Timothy R McGuire, PharmD

  • 1061 Citations
  • 17 h-Index
1985 …2020

Research output per year

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Research Output

  • 1061 Citations
  • 17 h-Index
  • 54 Article
  • 5 Review article
  • 2 Chapter
  • 1 Comment/debate
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Article
2020

A Novel Combination Approach Targeting an Enhanced Protein Synthesis Pathway in MYC-driven (Group 3) Medulloblastoma

Chaturvedi, N. K., Kling, M. J., Griggs, C. N., Kesherwani, V., Shukla, M., McIntyre, E. M., Ray, S., Liu, Y., McGuire, T. R., Sharp, J. G., Band, H., Joshi, S. S. & Coulter, D. W., Jun 1 2020, In : Molecular cancer therapeutics. 19, 6, p. 1351-1362 12 p.

Research output: Contribution to journalArticle

ApoE mimetic peptide targeted nanoparticles carrying a BRD4 inhibitor for treating Medulloblastoma in mice

Wang, Q., Kumar, V., Lin, F., Sethi, B., Coulter, D. W., McGuire, T. R. & Mahato, R. I., Jul 10 2020, In : Journal of Controlled Release. 323, p. 463-474 12 p.

Research output: Contribution to journalArticle

2019

Effects of novel pyrrolomycin MP1 in MYCN amplified chemoresistant neuroblastoma cell lines alone and combined with temsirolimus

McGuire, T. R., Coulter, D. W., Bai, D., Sughroue, J. A., Li, J., Yang, Z., Qiao, Z., Liu, Y., Murry, D. J., Chhonker, Y. S., McIntyre, E. M., Alexander, G., Sharp, J. G. & Li, R., Aug 27 2019, In : BMC cancer. 19, 1, 837.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Role of protein arginine methyltransferase 5 in group 3 (MYC-driven) Medulloblastoma

Chaturvedi, N. K., Mahapatra, S., Kesherwani, V., Kling, M. J., Shukla, M., Ray, S., Kanchan, R., Perumal, N., McGuire, T. R., Graham Sharp, J., Joshi, S. S. & Coulter, D. W., Nov 6 2019, In : BMC cancer. 19, 1, 1056.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2018

Antibacterial, antifungal, anticancer activities and structural bioinformatics analysis of six naturally occurring temporins

Mishra, B., Wang, X., Lushnikova, T., Zhang, Y., Golla, R. M., Narayana, J. L., Wang, C., McGuire, T. R. & Wang, G., Aug 2018, In : Peptides. 106, p. 9-20 12 p.

Research output: Contribution to journalArticle

8 Scopus citations

Dietary omega-3 and omega-6 polyunsaturated fatty acids modulate hepatic pathology

Khadge, S., Sharp, J. G., Thiele, G. M., McGuire, T. R., Klassen, L. W., Duryee, M. J., Britton, H. C., Dafferner, A. J., Beck, J., Black, P. N., DiRusso, C. C. & Talmadge, J. E., Feb 2018, In : Journal of Nutritional Biochemistry. 52, p. 92-102 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Impact of miRNA-mRNA Profiling and Their Correlation on Medulloblastoma Tumorigenesis

Kumar, V., Kumar, V., Chaudhary, A. K., Coulter, D. W., McGuire, T. & Mahato, R. I., Sep 7 2018, In : Molecular Therapy - Nucleic Acids. 12, p. 490-503 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Improved therapy for medulloblastoma: Targeting hedgehog and PI3K-mTOR signaling pathways in combination with chemotherapy

Chaturvedi, N. K., Kling, M. J., Coulter, D. W., McGuire, T. R., Ray, S., Kesherwani, V., Joshi, S. S. & Sharp, J. G., Mar 30 2018, In : Oncotarget. 9, 24, p. 16619-16633 15 p.

