Surinder Kumar Batra, PhD

  • 20980 Citations
  • 74 h-Index
1985 …2020

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2007

Human MUC4 mucin induces ultra-structural changes and tumorigenicity in pancreatic cancer cells

Moniaux, N., Chaturvedi, P., Varshney, G. C., Meza, J. L., Rodriguez-Sierra, J. F., Aubert, J. P. & Batra, S. K., Jul 31 2007, In : British journal of cancer. 97, 3, p. 345-357 13 p.

Research output: Contribution to journalArticle

49 Scopus citations

IFN-γ-induced expression of MUC4 in pancreatic cancer cells is mediated by STAT-1 upregulation: A novel mechanism for IFN-γ response

Andrianifahanana, M., Singh, A. P., Nemos, C., Ponnusamy, M. P., Moniaux, N., Mehta, P. P., Varshney, G. C. & Batra, S. K., Nov 8 2007, In : Oncogene. 26, 51, p. 7251-7261 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades

Mimeault, M., Mehta, P. P., Hauke, R., Henichart, J. P., Depreux, P., Lin, M. F. & Batra, K. S., Dec 2007, In : Growth Factors. 25, 6, p. 400-416 17 p.

Research output: Contribution to journalArticle

19 Scopus citations

MUC4 expression correlates with poor prognosis in small-sized lung adenocarcinoma

Tsutsumida, H., Goto, M., Kitajima, S., Kubota, I., Hirotsu, Y., Wakimoto, J., Batra, S. K., Imai, K. & Yonezawa, S., Feb 2007, In : Lung Cancer. 55, 2, p. 195-203 9 p.

Research output: Contribution to journalArticle

49 Scopus citations

MUC4 expression is regulated by cystic fibrosis transmembrane conductance regulator in pancreatic adenocarcinoma cells via transcriptional and post-translational mechanisms

Singh, A. P., Chauhan, S. C., Andrianifahanana, M., Moniaux, N., Meza, J. L., Copin, M. C., Van Seuningen, I., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., Jan 4 2007, In : Oncogene. 26, 1, p. 30-41 12 p.

Research output: Contribution to journalArticle

33 Scopus citations

MUC4 mucin potentiates pancreatic tumor cell proliferation, survival, and invasive properties and interferes with its interaction to extracellular matrix proteins

Chaturvedi, P., Singh, A. P., Moniaux, N., Senapati, S., Chakraborty, S., Meza, J. L. & Batra, S. K., Apr 2007, In : Molecular Cancer Research. 5, 4, p. 309-320 12 p.

Research output: Contribution to journalArticle

121 Scopus citations

Novel combination therapy against metastatic and androgen-independent prostate cancer by using gefitinib, tamoxifen and etoposide

Mimeault, M., Venkatraman, G., Johansson, S. L., Moore, E., Henichart, J. P., Depreux, P., Lin, M. F. & Batra, S. K., Jan 1 2007, In : International Journal of Cancer. 120, 1, p. 160-169 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Prostate-derived factor as a paracrine and autocrine factor for the proliferation of androgen receptor-positive human prostate cancer cells

Chen, S. J., Karan, D., Johansson, S. L., Lin, F. F., Zeckser, J., Singh, A. P., Batra, S. K. & Lin, M. F., Apr 1 2007, In : Prostate. 67, 5, p. 557-571 15 p.

Research output: Contribution to journalArticle

56 Scopus citations
197 Scopus citations
2006

Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-α converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinoma

Ringel, J., Jesnowski, R., Moniaux, N., Lüttges, J., Ringel, J., Choudhury, A., Batra, S. K., Klöppel, G. & Löhr, M., Sep 15 2006, In : Cancer Research. 66, 18, p. 9045-9053 9 p.

Research output: Contribution to journalArticle

48 Scopus citations

Aberrant expression of MUC4 in ovarian carcinoma: Diagnostic significance alone and in combination with MUC1 and MUC16 (CA125)

Chauhan, S. C., Singh, A. P., Ruiz, F., Johansson, S. L., Jain, M., Smith, L. M., Moniaux, N. & Batra, S. K., Oct 21 2006, In : Modern Pathology. 19, 10, p. 1386-1394 9 p.

