• 5641 Citations
  • 34 h-Index
1979 …2020

Research output per year

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Research Output

  • 5641 Citations
  • 34 h-Index
  • 77 Article
  • 17 Review article
  • 3 Comment/debate
  • 1 Chapter
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Article
2020
2019

Effect of nanoformulated copper/zinc superoxide dismutase on chronic ethanol-induced alterations in liver and adipose tissue

Natarajan, G., Perriotte-Olson, C., Casey, C. A., Donohue, T. M., Talmon, G. A., Harris, E. N., Kabanov, A. V. & Saraswathi, V., Sep 2019, In : Alcohol. 79, p. 71-79 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism

Thomes, P. G., Rasineni, K., Yang, L., Donohue, T. M., Kubik, J. L., McNiven, M. A. & Casey, C. A., Apr 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 4, p. G509-G518

Research output: Contribution to journalArticle

4 Scopus citations

Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis

Fonseca, T. L., Fernandes, G. W., Bocco, B. M. L. C., Keshavarzian, A., Jakate, S., Donohue, T. M., Gereben, B. & Bianco, A. C., Jul 2019, In : Alcoholism: Clinical and Experimental Research. 43, 7, p. 1376-1383 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Diurnal variations in intestinal barrier integrity and liver pathology in mice: Implications for alcohol binge

Voigt, R. M., Forsyth, C. B., Shaikh, M., Zhang, L., Raeisi, S., Aloman, C., Preite, N. Z., Donohue, T. M., Fogg, L. & Keshavarzian, A., Jan 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 1, p. G131-G141

Research output: Contribution to journalArticle

6 Scopus citations
2017

Alcoholic liver disease: Pathogenesis and current management

Osna, N. A., Donohue, T. M. & Kharbanda, K. K., Jan 1 2017, In : Alcohol Research: Current Reviews. 38, 2, p. 7-21 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

Data on the effect of pro-fibrotic cytokine TGF-β on hepatic stellate cell autophagy

Thomes, P. G., Brandon-Warner, E., Li, T., Donohue, T. M. & Schrum, L. W., Feb 1 2017, In : Data in Brief. 10, p. 312-314 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

Dietary fructose augments ethanol-induced liver pathology

Thomes, P. G., Benbow, J. H., Brandon-Warner, E., Thompson, K. J., Jacobs, C., Donohue, T. M. & Schrum, L. W., May 1 2017, In : Journal of Nutritional Biochemistry. 43, p. 141-150 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Neuropilin-2 regulates endosome maturation and EGFR trafficking to support cancer cell pathobiology

Dutta, S., Roy, S., Polavaram, N. S., Stanton, M. J., Zhang, H., Bhola, T., Hönscheid, P., Donohue, T. M., Band, H., Batra, S. K., Muders, M. H. & Datta, K., Jan 15 2016, In : Cancer Research. 76, 2, p. 418-428 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Rev-erb agonist and TGF-β similarly affect autophagy but differentially regulate hepatic stellate cell fibrogenic phenotype

Thomes, P. G., Brandon-Warner, E., Li, T., Donohue, T. M. & Schrum, L. W., Dec 1 2016, In : International Journal of Biochemistry and Cell Biology. 81, p. 137-147 11 p.

Research output: Contribution to journalArticle

6 Scopus citations
2015
24 Scopus citations

Acute and Chronic Ethanol Administration Differentially Modulate Hepatic Autophagy and Transcription Factor EB

Thomes, P. G., Trambly, C. S., Fox, H. S., Tuma, D. J. & Donohue, T. M., Dec 1 2015, In : Alcoholism: Clinical and Experimental Research. 39, 12, p. 2354-2363 10 p.

Research output: Contribution to journalArticle

40 Scopus citations
2013
16 Scopus citations
11 Scopus citations

Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury

Martin-Murphy, B. V., Kominsky, D. J., Orlicky, D. J., Donohue, T. M. & Ju, C., Apr 1 2013, In : Hepatology. 57, 4, p. 1575-1584 10 p.

Research output: Contribution to journalArticle

30 Scopus citations

Multilevel regulation of autophagosome content by ethanol oxidation in HepG2 cells

Thomes, P. G., Ehlers, R. A., Trambly, C. S., Clemens, D. L., Fox, H. S., Tuma, D. J. & Donohue, T. M., Jan 2013, In : Autophagy. 9, 1, p. 63-73 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

Early Growth Response-1 Contributes to Steatosis Development After Acute Ethanol Administration

Donohue, T. M., Osna, N. A., Trambly, C. S., Whitaker, N. P., Thomes, P. G., Todero, S. L. & Davis, J. S., May 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 5, p. 759-767 9 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation in Hepatocytes by Altering Proteasome Function

