Xuejun Wang, PhD, MBBS

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 11153 Citations
  • 48 h-Index
19962020

Research output per year

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Research Output

2014

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

Tian, Z., Wang, C., Hu, C., Tian, Y., Liu, J. & Wang, X., Jun 24 2014, In : PloS one. 9, 6, e100715.

Research output: Contribution to journalArticle

23 Scopus citations

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Liu, N., Li, X., Huang, H., Zhao, C., Liao, S., Yang, C., Liu, S., Song, W., Lu, X., Lan, X., Chen, X., Yi, S., Xu, L., Jiang, L., Zhao, C., Dong, X., Zhou, P., Li, S., Wang, S., Shi, X. & 3 others, Dou, P. Q., Wang, X. & Liu, J., 2014, In : Oncotarget. 5, 14, p. 5453-5471 19 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations

Defense Against Proteotoxic Stress in the Heart: Role of p62, Autophagy, and Ubiquitin-Proteasome System. Role of p62, Autophagy, and Ubiquitin-Proteasome System.

Su, H. & Wang, X., Jan 31 2014, Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. Elsevier Inc., Vol. 3. p. 187-210 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent bcr-abl downregulation AC

Shi, X., Chen, X., Li, X., Lan, X., Zhao, C., Liu, S., Huang, H., Liu, N., Liao, S., Song, W., Zhou, P., Wang, S., Xu, L., Wang, X., Dou, Q. P. & Liu, J., Jan 1 2014, In : Clinical Cancer Research. 20, 1, p. 151-163 13 p.

Research output: Contribution to journalArticle

80 Scopus citations

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T. & Molkentin, J. D., Aug 2014, In : Cell Death and Differentiation. 21, 8, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M. J., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Apr 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Proteasomal and lysosomal protein degradation and heart disease

Wang, X. & Robbins, J., Jun 2014, In : Journal of Molecular and Cellular Cardiology. 71, p. 16-24 9 p.

Research output: Contribution to journalReview article

71 Scopus citations

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., May 2014, In : Journal of Neurochemistry. 129, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

Gupta, M. K., Gulick, J., Liu, R., Wang, X., Molkentin, J. D. & Robbins, J., 2014, In : Circulation Research. 115, 8, p. 721-729 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., Apr 2014, In : Cellular and molecular neurobiology. 34, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice

Liu, Y., Lü, L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X. & Wang, H., 2014, In : Journal of Neuroscience. 34, 8, p. 2813-2821 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

Rajagopalan, V., Zhao, M., Reddy, S., Fajardo, G., Wang, X., Dewey, S., Gomes, A. V. & Bernstein, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H551-H562

Research output: Contribution to journalArticle

26 Scopus citations

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats.

Li, S., Wang, X., Li, Y., Kost, C. K. & Martin, D. S., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access
14 Scopus citations

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

Liu, C., Guo, L. Q., Menon, S., Jin, D., Pick, E., Wang, X., Deng, X. W. & Wei, N., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Li, X., Liu, S., Huang, H., Liu, N., Zhao, C., Liao, S., Yang, C., Liu, Y., Zhao, C., Li, S., Lu, X., Liu, C., Guan, L., Zhao, K., Shi, X., Song, W., Zhou, P., Dong, X., Guo, H., Wen, G. & 9 others, Zhang, C., Jiang, L., Ma, N., Li, B., Wang, S., Tan, H., Wang, X., Dou, Q. P. & Liu, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 211-222 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

Lei, D., Li, F., Su, H., Liu, J., Wei, N. & Wang, X., Jul 1 2013, In : PloS one. 8, 7, e67793.

Research output: Contribution to journalArticle

6 Scopus citations

Posttranslational modification and quality control

Wang, X., Pattison, J. S. & Su, H., Jan 18 2013, In : Circulation Research. 112, 2, p. 367-381 15 p.

Research output: Contribution to journalReview article

48 Scopus citations

Protein kinase G positively regulates proteasome-mediated degradation of misfolded proteins

Ranek, M. J., Terpstra, E. J. M., Li, J., Kass, D. A. & Wang, X., Jul 23 2013, In : Circulation. 128, 4, p. 365-376 12 p.

