K. & Batra, S. K., 2017, In : Oncotarget. 8, 4, p. 7025-7038 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Ovarian Cancer Stem Cells: Unraveling a Germline Connection

Parte, S. C., Smolenkov, A., Batra, S. K., Ratajczak, M. Z. & Kakar, S. S., Dec 15 2017, In : Stem Cells and Development. 26, 24, p. 1781-1803 23 p.

Research output: Contribution to journalArticle

6 Scopus citations

TET1-mediated DNA hypomethylation regulates the expression of MUC4 in lung cancer

Yokoyama, S., Higashi, M., Tsutsumida, H., Wakimoto, J., Hamada, T., Wiest, E., Matsuo, K., Kitazono, I., Goto, Y., Guo, X., Hamada, T., Yamada, S., Hiraki, T., Yonezawa, S., Batra, S. K., Hollingsworth, M. A. & Tanimoto, A., Mar 2017, In : Genes and Cancer. 8, 3-4, p. 517-527 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ubiquitin-Proteasome System Regulation of an Evolutionarily Conserved RNA Polymerase II-Associated Factor 1 Involved in Pancreatic Oncogenesis

Ferdoush, J., Karmakar, S., Barman, P., Kaja, A., Uprety, B., Batra, S. K. & Bhaumik, S. R., Nov 21 2017, In : Biochemistry. 56, 46, p. 6083-6086 4 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Aberrant methylation of MUC1 and MUC4 promoters are potential prognostic biomarkers for pancreatic ductal adenocarcinomas

Yokoyama, S., Higashi, M., Kitamoto, S., Oeldorf, M., Knippschild, U., Kornmann, M., Maemura, K., Kurahara, H., Wiest, E., Hamada, T., Kitazono, I., Goto, Y., Tasaki, T., Hiraki, T., Hatanaka, K., Mataki, Y., Taguchi, H., Hashimoto, S., Batra, S. K., Tanimoto, A. & 2 others, Yonezawa, S. & Hollingsworth, M. A., Jul 5 2016, In : Oncotarget. 7, 27, p. 42553-42565 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Bile acids-mediated overexpression of MUC4 via FAK-dependent c-Jun activation in pancreatic cancer

Joshi, S., Cruz, E., Rachagani, S., Guha, S., Brand, R. E., Ponnusamy, M. P., Kumar, S. & Batra, S. K., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1063-1077 15 p.

Research output: Contribution to journalArticle

4 Scopus citations

Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia

Suklabaidya, S., Das, B., Ali, S. A., Jain, S., Swaminathan, S., Mohanty, A. K., Panda, S. K., Dash, P., Chakraborty, S., Batra, S. K. & Senapati, S., Jul 5 2016, In : Oncotarget. 7, 27, p. 41825-41842 18 p.

Research output: Contribution to journalArticle

14 Scopus citations

CXCR2 signaling regulates KRAS(G12D)-induced autocrine growth of pancreatic cancer

Purohit, A., Varney, M., Rachagani, S., Ouellette, M. M., Batra, S. K. & Singh, R. K., 2016, In : Oncotarget. 7, 6, p. 7280-7296 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

FAK and paxillin, two potential targets in pancreatic cancer

Kanteti, R., Batra, S. K., Lennon, F. E. & Salgia, R., May 24 2016, In : Oncotarget. 7, 21, p. 31586-31601 16 p.

Research output: Contribution to journalArticle

37 Scopus citations
20 Scopus citations
14 Scopus citations

Mice deficient in Muc4 are resistant to experimental colitis and colitis-associated colorectal cancer

Das, S., Rachagani, S., Sheinin, Y., Smith, L. M., Gurumurthy, C. B., Roy, H. K. & Batra, S. K., May 19 2016, In : Oncogene. 35, 20, p. 2645-2654 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism

Muniyan, S., Haridas, D., Chugh, S., Rachagani, S., Lakshmanan, I., Gupta, S., Seshacharyulu, P., Smith, L. M., Ponnusamy, M. P. & Batra, S. K., Mar 2016, In : Genes and Cancer. 7, 3-4, p. 110-124 15 p.

Research output: Contribution to journalArticle

25 Scopus citations

MUC4 is negatively regulated through the Wnt/β-catenin pathway via the notch effector hath1 in colorectal cancer

Pai, P., Rachagani, S., Dhawan, P., Sheinin, Y. M., Macha, M. A., Qazi, A. K., Chugh, S., Ponnusamy, M. P., Mallya, K., Pothuraju, R. & Batra, S. K., May 2016, In : Genes and Cancer. 7, 5-6, p. 154-168 15 p.

