Wanfen Xiong, MD, PhD

  • 2334 Citations
  • 18 h-Index
19992020

Research output per year

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Research Output

  • 2334 Citations
  • 18 h-Index
  • 33 Article
  • 2 Comment/debate
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Article
2020

Enhanced Notch3 signaling contributes to pulmonary emphysema in a Murine Model of Marfan syndrome

Jespersen, K., Liu, Z., Li, C., Harding, P., Sestak, K., Batra, R., Stephenson, C. A., Foley, R. T., Greene, H., Meisinger, T., Baxter, B. T. & Xiong, W., Dec 1 2020, In : Scientific reports. 10, 1, 10949.

Research output: Contribution to journalArticle

Open Access

Ex vivo expansion of regulatory T cells from abdominal aortic aneurysm patients inhibits aneurysm in humanized murine model

Suh, M. K., Batra, R., Carson, J. S., Xiong, W., Dale, M. A., Meisinger, T., Killen, C., Mitchell, J. & Baxter, B. T., 2020, (Accepted/In press) In : Journal of vascular surgery.

Research output: Contribution to journalArticle

Open Access
2019

CD95-ligand contributes to abdominal aortic aneurysm progression by modulating inflammation

Liu, Z., Fitzgerald, M., Meisinger, T., Batra, R., Suh, M., Greene, H., Penrice, A. J., Sun, L., Baxter, B. T. & Xiong, W., Mar 15 2019, In : Cardiovascular research. 115, 4, p. 807-818 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

IL-1β (Interleukin-1β) and TNF-α (Tumor Necrosis Factor-α) Impact Abdominal Aortic Aneurysm Formation by Differential Effects on Macrophage Polarization

Batra, R., Suh, M. K., Carson, J. S., Dale, M. A., Meisinger, T. M., Fitzgerald, M., Opperman, P. J., Luo, J., Pipinos, I. I., Xiong, W. & Baxter, B. T., Feb 1 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 2, p. 457-463 7 p.

Research output: Contribution to journalArticle

15 Scopus citations
2017

Premature aortic smooth muscle cell differentiation contributes to matrix dysregulation in Marfan Syndrome

Dale, M., Fitzgerald, M. P., Liu, Z., Meisinger, T., Karpisek, A., Purcell, L. N., Carson, J. S., Harding, P., Lang, H., Koutakis, P., Batra, R., Mietus, C. J., Casale, G., Pipinos, I., Baxter, B. T. & Xiong, W., Oct 2017, In : PloS one. 12, 10, e0186603.

Research output: Contribution to journalArticle

16 Scopus citations
2016
4 Scopus citations

Elastin-derived peptides promote abdominal aortic aneurysm formation by modulating m1/m2 macrophage polarization

Dale, M. A., Xiong, W., Carson, J. S., Suh, M. K., Karpisek, A. D., Meisinger, T. M., Casale, G. P. & Baxter, B. T., Jun 1 2016, In : Journal of Immunology. 196, 11, p. 4536-4543 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2015

Background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility

Dale, M. A., Suh, M. K., Zhao, S., Meisinger, T., Gu, L., Swier, V. J., Agrawal, D. K., Greiner, T. C., Carson, J. S., Baxter, B. T. & Xiong, W., Dec 1 2015, In : Atherosclerosis. 243, 2, p. 621-629 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2012

Elevation of plasma high-density lipoproteins inhibits development of experimental abdominal aortic aneurysms

Torsney, E., Pirianov, G., Charolidi, N., Shoreim, A., Gaze, D., Petrova, S., Laing, K., Meisinger, T., Xiong, W., Baxter, B. T. & Cockerill, G. W., Nov 2012, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 32, 11, p. 2678-2686 9 p.

Research output: Contribution to journalArticle

27 Scopus citations

Low-dose alcohol consumption protects against transient focal cerebral ischemia in mice: Possible role of pparγ

Sun, H., Xiong, W., Arrick, D. M. & Mayhan, W. G., Jul 27 2012, In : PloS one. 7, 7, e41716.

Research output: Contribution to journalArticle

15 Scopus citations

MMP-2 Regulates Erk1/2 phosphorylation and aortic dilatation in marfan syndrome

Xiong, W., Meisinger, T., Knispel, R., Worth, J. M. & Baxter, B. T., Jun 8 2012, In : Circulation Research. 110, 12, p. e92-e101

Research output: Contribution to journalArticle

63 Scopus citations

MT1-MMP regulates the PI3Kδ-Mi-2/NuRD-dependent control of macrophage immune function

Shimizu-Hirota, R., Xiong, W., Baxter, B. T., Kunkel, S. L., Maillard, I., Chen, X. W., Sabeh, F., Liu, R., Li, X. Y. & Weiss, S. J., Feb 15 2012, In : Genes and Development. 26, 4, p. 395-413 19 p.

Research output: Contribution to journalArticle

52 Scopus citations
2011

Dose-Related Influence of Chronic Alcohol Consumption on Cerebral Ischemia/Reperfusion Injury

Zhao, H., Mayhan, W. G., Arrick, D. M., Xiong, W. & Sun, H., Jul 2011, In : Alcoholism: Clinical and Experimental Research. 35, 7, p. 1265-1269 5 p.

Research output: Contribution to journalArticle

28 Scopus citations
2010

Alcohol-induced exacerbation of ischemic brain injury: Role of NAD(P)H oxidase

Zhao, H., Mayhan, W. G., Arrick, D. M., Xiong, W. & Sun, H., Nov 2010, In : Alcoholism: Clinical and Experimental Research. 34, 11, p. 1948-1955 8 p.

