Xuejun Wang, PhD, MBBS

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 11456 Citations
  • 49 h-Index
1989 …2020

Research output per year

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Research Output

Article
77 Scopus citations

Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy

Hou, N., Wen, Y., Yuan, X., Xu, H., Wang, X., Li, F. & Ye, B., Dec 2017, In : Experimental and Molecular Pathology. 103, 3, p. 267-275 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

Rajagopalan, V., Zhao, M., Reddy, S., Fajardo, G., Wang, X., Dewey, S., Gomes, A. V. & Bernstein, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H551-H562

Research output: Contribution to journalArticle

28 Scopus citations

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment

Jiang, L., Zang, D., Yi, S., Li, X., Yang, C., Dong, X., Zhao, C., Lan, X., Chen, X., Liu, S., Liu, N., Huang, H., Shi, X., Wang, X. & Liu, J., Feb 22 2016, In : Scientific reports. 6, 21565.

Research output: Contribution to journalArticle

15 Scopus citations

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers

Cai, J., Xia, X., Liao, Y., Liu, N., Guo, Z., Chen, J., Yang, L., Long, H., Yang, Q., Zhang, X., Xiao, L., Wang, X., Huang, H. & Liu, J., 2017, In : Oncotarget. 8, 38, p. 63232-63246 15 p.

Research output: Contribution to journalArticle

21 Scopus citations

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

Zhao, C., Chen, X., Zang, D., Lan, X., Liao, S., Yang, C., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., He, Z., Dou, Q. P., Wang, X. & Liu, J., Nov 10 2016, In : Oncogene. 35, 45, p. 5916-5927 12 p.

Research output: Contribution to journalArticle

34 Scopus citations

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Liu, N., Liu, C., Li, X., Liao, S., Song, W., Yang, C., Zhao, C., Huang, H., Guan, L., Zhang, P., Liu, S., Hua, X., Chen, X., Zhou, P., Lan, X., Yi, S., Wang, S., Wang, X., Dou, Q. P. & Liu, J., Jun 10 2014, In : Scientific reports. 4, 5240.

Research output: Contribution to journalArticle

46 Scopus citations

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

Kumarapeli, A. R. K., Horak, K. M., Glasford, J. W., Li, J., Chen, Q., Liu, J., Zheng, H. & Wang, X., Dec 2005, In : FASEB Journal. 19, 14, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

92 Scopus citations

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Chen, X., Shi, X., Zhao, C., Li, X., Lan, X., Liu, S., Huang, H., Liu, N., Liao, S., Zang, D., Song, W., Liu, Q., Carter, B. Z., Ping Dou, Q., Wang, X. & Liu, J., 2014, In : Oncotarget. 5, 19, p. 9118-9132 15 p.

Research output: Contribution to journalArticle

Open Access
49 Scopus citations
58 Scopus citations

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

Liu, N., Guo, Z., Xia, X., Liao, Y., Zhang, F., Huang, C., Liu, Y., Deng, X., Jiang, L., Wang, X., Liu, J. & Huang, H., Mar 5 2019, In : European Journal of Pharmacology. 846, p. 1-11 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

Tian, Z., Wang, C., Hu, C., Tian, Y., Liu, J. & Wang, X., Jun 24 2014, In : PloS one. 9, 6, e100715.

Research output: Contribution to journalArticle

24 Scopus citations

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. J. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

124 Scopus citations

Bilirubin neurotoxicity is associated with proteasome inhibition

Huang, H., Guo, M., Liu, N., Zhao, C., Chen, H., Wang, X., Liao, S., Zhou, P., Liao, Y., Chen, X., Lan, X., Chen, J., Xu, D., Li, X., Shi, X., Yu, L., Nie, Y., Wang, X., Zhang, C. E. & Liu, J., Jun 15 2017, In : Cell Death and Disease. 8, 6, e2877.

Research output: Contribution to journalArticle

13 Scopus citations

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats.

