Yazen Alnouti, PhD

  • 2340 Citations
  • 27 h-Index
20022020

Research output per year

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Research Output

  • 2340 Citations
  • 27 h-Index
  • 70 Article
  • 4 Review article
  • 1 Paper
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Article
2020

A year-long extended release nanoformulated cabotegravir prodrug

Kulkarni, T. A., Bade, A. N., Sillman, B., Shetty, B. L. D., Wojtkiewicz, M. S., Gautam, N., Hilaire, J. R., Sravanam, S., Szlachetka, A., Lamberty, B. G., Morsey, B. M., Fox, H. S., Alnouti, Y., McMillan, J. E. M., Mosley, R. L., Meza, J., Domanico, P. L., Yue, T. Y., Moore, G., Edagwa, B. J. & 1 others, Gendelman, H. E., Aug 1 2020, In : Nature Materials. 19, 8, p. 910-920 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Synthesis and Characterization of Long-Acting Darunavir Prodrugs

Banoub, M. G., Bade, A. N., Lin, Z., Cobb, D., Gautam, N., Dyavar Shetty, B. L., Wojtkiewicz, M., Alnouti, Y., McMillan, J., Gendelman, H. E. & Edagwa, B., Jan 6 2020, In : Molecular Pharmaceutics. 17, 1, p. 155-166 12 p.

Research output: Contribution to journalArticle

1 Scopus citations
2019

A long acting nanoformulated lamivudine ProTide

Smith, N., Bade, A. N., Soni, D., Gautam, N., Alnouti, Y., Herskovitz, J., Ibrahim, I. M., Wojtkiewicz, M. S., Dyavar Shetty, B. L., McMillan, J. E., Gendelman, H. E. & Edagwa, B., Dec 2019, In : Biomaterials. 223, 119476.

Research output: Contribution to journalArticle

5 Scopus citations

Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice

Dyavar, S. R., Gautam, N., Podany, A. T., Winchester, L. C., Weinhold, J. A., Mykris, T. M., Campbell, K. M., Alnouti, Y. & Fletcher, C. V., Oct 1 2019, In : The Journal of antimicrobial chemotherapy. 74, 10, p. 2974-2978 5 p.

Research output: Contribution to journalArticle

Creation of a long-acting rilpivirine prodrug nanoformulation

Hilaire, J. R., Bade, A. N., Sillman, B., Gautam, N., Herskovitz, J., Dyavar Shetty, B. L., Wojtkiewicz, M. S., Szlachetka, A., Lamberty, B. G., Sravanam, S., Fox, H. S., Alnouti, Y., Dash, P. K., McMillan, J. E. M., Edagwa, B. J. & Gendelman, H. E., Oct 2019, In : Journal of Controlled Release. 311-312, p. 201-211 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques

McMillan, J., Szlachetka, A., Zhou, T., Morsey, B., Lamberty, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., Gendelman, H. E. & Fox, H. S., Mar 1 2019, In : AIDS. 33, 3, p. 585-588 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Synthesis and characterization of a long-acting emtricitabine prodrug nanoformulation

Ibrahim, I. M., Bade, A. N., Lin, Z., Soni, D., Wojtkiewicz, M., Shetty, B. L. D., Gautam, N., McMillan, J. M., Alnouti, Y., Edagwa, B. J. & Gendelman, H. E., 2019, In : International journal of nanomedicine. 14, p. 6231-6247 17 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Synthesis of a long acting nanoformulated emtricitabine ProTide

Soni, D., Bade, A. N., Gautam, N., Herskovitz, J., Ibrahim, I. M., Smith, N., Wojtkiewicz, M. S., Dyavar Shetty, B. L., Alnouti, Y., McMillan, J. E., Gendelman, H. E. & Edagwa, B. J., Nov 2019, In : Biomaterials. 222, 119441.

Research output: Contribution to journalArticle

4 Scopus citations
2018

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., McMillan, J., Gautam, N., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Dec 1 2018, In : Nature communications. 9, 1, 443.

Research output: Contribution to journalArticle

37 Scopus citations

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

Zhou, T., Su, H., Dash, P., Lin, Z., Dyavar Shetty, B. L., Kocher, T., Szlachetka, A., Lamberty, B., Fox, H. S., Poluektova, L., Gorantla, S., McMillan, J. E., Gautam, N., Mosley, R. L., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Jan 2018, In : Biomaterials. 151, p. 53-65 13 p.