Research output: Contribution to journalArticle

64 Scopus citations
3 Scopus citations

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice

Su, H., Li, J., Osinska, H., Li, F., Robbins, J., Liu, J., Wei, N. & Wang, X., Sep 2013, In : Circulation: Heart Failure. 6, 5, p. 1049-1057 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Ubiquitin receptors and protein quality control

Wang, X. & Terpstra, E. J. M., Feb 2013, In : Journal of Molecular and Cellular Cardiology. 55, 1, p. 73-84 12 p.

Research output: Contribution to journalReview article

41 Scopus citations
2012

Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in Mice

Tian, Z., Zheng, H., Li, J., Li, Y., Su, H. & Wang, X., Aug 17 2012, In : Circulation Research. 111, 5, p. 532-542 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

Guidelines for the use and interpretation of assays for monitoring autophagy

Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., Ait-Si-Ali, S., Akematsu, T., Akira, S., Al-Younes, H. M., Al-Zeer, M. A., Albert, M. L., Albin, R. L., Alegre-Abarrategui, J. & 1,249 others, Aleo, M. F., Alirezaei, M., Almasan, A., Almonte-Becerril, M., Amano, A., Amaravadi, R., Amarnath, S., Amer, A. O., Andrieu-Abadie, N., Anantharam, V., Ann, D. K., Anoopkumar-Dukie, S., Aoki, H., Apostolova, N., Arancia, G., Aris, J. P., Asanuma, K., Asare, N. Y. O., Ashida, H., Askanas, V., Askew, D. S., Auberger, P., Baba, M., Backues, S. K., Baehrecke, E. H., Bahr, B. A., Bai, X. Y., Bailly, Y., Baiocchi, R., Baldini, G., Balduini, W., Ballabio, A., Bamber, B. A., Bampton, E. T. W., Bánhegyi, G., Bartholomew, C. R., Bassham, D. C., Bast, R. C., Batoko, H., Bay, B. H., Beau, I., Béchet, D. M., Begley, T. J., Behl, C., Behrends, C., Bekri, S., Bellaire, B., Bendall, L. J., Benetti, L., Berliocchi, L., Bernardi, H., Bernassola, F., Besteiro, S., Bhatia-Kissova, I., Bi, X., Biard-Piechaczyk, M., Blum, J. S., Boise, L. H., Bonaldo, P., Boone, D. L., Bornhauser, B. C., Bortoluci, K. R., Bossis, I., Bost, F., Bourquin, J. P., Boya, P., Boyer-Guittaut, M., Bozhkov, P. V., Brady, N. R., Brancolini, C., Brech, A., Brenman, J. E., Brennand, A., Bresnick, E. H., Brest, P., Bridges, D., Bristol, M. L., Brookes, P. S., Brown, E. J., Brumell, J. H., Brunetti-Pierri, N., Brunk, U. T., Bulman, D. E., Bultman, S. J., Bultynck, G., Burbulla, L. F., Bursch, W., Butchar, J. P., Buzgariu, W., Bydlowski, S. P., Cadwell, K., Cahová, M., Cai, D., Cai, J., Cai, Q., Calabretta, B., Calvo-Garrido, J., Camougrand, N., Campanella, M., Campos-Salinas, J., Candi, E., Cao, L., Caplan, A. B., Carding, S. R., Cardoso, S. M., Carew, J. S., Carlin, C. R., Carmignac, V., Carneiro, L. A. M., Carra, S., Caruso, R. A., Casari, G., Casas, C., Castino, R., Cebollero, E., Cecconi, F., Celli, J., Chaachouay, H., Chae, H. J., Chai, C. Y., Chan, D. C., Chan, E. Y., Chang, R. C. C., Che, C. M., Chen, C. C., Chen, G. C., Chen, G. Q., Chen, M., Chen, Q., Chen, S. S. L., Chen, W. L., Chen, X., Chen, X., Chen, X., Chen, Y. G., Chen, Y., Chen, Y., Chen, Y. J., Chen, Z., Cheng, A., Cheng, C. H. K., Cheng, Y., Cheong, H., Cheong, J. H., Cherry, S., Chess-Williams, R., Cheung, Z. H., Chevet, E., Chiang, H. L., Chiarelli, R., Chiba, T., Chin, L. S., Chiou, S. H., Chisari, F. V., Cho, C. H., Cho, D. H., Choi, A. M. K., Choi, D. S., Choi, K. S., Choi, M. E., Chouaib, S., Choubey, D., Choubey, V., Chu, C. T., Chuang, T. H., Chueh, S. H., Chun, T., Chwae, Y. J., Chye, M. L., Ciarcia, R., Ciriolo, M. R., Clague, M. J., Clark, R. S. B., Clarke, P. G. H., Clarke, R., Codogno, P., Coller, H. A., Colombo, M. I., Comincini, S., Condello, M., Condorelli, F., Cookson, M. R., Coombs, G. H., Coppens, I., Corbalan, R., Cossart, P., Costelli, P., Costes, S., Coto-Montes, A., Couve, E., Coxon, F. P., Cregg, J. M., Crespo, J. L., Cronjé, M. J., Cuervo, A. M., Cullen, J. J., Czaja, M. J., D'Amelio, M., Darfeuille-Michaud, A., Davids, L. M., Davies, F. E., De Felici, M., De Groot, J. F., De Haan, C. A. M., De Martino, L., De Milito, A., De Tata, V., Debnath, J., Degterev, A., Dehay, B., Delbridge, L. M. D., Demarchi, F., Deng, Y. Z., Dengjel, J., Dent, P., Denton, D., Deretic, V., Desai, S. D., Devenish, R. J., Di Gioacchino, M., Di Paolo, G., Di Pietro, C., Díaz-Araya, G., Díaz-Laviada, I., Diaz-Meco, M. T., Diaz-Nido, J., Dikic, I., Dinesh-Kumar, S. P., Ding, W. X., Distelhorst, C. W., Diwan, A., Djavaheri-Mergny, M., Dokudovskaya, S., Dong, Z., Dorsey, F. C., Dosenko, V., Dowling, J. J., Doxsey, S., Dreux, M., Drew, M. E., Duan, Q., Duchosal, M. A., Duff, K., Dugail, I., Durbeej, M., Duszenko, M., Edelstein, C. L., Edinger, A. L., Egea, G., Eichinger, L., Eissa, N. T., Ekmekcioglu, S., El-Deiry, W. S., Elazar, Z., Elgendy, M., Ellerby, L. M., Er Eng, K., Engelbrecht, A. M., Engelender, S., Erenpreisa, J., Escalante, R., Esclatine, A., Eskelinen, E. L., Espert, L., Espina, V., Fan, H., Fan, J., Fan, Q. W., Fan, Z., Fang, S., Fang, Y., Fanto, M., Fanzani, A., Farkas, T., Farré, J. C., Faure, M., Fechheimer, M., Feng, C. G., Feng, J., Feng, Q., Feng, Y., Fésüs, L., Feuer, R., Figueiredo-Pereira, M. E., Fimia, G. M., Fingar, D. C., Finkbeiner, S., Finkel, T., Finley, K. D., Fiorito, F., Fisher, E. A., Fisher, P. B., Flajolet, M., Florez-McClure, M. L., Florio, S., Fon, E. A., Fornai, F., Fortunato, F., Fotedar, R., Fowler, D. H., Fox, H. S., Franco, R., Frankel, L. B., Fransen, M., Fuentes, J. M., Fueyo, J., Fujii, J., Fujisaki, K., Fujita, E., Fukuda, M., Furukawa, R. H., Gaestel, M., Gailly, P., Gajewska, M., Galliot, B., Galy, V., Ganesh, S., Ganetzky, B., Ganley, I. G., Gao, F. B., Gao, G. F., Gao, J., Garcia, L., Garcia-Manero, G., Garcia-Marcos, M., Garmyn, M., Gartel, A. L., Gatti, E., Gautel, M., Gawriluk, T. R., Gegg, M. E., Geng, J., Germain, M., Gestwicki, J. E., Gewirtz, D. A., Ghavami, S., Ghosh, P., Giammarioli, A. M., Giatromanolaki, A. N., Gibson, S. B., Gilkerson, R. W., Ginger, M. L., Ginsberg, H. N., Golab, J., Goligorsky, M. S., Golstein, P., Gomez-Manzano, C., Goncu, E., Gongora, C., Gonzalez, C. D., Gonzalez, R., González-Estévez, C., González-Polo, R. A., Gonzalez-Rey, E., Gorbunov, N. V., Gorski, S., Goruppi, S., Gottlieb, R. A., Gozuacik, D., Granato, G. E., Grant, G. D., Green, K. N., Gregorc, A., Gros, F., Grose, C., Grunt, T. W., Gual, P., Guan, J. L., Guan, K. L., Guichard, S. M., Gukovskaya, A. S., Gukovsky, I., Gunst, J., Gustafsson, A. B., Halayko, A. J., Hale, A. N., Halonen, S. K., Hamasaki, M., Han, F., Han, T., Hancock, M. K., Hansen, M., Harada, H., Harada, M., Hardt, S. E., Harper, J. W., Harris, A. L., Harris, J., Harris, S. D., Hashimoto, M., Haspel, J. A., Hayashi, S. I., Hazelhurst, L. A., He, C., He, Y. W., Hébert, M. J., Heidenreich, K. A., Helfrich, M. H., Helgason, G. V., Henske, E. P., Herman, B., Herman, P. K., Hetz, C., Hilfiker, S., Hill, J. A., Hocking, L. J., Hofman, P., Hofmann, T. G., Höhfeld, J., Holyoake, T. L., Hong, M. H., Hood, D. A., Hotamisligil, G. S., Houwerzijl, E. J., Høyer-Hansen, M., Hu, B., Hu, C. A. A., Hu, H. M., Hua, Y., Huang, C., Huang, J., Huang, S., Huang, W. P., Huber, T. B., Huh, W. K., Hung, T. H., Hupp, T. R., Hur, G. M., Hurley, J. B., Hussain, S. N. A., Hussey, P. J., Hwang, J. J., Hwang, S., Ichihara, A., Ilkhanizadeh, S., Inoki, K., Into, T., Iovane, V., Iovanna, J. L., Ip, N. Y., Isaka, Y., Ishida, H., Isidoro, C., Isobe, K. I., Iwasaki, A., Izquierdo, M., Izumi, Y., Jaakkola, P. M., Jäättelä, M., Jackson, G. R., Jackson, W. T., Janji, B., Jendrach, M., Jeon, J. H., Jeung, E. B., Jiang, H., Jiang, H., Jiang, J. X., Jiang, M., Jiang, Q., Jiang, X., Jiménez, A., Jin, M., Jin, S., Joe, C. O., Johansen, T., Johnson, D. E., Johnson, G. V. W., Jones, N. L., Joseph, B., Joseph, S. K., Joubert, A. M., Juhász, G., Juillerat-Jeanneret, L., Jung, C. H., Jung, Y. K., Kaarniranta, K., Kaasik, A., Kabuta, T., Kadowaki, M., Kagedal, K., Kamada, Y., Kaminskyy, V. O., Kampinga, H. H., Kanamori, H., Kang, C., Kang, K. B., Il Kang, K., Kang, R., Kang, Y. A., Kanki, T., Kanneganti, T. D., Kanno, H., Kanthasamy, A. G., Kanthasamy, A., Karantza, V., Kaushal, G. P., Kaushik, S., Kawazoe, Y., Ke, P. Y., Kehrl, J. H., Kelekar, A., Kerkhoff, C., Kessel, D. H., Khalil, H., Kiel, J. A. K. W., Kiger, A. A., Kihara, A., Kim, D. R., Kim, D. H., Kim, D. H., Kim, E. K., Kim, H. R., Kim, J. S., Kim, J. H., Kim, J. C., Kim, J. K., Kim, P. K., Kim, S. W., Kim, Y. S., Kim, Y., Kimchi, A., Kimmelman, A. C., King, J. S., Kinsella, T. J., Kirkin, V., Kirshenbaum, L. A., Kitamoto, K., Kitazato, K., Klein, L., Klimecki, W. T., Klucken, J., Knecht, E., Ko, B. C. B., Koch, J. C., Koga, H., Koh, J. Y., Koh, Y. H., Koike, M., Komatsu, M., Kominami, E., Kong, H. J., Kong, W. J., Korolchuk, V. I., Kotake, Y., Koukourakis, M. I., Kouri Flores, J. B., Kovács, A. L., Kraft, C., Krainc, D., Krämer, H., Kretz-Remy, C., Krichevsky, A. M., Kroemer, G., Krüger, R., Krut, O., Ktistakis, N. T., Kuan, C. Y., Kucharczyk, R., Kumar, A., Kumar, R., Kumar, S., Kundu, M., Kung, H. J., Kurz, T., Kwon, H. J., La Spada, A. R., Lafont, F., Lamark, T., Landry, J., Lane, J. D., Lapaquette, P., Laporte, J. F., László, L., Lavandero, S., Lavoie, J. N., Layfield, R., Lazo, P. A., Le, W., Le Cam, L., Ledbetter, D. J., Lee, A. J. X., Lee, B. W., Lee, G. M., Lee, J., Lee, J. H., Lee, M., Lee, M. S., Lee, S. H., Leeuwenburgh, C., Legembre, P., Legouis, R., Lehmann, M., Lei, H. Y., Lei, Q. Y., Leib, D. A., Leiro, J., Lemasters, J. J., Lemoine, A., Lesniak, M. S., Lev, D., Levenson, V. V., Levine, B., Levy, E., Li, F., Li, J. L., Li, L., Li, S., Li, W., Li, X. J., Li, Y. B., Li, Y. P., Liang, C., Liang, Q., Liao, Y. F., Liberski, P. P., Lieberman, A., Lim, H. J., Lim, K. L., Lim, K., Lin, C. F., Lin, F. C., Lin, J., Lin, J. D., Lin, K., Lin, W. W., Lin, W. C., Lin, Y. L., Linden, R., Lingor, P., Lippincott-Schwartz, J., Lisanti, M. P., Liton, P. B., Liu, B., Liu, C. F., Liu, K., Liu, L., Liu, Q. A., Liu, W., Liu, Y. C., Liu, Y., Lockshin, R. A., Lok, C. N., Lonial, S., Loos, B., Lopez-Berestein, G., López-Otín, C., Lossi, L., Lotze, M. T., Lõw, P., Lu, B., Lu, B., Lu, B., Lu, Z., Luciano, F., Lukacs, N. W., Lund, A. H., Lynch-Day, M. A., Ma, Y., Macian, F., MacKeigan, J. P., Macleod, K. F., Madeo, F., Maiuri, L., Maiuri, M. C., Malagoli, D., Malicdan, M. C. V., Malorni, W., Man, N., Mandelkow, E. M., Manon, S., Manov, I., Mao, K., Mao, X., Mao, Z., Marambaud, P., Marazziti, D., Marcel, Y. L., Marchbank, K., Marchetti, P., Marciniak, S. J., Marcondes, M., Mardi, M., Marfe, G., Mariño, G., Markaki, M., Marten, M. R., Martin, S. J., Martinand-Mari, C., Martinet, W., Martinez-Vicente, M., Masini, M., Matarrese, P., Matsuo, S., Matteoni, R., Mayer, A., Mazure, N. M., McConkey, D. J., McConnell, M. J., McDermott, C., McDonald, C., McInerney, G. M., McKenna, S. L., McLaughlin, B. A., McLean, P. J., McMaster, C. R., McQuibban, G. A., Meijer, A. J., Meisler, M. H., Meléndez, A., Melia, T. J., Melino, G., Mena, M. A., Menendez, J. A., Menna-Barreto, R. F. S., Menon, M. B., Menzies, F. M., Mercer, C. A., Merighi, A., Merry, D. E., Meschini, S., Meyer, C. G., Meyer, T. F., Miao, C. Y., Miao, J. Y., Michels, P. A. M., Michiels, C., Mijaljica, D., Milojkovic, A., Minucci, S., Miracco, C., Miranti, C. K., Mitroulis, I., Miyazawa, K., Mizushima, N., Mograbi, B., Mohseni, S., Molero, X., Mollereau, B., Mollinedo, F., Momoi, T., Monastyrska, I., Monick, M. M., Monteiro, M. J., Moore, M. N., Mora, R., Moreau, K., Moreira, P. I., Moriyasu, Y., Moscat, J., Mostowy, S., Mottram, J. C., Motyl, T., Moussa, C. E. H., Müller, S., Muller, S., Münger, K., Münz, C., Murphy, L. O., Murphy, M. E., Musarò, A., Mysorekar, I., Nagata, E., Nagata, K., Nahimana, A., Nair, U., Nakagawa, T., Nakahira, K., Nakano, H., Nakatogawa, H., Nanjundan, M., Naqvi, N. I., Narendra, D. P., Narita, M., Navarro, M., Nawrocki, S. T., Nazarko, T. Y., Nemchenko, A., Netea, M. G., Neufeld, T. P., Ney, P. A., Nezis, I. P., Nguyen, H. P., Nie, D., Nishino, I., Nislow, C., Nixon, R. A., Noda, T., Noegel, A. A., Nogalska, A., Noguchi, S., Notterpek, L., Novak, I., Nozaki, T., Nukina, N., Nürnberger, T., Nyfeler, B., Obara, K., Oberley, T. D., Oddo, S., Ogawa, M., Ohashi, T., Okamoto, K., Oleinick, N. L., Oliver, F. J., Olsen, L. J., Olsson, S., Opota, O., Osborne, T. F., Ostrander, G. K., Otsu, K., Ou, J. H. J., Ouimet, M., Overholtzer, M., Ozpolat, B., Paganetti, P., Pagnini, U., Pallet, N., Palmer, G. E., Palumbo, C., Pan, T., Panaretakis, T., Pandey, U. B., Papackova, Z., Papassideri, I., Paris, I., Park, J., Park, O. K., Parys, J. B., Parzych, K. R., Patschan, S., Patterson, C., Pattingre, S., Pawelek, J. M., Peng, J., Perlmutter, D. H., Perrotta, I., Perry, G., Pervaiz, S., Peter, M., Peters, G. J., Petersen, M., Petrovski, G., Phang, J. M., Piacentini, M., Pierre, P., Pierrefite-Carle, V., Pierron, G., Pinkas-Kramarski, R., Piras, A., Piri, N., Platanias, L. C., Pöggeler, S., Poirot, M., Poletti, A., Poüs, C., Pozuelo-Rubio, M., Prætorius-Ibba, M., Prasad, A., Prescott, M., Priault, M., Produit-Zengaffinen, N., Progulske-Fox, A., Proikas-Cezanne, T., Przedborski, S., Przyklenk, K., Puertollano, R., Puyal, J., Qian, S. B., Qin, L., Qin, Z. H., Quaggin, S. E., Raben, N., Rabinowich, H., Rabkin, S. W., Rahman, I., Rami, A., Ramm, G., Randall, G., Randow, F., Rao, V. A., Rathmell, J. C., Ravikumar, B., Ray, S. K., Reed, B. H., Reed, J. 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X., Zorzano, A., Zschocke, J. & Zuckerbraun, B., Apr 2012, In : Autophagy. 8, 4, p. 445-544 100 p.

