William Spanos, MD

  • 698 Citations
  • 13 h-Index
19952020

Research output per year

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Research Output

  • 698 Citations
  • 13 h-Index
  • 27 Article
2020

The multifarious roles of the chemokine CXCL14 in cancer progression and immune responses

Westrich, J. A., Vermeer, D. W., Colbert, P. L., Spanos, W. C. & Pyeon, D., Jul 1 2020, In : Molecular Carcinogenesis. 59, 7, p. 794-806 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

CXCL14 suppresses human papillomavirus-associated head and neck cancer through antigen-specific CD8+ T-cell responses by upregulating MHC-I expression

Westrich, J. A., Vermeer, D. W., Silva, A., Bonney, S., Berger, J. N., Cicchini, L., Greer, R. O., Song, J. I., Raben, D., Slansky, J. E., Lee, J. H., Spanos, W. C. & Pyeon, D., Nov 14 2019, In : Oncogene. 38, 46, p. 7166-7180 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Immune microenvironment modulation unmasks therapeutic benefit of radiotherapy and checkpoint inhibition

Newton, J. M., Hanoteau, A., Liu, H. C., Gaspero, A., Parikh, F., Gartrell-Corrado, R. D., Hart, T. D., Laoui, D., Van Ginderachter, J. A., Dharmaraj, N., Spanos, W. C., Saenger, Y., Young, S. & Sikora, A. G., Aug 13 2019, In : Journal for ImmunoTherapy of Cancer. 7, 1, 216.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Impact of PET/CT on Staging and Treatment of Advanced Head and Neck Squamous Cell Carcinoma

Jorgensen, J. B., Smith, R. B., Coughlin, A., Spanos, W. C., Lohr, M. M., Sperry, S. M., Militsakh, O., Zitsch, R. P., Yueh, B., Dooley, L. M., Panwar, A., Galloway, T. L. I. & Pagedar, N. A., Feb 1 2019, In : Otolaryngology - Head and Neck Surgery (United States). 160, 2, p. 261-266 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Adenoid Cystic Carcinoma of the Maxillary Sinus with Isolated Trigeminal Anesthesia

Bollinger, S. S., DeSautel, M. G., Spanos, W. C. & Tjarks, B. J., Jul 1 2018, In : South Dakota medicine : the journal of the South Dakota State Medical Association. 71, 7, p. 294-298 5 p.

Research output: Contribution to journalArticle

Cancer exosomes induce tumor innervation

Madeo, M., Colbert, P. L., Vermeer, D. W., Lucido, C. T., Cain, J. T., Vichaya, E. G., Grossberg, A. J., Muirhead, D. R., Rickel, A. P., Hong, Z., Zhao, J., Weimer, J. M., Spanos, W. C., Lee, J. H., Dantzer, R. & Vermeer, P. D., Dec 1 2018, In : Nature communications. 9, 1, 4284.

Research output: Contribution to journalArticle

31 Scopus citations

Oral cavity reconstruction outcomes using a porcine urinary bladder matrix: A retrospective case series

Assam, J. H. & Spanos, W. C., May 2018, In : Wounds. 30, 5, p. 131-137 7 p.

Research output: Contribution to journalArticle

Topical superoxide dismutase in posttreatment fibrosis in patients with head and neck cancer

Landeen, K. C., Spanos, W. C. & Gromer, L., Jul 2018, In : Head and Neck. 40, 7, p. 1400-1405 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

β2-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC

Lucido, C. T., Callejas-Valera, J. L., Colbert, P. L., Vermeer, D. W., Miskimins, W. K., Spanos, W. C. & Vermeer, P. D., Oct 1 2018, In : Oncogenesis. 7, 10, 81.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Treatment of Peritonsillar Abscess in Immunosuppressed Patients

Assam, J. H. & Spanos, W. C., Jul 1 2017, In : South Dakota medicine : the journal of the South Dakota State Medical Association. 70, 7, p. 314-316 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2016

Metastatic model of HPV+ oropharyngeal squamous cell carcinoma demonstrates heterogeneity in tumor metastasis

Vermeer, D. W., Coppock, J. D., Zeng, E., Lee, K. M., Spanos, W. C., Onken, M. D., Uppaluri, R., Lee, J. H. & Vermeer, P. D., Apr 26 2016, In : Oncotarget. 7, 17, p. 24194-24207 14 p.

Research output: Contribution to journalArticle

13 Scopus citations

mTOR inhibition as an adjuvant therapy in a metastatic model of HPV+ HNSCC

Coppock, J. D., Vermeer, P. D., Vermeer, D. W., Lee, K. M., Miskimins, W. K., Spanos, W. C. & Lee, J. H., Apr 26 2016, In : Oncotarget. 7, 17, p. 24228-24241 14 p.

Research output: Contribution to journalArticle

14 Scopus citations
8 Scopus citations
2015

Clinical Outcomes of a Team Approach to Thyroidectomy

Terrell, A., Gardner, P., Spanos, W. C., Allard, B., Barth, R., Bhatia, V. & Lee, J., Dec 1 2015, In : South Dakota medicine : the journal of the South Dakota State Medical Association. 68, 12, p. 539-541 3 p.

