Surinder Kumar Batra, PhD

  • 20980 Citations
  • 74 h-Index
1985 …2020

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Research Output

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Article
2002

Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model

Igawa, T., Lin, F. F., Lee, M. S., Karan, D., Batra, S. K. & Lin, M. F., 2002, In : Prostate. 50, 4, p. 222-235 14 p.

Research output: Contribution to journalArticle

156 Scopus citations
Open Access
117 Scopus citations

Genomic organization of MUC4 mucin gene: Towards the characterization of splice variants

Escande, F., Lemaitre, L., Moniaux, N., Batra, S. K., Aubert, J. P. & Buisine, M. P., 2002, In : European Journal of Biochemistry. 269, 15, p. 3637-3644 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

MUC4 expression increases progressively in pancreatic intraepithelial neoplasia

Swartz, M. J., Batra, S. K., Varshney, G. C., Hollingsworth, M. A., Yeo, C. J., Cameron, J. L., Wilentz, R. E., Hruban, R. H. & Argani, P., 2002, In : American journal of clinical pathology. 117, 5, p. 791-796 6 p.

Research output: Contribution to journalArticle

193 Scopus citations

Purification and characterization of a human pancreatic adenocarcinoma mucin

Khorrami, A. M., Choudhury, A., Andrianifahanana, M., Varshney, G. C., Bhattacharyya, S. N., Hollingsworth, M. A., Kaufman, B. & Batra, S. K., 2002, In : Journal of Biochemistry. 131, 1, p. 21-29 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

The pattern of xenobiotic-metabolizing enzymes in the human pancreas

Standop, J., Schneider, M. B., Ulrich, A., Chauhan, S., Moniaux, N., Büchler, M. W., Batra, S. K. & Pour, P. M., Oct 11 2002, In : Journal of Toxicology and Environmental Health - Part A. 65, 19, p. 1379-1400 22 p.

Research output: Contribution to journalArticle

13 Scopus citations
2001

99mTc-labeled divalent and tetravalent CC49 single-chain Fv's: Novel imaging agents for rapid in vivo localization of human colon carcinoma

Goel, A., Baranowska-Kortylewicz, J., Hinrichs, S. H., Wisecarver, J., Pavlinkova, G., Augustine, S., Colcher, D., Booth, B. J. M. & Batra, S. K., 2001, In : Journal of Nuclear Medicine. 42, 10, p. 1519-1527 9 p.

Research output: Contribution to journalArticle

68 Scopus citations

Antibody constructs for radioimmunodiagnosis and treatment of human pancreatic cancer

Ringel, J., Jesnowski, R., Schmidt, C., Ringel, J., Köhler, H. J., Rychly, J., Batra, S. K. & Löhr, M., 2001, In : Teratogenesis Carcinogenesis and Mutagenesis. 21, 1, p. 45-57 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

CD44 in normal human pancreas and pancreatic carcinoma cell lines

Ringel, J., Jesnowski, R., Schmidt, C., Ringel, J., Köhler, H. J., Rychly, J., Batra, S. K. & Löhr, M., 2001, In : Teratogenesis Carcinogenesis and Mutagenesis. 21, 1, p. 97-106 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells

Matsuzaki, H., Schmied, B. M., Ulrich, A., Standop, J., Schneider, M. B., Batra, S. K., Picha, K. S. & Pour, P. M., Feb 2001, In : Clinical Cancer Research. 7, 2, p. 407-414 8 p.

Research output: Contribution to journalArticle

58 Scopus citations

Decreased androgen-responsive growth of human prostate cancer is associated with increased genetic alterations

Karan, D., Schmied, B. M., Dave, B. J., Wittel, U. A., Lin, M. F. & Batra, S. K., 2001, In : Clinical Cancer Research. 7, 11, p. 3472-3480 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Early changes in islet hormone secretion in the hamster pancreatic cancer model

Goel, A. & Batra, S. K., 2001, In : Teratogenesis Carcinogenesis and Mutagenesis. 21, 1, p. 59-67 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effects of humanization and gene shuffling on immunogenicity and antigen binding of anti-TAG-72 single-chain Fvs

Pavlinkova, G., Colcher, D., Booth, B. J. M., Goel, A., Wittel, U. A. & Batra, S. K., Dec 1 2001, In : International Journal of Cancer. 94, 5, p. 717-726 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Identification and sequencing of the Syrian Golden hamster (Mesocricetus auratus) p16INK4a and p15INK4b cDNAs and their homozygous gene deletion in cheek pouch and pancreatic tumor cells