Research output: Contribution to journalArticle

17 Scopus citations
2009

Blocking TNF-α attenuates aneurysm formation in a murine Model

Xiong, W., MacTaggart, J., Knispel, R., Worth, J., Persidsky, Y. & Baxter, B. T., Aug 15 2009, In : Journal of Immunology. 183, 4, p. 2741-2746 6 p.

Research output: Contribution to journalArticle

106 Scopus citations

Inhibition of reactive oxygen species attenuates aneurysm formation in a murine model

Xiong, W., Mactaggart, J., Knispel, R., Worth, J., Zhu, Z., Li, Y., Sun, Y., Baxter, B. T. & Johanning, J., Jan 2009, In : Atherosclerosis. 202, 1, p. 128-134 7 p.

Research output: Contribution to journalArticle

81 Scopus citations
61 Scopus citations
2008

Doxycycline delays aneurysm rupture in a mouse model of Marfan syndrome

Xiong, W., Knispel, R. A., Dietz, H. C., Ramirez, F. & Baxter, B. T., Jan 2008, In : Journal of vascular surgery. 47, 1, p. 166-172 7 p.

Research output: Contribution to journalArticle

106 Scopus citations
2007

Deletion of CCR2 but not CCR5 or CXCR3 inhibits aortic aneurysm formation

MacTaggart, J. N., Xiong, W., Knispel, R. & Baxter, B. T., Aug 2007, In : Surgery. 142, 2, p. 284-288 5 p.

Research output: Contribution to journalArticle

39 Scopus citations

Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice

Sun, J., Sukhova, G. K., Yang, M., Wolters, P. J., MacFarlane, L. A., Libby, P., Sun, C., Zhang, Y., Liu, J., Ennis, T. L., Knispel, R., Xiong, W., Thompson, R. W., Baxter, B. T. & Shi, G. P., Nov 1 2007, In : Journal of Clinical Investigation. 117, 11, p. 3359-3368 10 p.

Research output: Contribution to journalArticle

168 Scopus citations
2006

Effects of tissue inhibitor of metalloproteinase 2 deficiency on aneurysm formation

Xiong, W., Knispel, R., Mactaggart, J. & Baxter, B. T., Nov 2006, In : Journal of vascular surgery. 44, 5, p. 1061-1066 6 p.

Research output: Contribution to journalArticle

36 Scopus citations

MOP3, a component of the molecular clock, regulates the development of B cells

Sun, Y., Yang, Z., Niu, Z., Peng, J., Li, Q., Xiong, W., Langnas, A. N., Ma, M. Y. & Zhao, Y., Dec 2006, In : Immunology. 119, 4, p. 451-460 10 p.

Research output: Contribution to journalArticle

53 Scopus citations
2005

MMP-12 has a role in abdominal aortic aneurysms in mice

Longo, G. M., Buda, S. J., Fiotta, N., Xiong, W., Griener, T., Shapiro, S. & Baxter, B. T., Apr 2005, In : Surgery. 137, 4, p. 457-462 6 p.

Research output: Contribution to journalArticle

106 Scopus citations
2004

Elastin degradation and calcification in an abdominal aorta injury model: Role of matrix metalloproteinases

Basalyga, D. M., Simionescu, D. T., Xiong, W., Baxter, B. T., Starcher, B. C. & Vyavahare, N. R., Nov 30 2004, In : Circulation. 110, 22, p. 3480-3487 8 p.

Research output: Contribution to journalArticle

209 Scopus citations

Key Roles of CD4+ T Cells and IFN-γ in the Development of Abdominal Aortic Aneurysms in a Murine Model

Xiong, W., Zhao, Y., Prall, A., Greiner, T. C. & Baxter, B. T., Feb 15 2004, In : Journal of Immunology. 172, 4, p. 2607-2612 6 p.

Research output: Contribution to journalArticle

Open Access
132 Scopus citations
2003

Genetic Dissection of Hyperthermia-Induced Neural Tube Defects in Mice

Lundberg, Y. W., Wing, M. J., Xiong, W., Zhao, J. & Finnell, R. H., Jun 2003, In : Birth Defects Research Part A - Clinical and Molecular Teratology. 67, 6, p. 409-413 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Mechanism of inhibition of matrix metalloproteinase-2 expression by doxycycline in human aortic smooth muscle cells

Liu, J., Xiong, W., Baca-Regen, L., Nagase, H. & Baxter, B. T., Dec 2003, In : Journal of vascular surgery. 38, 6, p. 1376-1383 8 p.

Research output: Contribution to journalArticle

91 Scopus citations

Xenogeneic skin graft rejection in M-CSF/macrophage deficient osteopetrotic mice

Zhao, Y., Xiong, W., Yang, T., Prall, A., Baxter, B. T. & Langnas, A. N., May 2003, In : Xenotransplantation. 10, 3, p. 232-239 8 p.

Research output: Contribution to journalArticle

5 Scopus citations
2002

Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

Matthew Longo, G., Xiong, W., Greiner, T. C., Zhao, Y., Fiotti, N. & Timothy Baxter, B., Sep 2002, In : Journal of Clinical Investigation. 110, 5, p. 625-632 8 p.

Research output: Contribution to journalArticle

807 Scopus citations
4 Scopus citations
2000
10 Scopus citations
1999
4 Scopus citations