Research output: Contribution to journalArticle

11 Scopus citations

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

Lakshmanan, I., Rachagani, S., Hauke, R., Krishn, S. R., Paknikar, S., Seshacharyulu, P., Karmakar, S., Nimmakayala, R. K., Kaushik, G., Johansson, S. L., Carey, G. B., Ponnusamy, M. P., Kaur, S., Batra, S. K. & Ganti, A. K., Aug 4 2016, In : Oncogene. 35, 31, p. 4112-4121 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Mucins and associated glycan signatures in colon adenoma-carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

Krishn, S. R., Kaur, S., Smith, L. M., Johansson, S. L., Jain, M., Patel, A., Gautam, S. K., Hollingsworth, M. A., Mandel, U., Clausen, H., Lo, W. C., Fan, W. T. L., Manne, U. & Batra, S. K., May 1 2016, In : Cancer Letters. 374, 2, p. 304-314 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Neuropilin-2 regulates endosome maturation and EGFR trafficking to support cancer cell pathobiology

Dutta, S., Roy, S., Polavaram, N. S., Stanton, M. J., Zhang, H., Bhola, T., Hönscheid, P., Donohue, T. M., Band, H., Batra, S. K., Muders, M. H. & Datta, K., Jan 15 2016, In : Cancer Research. 76, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

NRP2 transcriptionally regulates its downstream effector WDFY1

Dutta, S., Roy, S., Polavaram, N. S., Baretton, G. B., Muders, M. H., Batra, S. & Datta, K., Mar 30 2016, In : Scientific reports. 6, 23588.

Research output: Contribution to journalArticle

9 Scopus citations

Overexpression of PD2 leads to increased tumorigenicity and metastasis in pancreatic ductal adenocarcinoma

Vaz, A. P., Deb, S., Rachagani, S., Dey, P., Muniyan, S., Lakshmanan, I., Karmakar, S., Smith, L., Johansson, S., Lele, S., Ouellette, M., Ponnusamy, M. P. & Batra, S. K., 2016, In : Oncotarget. 7, 3, p. 3317-3331 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis

Wang, Y., Kumar, S., Rachagani, S., Sajja, B. R., Xie, Y., Hang, Y., Jain, M., Li, J., Boska, M. D., Batra, S. K. & Oupický, D., Sep 1 2016, In : Biomaterials. 101, p. 108-120 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Hein, A. L., Seshacharyulu, P., Rachagani, S., Sheinin, Y. M., Ouellette, M. M., Ponnusamy, M. P., Mumby, M. C., Batra, S. K. & Yan, Y., Apr 15 2016, In : Cancer Research. 76, 8, p. 2243-2253 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

RAC1 GTPase promotes the survival of breast cancer cells in response to hyper-fractionated radiation treatment

Hein, A. L., Post, C. M., Sheinin, Y. M., Lakshmanan, I., Natarajan, A., Enke, C. A., Batra, S. K., Ouellette, M. M. & Yan, Y., Dec 8 2016, In : Oncogene. 35, 49, p. 6319-6329 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Sildenafil (Viagra) sensitizes prostate cancer cells to doxorubicin-mediated apoptosis through CD95

Das, A., Durrant, D., Mitchell, C., Dent, P., Batra, S. K. & Kukreja, R. C., 2016, In : Oncotarget. 7, 4, p. 4399-4413 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Statin derivatives as therapeutic agents for castration-resistant prostate cancer

Ingersoll, M. A., Miller, D. R., Martinez, O., Wakefield, C. B., Hsieh, K. C., Simha, M. V., Kao, C. L., Chen, H. T., Batra, S. K. & Lin, M. F., Dec 1 2016, In : Cancer Letters. 383, 1, p. 94-105 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma

Pai, P., Rachagani, S., Lakshmanan, I., Macha, M. A., Sheinin, Y., Smith, L. M., Ponnusamy, M. P. & Batra, S. K., Feb 1 2016, In : Molecular Oncology. 10, 2, p. 224-239 16 p.

Research output: Contribution to journalArticle

16 Scopus citations
2015

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

Pandey, P., Rachagani, S., Das, S., Seshacharyulu, P., Sheinin, Y., Naslavsky, N., Pan, Z., Smith, B. L., Peters, H. L., Radhakrishnan, P., McKenna, N. R., Panapakkam Giridharan, S. S., Haridas, D., Kaur, S., Hollingsworth, M. A., MacDonald, R. G., Meza, J. L., Caplan, S., Batra, S. K. & Solheim, J. C., 2015, In : Oncotarget. 6, 4, p. 2064-2075 12 p.

