• 8437 Citations
  • 24 h-Index
1994 …2020

Research output per year

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Research Output

  • 8437 Citations
  • 24 h-Index
  • 35 Article
  • 1 Review article
2020

MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment

Haschka, M. D., Karbon, G., Soratroi, C., O’Neill, K. L., Luo, X. & Villunger, A., Aug 1 2020, In : Cell Death and Differentiation. 27, 8, p. 2297-2312 16 p.

Research output: Contribution to journalArticle

Open Access
2019

BH3-only proteins are dispensable for apoptosis induced by pharmacological inhibition of both MCL-1 and BCL-XL

Greaves, G., Milani, M., Butterworth, M., Carter, R. J., Byrne, D. P., Eyers, P. A., Luo, X., Cohen, G. M. & Varadarajan, S., Jun 1 2019, In : Cell Death and Differentiation. 26, 6, p. 1037-1047 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis

Huang, K., O’Neill, K. L., Li, J., Zhou, W., Han, N., Pang, X., Wu, W., Struble, L., Borgstahl, G., Liu, Z., Zhang, L. & Luo, X., Nov 1 2019, In : Cell Research. 29, 11, p. 942-952 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

CDK5 inhibitor downregulates Mcl-1 and sensitizes pancreatic cancer cell lines to navitoclax

Kour, S., Rana, S., Contreras, J. I., King, H. M., Robb, C. M., Sonawane, Y. A., Bendjennat, M., Crawford, A. J., Barger, C. J., Kizhake, S., Luo, X., Hollingsworth, M. A. & Natarajan, A., Oct 2019, In : Molecular pharmacology. 96, 4, p. 419-429 11 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis

Milani, M., Beckett, A. J., Al-Zebeeby, A., Luo, X., Prior, I. A., Cohen, G. M. & Varadarajan, S., Dec 1 2019, In : Cell Death Discovery. 5, 1, 117.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Retromer facilitates the localization of Bcl-xL to the mitochondrial outer membrane

Farmer, T., O'Neill, K. L., Naslavsky, N., Luo, X. & Caplan, S., 2019, In : Molecular biology of the cell. 30, 10, p. 1138-1146 9 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p

Wu, W., He, K., Guo, Q., Chen, J., Zhang, M., Huang, K., Yang, D., Wu, L., Deng, Y., Luo, X., Yu, H., Ding, Q. & Xiang, G., May 2019, In : Journal of cellular and molecular medicine. 23, 5, p. 3118-3129 12 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations
2018

Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

Contreras, J. I., Robb, C. M., King, H. M., Baxter, J., Crawford, A. J., Kour, S., Kizhake, S., Sonawane, Y. A., Rana, S., Hollingsworth, M. A., Luo, X. & Natarajan, A., May 18 2018, In : ACS chemical biology. 13, 5, p. 1148-1152 5 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Bax/bak activation in the absence of Bid, Bim, Puma, and p53

Zhang, J., Huang, K., O’neill, K. L., Pang, X. & Luo, X., 2016, In : Cell Death and Disease. 7, 6, e2266.

Research output: Contribution to journalArticle

32 Scopus citations

Cleavage by caspase 8 and mitochondrial membrane association activate the BH3-only protein bid during TRAIL-induced apoptosis

Huang, K., Zhang, J., O'Neill, K. L., Gurumurthy, C. B., Quadros, R. M., Tu, Y. & Luo, X., May 27 2016, In : Journal of Biological Chemistry. 291, 22, p. 11843-11851 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane

O’neill, K. L., Huang, K., Zhang, J., Chen, Y. & Luo, X., Apr 15 2016, In : Genes and Development. 30, 8, p. 973-988 16 p.

Research output: Contribution to journalArticle

121 Scopus citations
2014

The carboxyl-terminal tail of Noxa protein regulates the stability of Noxa and Mcl-1

Pang, X., Zhang, J., Lopez, H., Wang, Y., Li, W., O'Neill, K. L., Evans, J. J. D., George, N. M., Long, J., Chen, Y. & Luo, X., Jun 20 2014, In : Journal of Biological Chemistry. 289, 25, p. 17802-17811 10 p.

Research output: Contribution to journalArticle

20 Scopus citations
2012

Perturbing pro-survival proteins using quinoxaline derivatives: A structure-activity relationship study

Rajule, R., Bryant, V. C., Lopez, H., Luo, X. & Natarajan, A., Apr 1 2012, In : Bioorganic and Medicinal Chemistry. 20, 7, p. 2227-2234 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Pivotal role of inosine triphosphate pyrophosphatase in maintaining genome stability and the prevention of apoptosis in human cells

Menezes, M. R., Waisertreiger, I. S. R., Lopez-Bertoni, H., Luo, X. & Pavlov, Y. I., Feb 27 2012, In : PloS one. 7, 2, e32313.

Research output: Contribution to journalArticle

25 Scopus citations
2011

2,3-Substituted quinoxalin-6-amine analogs as antiproliferatives: A structure-activity relationship study

Chen, Q., Bryant, V. C., Lopez, H., Kelly, D. L., Luo, X. & Natarajan, A., Apr 1 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 7, p. 1929-1932 4 p.

Research output: Contribution to journalArticle

25 Scopus citations

Active Bax and Bak are functional holins

Pang, X., Moussa, S. H., Targy, N. M., Bose, J. L., George, N. M., Gries, C., Lopez, H., Zhang, L., Bayles, K. W., Young, R. & Luo, X., Nov 1 2011, In : Genes and Development. 25, 21, p. 2278-2290 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

Cleland, M. M., Norris, K. L., Karbowski, M., Wang, C., Suen, D. F., Jiao, S., George, N. M., Luo, X., Li, Z. & Youle, R. J., Feb 2011, In : Cell Death and Differentiation. 18, 2, p. 235-247 13 p.