Research output: Contribution to journalArticle

39 Scopus citations

Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy

Kindel, T. L., Krause, C., Helm, M. C., McBride, C. L., Oleynikov, D., Thakare, R., Alamoudi, J., Kothari, V., Alnouti, Y. & Kohli, R., Feb 1 2018, In : Surgical endoscopy. 32, 2, p. 805-812 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C. T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D. E., Stärkel, P., Loomba, R., Coulter, S., Liddle, C., Yu, R. T., Ling, L., Rossi, S. J., DePaoli, A. M., Downes, M., Evans, R. M., Brenner, D. A. & 1 others, Schnabl, B., Jun 2018, In : Hepatology. 67, 6, p. 2150-2166 17 p.

Research output: Contribution to journalArticle

46 Scopus citations

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

Zhou, T., Lin, Z., Puligujja, P., Palandri, DI., Hilaire, J., Araínga, M., Smith, N., Gautam, N., McMillan, J., Alnouti, Y., Liu, X., Edagwa, B. & Gendelman, H. E., Apr 2018, In : Nanomedicine. 13, 8, p. 871-885 15 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pharmacokinetics of a long-acting nanoformulated dolutegravir prodrug in rhesus macaques

McMillan, J. E., Szlachetka, A., Slack, L., Sillman, B., Lamberty, B., Morsey, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., Gendelman, H. E. & Fox, H. S., Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01316-17.

Research output: Contribution to journalArticle

16 Scopus citations

ProTide generated long-acting abacavir nanoformulations

Lin, Z., Gautam, N., Alnouti, Y., McMillan, J., Bade, A. N., Gendelman, H. E. & Edagwa, B., 2018, In : Chemical Communications. 54, 60, p. 8371-8374 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Simultaneous LC–MS/MS analysis of eicosanoids and related metabolites in human serum, sputum and BALF

Thakare, R., Chhonker, Y. S., Gautam, N., Nelson, A., Casaburi, R., Criner, G., Dransfield, M. T., Make, B., Schmid, K. K., Rennard, S. I. & Alnouti, Y., Mar 2018, In : Biomedical Chromatography. 32, 3, e4102.

Research output: Contribution to journalArticle

13 Scopus citations

Simultaneous quantification of intracellular lamivudine and abacavir triphosphate metabolites by LC–MS/MS

Gautam, N., Lin, Z., Banoub, M. G., Smith, N. A., Maayah, A., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., May 10 2018, In : Journal of Pharmaceutical and Biomedical Analysis. 153, p. 248-259 12 p.

Research output: Contribution to journalArticle

7 Scopus citations

Species differences in bile acids I. Plasma and urine bile acid composition

Thakare, R., Alamoudi, J. A., Gautam, N., Rodrigues, A. D. & Alnouti, Y., Oct 2018, In : Journal of Applied Toxicology. 38, 10, p. 1323-1335 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Species differences in bile acids II. Bile acid metabolism

Thakare, R., Alamoudi, J. A., Gautam, N., Rodrigues, A. D. & Alnouti, Y., Oct 2018, In : Journal of Applied Toxicology. 38, 10, p. 1336-1352 17 p.

Research output: Contribution to journalArticle

7 Scopus citations
2017
2 Scopus citations

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

Gnanadhas, D. P., Dash, P. K., Sillman, B., Bade, A. N., Lin, Z., Palandri, D. L., Gautam, N., Alnouti, Y., Gelbard, H. A., McMillan, J. M., Mosley, R. L., Edagwa, B. J., Gendelman, H. E. & Gorantla, S., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 857-873 17 p.

Research output: Contribution to journalArticle

27 Scopus citations

Creation of a long-acting nanoformulated 29,39-dideoxy-39-thiacytidine

Guo, D., Zhou, T., Araínga, M., Palandri, D., Gautam, N., Bronich, T., Alnouti, Y., McMillan, J., Edagwa, B. & Gendelman, H. E., Mar 1 2017, In : Journal of Acquired Immune Deficiency Syndromes. 74, 3, p. e75-e83