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

A novel function of HER2/Neu in the activation of G2/M checkpoint in response to γ-irradiation

Yan, Y., Hein, A. L., Greer, P. M., Wang, Z., Kolb, R. H., Batra, S. K. & Cowan, K. H., Apr 23 2015, In : Oncogene. 34, 17, p. 2215-2226 12 p.

Research output: Contribution to journalArticle

16 Scopus citations

Carboxyl-terminal domain of MUC16 imparts tumorigenic and metastatic functions through nuclear translocation of JAK2 to pancreatic cancer cells

Das, S., Rachagani, S., Torres-Gonzalez, M. P., Lakshmanan, I., Majhi, P. D., Smith, L. M., Wagner, K. U. & Batra, S. K., 2015, In : Oncotarget. 6, 8, p. 5772-5787 16 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations

Changes in microRNA (miRNA) expression during pancreatic cancer development and progression in a genetically engineered KrasG12D;Pdx1-Cre mouse (KC) model

Rachagani, S., Macha, M. A., Menning, M. S., Dey, P., Pai, P., Smith, L. M., Mo, Y. Y. & Batra, S. K., 2015, In : Oncotarget. 6, 37, p. 40295-40309 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Codelivery of small molecule hedgehog inhibitor and miRNA for treating pancreatic cancer

Kumar, V., Mondal, G., Slavik, P., Rachagani, S., Batra, S. K. & Mahato, R. I., Apr 6 2015, In : Molecular Pharmaceutics. 12, 4, p. 1289-1298 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Combination of MUC1 and MUC4 expression predicts clinical outcome in patients with oral squamous cell carcinoma

Kamikawa, Y., Kanmura, Y., Hamada, T., Yamada, N., Macha, M. A., Batra, S. K., Higashi, M., Yonezawa, S. & Sugihara, K., Apr 1 2015, In : International Journal of Clinical Oncology. 20, 2, p. 298-307 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

ErbB-2 signaling plays a critical role in regulating androgen-sensitive and castration-resistant androgen receptor-positive prostate cancer cells

Muniyan, S., Chen, S. J., Lin, F. F., Wang, Z., Mehta, P. P., Batra, S. K. & Lin, M. F., Nov 1 2015, In : Cellular Signalling. 27, 11, p. 2261-2271 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Mimeault, M., Rachagani, S., Muniyan, S., Seshacharyulu, P., Johansson, S. L., Datta, K., Lin, M. F. & Batra, S. K., 2015, In : Oncotarget. 6, 6, p. 3887-3903 17 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations

Membrane proximal ectodomain cleavage of MUC16 occurs in the acidifying Golgi/post-Golgi compartments

Das, S., Majhi, P. D., Al-Mugotir, M. H., Rachagani, S., Sorgen, P. & Batra, S. K., Jun 5 2015, In : Scientific reports. 5, 9759.

Research output: Contribution to journalArticle

21 Scopus citations

MUC16-mediated activation of mTOR and c-MYC reprograms pancreatic cancer metabolism

Shukla, S. K., Gunda, V., Abrego, J., Haridas, D., Mishra, A., Souchek, J., Chaika, N. V., Yu, F., Sasson, A. R., Lazenby, A. J., Batra, S. K. & Singh, P. K., 2015, In : Oncotarget. 6, 22, p. 19118-19131 14 p.

Research output: Contribution to journalArticle

Open Access
32 Scopus citations

MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway

Macha, M. A., Rachagani, S., Pai, P., Gupta, S., Lydiatt, W. M., Smith, R. B., Johansson, S. L., Lele, S. M., Kakar, S. S., Lee, J. H., Meza, J., Ganti, A. K., Jain, M. & Batra, S. K., Mar 26 2015, In : Oncogene. 34, 13, p. 1698-1708 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mucin Expression in Endoscopic Ultrasound-Guided Fine-Needle Aspiration Specimens Is a Useful Prognostic Factor in Pancreatic Ductal Adenocarcinoma

Higashi, M., Yokoyama, S., Yamamoto, T., Goto, Y., Kitazono, I., Hiraki, T., Taguchi, H., Hashimoto, S., Fukukura, Y., Koriyama, C., Mataki, Y., Maemura, K., Shinchi, H., Jain, M., Batra, S. K. & Yonezawa, S., Jul 25 2015, In : Pancreas. 44, 5, p. 728-734 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Nano-immunoassay with improved performance for detection of cancer biomarkers

Krasnoslobodtsev, A. V., Torres, M. P., Kaur, S., Vlassiouk, I. V., Lipert, R. J., Jain, M., Batra, S. K. & Lyubchenko, Y. L., Jan 1 2015, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 11, 1, p. 167-173 7 p.

