Xuejun Wang, PhD, MBBS

  • Professor of Basic Biomedical Sciences, Director USD MD/PhD Program, University of South Dakota, Great Plains IDeA-CTR
  • 11153 Citations
  • 48 h-Index
19962020

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Research Output

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Article
2013

COP9 signalosome subunit Csn8 is involved in maintaining proper duration of the G1 phase

Liu, C., Guo, L. Q., Menon, S., Jin, D., Pick, E., Wang, X., Deng, X. W. & Wei, N., Jul 12 2013, In : Journal of Biological Chemistry. 288, 28, p. 20443-20452 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Gambogic Acid Is a Tissue-Specific Proteasome Inhibitor In Vitro and In Vivo

Li, X., Liu, S., Huang, H., Liu, N., Zhao, C., Liao, S., Yang, C., Liu, Y., Zhao, C., Li, S., Lu, X., Liu, C., Guan, L., Zhao, K., Shi, X., Song, W., Zhou, P., Dong, X., Guo, H., Wen, G. & 9 others, Zhang, C., Jiang, L., Ma, N., Li, B., Wang, S., Tan, H., Wang, X., Dou, Q. P. & Liu, J., Jan 31 2013, In : Cell Reports. 3, 1, p. 211-222 12 p.

Research output: Contribution to journalArticle

65 Scopus citations

Hepatic Deficiency of COP9 Signalosome Subunit 8 Induces Ubiquitin-Proteasome System Impairment and Bim-Mediated Apoptosis in Murine Livers

Lei, D., Li, F., Su, H., Liu, J., Wei, N. & Wang, X., Jul 1 2013, In : PloS one. 8, 7, e67793.

Research output: Contribution to journalArticle

6 Scopus citations

Protein kinase G positively regulates proteasome-mediated degradation of misfolded proteins

Ranek, M. J., Terpstra, E. J. M., Li, J., Kass, D. A. & Wang, X., Jul 23 2013, In : Circulation. 128, 4, p. 365-376 12 p.

Research output: Contribution to journalArticle

64 Scopus citations

The COP9 signalosome is required for autophagy, proteasome-mediated proteolysis, and cardiomyocyte survival in adult mice

Su, H., Li, J., Osinska, H., Li, F., Robbins, J., Liu, J., Wei, N. & Wang, X., Sep 2013, In : Circulation: Heart Failure. 6, 5, p. 1049-1057 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2012

Genetically induced moderate inhibition of the proteasome in cardiomyocytes exacerbates myocardial ischemia-reperfusion injury in Mice

Tian, Z., Zheng, H., Li, J., Li, Y., Su, H. & Wang, X., Aug 17 2012, In : Circulation Research. 111, 5, p. 532-542 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

L-Carnitine Is an Endogenous HDAC Inhibitor Selectively Inhibiting Cancer Cell Growth In Vivo and In Vitro

Huang, H., Liu, N., Guo, H., Liao, S., Li, X., Yang, C., Liu, S., Song, W., Liu, C., Guan, L., Li, B., Xu, L., Zhang, C., Wang, X., Dou, Q. P. & Liu, J., Nov 5 2012, In : PloS one. 7, 11, e49062.

Research output: Contribution to journalArticle

56 Scopus citations
2011

Autophagy and p62 in cardiac proteinopathy

Zheng, Q., Su, H., Ranek, M. J. & Wang, X., Jul 22 2011, In : Circulation Research. 109, 3, p. 296-308 13 p.

Research output: Contribution to journalArticle

121 Scopus citations

COP9 signalosome regulates autophagosome maturation

Su, H., Li, F., Ranek, M. J., Wei, N. & Wang, X., Nov 8 2011, In : Circulation. 124, 19, p. 2117-2128 12 p.

Research output: Contribution to journalArticle

67 Scopus citations

COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation

Lei, D., Li, F., Su, H., Tian, Z., Ye, B., Wei, N. & Wang, X., Feb 2011, In : Cell Death and Differentiation. 18, 2, p. 259-270 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice

Li, J., Horak, K. M., Su, H., Sanbe, A., Robbins, J. & Wang, X., Sep 1 2011, In : Journal of Clinical Investigation. 121, 9, p. 3689-3700 12 p.