Research output: Contribution to journalArticle

101 Scopus citations

Aberrant expression of transmembrane mucins, MUCI and MUC4, in human prostate carcinomas

Singh, A. P., Chauhan, S. C., Bafna, S., Johansson, S. L., Smith, L. M., Moniaux, N., Lin, M. F. & Batra, S. K., Mar 1 2006, In : Prostate. 66, 4, p. 421-429 9 p.

Research output: Contribution to journalArticle

75 Scopus citations

Androgen deprivation induces human prostate epithelial neuroendocrine differentiation of androgen-sensitive LNCaP cells

Yuan, T. C., Veeramani, S., Lin, F. F., Kondrikou, D., Zelivianski, S., Igawa, T., Karan, D., Batra, S. K. & Lin, M. F., Mar 2006, In : Endocrine-Related Cancer. 13, 1, p. 151-167 17 p.

Research output: Contribution to journalArticle

105 Scopus citations

Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells

Mitra, S., Annamalai, L., Chakraborty, S., Johnson, K., Song, X. H., Batra, S. K. & Mehta, P. P., Dec 2006, In : Molecular biology of the cell. 17, 12, p. 5400-5416 17 p.

Research output: Contribution to journalArticle

33 Scopus citations

Biomarkers in diagnosis of pancreatic carcinoma in fine-needle aspirates: A translational research application

Jhala, N., Jhala, D., Vickers, S. M., Eltoum, I., Batra, S. K., Manne, U., Eloubeidi, M., Jones, J. J. & Grizzle, W. E., Oct 2006, In : American journal of clinical pathology. 126, 4, p. 572-579 8 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

Characterization of human mucin MUC17: Complete coding sequence and organization

Moniaux, N., Junker, W. M., Singh, A. P., Jones, A. M. & Batra, S. K., Aug 18 2006, In : Journal of Biological Chemistry. 281, 33, p. 23676-23685 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats

Wittel, U. A., Pandey, K. K., Andrianifahanana, M., Johansson, S. L., Cullen, D. M., Akhter, M. P., Brand, R. E., Prokopczyk, B. & Batra, S. K., Jan 2006, In : American Journal of Gastroenterology. 101, 1, p. 148-159 12 p.

Research output: Contribution to journalArticle

100 Scopus citations

Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas

Wittel, U. A., Singh, A. P., Henley, B. J., Andrianifahanana, M., Akhter, M. P., Cullen, D. M. & Batra, S. K., Nov 2006, In : Pancreas. 33, 4, p. 364-370 7 p.

Research output: Contribution to journalArticle

31 Scopus citations

Cytotoxic effects induced by a combination of cydopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells

Mimeault, M., Moore, E., Moniaux, N., Hénichart, J. P., Depreux, P., Lin, M. F. & Batra, S. K., Feb 15 2006, In : International Journal of Cancer. 118, 4, p. 1022-1031 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

MUC4-expressing pancreatic adenocarcinomas show elevated levels of both TH1 and TH2 cytokines: Potential pathobiologic implications

Andrianifahanana, M., Chauhan, S. C., Choudhury, A., Moniaux, N., Brand, R. E., Sasson, A. A., Pour, P. M. & Batra, S. K., Oct 2006, In : American Journal of Gastroenterology. 101, 10, p. 2319-2329 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

MUC4 is a novel prognostic factor of extrahepatic bile duct carcinoma.

Tamada, S., Shibahara, H., Higashi, M., Goto, M., Batra, S. K., Imai, K. & Yonezawa, S., Jul 15 2006, In : Clinical cancer research : an official journal of the American Association for Cancer Research. 12, 14 Pt 1, p. 4257-4264 8 p.