Li, S., Wang, X., Li, Y., Kost, C. K. & Martin, D. S., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase

Chen, X., Wu, J., Yang, Q., Zhang, X., Zhang, P., Liao, S., He, Z., Wang, X., Zhao, C. & Liu, J., Feb 1 2018, In : BioMetals. 31, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

Li, J., Ma, W., Yue, G., Tang, Y., Kim, I. M., Weintraub, N. L., Wang, X. & Su, H., Jan 1 2017, In : Journal of Molecular and Cellular Cardiology. 102, p. 53-60 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Cardiac-specific haploinsufficiency of β-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction

Qu, J., Zhou, J., Ping Yi, X., Dong, B., Zheng, H., Miller, L. M., Wang, X., Schneider, M. D. & Li, F., Sep 2007, In : Journal of Molecular and Cellular Cardiology. 43, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

Wang, X., Li, F. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 307-317 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

Wang, X. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 333-343 11 p.

Research output: Contribution to journalArticle

88 Scopus citations

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

Wang, X., Faqian, L., Campbell, S. E. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Liu, N., Li, X., Huang, H., Zhao, C., Liao, S., Yang, C., Liu, S., Song, W., Lu, X., Lan, X., Chen, X., Yi, S., Xu, L., Jiang, L., Zhao, C., Dong, X., Zhou, P., Li, S., Wang, S., Shi, X. & 3 others, Dou, P. Q., Wang, X. & Liu, J., 2014, In : Oncotarget. 5, 14, p. 5453-5471 19 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac Proteotoxicity

Su, H., Li, J., Zhang, H., Ma, W., Wei, N., Liu, J. & Wang, X., Nov 6 2015, In : Circulation Research. 117, 11, p. 956-966 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M. J., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

69 Scopus citations

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation

Lei, D., Li, F., Su, H., Tian, Z., Ye, B., Wei, N. & Wang, X., Feb 2011, In : Cell Death and Differentiation. 18, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

Liu, C., Guo, L. Q., Menon, S., Jin, D., Pick, E., Wang, X., Deng, X. W. & Wei, N., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

COP9 Signalosome Suppresses RIPK1-RIPK3-Mediated Cardiomyocyte Necroptosis in Mice

Xiao, P., Wang, C., Li, J., Su, H., Yang, L., Wu, P., Lewno, M. T., Liu, J. & Wang, X., 2020, (Accepted/In press) In : Circulation: Heart Failure. p. 283-294 12 p.

Research output: Contribution to journalArticle

CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

Qi, L., Zang, H., Wu, W., Nagarkatti, P., Nagarkatti, M., Liu, Q., Robbins, J., Wang, X. & Cui, T., Aug 2020, In : Journal of Molecular and Cellular Cardiology. 145, p. 59-73 15 p.

Research output: Contribution to journalArticle

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

Xiao, L., Lan, X., Shi, X., Zhao, K., Wang, D., Wang, X., Li, F., Huang, H. & Liu, J., May 18 2017, In : Cell death & disease. 8, 5, p. e2803

Research output: Contribution to journalArticle

19 Scopus citations

Desmin filaments and cardiac disease: Establishing causality

Wang, X., Osinska, H., Gerdes, A. M. & Robbins, J., Dec 2002, In : Journal of Cardiac Failure. 8, 6 SUPPL., p. S287-S292

Research output: Contribution to journalArticle

42 Scopus citations

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

Tydlacka, S., Wang, C. E., Wang, X., Li, S. & Li, X. J., Dec 3 2008, In : Journal of Neuroscience. 28, 49, p. 13285-13295 11 p.

Research output: Contribution to journalArticle

112 Scopus citations

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury

Kobayashi, S., Mao, K., Zheng, H., Wang, X., Patterson, C., O'Connell, T. D. & Liang, Q., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 21945-21952 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Zheng, H., Tang, M., Zheng, Q., Kumarapeli, A. R. K., Horak, K. M., Tian, Z. & Wang, X., Oct 19 2010, In : Journal of the American College of Cardiology. 56, 17, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J. & Wang, X., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3689-3700 12 p.