Research output: Contribution to journalArticle

9 Scopus citations
10 Scopus citations
4 Scopus citations
4 Scopus citations
2016

Improved therapy for neuroblastoma using a combination approach: Superior efficacy with vismodegib and topotecan

Chaturvedi, N. K., McGuire, T. R., Coulter, D. W., Shukla, A., McIntyre, E. M., Sharp, J. G. & Joshi, S. S., Mar 22 2016, In : Oncotarget. 7, 12, p. 15215-15229 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Coulter, D. W., McGuire, T. R., Sharp, J. G., McIntyre, E. M., Dong, Y., Wang, X., Gray, S., Alexander, G. R., Chatuverdi, N. K., Joshi, S. S., Chen, X. & Vennerstrom, J. L., Nov 8 2016, In : BMC cancer. 16, 1, 867.

Research output: Contribution to journalArticle

2015

Lenalidomide and cyclophosphamide immunoregulation in patients with metastatic, castration-resistant prostate cancer

Wang, J., McGuire, T. R., Britton, H. C., Schwarz, J. K., Loberiza, F. R., Meza, J. L. & Talmadge, J. E., Feb 6 2015, In : Clinical and Experimental Metastasis. 32, 2, p. 111-124 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2014
7 Scopus citations

Changes in the frequencies of human hematopoietic stem and progenitor cells with age and site

Farrell, T. L., McGuire, T. R., Bilek, L. D., Brusnahan, S. K., Jackson, J. D., Lane, J. T., Garvin, K. L., O'Kane, B. J., Berger, A. M., Tuljapurkar, S. R., Kessinger, M. A. & Sharp, J. G., Feb 2014, In : Experimental Hematology. 42, 2, p. 146-154 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

IL6 plasma concentrations in patients with sepsis receiving SLED and antibiotics: A predictor for survival

McGuire, T. R., Reardon, N. T., Bogard, K., Plumb, T. J., Bultsma, C. J., Nissen, S. W., Fuller, P. D. & Olsen, K. M., Nov 1 2014, In : In Vivo. 28, 6, p. 1131-1134 4 p.

Research output: Contribution to journalArticle

4 Scopus citations
2013

Clinical pharmacology of etoposide in children undergoing autologous stem cell transplantation for various solid tumours

Baheti, G., McGuire, T. R., Davda, J. P., Manouilov, K. K., Wall, D., Gwilt, P. R. & Gordon, B. B., Mar 2013, In : Xenobiotica. 43, 3, p. 276-282 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Heterogeneity of functional properties of clone 66 murine breast cancer cells expressing various stem cell phenotypes

Mukhopadhyay, P., Farrell, T., Sharma, G., McGuire, T. R., O'Kane, B. & Sharp, J. G., Nov 12 2013, In : PloS one. 8, 11, e78725.

Research output: Contribution to journalArticle

7 Scopus citations
2011

Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging

Tuljapurkar, S. R., Mcguire, T. R., Brusnahan, S. K., Jackson, J. D., Garvin, K. L., Kessinger, M. A., Lane, J. T., O'Kane, B. J. & Sharp, J. G., Nov 2011, In : Journal of Anatomy. 219, 5, p. 574-581 8 p.

Research output: Contribution to journalArticle

53 Scopus citations

Inflammation associated with obesity: Relationship with blood and bone marrow endothelial cells

McGuire, T. R., Brusnahan, S. K., Bilek, L. D., Jackson, J. D., Kessinger, M. A., Berger, A. M., Garvin, K. L., O'Kane, B. J., Tuljapurkar, S. R. & Sharp, J. G., Nov 2011, In : Obesity. 19, 11, p. 2130-2136 7 p.

Research output: Contribution to journalArticle

20 Scopus citations
2010

Human blood and marrow side population stem cell and Stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: Correlation with cytokines

Brusnahan, S. K., McGuire, T. R., Jackson, J. D., Lane, J. T., Garvin, K. L., O'Kane, B. J., Berger, A. M., Tuljapurkar, S. R., Kessinger, M. A. & Sharp, J. G., Nov 2010, In : Mechanisms of Ageing and Development. 131, 11-12, p. 718-722 5 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009

Clinically important interaction between statin drugs and Clostridium difficile toxin?

McGuire, T., Dobesh, P., Klepser, D., Rupp, M. & Olsen, K., Dec 2009, In : Medical Hypotheses. 73, 6, p. 1045-1047 3 p.