Research output: Contribution to journalArticle

127 Scopus citations

Enhancement of proteasome function by PA28α overexpression protects against oxidative stress

Li, J., Powell, S. R. & Wang, X., Mar 2011, In : FASEB Journal. 25, 3, p. 883-893 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Perturbation of cullin deneddylation via conditional Csn8 ablation impairs the ubiquitin-proteasome system and causes cardiomyocyte necrosis and dilated cardiomyopathy in mice

Su, H., Li, J., Menon, S., Liu, J., Kumarapeli, A. R., Wei, N. & Wang, X., Jan 7 2011, In : Circulation Research. 108, 1, p. 40-50 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Proteasome functional insufficiency in cardiac pathogenesis

Wang, X., Li, J., Zheng, H., Su, H. & Powell, S. R., Dec 2011, In : American Journal of Physiology - Heart and Circulatory Physiology. 301, 6, p. 2207-2219 13 p.

Research output: Contribution to journalArticle

50 Scopus citations

Sanggenon C decreases tumor cell viability associated with proteasome inhibition

Huang, H., Liu, N., Zhao, K., Zhu, C., Lu, X., Li, S., Lian, W., Zhou, P., Dong, X., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Lu, L., Li, X., Guan, L., Liu, C., Wang, X., Dou, Q. P. & 1 others, Liu, J., Jan 6 2011, In : Frontiers in Bioscience - Elite. 3 E, 4, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Shikonin extracted from medicinal Chinese herbs exerts anti-inflammatory effect via proteasome inhibition

Lu, L., Qin, A., Huang, H., Zhou, P., Zhang, C., Liu, N., Li, S., Wen, G., Zhang, C., Dong, W., Wang, X., Dou, Q. P. & Liu, J., May 11 2011, In : European Journal of Pharmacology. 658, 2-3, p. 242-247 6 p.

Research output: Contribution to journalArticle

94 Scopus citations
2010

Doxycycline attenuates protein aggregation in cardiomyocytes and improves survival of a mouse model of cardiac proteinopathy

Zheng, H., Tang, M., Zheng, Q., Kumarapeli, A. R. K., Horak, K. M., Tian, Z. & Wang, X., Oct 19 2010, In : Journal of the American College of Cardiology. 56, 17, p. 1418-1426 9 p.

Research output: Contribution to journalArticle

21 Scopus citations

Physiological levels of ATP negatively regulate proteasome function

Huang, H., Zhang, X., Li, S., Liu, N., Lian, W., McDowell, E., Zhou, P., Zhao, C., Guo, H., Zhang, C., Yang, C., Wen, G., Dong, X., Lu, L., Ma, N., Dong, W., Dou, Q. P., Wang, X. & Liu, J., Dec 2010, In : Cell Research. 20, 12, p. 1372-1385 14 p.

Research output: Contribution to journalArticle

83 Scopus citations

Proteasome functional insufficiency activates the calcineurin-NFAT pathway in cardiomyocytes and promotes maladaptive remodelling of stressed mouse hearts

Tang, M., Li, J., Huang, W., Su, H., Liang, Q., Tian, Z., Horak, K. M., Molkentin, J. D. & Wang, X., Dec 1 2010, In : Cardiovascular research. 88, 3, p. 424-433 10 p.

Research output: Contribution to journalArticle

73 Scopus citations

Protein quality control in protection against systolic overload cardiomyopathy: The long term role of small heat shock proteins

Kumarapeli, A. R. K., Horak, K. & Wang, X., 2010, In : American Journal of Translational Research. 2, 4, p. 390-401 12 p.

Research output: Contribution to journalArticle

11 Scopus citations
2009

Shikonin exerts antitumor activity via proteasome inhibition and cell death induction in vitro and in vivo

Yang, H., Zhou, P., Huang, H., Chen, D., Ma, N., Cui, Q. C., Shen, S., Dong, W., Zhang, X., Lian, W., Wang, X., Dou, Q. P. & Liu, J., May 15 2009, In : International Journal of Cancer. 124, 10, p. 2450-2459 10 p.