Research output: Contribution to journalArticle

27 Scopus citations

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in frozen human plasma

Bowden, J. A., Heckert, A., Ulmer, C. Z., Jones, C. M., Koelmel, J. P., Abdullah, L., Ahonen, L., Alnouti, Y., Armando, A. M., Asara, J. M., Bamba, T., Barr, J. R., Bergquist, J., Borchers, C. H., Brandsma, J., Breitkopf, S. B., Cajka, T., Cazenave-Gassiot, A., Checa, A., Cinel, M. A. & 74 others, Colas, R. A., Cremers, S., Dennis, E. A., Evans, J. E., Fauland, A., Fiehn, O., Gardner, M. S., Garrett, T. J., Gotlinger, K. H., Han, J., Huang, Y., Neo, A. H., Hyötyläinen, T., Izumi, Y., Jiang, H., Jiang, H., Jiang, J., Kachman, M., Kiyonami, R., Klavins, K., Klose, C., Köfeler, H. C., Kolmert, J., Koal, T., Koster, G., Kuklenyik, Z., Kurland, I. J., Leadley, M., Lin, K., Maddipati, K. R., McDougall, D., Meikle, P. J., Mellett, N. A., Monnin, C., Moseley, M. A., Nandakumar, R., Oresic, M., Patterson, R., Peake, D., Pierce, J. S., Post, M., Postle, A. D., Pugh, R., Qiu, Y., Quehenberger, O., Ramrup, P., Rees, J., Rembiesa, B., Reynaud, D., Roth, M. R., Sales, S., Schuhmann, K., Schwartzman, M. L., Serhan, C. N., Shevchenko, A., Somerville, S. E., St John-Williams, L., Surma, M. A., Takeda, H., Thakare, R., Thompson, J. W., Torta, F., Triebl, A., Trötzmüller, M., Ubhayasekera, S. J. K., Vuckovic, D., Weir, J. M., Welti, R., Wenk, M. R., Wheelock, C. E., Yao, L., Yuan, M., Zhao, X. H. & Zhou, S., 2017, In : Journal of Lipid Research. 58, 12, p. 2275-2288 14 p.

Research output: Contribution to journalArticle

109 Scopus citations

Leveraging of rifampicin-dosed cynomolgus monkeys to identify bile acid 3-O-sulfate conjugates as potential novel biomarkers for organic anion-transporting polypeptidess

Thakare, R., Gao, H., Kosa, R. E., Bi, Y. A., Varma, M. V. S., Cerny, M. A., Sharma, R., Kuhn, M., Huang, B., Liu, Y., Yu, A., Walker, G. S., Niosi, M., Tremaine, L., Alnouti, Y. & Rodrigues, A. D., Jul 2017, In : Drug Metabolism and Disposition. 45, 7, p. 721-733 13 p.

Research output: Contribution to journalArticle

20 Scopus citations

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Wei, X., Li, F., Zhao, G., Chhonker, Y. S., Averill, C., Galdamez, J., Purdue, P. E., Wang, X., Fehringer, E. V., Garvin, K. L., Goldring, S. R., Alnouti, Y. & Wang, D., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

9 Scopus citations
2016

Development and characterization of a long-acting nanoformulated abacavir prodrug

Singh, D., McMillan, J. E., Hilaire, J., Gautam, N., Palandri, D., Alnouti, Y., Gendelman, H. E. & Edagwa, B., Aug 2016, In : Nanomedicine. 11, 15, p. 1913-1927 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities

Yang, Z., Liu, Y., Ahn, J., Qiao, Z., Endres, J. L., Gautam, N., Huang, Y., Li, J., Zheng, J. C., Alnouti, Y., Bayles, K. W. & Li, R., 2016, In : European Journal of Medicinal Chemistry. 124, p. 129-137 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

A major human oral lysophosphatidic acid species, LPA 18:1, regulates novel genes in human gingival fibroblasts

Cerutis, D. R., Weston, M. D., Alnouti, Y., Bathena, S. P., Nunn, M. E., Ogunleye, A. O., McVaney, T. P., Headen, K. V. & Miyamoto, T., May 1 2015, In : Journal of periodontology. 86, 5, p. 713-725 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

Coiro, P., Padmashri, R., Suresh, A., Spartz, E., Pendyala, G. N., Chou, S., Jung, Y., Meays, B., Roy, S., Gautam, N., Alnouti, Y., Li, M. & Dunaevsky-Hutt, A., Nov 1 2015, In : Brain, Behavior, and Immunity. 50, p. 249-258 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

Gautam, N., Thakare, R., Rana, S., Natarajan, A. & Alnouti, Y., Oct 3 2015, In : Xenobiotica. 45, 10, p. 858-873 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Urinary bile acids as biomarkers for liver diseases I. stability of the baseline profile in healthy subjects

Bathena, S. P. R., Thakare, R., Gautam, N., Mukherjee, S., Olivera, M., Meza, J. & Alnouti, Y., Feb 1 2015, In : Toxicological Sciences. 143, 2, p. 296-307 12 p., kfu227.