Research output: Contribution to journalArticle

21 Scopus citations
14 Scopus citations

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Lakshmanan, I., Seshacharyulu, P., Haridas, D., Rachagani, S., Gupta, S., Joshi, S., Guda, C., Yan, Y., Jain, M., Ganti, A. K., Ponnusamy, M. P. & Batra, S. K., 2015, In : Oncotarget. 6, 25, p. 21085-21099 15 p.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

Novel imidazopyridine derivatives possess anti-tumor effect on human castration-resistant prostate cancer cells

Ingersoll, M. A., Lyons, A. S., Muniyan, S., D'Cunha, N., Robinson, T., Hoelting, K., Dwyer, J. G., Bu, X. R., Batra, S. K. & Lin, M. F., Jun 29 2015, In : PloS one. 10, 6, e0131811.

Research output: Contribution to journalArticle

9 Scopus citations

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., Xiang, J., Zhang, T., Theilen, T. M., García-Santos, G., Williams, C., Ararso, Y., Huang, Y., Rodrigues, G., Shen, T. L., Labori, K. J. & 17 others, Lothe, I. M. B., Kure, E. H., Hernandez, J., Doussot, A., Ebbesen, S. H., Grandgenett, P. M., Hollingsworth, M. A., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Schwartz, R. E., Matei, I., Peinado, H., Stanger, B. Z., Bromberg, J. & Lyden, D., Jun 1 2015, In : Nature Cell Biology. 17, 6, p. 816-826 11 p.

Research output: Contribution to journalArticle

923 Scopus citations

Pancreatic cancer metastasis: Are we being pre-EMTed?

Das, S. & Batra, S. K., Jan 1 2015, In : Current Pharmaceutical Design. 21, 10, p. 1249-1255 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Seshacharyulu, P., Ponnusamy, M. P., Rachagani, S., Lakshmanan, I., Haridas, D., Yan, Y., Ganti, A. K. & Batra, S. K., 2015, In : Oncotarget. 6, 7, p. 5164-5181 18 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

TLR4 activation by lipopolysaccharide confers survival advantage to growth factor deprived prostate cancer cells

Jain, S., Suklabaidya, S., Das, B., Raghav, S. K., Batra, S. K. & Senapati, S., Jul 1 2015, In : Prostate. 75, 10, p. 1020-1033 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T. L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., Singh, S., Williams, C., Soplop, N., Uryu, K., Pharmer, L., King, T., Bojmar, L., Davies, A. E., Ararso, Y., Zhang, T. & 34 others, Zhang, H., Hernandez, J., Weiss, J. M., Dumont-Cole, V. D., Kramer, K., Wexler, L. H., Narendran, A., Schwartz, G. K., Healey, J. H., Sandstrom, P., Jørgen Labori, K., Kure, E. H., Grandgenett, P. M., Hollingsworth, M. A., De Sousa, M., Kaur, S., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Brady, M. S., Fodstad, O., Muller, V., Pantel, K., Minn, A. J., Bissell, M. J., Garcia, B. A., Kang, Y., Rajasekhar, V. K., Ghajar, C. M., Matei, I., Peinado, H., Bromberg, J. & Lyden, D., Nov 19 2015, In : Nature. 527, 7578, p. 329-335 7 p.

Research output: Contribution to journalArticle

1489 Scopus citations
2014

A comprehensive expression analysis of mucins in appendiceal carcinoma in a multicenter study: MUC3 is a novel prognostic factor

Shibahara, H., Higashi, M., Yokoyama, S., Rousseau, K., Kitazono, I., Osako, M., Shirahama, H., Tashiro, Y., Kurumiya, Y., Narita, M., Kuze, S., Hasagawa, H., Kato, T., Kubota, H., Suzuki, H., Arai, T., Sakai, Y., Yuasa, N., Fujino, M., Kondo, S. & 14 others, Okamoto, Y., Yamamoto, T., Hiromatsu, T., Sasaki, E., Shirai, K., Kawai, S., Hattori, K., Tsuji, H., Okochi, O., Sakamoto, M., Kondo, A., Konishi, N., Batra, S. K. & Yonezawa, S., Dec 31 2014, In : PloS one. 9, 12, e115613.

Research output: Contribution to journalArticle

6 Scopus citations