Research output: Contribution to journalArticle

128 Scopus citations
26 Scopus citations
2008
58 Scopus citations

Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons

Tydlacka, S., Wang, C. E., Wang, X., Li, S. & Li, X. J., Dec 3 2008, In : Journal of Neuroscience. 28, 49, p. 13285-13295 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Upregulation of myocardial 11S-activated proteasome in experimental hyperglycemia

Powell, S. R., Samuel, S. M., Wang, P., Divald, A., Thirunavukkarasu, M., Koneru, S., Wang, X. & Maulik, N., Mar 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 618-621 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

αb-crystallin suppresses pressure overload cardiac hypertrophy

Kumarapeli, A. R. K., Su, H., Huang, W., Tang, M., Zheng, H., Horak, K. M., Li, M. & Wang, X., Dec 5 2008, In : Circulation Research. 103, 12, p. 1473-1482 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

Cardiac-specific haploinsufficiency of β-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction

Qu, J., Zhou, J., Ping Yi, X., Dong, B., Zheng, H., Miller, L. M., Wang, X., Schneider, M. D. & Li, F., Sep 2007, In : Journal of Molecular and Cellular Cardiology. 43, 3, p. 319-326 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Diminished GATA4 protein levels contribute to hyperglycemia-induced cardiomyocyte injury

Kobayashi, S., Mao, K., Zheng, H., Wang, X., Patterson, C., O'Connell, T. D. & Liang, Q., Jul 27 2007, In : Journal of Biological Chemistry. 282, 30, p. 21945-21952 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Upregulation of γ-catenin compensates for the loss of β-catenin in adult cardiomyocytes

Zhou, J., Qu, J., Xian, P. Y., Graber, K., Huber, L., Wang, X., Gerdes, A. M. & Li, F., Jan 2007, In : American Journal of Physiology - Heart and Circulatory Physiology. 292, 1, p. H270-H276

Research output: Contribution to journalArticle

59 Scopus citations
2006
76 Scopus citations

Impairment of the ubiquitin-proteasome system in desminopathy mouse hearts

Liu, J., Chen, Q., Huang, W., Horak, K. M., Zheng, H., Mestril, R. & Wang, X., Feb 2006, In : FASEB Journal. 20, 2, p. 362-364 3 p.

Research output: Contribution to journalArticle

123 Scopus citations

Nuclear compartmentalization of FAK and FRNK in cardiac myocytes

Xian, P. Y., Zhou, J., Huber, L., Qu, J., Wang, X., Gerdes, A. M. & Li, F., Jun 2006, In : American Journal of Physiology - Heart and Circulatory Physiology. 290, 6, p. H2509-H2515

Research output: Contribution to journalArticle

20 Scopus citations
2005

A novel transgenic mouse model reveals deregulation of the ubiquitin-proteasome system in the heart by doxorubicin

Kumarapeli, A. R. K., Horak, K. M., Glasford, J. W., Li, J., Chen, Q., Liu, J., Zheng, H. & Wang, X., Dec 2005, In : FASEB Journal. 19, 14, p. 2051-2053 3 p.

Research output: Contribution to journalArticle

91 Scopus citations

Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake

Chen, Q., Liu, J. B., Horak, K. M., Zheng, H., Kumarapeli, A. R. K., Li, J., Li, F., Gerdes, A. M., Wawrousek, E. F. & Wang, X., Nov 2005, In : Circulation Research. 97, 10, p. 1018-1026 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Low thyroid function leads to cardiac atrophy with chamber dilatation, impaired myocardial blood flow, loss of arterioles, and severe systolic dysfunction

Tang, Y. D., Kuzman, J. A., Said, S., Anderson, B. E., Wang, X. & Gerdes, A. M., Nov 2005, In : Circulation. 112, 20, p. 3122-3130 9 p.

Research output: Contribution to journalArticle

113 Scopus citations

Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure

Xian, P. Y., Zhou, J., Baker, J., Wang, X., Gerdes, A. M. & Li, F., Jan 2005, In : Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 282, 1, p. 13-23 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy

Gard, J. J., Yamada, K., Green, K. G., Eloff, B. C., Rosenbaum, D. S., Wang, X., Robbins, J., Schuessler, R. B., Yamada, K. A. & Saffitz, J. E., Aug 15 2005, In : Cardiovascular research. 67, 3, p. 539-547 9 p.