Research output: Contribution to journalArticle

25 Scopus citations

Urinary bile acids as biomarkers for liver diseases II. signature profiles in patients

Bathena, S. P. R., Thakare, R., Gautam, N., Mukherjee, S., Olivera, M., Meza, J. & Alnouti, Y., Feb 1 2015, In : Toxicological Sciences. 143, 2, p. 308-318 11 p., kfu228.

Research output: Contribution to journalArticle

19 Scopus citations
2014

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

Wang, L., Hartmann, P., Haimerl, M., Bathena, S. P., Sjöwall, C., Almer, S., Alnouti, Y., Hofmann, A. F. & Schnabl, B., Jun 2014, In : Journal of Hepatology. 60, 6, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pharmacokinetics, biodistribution, and toxicity of folic acid-coated antiretroviral nanoformulations

Gautam, N., Puligujja, P., Balkundi, S., Thakare, R., Liu, X. M., Fox, H. S., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., Dec 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7510-7519 10 p.

Research output: Contribution to journalArticle

14 Scopus citations
2013

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection

Epstein, A. A., Narayanasamy, P., Dash, P. K., High, R., Bathena, S. P. R., Gorantla, S., Poluektova, L. Y., Alnouti, Y., Gendelman, H. E. & Boska, M. D., Dec 2013, In : Journal of Neuroimmune Pharmacology. 8, 5, p. 1224-1238 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS

Gautam, N., Bathena, S. P. R., Chen, Q., Natarajan, A. & Alnouti, Y., Jul 2013, In : Biomedical Chromatography. 27, 7, p. 900-909 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy

Gautam, N., Roy, U., Balkundi, S., Puligujja, P., Guo, D., Smith, N., Liu, X. M., Lamberty, B., Morsey, B., Fox, H. S., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., Jul 2013, In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 3110-3120 11 p.

Research output: Contribution to journalArticle

43 Scopus citations

Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

Radhakrishnan, P., Bryant, V. C., Blowers, E. C., Rajule, R. N., Gautam, N., Anwar, M. M., Mohr, A. M., Grandgenett, P. M., Bunt, S. K., Arnst, J. L., Lele, S. M., Alnouti, Y., Hollingsworth, M. A. & Natarajan, A., Apr 15 2013, In : Clinical Cancer Research. 19, 8, p. 2025-2035 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

The profile of bile acids and their sulfate metabolites in human urine and serum

Bathena, S. P. R., Mukherjee, S., Olivera, M. & Alnouti, Y., Dec 30 2013, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 942-943, p. 53-62 10 p.

Research output: Contribution to journalArticle

54 Scopus citations
2012

Cisplatin-loaded core cross-linked micelles: Comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi, H. S., Nukolova, N. V., Laquer, F. C., Poluektova, L. Y., Huang, J., Alnouti, Y., Yokohira, M., Arnold, L. L., Kabanov, A. V., Cohen, S. M. & Bronich, T. K., 2012, In : International journal of nanomedicine. 7, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

40 Scopus citations

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

Dash, P. K., Gendelman, H. E., Roy, U., Balkundi, S., Alnouti, Y., Mosley, R. L., Gelbard, H. A., McMillan, J., Gorantla, S. & Poluektova, L. Y., Nov 13 2012, In : AIDS. 26, 17, p. 2135-2144 10 p.

Research output: Contribution to journalArticle

81 Scopus citations
42 Scopus citations
49 Scopus citations
20 Scopus citations
2011

Buspirone, fexofenadine, and omeprazole: Quantification of probe drugs and their metabolites in human plasma

Gor, P., Alnouti, Y. & Reed, G. A., Jul 15 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults)

Alnouti, Y. & Klaassen, C. D., Mar 2011, In : Xenobiotica. 41, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

35 Scopus citations

Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.

Flynn, C. A., Alnouti, Y. & Reed, G. A., Aug 30 2011, In : Rapid communications in mass spectrometry : RCM. 25, 16, p. 2361-2366 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS

Bathena, S. P., Huang, J., Nunn, M. E., Miyamoto, T., Parrish, L. C., Lang, M. S., McVaney, T. P., Toews, M. L., Cerutis, D. R. & Alnouti, Y., Sep 10 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 56, 2, p. 402-407 6 p.

Research output: Contribution to journalArticle

16 Scopus citations