Research output: Contribution to journalArticle

68 Scopus citations

Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways

Zhang, L., Lopez, H., George, N. M., Liu, X., Pang, X. & Luo, X., May 2011, In : Cell Death and Differentiation. 18, 5, p. 864-873 10 p.

Research output: Contribution to journalArticle

49 Scopus citations
2010

Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process

George, N. M., Targy, N., Evans, J. J. D., Zhang, L. & Luo, X., 2010, In : Journal of Biological Chemistry. 285, 2, p. 1384-1392 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damage

Lopez, H., Zhang, L., George, N. M., Liu, X., Pang, X., Evans, J. J. D., Targy, N. M. & Luo, X., May 14 2010, In : Journal of Biological Chemistry. 285, 20, p. 15016-15026 11 p.

Research output: Contribution to journalArticle

41 Scopus citations

Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes

Cox, J. L., Mallanna, S. K., Luo, X. & Rizzino, A., 2010, In : PloS one. 5, 11, e15486.

Research output: Contribution to journalArticle

35 Scopus citations
2009

The heparin binding motif of endostatin mediates its interaction with receptor nucleolin

Fu, Y., Chen, Y., Luo, X., Liang, Y., Shi, H., Gao, L., Zhan, S., Zhou, D. & Luo, Y., Dec 15 2009, In : Biochemistry. 48, 49, p. 11655-11663 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Poly (ADP-ribose) polymerase activity regulates apoptosis in HeLa cells after alkylating DNA damage

Liu, X., Luo, X., Shi, Y., Zhu, G. D., Penning, T., Giranda, V. L. & Luo, Y., Jun 2008, In : Cancer Biology and Therapy. 7, 6, p. 934-941 8 p.

Research output: Contribution to journalArticle

Open Access
11 Scopus citations
2007

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax

George, N. M., Evans, J. J. D. & Luo, X., Aug 1 2007, In : Genes and Development. 21, 15, p. 1937-1948 12 p.

Research output: Contribution to journalArticle

101 Scopus citations
2006

TRAIL-mediated apoptosis in HIV-1-infected macrophages is dependent on the inhibition of Akt-1 phosphorylation

Huang, Y., Erdmann, N., Peng, H., Herek, S., Davis, J. S., Luo, X., Ikezu, T. & Zheng, J., Aug 15 2006, In : Journal of Immunology. 177, 4, p. 2304-2313 10 p.

Research output: Contribution to journalArticle

Open Access
33 Scopus citations
2005

BCL-2 antisense and cisplatin combination treatment of MCF-7 breast cancer cells with or without functional p53

Basma, H., El-Refaey, H., Sgagias, M. K., Cowan, K. H., Luo, X. & Cheng, P. W., Dec 2005, In : Journal of Biomedical Science. 12, 6, p. 999-1011 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
2001

Endonuclease G is an apoptotic DNase when released from mitochondria

Li, L. Y., Luo, X. & Wang, X., Jul 5 2001, In : Nature. 412, 6842, p. 95-99 5 p.

Research output: Contribution to journalArticle

1287 Scopus citations
2000

Cardiolipin provides specificity for targeting of tBid to mitochondria

Lutter, M., Fang, M., Luo, X., Nishijima, M., Xie, X. S. & Wang, X., Oct 2000, In : Nature Cell Biology. 2, 10, p. 754-756 3 p.

Research output: Contribution to journalArticle

384 Scopus citations
1999

Biochemical pathways of caspase activation during apoptosis

Budihardjo, I., Oliver, H., Lutter, M., Luo, X. & Wang, X., 1999, In : Annual Review of Cell and Developmental Biology. 15, p. 269-290 22 p.

Research output: Contribution to journalReview article

2130 Scopus citations

Cell-type-dependent activity of the ubiquitous transcription factor USF in cellular proliferation and transcriptional activation

Qyang, Y., Luo, X., Lu, T., Ismail, P. M., Krylov, D., Vinson, C. & Sawadogo, M., Feb 1999, In : Molecular and cellular biology. 19, 2, p. 1508-1517 10 p.

Research output: Contribution to journalArticle

Open Access
141 Scopus citations
1998

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

Luo, X., Budihardjo, I., Zou, H., Slaughter, C. & Wang, X., Aug 21 1998, In : Cell. 94, 4, p. 481-490 10 p.

Research output: Contribution to journalArticle

Open Access
2876 Scopus citations

The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis

Liu, X., Li, P., Widlak, P., Zou, H., Luo, X., Garrard, W. T. & Wang, X., Jul 21 1998, In : Proceedings of the National Academy of Sciences of the United States of America. 95, 15, p. 8461-8466 6 p.

Research output: Contribution to journalArticle

479 Scopus citations
1996
Open Access
110 Scopus citations
Open Access
113 Scopus citations
1994

Archaic structure of the gene encoding transcription factor USF

Lin, Q., Luo, X. & Sawadogo, M., Sep 30 1994, In : Journal of Biological Chemistry. 269, 39, p. 23894-23903 10 p.

Research output: Contribution to journalArticle

44 Scopus citations

The cellular transcription factor USF cooperates with varicella-zoster virus immediate-early protein 62 to symmetrically activate a bidirectional viral promoter

Meier, J. L., Luo, X., Sawadogo, M. & Straus, S. E., Oct 1994, In : Molecular and cellular biology. 14, 10, p. 6896-6906 11 p.

Research output: Contribution to journalArticle

Open Access
102 Scopus citations