Research output: Contribution to journalArticle

16 Scopus citations

Reduction in mortality associated with statin therapy in patients with severe sepsis

Dobesh, P. P., Klepser, D. G., McGuire, T. R., Morgan, C. W. & Olsen, K. M., Jun 2009, In : Pharmacotherapy. 29, 6, p. 621-630 10 p.

Research output: Contribution to journalArticle

64 Scopus citations
2008

Effects of exercise on hematological parameters, circulating side population cells, and cytokines

Wardyn, G. G., Rennard, S. I., Brusnahan, S. K., McGuire, T. R., Carlson, M. L., Smith, L. M., McGranaghan, S. & Sharp, J. G., Feb 2008, In : Experimental Hematology. 36, 2, p. 216-223 8 p.

Research output: Contribution to journalArticle

51 Scopus citations
2007

Accessing rural populations: Role of the community pharmacist in a breast and cervical cancer screening programme

McGuire, T. R., Leypoldt, M., Narducci, W. A. & Ward, K., Feb 2007, In : Journal of Evaluation in Clinical Practice. 13, 1, p. 146-149 4 p.

Research output: Contribution to journalArticle

17 Scopus citations
2005

Release of TNF-α and IL-1β from porcine brain endothelium corresponds to the pyrogenic potential of three marketed formulations of amphotericin

McGuire, T. R., Trickler, W. J., Smith, L., Hoie, E. B. & Miller, D. W., Sep 2005, In : Inflammation Research. 54, 9, p. 375-379 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2004

Pentoxifylline inhibits tumor necrosis factor-alpha induced synthesis of complement component C3 in human endothelial cells

Hoie, E. B., McGuire, T. R., Leuschen, P. M. & Zach, T. L., Oct 2004, In : Biological and Pharmaceutical Bulletin. 27, 10, p. 1670-1673 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2003

High-dose cyclophosphamide in multiple sclerosis patients undergoing autologous stem cell transplantation

McGuire, T. R., Gwilt, P., Manouvilov, K., Healey, K., Ursick, M. M., Nash, R. A. & Pavletic, S. Z., Feb 2003, In : International Immunopharmacology. 3, 2, p. 279-283 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Lymphodepleting effects and safety of pentostatin for nonmyeloablative allogeneic stem-cell transplantation

Pavletic, S. Z., Gregory Bociek, R., Foran, J. M., Rubocki, R. J., Kuszynski, C. A., Wisecarver, J. L., Hatcher, L., Lucas, D. M., Byrd, J. C., Grever, M. R., Joshi, S. S., Hardiman, P., Smith, L. M., McGuire, T. R., Bierman, P. J., Vose, J. M., Armitage, J. O. & Talmadge, J. E., Sep 15 2003, In : Transplantation. 76, 5, p. 877-881 5 p.

Research output: Contribution to journalArticle

13 Scopus citations

Release of prostaglandin E-2 in bovine brain endothelial cells after exposure to three unique forms of the antifungal drug amphotericin-B: Role of COX-2 in amphotericin-B induced fever

McGuire, T. R., Trickler, W. J., Smith, L. M., Vrana, A., Hoie, E. B. & Miller, D. W., Apr 25 2003, In : Life Sciences. 72, 23, p. 2581-2590 10 p.

Research output: Contribution to journalArticle

23 Scopus citations

The effect of hydroxyurea on the phosphorylation of zidovudine and lamivudine in human umbilical vein endothelial cells

McGuire, T. R., Hoie, E. B., Manouilov, K. K. & Gwilt, P. G., Jul 2003, In : In Vitro Cellular and Developmental Biology - Animal. 39, 7, p. 280-282 3 p.

Research output: Contribution to journalArticle

2002

Plasma from poorly mobilizing human subjects inhibits cytokine-induced murine blood stem-cell mobilization

Sharp, J., McGuire, T., Mann, S., Murphy, B. & Kessinger, A., 2002, In : Cytotherapy. 4, 4, p. 365-373 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
2001
7 Scopus citations

Organ dysfunction following stem cell transplantation: Relationship to plasma cytokine concentrations

McGuire, T. R., Bociek, G. R., Pavletic, S. Z., Hock, L., Lynch, J., Schneider, J., Hoie, E. B., Tarantolo, S. & Haire, W. D., 2001, In : Bone marrow transplantation. 28, 9, p. 889-893 5 p.

