Xuejun Wang, PhD, MBBS

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 11153 Citations
  • 48 h-Index
19962020

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2019

Auranofin lethality to prostate cancer includes inhibition of proteasomal deubiquitinases and disrupted androgen receptor signaling

Liu, N., Guo, Z., Xia, X., Liao, Y., Zhang, F., Huang, C., Liu, Y., Deng, X., Jiang, L., Wang, X., Liu, J. & Huang, H., Mar 5 2019, In : European Journal of Pharmacology. 846, p. 1-11 11 p.

Research output: Contribution to journalArticle

7 Scopus citations

Highly dynamic changes in the activity and regulation of macroautophagy in hearts subjected to increased proteotoxic stress

Pan, B., Lewno, M. T., Wu, P. & Wang, X., 2019, In : Frontiers in Physiology. 10, JUN, 758.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Inhibition of EGFR signaling with Spautin-1 represents a novel therapeutics for prostate cancer

Liao, Y., Guo, Z., Xia, X., Liu, Y., Huang, C., Jiang, L., Wang, X., Liu, J. & Huang, H., Apr 11 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 157.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Inhibition of USP14 enhances the sensitivity of breast cancer to enzalutamide

Xia, X., Huang, C., Liao, Y., Liu, Y., He, J., Guo, Z., Jiang, L., Wang, X., Liu, J. & Huang, H., May 24 2019, In : Journal of Experimental and Clinical Cancer Research. 38, 1, 220.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

Zhang, H., Pan, B., Wu, P., Parajuli, N., Rekhter, M. D., Goldberg, A. L. & Wang, X., 2019, In : Science Advances. 5, 5, aaw5870.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and -resistant NSCLC

Xia, X., Liu, Y., Liao, Y., Guo, Z., Huang, C., Zhang, F., Jiang, L., Wang, X., Liu, J. & Huang, H., Aug 5 2019, In : European Journal of Pharmacology. 856, 172409.

Research output: Contribution to journalArticle

6 Scopus citations

UCHL1 regulates muscle fibers and mTORC1 activity in skeletal muscle

Gao, H., Freeling, J., Wu, P., Liang, A. P., Wang, X. & Li, Y., Sep 15 2019, In : Life Sciences. 233, 116699.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase

Chen, X., Wu, J., Yang, Q., Zhang, X., Zhang, P., Liao, S., He, Z., Wang, X., Zhao, C. & Liu, J., Feb 1 2018, In : BioMetals. 31, 1, p. 29-43 15 p.

Research output: Contribution to journalArticle

3 Scopus citations

Inadequate ubiquitination-proteasome coupling contributes to myocardial ischemia-reperfusion injury

Hu, C., Tian, Y., Xu, H., Pan, B., Terpstra, E. M., Wu, P., Wang, H., Li, F., Liu, J. & Wang, X., Dec 3 2018, In : Journal of Clinical Investigation. 128, 12, p. 5294-5306 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Inhibition of Proteasomal Deubiquitinase by Silver Complex Induces Apoptosis in Non-Small Cell Lung Cancer Cells

Chen, X., Yang, Q., Chen, J., Zhang, P., Huang, Q., Zhang, X., Yang, L., Xu, D., Zhao, C., Wang, X. & Liu, J., Sep 1 2018, In : Cellular Physiology and Biochemistry. 49, 2, p. 780-797 18 p.

Research output: Contribution to journalArticle

6 Scopus citations

Targeting proteasome-associated deubiquitinases as a novel strategy for the treatment of estrogen receptor-positive breast cancer

Xia, X., Liao, Y., Guo, Z., Li, Y., Jiang, L., Zhang, F., Huang, C., Liu, Y., Wang, X., Liu, N., Liu, J. & Huang, H., Sep 1 2018, In : Oncogenesis. 7, 9, 75.

Research output: Contribution to journalArticle

Open Access
20 Scopus citations

UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

Sane, S., Hafner, A., Srinivasan, R., Masood, D., Slunecka, J. L., Noldner, C. J., Hanson, A. D., Kruisselbrink, T., Wang, X., Wang, Y., Yin, J. & Rezvani, K., Oct 2018, In : Molecular Oncology. 12, 10, p. 1753-1777 25 p.

Research output: Contribution to journalArticle

3 Scopus citations
2017

Activation of Yap1/Taz signaling in ischemic heart disease and dilated cardiomyopathy

Hou, N., Wen, Y., Yuan, X., Xu, H., Wang, X., Li, F. & Ye, B., Dec 2017, In : Experimental and Molecular Pathology. 103, 3, p. 267-275 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

A novel deubiquitinase inhibitor b-AP15 triggers apoptosis in both androgen receptor-dependent and -independent prostate cancers

Cai, J., Xia, X., Liao, Y., Liu, N., Guo, Z., Chen, J., Yang, L., Long, H., Yang, Q., Zhang, X., Xiao, L., Wang, X., Huang, H. & Liu, J., 2017, In : Oncotarget. 8, 38, p. 63232-63246 15 p.