Muscarella, P., Knobloch, T. J., Ulrich, A. B., Casto, B. C., Moniaux, N., Wittel, U. A., Melvin, W. S., Pour, P. M., Song, H., Gold, B., Batra, S. K. & Weghorst, C. M., Oct 31 2001, In : Gene. 278, 1-2, p. 235-243 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

In vivo glycosylation of mucin tandem repeats

Silverman, H. S., Parry, S., Sutton-Smith, M., Burdick, M. D., McDermott, K., Reid, C. J., Batra, S. K., Morris, H. R., Hollingsworth, M. A., Dell, A. & Harris, A., 2001, In : Glycobiology. 11, 6, p. 459-471 13 p.

Research output: Contribution to journalArticle

Open Access
36 Scopus citations

Mucin (MUC) gene expression in human pancreatic adenocarcinoma and chronic pancreatitis: A potential role of MUC4 as a tumormarker of diagnostic significance

Andrianifahanana, M., Moniaux, N., Ringel, J., Batra, S. K., Hollingsworth, M. A., Batra, S. K., Aubert, J. P., Schmied, B. M., Friess, H. & Büchler, M. W., 2001, In : Clinical Cancer Research. 7, 12, p. 4033-4040 8 p.

Research output: Contribution to journalArticle

208 Scopus citations

Single-dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using 131I-labeled multivalent CC49 single-chain Fvs1

Goel, A., Augustine, S., Baranowska-Kortylewicz, J., Colcher, D., Booth, B. J. M., Pavlinkova, G., Tempero, M. & Batra, S. K., 2001, In : Clinical Cancer Research. 7, 1, p. 175-184 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Transdifferentiation of human islet cells in a long-term culture

Schmied, B. M., Ulrich, A., Matsuzaki, H., Ding, X., Ricordi, C., Weide, L., Moyer, M. P., Batra, S. K., Adrian, T. E. & Pour, P. M., 2001, In : Pancreas. 23, 2, p. 157-171 15 p.

Research output: Contribution to journalArticle

59 Scopus citations
2000

Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins

Moniaux, N., Escande, F., Batra, S. K., Porchet, N., Laine, A. & Aubert, J. P., 2000, In : European Journal of Biochemistry. 267, 14, p. 4536-4544 9 p.

Research output: Contribution to journalArticle

81 Scopus citations

Biologic instability of pancreatic cancer xenografts in the nude mouse

Schmied, B. M., Ulrich, A. B., Matsuzaki, H., El-Metwally, T. H., Ding, X., Fernandes, M. E., Adrian, T. E., Chaney, W. G., Batra, S. K. & Pour, P. M., 2000, In : Carcinogenesis. 21, 6, p. 1121-1127 7 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Differentiation of islet cells in long-term culture

Schmied, B. M., Liu, G., Matsuzaki, H., Ulrich, A., Hernberg, S., Moyer, M. P., Weide, L., Murphy, L., Batra, S. K. & Pour, P. M., May 2000, In : Pancreas. 20, 4, p. 337-347 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

Divalent forms of CC49 single-chain antibody constructs in Pichia pastoris: Expression, purification, and characterization

Goel, A., Beresford, G. W., Colcher, D., Pavlinkova, G., Booth, B. J. M., Baranowska-Kortylewicz, J. & Batra, S. K., 2000, In : Journal of Biochemistry. 127, 5, p. 829-836 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Establishment of human pancreatic ductal cells in a long-term culture

Ulrich, A. B., Schmied, B. M., Matsuzaki, H., El-Metwally, T., Moyer, M. P., Ricordi, C., Adrian, T. E., Batra, S. K. & Pour, P. M., 2000, In : Pancreas. 21, 4, p. 358-368 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Genetically engineered tetravalent single-chain Fv of the pancarcinoma monoclonal antibody CC49: Improved biodistribution and potential for therapeutic application

Goel, A., Colcher, D., Baranowska-Kortylewiez, J., Augustine, S., Booth, B. J. M., Pavlinkova, G. & Batra, S. K., Dec 15 2000, In : Cancer Research. 60, 24, p. 6964-6971 8 p.

Research output: Contribution to journalArticle

103 Scopus citations

Human MUC4 mucin cDNA and its variants in pancreatic carcinoma

Choudhury, A., Moniaux, N., Winpenny, J. P., Hollingsworth, M. A., Aubert, J. P. & Batra, S. K., 2000, In : Journal of Biochemistry. 128, 2, p. 233-243 11 p.