Research output: Contribution to journalReview article

2478 Scopus citations

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

Huang, H., Liu, N., Guo, H., Liao, S., Li, X., Yang, C., Liu, S., Song, W., Liu, C., Guan, L., Li, B., Xu, L., Zhang, C., Wang, X., Dou, Q. P. & Liu, J., Nov 5 2012, In : PloS one. 7, 11, e49062.

Research output: Contribution to journalArticle

56 Scopus citations

Protein quality control in cardiomyocytes

Wang, X. & Patterson, C., 2012, Muscle. Elsevier Inc., Vol. 1. p. 353-367 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

The ubiquitin-proteasome system and cardiovascular disease

Powell, S. R., Herrmann, J., Lerman, A., Patterson, C. & Wang, X., 2012, Progress in Molecular Biology and Translational Science. Elsevier B.V., p. 295-346 52 p. (Progress in Molecular Biology and Translational Science; vol. 109).

Research output: Chapter in Book/Report/Conference proceedingChapter

54 Scopus citations
2011

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. J. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

121 Scopus citations

Autophagy and p62 in cardiac protein quality control

Su, H. & Wang, X., Nov 2011, In : Autophagy. 7, 11, p. 1382-1383 2 p.

Research output: Contribution to journalShort survey

8 Scopus citations

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M. J., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation

Lei, D., Li, F., Su, H., Tian, Z., Ye, B., Wei, N. & Wang, X., Feb 2011, In : Cell Death and Differentiation. 18, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J. & Wang, X., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3689-3700 12 p.