Research output: Contribution to journalArticle

13 Scopus citations
1998
19 Scopus citations

Colorimetric determination of hydroxyurea in human serum using high- performance liquid chromatography

Manouilov, K. K., McGuire, T. R. & Gwilt, P. R., Apr 24 1998, In : Journal of Chromatography B: Biomedical Applications. 708, 1-2, p. 321-324 4 p.

Research output: Contribution to journalArticle

18 Scopus citations

Peripheral blood progenitor cells: Enabling outpatient transplantation

McGuire, T. R., Tarantolo, S. & Reed, E., 1998, In : Pharmacotherapy. 18, 1, p. 17S-23S

Research output: Contribution to journalArticle

1 Scopus citations
1996

Antiproliferative activity of shark cartilage with and without tumor necrosis factor-α in human umbilical vein endothelium

McGuire, T. R., Kazakoff, P. W., Hoie, E. B. & Fienhold, M. A., 1996, In : Pharmacotherapy. 16, 2 I, p. 237-244 8 p.

Research output: Contribution to journalArticle

28 Scopus citations
1995

An in vitro model for endothelial permeability: Assessment of monolayer integrity

Kazakoff, P. W., McGuire, T. R., Hoie, E. B., Cano, M. & Iversen, P. L., Dec 1995, In : In Vitro Cellular & Developmental Biology - Animal: Journal of the Society for In Vitro Biology. 31, 11, p. 846-852 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Evaluation of the pharmacokinetic interaction between cimetidine or famotidine and cyclosporine in healthy men

Shaefer, M. S., Rossi, S. J., McGuire, T. R., Schaaf, L. J., Collier, D. S. & Stratta, R. J., 1995, In : Annals of Pharmacotherapy. 29, 11, p. 1088-1091 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1993

Compatibility and stability of ondansetron hydrochloride, dexamethasone, and lorazepam in injectable solutions

McGuire, T. R., Narducci, W. A. & Fox, J. L., 1993, In : American Journal of Hospital Pharmacy. 50, 7, p. 1410-1414 5 p.

Research output: Contribution to journalArticle

10 Scopus citations
1992

Pharmacodynamic studies of cyclosporine in marrow transplant recipients: A comparison of three assay methods

McGuire, T. R., Yee, G. C., Emerson, S., Gmur, D. J. & Carlin, J., Jun 1992, In : Transplantation. 53, 6, p. 1272-1275 4 p.

Research output: Contribution to journalArticle

15 Scopus citations

Stability of cyclosporine in dextrose 5%, NaCl 0.9%, dextrose/amino acid solution, and lipid emulsion

McLeod, H. L., McGuire, T. R. & Yee, G. C., Feb 1992, In : Annals of Pharmacotherapy. 26, 2, p. 172-175 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1991
34 Scopus citations
1990

Acute leukemia: Detection and therapeutics

McGuire, T. R., 1990, In : American pharmacy. 30, 2, p. 29-34 6 p.

Research output: Contribution to journalArticle

Pharmacokinetic Drug Interactions with Cyclosporin (Part I)

Yee, G. C. & McGuire, T. R., Oct 1990, In : Clinical Pharmacokinetics. 19, 4, p. 319-332 14 p.

Research output: Contribution to journalArticle

134 Scopus citations

Pharmacokinetic Drug Interactions with Cyclosporin (Part II)

Yee, G. C. & McGuire, T. R., Nov 1990, In : Clinical Pharmacokinetics. 19, 5, p. 400-415 16 p.

Research output: Contribution to journalArticle

67 Scopus citations
1989

Minimal risk of chronic renal dysfunction in marrow transplant recipients treated with cyclosporine for 6 months

Yee, G. C., McGuire, T. R., St Pierre, B. A., Self, S. G., Zager, R. A., Sullivan, K. M. & Deeg, H. J., 1989, In : Bone marrow transplantation. 4, 6, p. 691-694 4 p.

Research output: Contribution to journalArticle

6 Scopus citations