Research output: Contribution to journalArticle

61 Scopus citations

In vitro induction of giant cell tumors from cultured hamster islets treated with N-nitrosobis(2-oxopropyl)amine

Matsuzaki, H., Schmied, B. M., Ulrich, A., Batra, S. K. & Pour, P. M., 2000, In : American Journal of Pathology. 156, 2, p. 439-443 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Maintenance of human islets in long term culture

Schmied, B. M., Ulrich, A., Matsuzaki, H., Ding, X., Ricordi, C., Moyer, M. P., Batra, S. K., Adrian, T. E. & Pour, P. M., 2000, In : Differentiation. 66, 4-5, p. 173-180 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Pharmacokinetics and biodistribution of a light-chain-shuffled CC49 single-chain Fv antibody construct

Pavlinkova, G., Colcher, D., Booth, B. J. M., Goel, A. & Batra, S. K., 2000, In : Cancer Immunology Immunotherapy. 49, 4-5, p. 267-275 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Relative position of the hexahistidine tag effects binding properties of a tumor-associated single-chain Fv construct

Goel, A., Colcher, D., Koo, J. S., Booth, B. J. M., Pavlinkova, G. & Batra, S. K., Sep 1 2000, In : Biochimica et Biophysica Acta - General Subjects. 1523, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

82 Scopus citations

Retinoic acid-dependent transforming growth factor-β2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-α signaling pathway

Choudhury, A., Singh, R. K., Moniaux, N., El-Metwally, T. H., Aubert, J. P. & Batra, S. K., Oct 27 2000, In : Journal of Biological Chemistry. 275, 43, p. 33929-33936 8 p.

Research output: Contribution to journalArticle

64 Scopus citations
1999

Binding characteristics and tumor targeting of a covalently linked divalent CC49 single-chain antibody

Beresford, G. W., Pavlinkova, G., Booth, B. J. M., Batra, S. K. & Colcher, D., 1999, In : International Journal of Cancer. 81, 6, p. 911-917 7 p.

Research output: Contribution to journalArticle

43 Scopus citations

Charge-modified single chain antibody constructs of monoclonal antibody CC49: Generation, characterization, pharmacokinetics, and biodistribution analysis

Pavlinkova, G., Beresford, G., Booth, B. J. M., Batra, S. K. & Colcher, D., Jan 1999, In : Nuclear Medicine and Biology. 26, 1, p. 27-34 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Induction of adenocarcinoma from hamster pancreatic islet cells treated with N-nitrosobis(2-oxopropyl)amine in vitro

Schmied, B., Liu, G., Moyer, M. P., Hernberg, I. S. B., Sanger, W., Batra, S. & Pour, P. M., 1999, In : Carcinogenesis. 20, 2, p. 317-324 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Pharmacokinetics and biodistribution of engineered single-chain antibody constructs of MAb CC49 in colon carcinoma xenografts

Pavlinkova, G., Beresford, G. W., Booth, B. J. M., Batra, S. K. & Colcher, D., Sep 1999, In : Journal of Nuclear Medicine. 40, 9, p. 1536-1546 11 p.

Research output: Contribution to journalArticle

100 Scopus citations

Radioimmunotherapy of human colon cancer xenografts using a dimeric single-chain Fv antibody construct

Pavlinkova, G., Booth, B. J. M., Batra, S. K. & Colcher, D., Sep 1999, In : Clinical Cancer Research. 5, 9, p. 2613-2619 7 p.

Research output: Contribution to journalArticle

34 Scopus citations

Single-chain antibodies in pancreatic cancer

Colcher, D., Pavlinkova, G., Beresford, G., Booth, B. J. M. & Batra, S. K., 1999, In : Annals of the New York Academy of Sciences. 880, p. 263-280 18 p.

Research output: Contribution to journalArticle

33 Scopus citations
1997

A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo

Ashley, D. M., Sampson, J. H., Archer, G. E., Batra, S. K., Bigner, D. D. & Hale, L. P., Sep 1997, In : Journal of Neuroimmunology. 78, 1-2, p. 34-46 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: Comparison with its murine parent

Reist, C. J., Batra, S. K., Pegram, C. N., Bigner, D. D. & Zalutsky, M. R., Oct 1997, In : Nuclear Medicine and Biology. 24, 7, p. 639-647 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)

Chu, C. T., Everiss, K. D., Wikstrand, C. J., Batra, S. K., Kung, H. J. & Bigner, D. D., Jun 15 1997, In : Biochemical Journal. 324, 3, p. 855-861 7 p.