Osna, N. A., Bardag-Gorce, F., White, R. L., Weinman, S. A., Donohue, T. M. & Kharbanda, K. K., Dec 1 2012, In : Alcoholism: Clinical and Experimental Research. 36, 12, p. 2028-2035 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
43 Scopus citations
2010

Acetyl-l-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain

Rump, T. J., Muneer, P. M. A., Szlachetka, A. M., Lamb, A., Haorei, C., Alikunju, S., Xiong, H., Keblesh, J., Liu, J., Zimmerman, M. C., Jones, J., Donohue, T. M., Persidsky, Y. & Haorah, J., Nov 30 2010, In : Free Radical Biology and Medicine. 49, 10, p. 1494-1504 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Chronic Ethanol Consumption Results in Atypical Liver Injury in Copper/Zinc Superoxide Dismutase Deficient Mice

Curry-Mccoy, T. V., Osna, N. A., Nanji, A. A. & Donohue, T. M., Feb 1 2010, In : Alcoholism: Clinical and Experimental Research. 34, 2, p. 251-261 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Impaired methylation as a novel mechanism for proteasome suppression in liver cells

Osna, N. A., White, R. L., Donohue, T. M., Beard, M. R., Tuma, D. J. & Kharbanda, K. K., Jan 8 2010, In : Biochemical and Biophysical Research Communications. 391, 2, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

Ethanol metabolism alters major histocompatibility complex class I-restricted antigen presentation in liver cells

Osna, N. A., White, R. L., Thiele, G. M. & Donohue, T. M., Jun 24 2009, In : Hepatology. 49, 4, p. 1308-1315 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Modulation of lysozyme function and degradation after nitration with peroxynitrite

Curry-McCoy, T. V., Osna, N. A. & Donohue, T. M., Aug 1 2009, In : Biochimica et Biophysica Acta - General Subjects. 1790, 8, p. 778-786 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

A voluntary oral ethanol-feeding rat model associated with necroinflammatory liver injury

Tipoe, G. L., Liong, E. C., Casey, C. A., Donohue, T. M., Eagon, P. K., So, H., Leung, T. M., Fogt, F. & Nanji, A. A., Apr 1 2008, In : Alcoholism: Clinical and Experimental Research. 32, 4, p. 669-682 14 p.

Research output: Contribution to journalArticle

37 Scopus citations

Proteasome Activation by Hepatitis C Core Protein Is Reversed by Ethanol-Induced Oxidative Stress

Osna, N. A., White, R. L., Krutik, V. M., Wang, T., Weinman, S. A. & Donohue, T. M., Jun 2008, In : Gastroenterology. 134, 7, p. 2144-2152 9 p.

Research output: Contribution to journalArticle

38 Scopus citations
2007

Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells

Osna, N. A., White, R. L., Todero, S., Mc Vicker, B. L., Thiele, G. M., Clemens, D. L., Tuma, D. J. & Donohue, T. M., Jan 1 2007, In : Hepatology. 45, 1, p. 53-61 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Implication of altered proteasome function in alcoholic liver injury

Osna, N. A. & Donohue, T. M., Oct 7 2007, In : World Journal of Gastroenterology. 13, 37, p. 4931-4937 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury

Donohue, T. M., Curry-McCoy, T. V., Todero, S. L., White, R. L., Kharbanda, K. K., Nanji, A. A. & Osna, N. A., Jun 2007, In : Alcoholism: Clinical and Experimental Research. 31, 6, p. 1053-1060 8 p.

Research output: Contribution to journalArticle

22 Scopus citations
23 Scopus citations
2006
91 Scopus citations
2005

Inhibition of bone repair in a rat model for chronic and excessive alcohol consumption

Chakkalakal, D. A., Novak, J. R., Fritz, E. D., Mollner, T. J., McVicker, D. L., Garvin, K. L., McGuire, M. H. & Donohue, T. M., Jul 1 2005, In : Alcohol. 36, 3, p. 201-214 14 p.

Research output: Contribution to journalArticle

43 Scopus citations

Use of CYP2E1-transfected human liver cell lines in elucidating the actions of ethanol

Lakshman, R., Cederbaum, A. I., Hoek, J. B., Konishi, M., Koop, D. & Donohue, T. M., Sep 1 2005, In : Alcoholism: Clinical and Experimental Research. 29, 9, p. 1726-1734 9 p.

Research output: Contribution to journalArticle

8 Scopus citations
2004

Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: Implications for impaired immune function during disease

Haorah, J., Heilman, D., Diekmann, C., Osna, N., Donohue, T. M., Ghorpade, A. & Persidsky, Y., Jun 1 2004, In : Cellular Immunology. 229, 2, p. 139-148 10 p.