Research output: Contribution to journalArticle

127 Scopus citations

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress

Li, J., Powell, S. R. & Wang, X., Mar 2011, In : FASEB Journal. 25, 3, p. 883-893 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

FoxO3 hastens autophagy and shrinks the heart but does not curtail pathological hypertrophy in adult mice

Wang, X. & Su, H., Sep 1 2011, In : Cardiovascular research. 91, 4, p. 561-562 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations
45 Scopus citations

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice

Su, H., Li, J., Menon, S., Liu, J., Kumarapeli, A. R., Wei, N. & Wang, X., Jan 7 2011, In : Circulation Research. 108, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Proteasome functional insufficiency in cardiac pathogenesis

Wang, X., Li, J., Zheng, H., Su, H. & Powell, S. R., Dec 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 6, p. 2207-2219 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Sanggenon C decreases tumor cell viability associated with proteasome inhibition

Huang, H., Liu, N., Zhao, K., Zhu, C., Lu, X., Li, S., Lian, W., Zhou, P., Dong, X., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Lu, L., Li, X., Guan, L., Liu, C., Wang, X., Dou, Q. P. & 1 others, Liu, J., Jan 6 2011, In : Frontiers in Bioscience - Elite. 3 E, 4, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

Lu, L., Qin, A., Huang, H., Zhou, P., Zhang, C., Liu, N., Li, S., Wen, G., Zhang, C., Dong, W., Wang, X., Dou, Q. P. & Liu, J., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 242-247 6 p.

Research output: Contribution to journalArticle

94 Scopus citations

The role of the proteasome in heart disease

Li, Y. F. & Wang, X., Feb 2011, In : Biochimica et Biophysica Acta - Gene Regulatory Mechanisms. 1809, 2, p. 141-149 9 p.

Research output: Contribution to journalReview article

33 Scopus citations
2010

Autophagy and the ubiquitin-proteasome system in cardiac dysfunction

Zheng, Q. & Wang, X., Mar 2010, In : Panminerva Medica. 52, 1, p. 9-25 17 p.

Research output: Contribution to journalReview article

33 Scopus citations

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Zheng, H., Tang, M., Zheng, Q., Kumarapeli, A. R. K., Horak, K. M., Tian, Z. & Wang, X., Oct 19 2010, In : Journal of the American College of Cardiology. 56, 17, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Physiological levels of ATP negatively regulate proteasome function

Huang, H., Zhang, X., Li, S., Liu, N., Lian, W., McDowell, E., Zhou, P., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Dong, X., Lu, L., Ma, N., Dong, W., Dou, Q. P., Wang, X. & Liu, J., Dec 2010, In : Cell Research. 20, 12, p. 1372-1385 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

Tang, M., Li, J., Huang, W., Su, H., Liang, Q., Tian, Z., Horak, K. M., Molkentin, J. D. & Wang, X., Dec 1 2010, In : Cardiovascular research. 88, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Protein quality control in protection against systolic overload cardiomyopathy: The long term role of small heat shock proteins

Kumarapeli, A. R. K., Horak, K. & Wang, X., 2010, In : American Journal of Translational Research. 2, 4, p. 390-401 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

The role of the ubiquitin-proteasome pathway in cardiovascular disease

Depre, C., Powell, S. R. & Wang, X., Jan 2010, In : Cardiovascular research. 85, 2, p. 251-252 2 p.

Research output: Contribution to journalEditorial

20 Scopus citations

The ubiquitin-proteasome system in cardiac proteinopathy: A quality control perspective

Su, H. & Wang, X., Jan 2010, In : Cardiovascular research. 85, 2, p. 253-262 10 p.

Research output: Contribution to journalReview article

79 Scopus citations

Unraveling enigma in the z-disk

Wang, X. & Su, H., Aug 6 2010, In : Circulation Research. 107, 3, p. 321-323 3 p.

Research output: Contribution to journalEditorial

4 Scopus citations
2009

Activation of the ubiquitin-proteasome system in doxorubicin cardiomyopathy

Wang, X. & Ranek, M. J., Dec 2009, In : Current Hypertension Reports. 11, 6, p. 389-395 7 p.

Research output: Contribution to journalReview article

39 Scopus citations

Interplay between the ubiquitin-proteasome system and autophagy in proteinopathies

Zheng, Q., Li, J. & Wang, X., 2009, In : International Journal of Physiology, Pathophysiology and Pharmacology. 1, 2, p. 127-142 16 p.

Research output: Contribution to journalReview article

40 Scopus citations

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo

Yang, H., Zhou, P., Huang, H., Chen, D., Ma, N., Cui, Q. C., Shen, S., Dong, W., Zhang, X., Lian, W., Wang, X., Dou, Q. P. & Liu, J., May 15 2009, In : International Journal of Cancer. 124, 10, p. 2450-2459 10 p.

Research output: Contribution to journalArticle

128 Scopus citations