Research output: Contribution to journalArticle

1 Scopus citations
2013

Pathology quiz case 2: Folliculitis keloidalis nuchae

Miller, R. A., Spanos, W. C. & Jassim, A. D., Apr 2013, In : JAMA Otolaryngology - Head and Neck Surgery. 139, 4, p. 425-426 2 p.

Research output: Contribution to journalArticle

Radiation-induced loss of cell surface CD47 enhances immune-mediated clearance of human papillomavirus-positive cancer

Vermeer, D. W., Spanos, W. C., Vermeer, P. D., Bruns, A. M., Lee, K. M. & Lee, J. H., Jul 2013, In : International Journal of Cancer. 133, 1, p. 120-129 10 p.

Research output: Contribution to journalArticle

49 Scopus citations

Ultrasound for localization in primary hyperparathyroidism

Smith, R. B., Evasovich, M., Girod, D. A., Jorgensen, J. B., Lydiatt, W. M., Pagedar, N. A. & Spanos, W. C., Sep 2013, In : Otolaryngology - Head and Neck Surgery (United States). 149, 3, p. 366-371 6 p.

Research output: Contribution to journalArticle

12 Scopus citations
2012

A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors

Wieking, B. G., Vermeer, D. W., Spanos, W. C., Lee, K. M., Vermeer, P., Lee, W. T., Xu, Y., Gabitzsch, E. S., Balcaitis, S., Balint, J. P., Jones, F. R. & Lee, J. H., Oct 2012, In : Cancer Gene Therapy. 19, 10, p. 667-674 8 p.

Research output: Contribution to journalArticle

29 Scopus citations
2009

Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer

Spanos, W. C., Nowicki, P., Lee, D. W., Hoover, A., Hostager, B., Gupta, A., Anderson, M. E. & Lee, J. H., Nov 2009, In : Archives of Otolaryngology - Head and Neck Surgery. 135, 11, p. 1137-1146 10 p.

Research output: Contribution to journalArticle

160 Scopus citations

Unilateral vocal fold paralysis in premature infants after ligation of patent ductus arteriosus: Vascular clip versus suture ligature

Spanos, W. C., Brookes, J. T., Smith, M. C., Burkhart, H. M., Bell, E. F. & Smith, R. J. H., Oct 2009, In : Annals of Otology, Rhinology and Laryngology. 118, 10, p. 750-753 4 p.

Research output: Contribution to journalArticle

24 Scopus citations
2008

Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells

Spanos, W. C., Geiger, J., Anderson, M. E., Harris, G. F., Bossler, A. D., Smith, R. B., Klingelhutz, A. J. & Lee, J. H., Feb 2008, In : Head and Neck. 30, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

The PDZ binding motif of human papillomavirus type 16 E6 induces PTPN13 loss, which allows anchorage-independent growth and synergizes with ras for invasive growth

Spanos, W. C., Hoover, A., Harris, G. F., Wu, S., Strand, G. L., Anderson, M. E., Klingelhutz, A. J., Hendriks, W., Bossler, A. D. & Lee, J. H., Mar 2008, In : Journal of virology. 82, 5, p. 2493-2500 8 p.

Research output: Contribution to journalArticle

88 Scopus citations
2007

The role of human papillomavirus 16 E6 in anchorage-independent and invasive growth of mouse tonsil epithelium

Hoover, A. C., Spanos, W. C., Harris, G. F., Anderson, M. E., Klingelhutz, A. J. & Lee, J. H., May 2007, In : Archives of Otolaryngology - Head and Neck Surgery. 133, 5, p. 495-502 8 p.

Research output: Contribution to journalArticle

42 Scopus citations
2005

Cidofovir incorporation into human keratinocytes with episomal HPV 16 results in nonselective cytotoxicity

Spanos, W. C., El-Deiry, M. & Lee, J. H., Nov 2005, In : Annals of Otology, Rhinology and Laryngology. 114, 11, p. 840-846 7 p.

Research output: Contribution to journalArticle

13 Scopus citations
1997

Characterization of the substrate specificity of p21-activated protein kinase (PAK) I

Tuazon, P. T., Spanos, W. C., Chinwah, M. & Traugh, J. A., 1997, In : FASEB Journal. 11, 3, p. A327

Research output: Contribution to journalArticle

Determinants for substrate phosphorylation by p21-activated protein kinase (γ-PAK)

Tuazon, P. T., Spanos, W. C., Gump, E. L., Monnig, C. A. & Traugh, J. A., 1997, In : Biochemistry. 36, 51, p. 16059-16064 6 p.

Research output: Contribution to journalArticle

55 Scopus citations
1995

Late injury of cancer therapy on the female reproductive tract

Grigsby, P. W., Russell, A., Bruner, D., Eifel, P., Koh, W. J., Spanos, W., Stetz, J., Stitt, J. A. & Sullivan, J., Mar 30 1995, In : International Journal of Radiation Oncology, Biology, Physics. 31, 5, p. 1281-1299 19 p.

Research output: Contribution to journalArticle

114 Scopus citations