Research output: Contribution to journalArticle

130 Scopus citations

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress

Li, J., Powell, S. R. & Wang, X., Mar 2011, In : FASEB Journal. 25, 3, p. 883-893 11 p.

Research output: Contribution to journalArticle

98 Scopus citations

Expression and distribution of desmosomal proteins in a transgenic mouse model of desmin-related cardiomyopathy

Huang, W., Ma, W. Z. & Wang, X. J., Jul 2003, In : Chinese Journal of Clinical Rehabilitation. 7, 15, p. 2152-2154 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice

Wang, X., Osinska, H., Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, T. & Robbins, J., Jul 6 2001, In : Circulation Research. 89, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
233 Scopus citations

Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation

Li, F., Wang, X. & Gerdes, A. M., Jun 1997, In : Journal of Molecular and Cellular Cardiology. 29, 6, p. 1553-1565 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring

Li, F., Wang, X., Bunger, P. C. & Gerdes, A. M., Jun 1997, In : Journal of Molecular and Cellular Cardiology. 29, 6, p. 1541-1551 11 p.

Research output: Contribution to journalArticle

74 Scopus citations

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

Shi, X., Lan, X., Chen, X., Zhao, C., Li, X., Liu, S., Huang, H., Liu, N., Zang, D., Liao, Y., Zhang, P., Wang, X. & Liu, J., Apr 13 2015, In : Scientific reports. 5, 9694.

Research output: Contribution to journalArticle

14 Scopus citations

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent bcr-abl downregulation AC

Shi, X., Chen, X., Li, X., Lan, X., Zhao, C., Liu, S., Huang, H., Liu, N., Liao, S., Song, W., Zhou, P., Wang, S., Xu, L., Wang, X., Dou, Q. P. & Liu, J., Jan 1 2014, In : Clinical Cancer Research. 20, 1, p. 151-163 13 p.

Research output: Contribution to journalArticle

81 Scopus citations

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Li, X., Liu, S., Huang, H., Liu, N., Zhao, C., Liao, S., Yang, C., Liu, Y., Zhao, C., Li, S., Lu, X., Liu, C., Guan, L., Zhao, K., Shi, X., Song, W., Zhou, P., Dong, X., Guo, H., Wen, G. & 9 others, Zhang, C., Jiang, L., Ma, N., Li, B., Wang, S., Tan, H., Wang, X., Dou, Q. P. & Liu, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 211-222 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Ranek, M. J., Zheng, H., Huang, W., Kumarapeli, A. R., Li, J., Liu, J. & Wang, X., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 273-281 9 p.

Research output: Contribution to journalArticle

19 Scopus citations

Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in Mice

Tian, Z., Zheng, H., Li, J., Li, Y., Su, H. & Wang, X., Aug 17 2012, In : Circulation Research. 111, 5, p. 532-542 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T. & Molkentin, J. D., Aug 2014, In : Cell Death and Differentiation. 21, 8, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

87 Scopus citations

Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

Lei, D., Li, F., Su, H., Liu, J., Wei, N. & Wang, X., Jul 1 2013, In : PloS one. 8, 7, e67793.

Research output: Contribution to journalArticle

7 Scopus citations

Highly dynamic changes in the activity and regulation of macroautophagy in hearts subjected to increased proteotoxic stress

Pan, B., Lewno, M. T., Wu, P. & Wang, X., 2019, In : Frontiers in Physiology. 10, JUN, 758.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells

Chen, X., Zhang, X., Chen, J., Yang, Q., Yang, L., Xu, D., Zhang, P., Wang, X. & Liu, J., Nov 15 2017, In : European Journal of Pharmacology. 815, p. 147-155 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts

Liu, J., Chen, Q., Huang, W., Horak, K. M., Zheng, H., Mestril, R. & Wang, X., Feb 2006, In : FASEB Journal. 20, 2, p. 362-364 3 p.

Research output: Contribution to journalArticle

125 Scopus citations