Research output: Contribution to journalArticle

152 Scopus citations
1996

Chimeric anti-tenascin antibody 81C6: Increased tumor localization compared with its murine parent

Zalutsky, M. R., Archer, G. E., Garg, P. K., Batra, S. K. & Bigner, D. D., May 1996, In : Nuclear Medicine and Biology. 23, 4, p. 449-458 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

Microsatellite analysis of childhood brain tumors

Blaeker, H., Rasheed, B. K. A., McLendon, R. E., Friedman, H. S., Batra, S. K., Fuchs, H. E. & Bigner, S. H., Jan 1996, In : Genes Chromosomes and Cancer. 15, 1, p. 54-63 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
1995

Epidermal growth factor ligand-independent, unregulated, cell- transforming potential of a naturally occurring human mutant EGFRvIII gene

Batra, S. K., Castelino-Prabhu, S., Wikstrand, C. J., Zhu, X., Humphrey, P. A., Friedman, H. S. & Bigner, D. D., 1995, In : Cell Growth and Differentiation. 6, 10, p. 1251-1259 9 p.

Research output: Contribution to journalArticle

233 Scopus citations

Monoclonal Antibodies against EGFRvIII Are Tumor Specific and React with Breast and Lung Carcinomas and Malignant Gliomas

Wikstrand, C. J., Hale, L. P., Batra, S. K., Hill, M. L., Humphrey, P. A., Kurpad, S. N., McLendon, R. E., Moscatello, D., Pegram, C. N., Reist, C. J., Traweek, S. T., Wong, A. J., Zalutsky, M. R. & Bigner, D. D., Jul 15 1995, In : Cancer Research. 55, 14, p. 3140-3148 9 p.

Research output: Contribution to journalArticle

441 Scopus citations

Prognostic implications of chromosome 17p deletions in human medulloblastomas

Batra, S. K., McLendon, R. E., Koo, J. S., Castelino-Prabhu, S., Fuchs, H. E., Krischer, J. P., Friedman, H. S., Bigner, D. D. & Bigner, S. H., Feb 1995, In : Journal of Neuro-Oncology. 24, 1, p. 39-45 7 p.

Research output: Contribution to journalArticle

122 Scopus citations

Tumor antigens in astrocytic gliomas

Kurpad, S. N., Zhao., X. G., Wikstrand, C. J., Batra, S. K., McLendon, R. E. & Bigner, D. D., Nov 1995, In : Glia. 15, 3, p. 244-256 13 p.

Research output: Contribution to journalArticle

102 Scopus citations
1994

Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin

He, X., Archer, G. E., Wikstrand, C. J., Morrison, S. L., Zalutsky, M. R., Bigner, D. D. & Batra, S. K., Jul 1994, In : Journal of Neuroimmunology. 52, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mouse/human chimeric Me1-14 antibody: Genomic cloning of the variable region genes, linkage to human constant region genes, expression, and characterization

Batra, S. K., Niswonger, M. L., Wikstrand, C. J., Pegram, C. N., Zalutsky, M. R., Morrison, S. L. & Bigner, D. D., 1994, In : Hybridoma. 13, 2, p. 87-97 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

Oxidant stress increases heat shock protein 70 mRNA in isolated perfused rat heart

Kukreja, R. C., Kontos, M. C., Loesser, K. E., Batra, S. K., Qian, Y. Z., Gbur, C. J., Naseem, S. A., Jesse, R. L. & Hess, M. L., 1994, In : American Journal of Physiology - Heart and Circulatory Physiology. 267, 6 36-6, p. H2213-H2219

Research output: Contribution to journalArticle

128 Scopus citations
1992

Expression of O6-Methylguanine-DNA Methyltransferase in Six Human Medulloblastoma Cell Lines

He, X., Ostrowski, L. E., Friedman, H. S., Wikstrand, C. J., Bigner, S. H., Rasheed, A., Batra, S. K. & Signer, D. D., Mar 1992, In : Cancer Research. 52, 5, p. 1144-1148 5 p.

Research output: Contribution to journalArticle

28 Scopus citations

Expression of the human MUC1 mucin cDNA in a hamster pancreatic tumor cell line HP-1

Batra, S. K., Metzgar, R. S., Worlock, A. J. & Hollingsworth, M. A., Dec 1992, In : International Journal of Pancreatology. 12, 3, p. 271-283 13 p.

Research output: Contribution to journalArticle

10 Scopus citations