Research output: Contribution to journalArticle

20 Scopus citations

Bilirubin neurotoxicity is associated with proteasome inhibition

Huang, H., Guo, M., Liu, N., Zhao, C., Chen, H., Wang, X., Liao, S., Zhou, P., Liao, Y., Chen, X., Lan, X., Chen, J., Xu, D., Li, X., Shi, X., Yu, L., Nie, Y., Wang, X., Zhang, C. E. & Liu, J., Jun 15 2017, In : Cell Death and Disease. 8, 6, e2877.

Research output: Contribution to journalArticle

12 Scopus citations

Cardiac proteasome functional insufficiency plays a pathogenic role in diabetic cardiomyopathy

Li, J., Ma, W., Yue, G., Tang, Y., Kim, I. M., Weintraub, N. L., Wang, X. & Su, H., Jan 1 2017, In : Journal of Molecular and Cellular Cardiology. 102, p. 53-60 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer

Xiao, L., Lan, X., Shi, X., Zhao, K., Wang, D., Wang, X., Li, F., Huang, H. & Liu, J., May 18 2017, In : Cell death & disease. 8, 5, p. e2803

Research output: Contribution to journalArticle

17 Scopus citations

Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells

Chen, X., Zhang, X., Chen, J., Yang, Q., Yang, L., Xu, D., Zhang, P., Wang, X. & Liu, J., Nov 15 2017, In : European Journal of Pharmacology. 815, p. 147-155 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Murine myocardial transcriptome analysis reveals a critical role of COPS8 in the gene expression of cullin-RING ligase substrate receptors and redox and vesicle trafficking pathways

Abdullah, A., Eyster, K. M., Bjordahl, T., Xiao, P., Zeng, E. & Wang, X., Aug 17 2017, In : Frontiers in Physiology. 8, AUG, 594.

Research output: Contribution to journalArticle

1 Scopus citations

Myocardial Upregulation of Cathepsin D by Ischemic Heart Disease Promotes Autophagic Flux and Protects Against Cardiac Remodeling and Heart Failure

Wu, P., Yuan, X., Li, F., Zhang, J., Zhu, W., Wei, M., Li, J. & Wang, X., Jul 1 2017, In : Circulation: Heart Failure. 10, 7, e004044.

Research output: Contribution to journalArticle

17 Scopus citations

Platinum pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via DUB inhibition-dependent caspase activation and Bcr-Abl downregulation

Lan, X., Zhao, C., Chen, X., Zhang, P., Zang, D., Wu, J., Chen, J., Long, H., Yang, L., Huang, H., Wang, X., Shi, X. & Liu, J., Jul 6 2017, In : Cell Death and Disease. 8, 7, e2913.

Research output: Contribution to journalArticle

7 Scopus citations

Proteasome-associated deubiquitinase ubiquitin-specific protease 14 regulates prostate cancer proliferation by deubiquitinating and stabilizing androgen receptor

Liao, Y., Liu, N., Hua, X., Cai, J., Xia, X., Wang, X., Huang, H. & Liu, J., Feb 2 2017, In : Cell Death and Disease. 8, 2, e2585.

Research output: Contribution to journalArticle

44 Scopus citations

Repurposing an antidandruff agent to treating cancer: Zinc pyrithione inhibits tumor growth via targeting proteasome-associated deubiquitinases

Zhao, C., Chen, X., Yang, C., Zang, D., Lan, X., Liao, S., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., Ping Dou, Q., Wang, X. & Liu, J., 2017, In : Oncotarget. 8, 8, p. 13942-13956 15 p.

Research output: Contribution to journalArticle

9 Scopus citations

TFEB activation protects against cardiac proteotoxicity via increasing autophagic flux

Pan, B., Zhang, H., Cui, T. & Wang, X., Dec 2017, In : Journal of Molecular and Cellular Cardiology. 113, p. 51-62 12 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment

Jiang, L., Zang, D., Yi, S., Li, X., Yang, C., Dong, X., Zhao, C., Lan, X., Chen, X., Liu, S., Liu, N., Huang, H., Shi, X., Wang, X. & Liu, J., Feb 22 2016, In : Scientific reports. 6, 21565.