Research output: Contribution to journalArticle

46 Scopus citations
32 Scopus citations

Effects of chronic alcohol consumption on dermal penetration of pesticides in rats

Brand, R. M., Charron, A. R., Dutton, L., Gavlik, T. L., Mueller, C., Hamel, F. G., Chakkalakal, D. & Donohue, T. M., Jan 2004, In : Journal of Toxicology and Environmental Health - Part A. 67, 2, p. 153-161 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats

Casey, C. A., McVicker, B. L., Donohue, T. M., McFarland, M. A., Wiegert, R. L. & Nanji, A. A., Jan 1 2004, In : Journal of Applied Physiology. 96, 1, p. 76-80 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Peroxynitrite alters the catalytic activity of rodent liver proteasome in vitro and in vivo

Osna, N. A., Haorah, J., Krutik, V. M. & Donohue, T. M., Sep 1 2004, In : Hepatology. 40, 3, p. 574-582 9 p.

Research output: Contribution to journalArticle

45 Scopus citations
2003
9 Scopus citations
48 Scopus citations
2002
10 Scopus citations

Chronic ethanol consumption results in deficient bone repair in rats

Chakkalakal, D. A., Novak, J. R., Fritz, E. D., Mollner, T. J., McVicker, D. L., Lybarger, D. L., McGuire, M. H. & Donohue, T. M., Mar 7 2002, In : Alcohol and Alcoholism. 37, 1, p. 13-20 8 p.

Research output: Contribution to journalArticle

41 Scopus citations

Effect of acute and chronic alcohol treatment and their superimposition on lysosomal, cytoplasmic, and proteosomal protease activities in rat skeletal muscle in vivo

Koll, M., Ahmed, S., Mantle, D., Donohue, T. M., Palmer, T. N., Simanowski, U. A., Seitz, H. K., Peters, T. J. & Preedy, V. R., Jan 2002, In : Metabolism: Clinical and Experimental. 51, 1, p. 97-104 8 p.

Research output: Contribution to journalArticle

32 Scopus citations
2001

Use of cultured cells in assessing ethanol toxicity and ethanol-related metabolism

Donohue, J., Clemens, D. L., Galli, A., Crabb, D., Nieto, N., Kato, J. & Barve, S. S., Jun 27 2001, In : Alcoholism: Clinical and Experimental Research. 25, 5 SUPPL., p. 87S-93S

Research output: Contribution to journalArticle

15 Scopus citations
2000

Inhibition of ethanol-induced liver disease in the intragastric feeding rat model by chlormethiazole (44545)

Gouillon, Z. Q., Lucas, D., Li, J., Hagbjork, A. L., French, B. A., Fu, P., Fang, C., Ingelman-Sundberg, M., Donohue, T. M. & French, S. W., Dec 1 2000, In : Experimental Biology and Medicine. 224, 4, p. 302-308 7 p.

Research output: Contribution to journalArticle

145 Scopus citations
1999

Role of CYP2E1 in the pathogenesis of alcoholic liver disease: modifications by cAMP and ubiquitin-proteasome pathway.

Gouillon, Z. Q., Miyamoto, K., Donohue, T. M., Wan, Y. J., French, B. A., Nagao, Y., Fu, P., Reitz, R. C., Hagbjork, A., Yap, C., Yuan, Q. X., Ingelman-Sundberg, M. & French, S. W., Sep 1 1999, In : Frontiers in bioscience : a journal and virtual library. 4, p. A16-25

Research output: Contribution to journalArticle

28 Scopus citations
1998

Contrasting effects of acute and chronic ethanol administration on rat liver tyrosine aminotransferase

Donohue, T. M., Drey, M. L. & Zetterman, R. K., Feb 1 1998, In : Alcohol. 15, 2, p. 141-146 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Peptidase activities of the multicatalytic protease in rat liver after voluntary and intragastric ethanol administration

Donohue, T. M., Zetterman, R. K., Zhang-Gouillon, Z. Q. & French, S. W., Aug 17 1998, In : Hepatology. 28, 2, p. 486-491 6 p.

Research output: Contribution to journalArticle

59 Scopus citations
1997

Flow cytometric analysis of vesicular pH in rat hepatocytes after ethanol administration

Kharbanda, K. K., McVicker, D. L., Zetterman, R. K., MacDonald, R. G. & Donohue, T. M., Oct 1997, In : Hepatology. 26, 4, p. 929-934 6 p.

Research output: Contribution to journalArticle

25 Scopus citations
1996

Effects of ethanol administration on components of the ubiquitin proteolytic pathway in rat liver

Born, L. J., Kharbanda, K. K., McVicker, D. L., Zetterman, R. K. & Donohue, T. M., Jan 1 1996, In : Hepatology. 23, 6, p. 1556-1563 8 p.

Research output: Contribution to journalArticle

22 Scopus citations