Research output: Contribution to journalArticle

73 Scopus citations

The human homologue of the RNA polymerase II-associated factor 1 (hPaf1), localized on the 19q13 amplicon, is associated with tumorigenesis

Moniaux, N., Nemos, C., Schmied, B. M., Chauhan, S. C., Deb, S., Morikane, K., Choudhury, A., VanLith, M., Sutherlin, M., Sikela, J. M., Hollingsworth, M. A. & Batra, S. K., Jun 1 2006, In : Oncogene. 25, 23, p. 3247-3257 11 p.

Research output: Contribution to journalArticle

54 Scopus citations

Tumor progression and metastasis from genetic to microenvironmental determinants: A Workshop of the Tumor Progression and Metastasis NIH Study Section in Honor of Dr. Martin L. Padarathsingh, May 31, 2006, Georgetown, Washington, DC

De Clerck, Y. A., Weissman, B. E., Yu, D., Parsons, R., Bar-Eli, M., Roy-Burman, P., Seewaldt, V. L., Cress, A. E., Languino, L. R., Batra, S. K., Tang, C. K., Sheng, S., Chen, W. T., Chellappan, S., Cheng, S. Y., Ladisch, S., McCarthy, J. B., Coussens, L. M. & Cohen, M. B., Dec 2006, In : Cancer Biology and Therapy. 5, 12, p. 1588-1599 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2005

Engineering and characterization of a divalent single-chain Fv angiotensin II fusion construct of the monoclonal antibody CC49

Wittel, U. A., Jain, M., Goel, A., Baranowska-Kortylewicz, J., Kurizaki, T., Chauhan, S. C., Agrawal, D. K., Colcher, D. & Batra, S. K., Apr 1 2005, In : Biochemical and Biophysical Research Communications. 329, 1, p. 168-176 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

ErbB2 growth factor receptor, a marker for neuroendocrine cells?

Standop, J., Andrianifahanana, M., Moniaux, N., Schneider, M., Ulrich, A., Brand, R. E., Wisecarver, J. L., Bridge, J. A., Büchler, M. W., Adrian, T. E., Batra, S. K. & Pour, P. M., 2005, In : Pancreatology. 5, 1, p. 44-58 15 p.

Research output: Contribution to journalArticle

1 Scopus citations

MUC4 expression is a novel prognostic factor in patients with invasive ductal carcinoma of the pancreas

Saitou, M., Goto, M., Horinouchi, M., Tamada, S., Nagata, K., Hamada, T., Osako, M., Takao, S., Batra, S. K., Aikou, T., Imai, K. & Yonezawa, S., Aug 2005, In : Journal of Clinical Pathology. 58, 8, p. 845-852 8 p.

Research output: Contribution to journalArticle

108 Scopus citations

Penetratin improves tumor retention of single-chain antibodies: A novel step toward optimization of radioimmunotherapy of solid tumors

Jain, M., Chauhan, S. C., Singh, A. P., Venkatraman, G., Colcher, D. & Batra, S. K., Sep 1 2005, In : Cancer Research. 65, 17, p. 7840-7846 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

Pharmacokinetics and biodistribution of 177Lu-labeled multivalent single-chain Fv construct of the pancarcinoma monoclonal antibody CC49

Chauhan, S. C., Jain, M., Moore, E. D., Wittel, U. A., Li, J., Gwilt, P. R., Colcher, D. & Batra, S. K., Mar 2005, In : European Journal of Nuclear Medicine and Molecular Imaging. 32, 3, p. 264-273 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Synergistic induction of the MUC4 mucin gene by interferon-γ and retinoic acid in human pancreatic tumour cells involves a reprogramming of signalling pathways

Andrianifahanana, M., Agrawal, A., Singh, A. P., Moniaux, N., Van Seuningen, I., Aubert, J. P., Meza, J. & Batra, S. K., Sep 8 2005, In : Oncogene. 24, 40, p. 6143-6154 12 p.

Research output: Contribution to journalArticle

35 Scopus citations

The human PAF complex coordinates transcription with events downstream of RNA synthesis

Zhu, B., Mandal, S. S., Pham, A. D., Zheng, Y., Erdjument-Bromage, H., Batra, S. K., Tempst, P. & Reinberg, D., Jul 2005, In : Genes and Development. 19, 14, p. 1668-1673 6 p.

Research output: Contribution to journalArticle

140 Scopus citations

The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs

Wittel, U. A., Jain, M., Goel, A., Chauhan, S. C., Colcher, D. & Batra, S. K., Feb 2005, In : Nuclear Medicine and Biology. 32, 2, p. 157-164 8 p.

Research output: Contribution to journalArticle

33 Scopus citations
2004

A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-β in pancreatic carcinogenesis

Jonckheere, N., Perrais, M., Mariette, C., Batra, S. K., Aubert, J. P., Pigny, P. & Van Seuningen, I., Jul 29 2004, In : Oncogene. 23, 34, p. 5729-5738 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Diagnostic value of MUC4 immunostaining in distinguishing epithelial mesothelioma and lung adenocarcinoma

Llinares, K., Escande, F., Aubert, S., Buisine, M. P., De Bolos, C., Batra, S. K., Gosselin, B., Aubert, J. P., Porchet, N. & Copin, M. C., Feb 2004, In : Modern Pathology. 17, 2, p. 150-157 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Frequent HIN-1 promoter methylation and lack of expression in multiple human tumor types

Krop, I., Player, A., Tablante, A., Taylor-Parker, M., Lahti-Domenici, J., Fukuoka, J., Batra, S. K., Papadopoulos, N., Richards, W. G., Sugarbaker, D. J., Wright, R. L., Shim, J., Stamey, T. A., Sellers, W. R., Loda, M., Meyerson, M., Hruban, R., Jen, J. & Polyak, K., Sep 2004, In : Molecular Cancer Research. 2, 9, p. 489-494 6 p.

Research output: Contribution to journalArticle

35 Scopus citations

Generation and Characterization of Anti-MUC4 Monoclonal Antibodies Reactive with Normal and Cancer Cells in Humans

Moniaux, N., Varshney, G. C., Chauhan, S. C., Copin, M. C., Jain, M., Wittel, U. A., Andrianifahanana, M., Aubert, J. P. & Batra, S. K., Feb 2004, In : Journal of Histochemistry and Cytochemistry. 52, 2, p. 253-261 9 p.

Research output: Contribution to journalArticle

Open Access
68 Scopus citations

Inhibition of MUC4 Expression Suppresses Pancreatic Tumor Cell Growth and Metastasis

Singh, A. P., Moniaux, N., Chauhan, S. C., Meza, J. L. & Batra, S. K., Jan 15 2004, In : Cancer Research. 64, 2, p. 622-630 9 p.

Research output: Contribution to journalArticle

188 Scopus citations

In vivo effect of wood smoke on the expression of two mucin genes in rat airways

Bhattacharyya, S. N., Dubick, M. A., Yantis, L. D., Enriquez, J. I., Buchanan, K. C., Batra, S. K. & Smiley, R. A., Apr 2004, In : Inflammation. 28, 2, p. 67-76 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

MUC4 Is a Novel Prognostic Factor of Intrahepatic Cholangiocarcinoma-Mass Forming Type

Shibahara, H., Tamada, S., Higashi, M., Goto, M., Batra, S. K., Hollingsworth, M. A., Imai, K. & Yonezawa, S., Jan 2004, In : Hepatology. 39, 1, p. 220-229 10 p.