Research output: Contribution to journalArticle

15 Scopus citations

A novel nickel complex works as a proteasomal deubiquitinase inhibitor for cancer therapy

Zhao, C., Chen, X., Zang, D., Lan, X., Liao, S., Yang, C., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., He, Z., Dou, Q. P., Wang, X. & Liu, J., Nov 10 2016, In : Oncogene. 35, 45, p. 5916-5927 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors

Zhang, L., Hapon, M. B., Goyeneche, A. A., Srinivasan, R., Gamarra-Luques, C. D., Callegari, E. A., Drappeau, D. D., Terpstra, E. J., Pan, B., Knapp, J. R., Chien, J., Wang, X., Eyster, K. M. & Telleria, C. M., Aug 1 2016, In : Molecular Oncology. 10, 7, p. 1099-1117 19 p.

Research output: Contribution to journalArticle

10 Scopus citations

Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms

Lan, X., Zhao, C., Chen, X., Zhang, P., Zang, D., Wu, J., Chen, J., Long, H., Yang, L., Huang, H., Carter, B. Z., Wang, X., Shi, X. & Liu, J., Nov 25 2016, In : Journal of Hematology and Oncology. 9, 1, 129.

Research output: Contribution to journalArticle

9 Scopus citations

Nrf2-Mediated Cardiac Maladaptive Remodeling and Dysfunction in a Setting of Autophagy Insufficiency

Qin, Q., Qu, C., Niu, T., Zang, H., Qi, L., Lyu, L., Wang, X., Nagarkatti, M., Nagarkatti, P., Janicki, J. S., Wang, X. L. & Cui, T., Jan 1 2016, In : Hypertension. 67, 1, p. 107-117 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Nuclear factor erythroid-2 related factor 2 (Nrf2)-mediated Protein quality control in cardiomyocytes

Cui, T., Lai, Y., Janicki, J. S. & Wang, X., Jan 1 2016, In : Frontiers in Bioscience - Landmark. 21, 1, p. 192-202 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Platinum-containing compound platinum pyrithione is stronger and safer than cisplatin in cancer therapy

Zhao, C., Chen, X., Zang, D., Lan, X., Liao, S., Yang, C., Zhang, P., Wu, J., Li, X., Liu, N., Liao, Y., Huang, H., Shi, X., Jiang, L., Liu, X., He, Z., Wang, X. & Liu, J., Sep 15 2016, In : Biochemical Pharmacology. 116, p. 22-38 17 p.

Research output: Contribution to journalArticle

20 Scopus citations

Transcription Factor 7-like 2 Mediates Canonical Wnt/β-Catenin Signaling and c-Myc Upregulation in Heart Failure

Hou, N., Ye, B., Li, X., Margulies, K. B., Xu, H., Wang, X. & Li, F., Jun 1 2016, In : Circulation: Heart Failure. 9, 6, e003010.

Research output: Contribution to journalArticle

23 Scopus citations

Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo

Huang, H., Liao, Y., Liu, N., Hua, X., Cai, J., Yang, C., Long, H., Zhao, C., Chen, X., Lan, X., Zang, D., Wu, J., Li, X., Shi, X., Wang, X. & Liu, J., 2016, In : Oncotarget. 7, 3, p. 2796-2808 13 p.

Research output: Contribution to journalArticle

30 Scopus citations
2015

COP9 Signalosome Controls the Degradation of Cytosolic Misfolded Proteins and Protects Against Cardiac Proteotoxicity

Su, H., Li, J., Zhang, H., Ma, W., Wei, N., Liu, J. & Wang, X., Nov 6 2015, In : Circulation Research. 117, 11, p. 956-966 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Gambogic acid induces apoptosis in diffuse large B-cell lymphoma cells via inducing proteasome inhibition

Shi, X., Lan, X., Chen, X., Zhao, C., Li, X., Liu, S., Huang, H., Liu, N., Zang, D., Liao, Y., Zhang, P., Wang, X. & Liu, J., Apr 13 2015, In : Scientific reports. 5, 9694.

Research output: Contribution to journalArticle

14 Scopus citations

Genetically induced moderate inhibition of 20S proteasomes in cardiomyocytes facilitates heart failure in mice during systolic overload

Ranek, M. J., Zheng, H., Huang, W., Kumarapeli, A. R., Li, J., Liu, J. & Wang, X., Aug 1 2015, In : Journal of Molecular and Cellular Cardiology. 85, p. 273-281 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

NEDD8 Ultimate Buster 1 Long (NUB1L) protein suppresses atypical neddylation and promotes the proteasomal degradation of misfolded proteins

Li, J., Ma, W., Li, H., Hou, N., Wang, X., Kim, I. M., Li, F. & Su, H., Sep 25 2015, In : Journal of Biological Chemistry. 290, 39, p. 23850-23862 13 p.