Research output: Contribution to journalArticle

41 Scopus citations
2004

In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes

Dong, X., Liu, J., Zheng, H., Glasford, J. W., Huang, W., Chen, Q. H., Harden, N. R., Li, F., Gerdes, A. M. & Wang, X., Sep 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 287, 3 56-3, p. H1417-H1425

Research output: Contribution to journalArticle

50 Scopus citations
2003

Expression and distribution of desmosomal proteins in a transgenic mouse model of desmin-related cardiomyopathy

Huang, W., Ma, W. Z. & Wang, X. J., Jul 2003, In : Chinese Journal of Clinical Rehabilitation. 7, 15, p. 2152-2154 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium

Yi, X. P., Wang, X., Gerdes, A. M. & Li, F., Jun 1 2003, In : Hypertension. 41, 6, p. 1317-1323 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

αB-Crystallin Modulates Protein Aggregation of Abnormal Desmin

Wang, X., Klevitsky, R., Huang, W., Glasford, J., Li, F. & Robbins, J., Nov 14 2003, In : Circulation Research. 93, 10, p. 998-1005 8 p.

Research output: Contribution to journalArticle

93 Scopus citations
2002

Desmin filaments and cardiac disease: Establishing causality

Wang, X., Osinska, H., Gerdes, A. M. & Robbins, J., Dec 2002, In : Journal of Cardiac Failure. 8, 6 SUPPL., p. S287-S292

Research output: Contribution to journalArticle

42 Scopus citations
2001

Expression of R120G-αB-crystallin causes aberrant desmin and αB-crystallin aggregation and cardiomyopathy in mice

Wang, X., Osinska, H., Klevitsky, R., Gerdes, A. M., Nieman, M., Lorenz, J., Hewett, T. & Robbins, J., Jul 6 2001, In : Circulation Research. 89, 1, p. 84-91 8 p.

Research output: Contribution to journalArticle

Open Access
233 Scopus citations

Increased myocardial Rab GTPase expression: A consequence and cause of cardiomyopathy

Wu, G., Yussman, M. G., Barrett, T. J., Hahn, H. S., Osinska, H., Hilliard, G. M., Wang, X., Toyokawa, T., Yatani, A., Lynch, R. A., Robbins, J. & Dorn, G. W., Dec 7 2001, In : Circulation Research. 89, 12, p. 1130-1137 8 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Mouse model of desmin-related cardiomyopathy

Wang, X., Osinska, H., Dorn, G. W., Nieman, M., Lorenz, J. N., Gerdes, A. M., Witt, S., Kimball, T., Gulick, J. & Robbins, J., May 15 2001, In : Circulation. 103, 19, p. 2402-2407 6 p.

Research output: Contribution to journalArticle

162 Scopus citations

PKA-dependent phosphorylation of cardiac myosin binding protein C in transgenic mice

Yang, Q., Hewett, T. E., Klevitsky, R., Sanbe, A., Wang, X. & Robbins, J., 2001, In : Cardiovascular research. 51, 1, p. 80-88 9 p.

Research output: Contribution to journalArticle

17 Scopus citations
2000

In vivo analysis of an essential myosin light chain mutation linked to familial hypertrophic cardiomyopathy

Sanbe, A., Nelson, D., Gulick, J., Setser, E., Osinska, H., Wang, X., Hewett, T. E., Klevitsky, R., Hayes, E., Warshaw, D. M. & Robbins, J., Aug 18 2000, In : Circulation Research. 87, 4, p. 296-302 7 p.

Research output: Contribution to journalArticle

37 Scopus citations
1999

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling

Wang, X., Faqian, L., Campbell, S. E. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 319-331 13 p.

Research output: Contribution to journalArticle

73 Scopus citations

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling

Wang, X., Li, F. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 307-317 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: III. Intercalated disc remodeling

Wang, X. & Gerdes, A. M., Feb 1999, In : Journal of Molecular and Cellular Cardiology. 31, 2, p. 333-343 11 p.

Research output: Contribution to journalArticle

88 Scopus citations