Research output: Contribution to journalArticle

104 Scopus citations

MUC4 mucin expression in human pancreatic tumours is affected by organ environment: The possible role of TGFβ2

Choudhury, A., Moniaux, N., Ulrich, A. B., Schmied, B. M., Standop, J., Pour, P. M., Gendler, S. J., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., Feb 9 2004, In : British journal of cancer. 90, 3, p. 657-664 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Mucin expression in pleomorphic adenoma of salivary gland: A potential role of MUC1 as a marker to predict recurrence

Hamada, T., Matsukita, S., Goto, M., Kitajima, S., Batra, S. K., Irimura, T., Sueyoshi, K., Sugihara, K. & Yonezawa, S., Aug 2004, In : Journal of Clinical Pathology. 57, 8, p. 813-821 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Pancreatic Enzyme Extract Improves Survival in Murine Pancreatic Cancer

Saruc, M., Standop, S., Standop, J., Nozawa, F., Itami, A., Pandey, K. K., Batra, S. K., Gonzalez, N. J., Guesry, P. & Pour, P. M., May 2004, In : Pancreas. 28, 4, p. 401-412 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pathologic Features of Mucin-producing Bile Duct Tumors: Two Histopathologic Categories as Counterparts of Pancreatic Intraductal Papillary-mucinous Neoplasms

Shibahara, H., Tamada, S., Goto, M., Oda, K., Nagino, M., Nagasaka, T., Batra, S. K., Hollingsworth, M. A., Imai, K., Nimura, Y. & Yonezawa, S., Mar 2004, In : American Journal of Surgical Pathology. 28, 3, p. 327-338 12 p.

Research output: Contribution to journalArticle

141 Scopus citations

Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Mariette, C., Perrais, M., Leteurtre, E., Jonckheere, N., Hémon, B., Pigny, P., Batra, S., Aubert, J. P., Triboulet, J. P. & Van Seuningen, I., Feb 1 2004, In : Biochemical Journal. 377, 3, p. 701-708 8 p.

Research output: Contribution to journalArticle

41 Scopus citations
2003

Aberrant expression of muc3 and muc4 membrane-associated mucins and sialyl lex antigen in pancreatic intraepithelial neoplasia

Park, H. U., Kim, J. W., Kim, G. E., Bae, H. I., Crawley, S. C., Yang, S. C., Gum, J. R., Batra, S. K., Rousseau, K., Swallow, D. M., Sleisenger, M. H. & Kim, Y. S., Apr 2003, In : Nursing. 26, 3, p. e48-e54

Research output: Contribution to journalArticle

74 Scopus citations

Constructs of biotin mimetic peptide with CC49 single-chain Fv designed for tumor pretargeting

Pavlinkova, G., Batra, S. K., Colcher, D., Booth, B. J. M. & Baranowska-Kortylewicz, J., Mar 1 2003, In : Peptides. 24, 3, p. 353-362 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Dysregulated expression of MIC-1/PDF in human prostate tumor cells

Karan, D., Chen, S. J., Johansson, S. L., Singh, A. P., Paralkar, V. M., Lin, M. F. & Batra, S. K., Jun 6 2003, In : Biochemical and Biophysical Research Communications. 305, 3, p. 598-604 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.

Karan, D., Lin, F. C., Bryan, M., Ringel, J., Moniaux, N., Lin, M. F. & Batra, S. K., Nov 2003, In : International journal of oncology. 23, 5, p. 1365-1371 7 p.

Research output: Contribution to journalArticle

70 Scopus citations

In Vitro Affinity Maturation of a Specificity-Determining Region-Grafted Humanized Anticarcinoma Antibody: Isolation and Characterization of Minimally Immunogenic High-Affinity Variants

De Pascalis, R., Gonzales, N. R., Padlan, E. A., Schuck, P., Batra, S. K., Schlom, J. & Kashmiri, S. V. S., Nov 15 2003, In : Clinical Cancer Research. 9, 15, p. 5521-5531 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Neural invasion in the staging of pancreatic cancer

Pour, P. M., Bell, R. H. & Batra, S. K., May 2003, In : Pancreas. 26, 4, p. 322-325 4 p.

Research output: Contribution to journalArticle

81 Scopus citations

RXRα: A novel target for prostate cancer

Pandey, K. K. & Batra, S. K., Mar 2003, In : Cancer Biology and Therapy. 2, 2, p. 185-186 2 p.

Research output: Contribution to journalArticle