Research output: Contribution to journalArticle

12 Scopus citations
2014

A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

Liu, N., Liu, C., Li, X., Liao, S., Song, W., Yang, C., Zhao, C., Huang, H., Guan, L., Zhang, P., Liu, S., Hua, X., Chen, X., Zhou, P., Lan, X., Yi, S., Wang, S., Wang, X., Dou, Q. P. & Liu, J., Jun 10 2014, In : Scientific reports. 4, 5240.

Research output: Contribution to journalArticle

46 Scopus citations

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms

Chen, X., Shi, X., Zhao, C., Li, X., Lan, X., Liu, S., Huang, H., Liu, N., Liao, S., Zang, D., Song, W., Liu, Q., Carter, B. Z., Ping Dou, Q., Wang, X. & Liu, J., 2014, In : Oncotarget. 5, 19, p. 9118-9132 15 p.

Research output: Contribution to journalArticle

Open Access
48 Scopus citations

Autophagic-lysosomal inhibition compromises ubiquitin-proteasome system performance in a p62 dependent manner in cardiomyocytes

Tian, Z., Wang, C., Hu, C., Tian, Y., Liu, J. & Wang, X., Jun 24 2014, In : PloS one. 9, 6, e100715.

Research output: Contribution to journalArticle

23 Scopus citations

Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

Liu, N., Li, X., Huang, H., Zhao, C., Liao, S., Yang, C., Liu, S., Song, W., Lu, X., Lan, X., Chen, X., Yi, S., Xu, L., Jiang, L., Zhao, C., Dong, X., Zhou, P., Li, S., Wang, S., Shi, X. & 3 others, Dou, P. Q., Wang, X. & Liu, J., 2014, In : Oncotarget. 5, 14, p. 5453-5471 19 p.

Research output: Contribution to journalArticle

Open Access
81 Scopus citations

Gambogic acid induces apoptosis in imatinib-resistant chronic myeloid leukemia cells via inducing proteasome inhibition and caspase-dependent bcr-abl downregulation AC

Shi, X., Chen, X., Li, X., Lan, X., Zhao, C., Liu, S., Huang, H., Liu, N., Liao, S., Song, W., Zhou, P., Wang, S., Xu, L., Wang, X., Dou, Q. P. & Liu, J., Jan 1 2014, In : Clinical Cancer Research. 20, 1, p. 151-163 13 p.

Research output: Contribution to journalArticle

80 Scopus citations

Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy

Kwong, J. Q., Davis, J., Baines, C. P., Sargent, M. A., Karch, J., Wang, X., Huang, T. & Molkentin, J. D., Aug 2014, In : Cell Death and Differentiation. 21, 8, p. 1209-1217 9 p.

Research output: Contribution to journalArticle

85 Scopus citations

Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner

Ranek, M. J., Kost, C. K., Hu, C., Martin, D. S. & Wang, X., Apr 2014, In : Journal of Molecular and Cellular Cardiology. 69, p. 43-51 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Sulforaphane enhances proteasomal and autophagic activities in mice and is a potential therapeutic reagent for Huntington's disease

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., May 2014, In : Journal of Neurochemistry. 129, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

53 Scopus citations

Sumo E2 enzyme UBC9 is required for efficient protein quality control in cardiomyocytes

Gupta, M. K., Gulick, J., Liu, R., Wang, X., Molkentin, J. D. & Robbins, J., 2014, In : Circulation Research. 115, 8, p. 721-729 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

The proteasome function reporter GFPu accumulates in young brains of the APPswe/PS1dE9 Alzheimer's disease mouse model

Liu, Y., Hettinger, C. L., Zhang, D., Rezvani, K., Wang, X. & Wang, H., Apr 2014, In : Cellular and molecular neurobiology. 34, 3, p. 315-322 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ubiquilin-1 protects cells from oxidative stress and ischemic stroke caused tissue injury in mice

Liu, Y., Lü, L., Hettinger, C. L., Dong, G., Zhang, D., Rezvani, K., Wang, X. & Wang, H., 2014, In : Journal of Neuroscience. 34, 8, p. 2813-2821 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Altered ubiquitin-proteasome signaling in right ventricular hypertrophy and failure

Rajagopalan, V., Zhao, M., Reddy, S., Fajardo, G., Wang, X., Dewey, S., Gomes, A. V. & Bernstein, D., May 8 2013, In : American Journal of Physiology - Heart and Circulatory Physiology. 305, 4, p. H551-H562

Research output: Contribution to journalArticle

26 Scopus citations

Bortezomib, a proteasome inhibitor, attenuates angiotensin II-induced hypertension and aortic remodeling in rats.

Li, S., Wang, X., Li, Y., Kost, C. K. & Martin, D. S., 2013, In : PloS one. 8, 10

Research output: Contribution to journalArticle

Open Access
14 Scopus citations