Yazen Alnouti, PhD

  • 2417 Citations
  • 28 h-Index
20022020

Research output per year

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Research Output

  • 2417 Citations
  • 28 h-Index
  • 73 Article
  • 4 Review article
  • 1 Paper
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Article
2002
15 Scopus citations
2004
29 Scopus citations

Simultaneous determination of zidovudine and lamivudine from rat plasma, amniotic fluid and tissues by HPLC

Alnouti, Y., White, C. A. & Bartlett, M. G., Nov 2004, In : Biomedical Chromatography. 18, 9, p. 641-647 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Simultaneous quantitation of zidovudine and zidovudine monophosphate from plasma, amniotic fluid and tissues by micellar capillary electrophoresis

Alnouti, Y., White, C. A. & Bartlett, M. G., Oct 2004, In : Biomedical Chromatography. 18, 8, p. 523-531 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2005

Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma

Alnouti, Y., Srinivasan, K., Waddell, D., Bi, H., Kavetskaia, O. & Gusev, A. I., Jul 8 2005, In : Journal of Chromatography A. 1080, 2, p. 99-106 8 p.

Research output: Contribution to journalArticle

84 Scopus citations
26 Scopus citations

Simultaneous determination of zidovudine and lamivudine from rat tissues by liquid chromatography/tandem mass spectrometry

Alnouti, Y., Lewis, S. R., White, C. A. & Bartlett, M. G., 2005, In : Rapid Communications in Mass Spectrometry. 19, 4, p. 503-508 6 p.

Research output: Contribution to journalArticle

18 Scopus citations
2006

Method for internal standard introduction for quantitative analysis using on-line solid-phase extraction LC-MS/MS

Alnouti, Y., Li, M., Kavetskaia, O., Bi, H., Hop, C. E. C. A. & Gusev, A. I., Feb 15 2006, In : Analytical chemistry. 78, 4, p. 1331-1336 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Tissue distribution and ontogeny of organic cation transporters in mice

Alnouti, Y., Petrick, J. S. & Klaassen, C. D., Mar 2006, In : Drug Metabolism and Disposition. 34, 3, p. 477-482 6 p.

Research output: Contribution to journalArticle

105 Scopus citations

Tissue distribution and ontogeny of sulfotransferase enzymes in mice

Alnouti, Y. & Klaassen, C. D., Oct 2006, In : Toxicological Sciences. 93, 2, p. 242-255 14 p.

Research output: Contribution to journalArticle

144 Scopus citations
2008
168 Scopus citations

Regulation of sulfotransferase enzymes by prototypical microsomal enzyme inducers in mice

Alnouti, Y. & Klaassen, C. D., Feb 2008, In : Journal of Pharmacology and Experimental Therapeutics. 324, 2, p. 612-621 10 p.

Research output: Contribution to journalArticle

69 Scopus citations

Synthesis and evaluation of a well-defined HPMA copolymer-dexamethasone conjugate for effective treatment of rheumatoid arthritis

Liu, X. M., Quan, L. D., Tian, J., Alnouti, Y., Fu, K., Thiele, G. M. & Wang, D., Dec 2008, In : Pharmaceutical Research. 25, 12, p. 2910-2919 10 p.

Research output: Contribution to journalArticle

78 Scopus citations
92 Scopus citations
2010

Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)

Huang, J., Bathena, S. P., Tong, J., Roth, M., Hagenbuch, B. & Alnouti, Y., Mar 2010, In : Xenobiotica. 40, 3, p. 184-194 11 p.

Research output: Contribution to journalArticle

36 Scopus citations
31 Scopus citations

Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Quan, L. D., Yuan, F., Liu, X. M., Huang, J. G., Alnouti, Y. & Wang, D., Aug 2 2010, In : Molecular Pharmaceutics. 7, 4, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Praziquantel analogs with activity against juvenile Schistosoma mansoni

Dong, Y., Chollet, J., Vargas, M., Mansour, N. R., Bickle, Q., Alnouti, Y., Huang, J., Keiser, J. & Vennerstrom, J. L., Apr 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 8, p. 2481-2484 4 p.

Research output: Contribution to journalArticle

44 Scopus citations
2011

Buspirone, fexofenadine, and omeprazole: Quantification of probe drugs and their metabolites in human plasma

Gor, P., Alnouti, Y. & Reed, G. A., Jul 15 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults)

Alnouti, Y. & Klaassen, C. D., Mar 2011, In : Xenobiotica. 41, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.

Flynn, C. A., Alnouti, Y. & Reed, G. A., Aug 30 2011, In : Rapid communications in mass spectrometry : RCM. 25, 16, p. 2361-2366 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS

Bathena, S. P., Huang, J., Nunn, M. E., Miyamoto, T., Parrish, L. C., Lang, M. S., McVaney, T. P., Toews, M. L., Cerutis, D. R. & Alnouti, Y., Sep 10 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 56, 2, p. 402-407 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC-MS/MS

Huang, J., Bathena, S. P. R., Csanaky, I. L. & Alnouti, Y., Jul 15 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1111-1119 9 p.

Research output: Contribution to journalArticle

64 Scopus citations
25 Scopus citations
2012

Cisplatin-loaded core cross-linked micelles: Comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi, H. S., Nukolova, N. V., Laquer, F. C., Poluektova, L. Y., Huang, J., Alnouti, Y., Yokohira, M., Arnold, L. L., Kabanov, A. V., Cohen, S. M. & Bronich, T. K., 2012, In : International journal of nanomedicine. 7, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

40 Scopus citations

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

Dash, P. K., Gendelman, H. E., Roy, U., Balkundi, S., Alnouti, Y., Mosley, R. L., Gelbard, H. A., McMillan, J., Gorantla, S. & Poluektova, L. Y., Nov 13 2012, In : AIDS. 26, 17, p. 2135-2144 10 p.

Research output: Contribution to journalArticle

83 Scopus citations
42 Scopus citations
49 Scopus citations
20 Scopus citations
2013

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection

Epstein, A. A., Narayanasamy, P., Dash, P. K., High, R., Bathena, S. P. R., Gorantla, S., Poluektova, L. Y., Alnouti, Y., Gendelman, H. E. & Boska, M. D., Dec 2013, In : Journal of Neuroimmune Pharmacology. 8, 5, p. 1224-1238 15 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS

Gautam, N., Bathena, S. P. R., Chen, Q., Natarajan, A. & Alnouti, Y., Jul 2013, In : Biomedical Chromatography. 27, 7, p. 900-909 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy

Gautam, N., Roy, U., Balkundi, S., Puligujja, P., Guo, D., Smith, N., Liu, X. M., Lamberty, B., Morsey, B., Fox, H. S., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., Jul 2013, In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 3110-3120 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy

Radhakrishnan, P., Bryant, V. C., Blowers, E. C., Rajule, R. N., Gautam, N., Anwar, M. M., Mohr, A. M., Grandgenett, P. M., Bunt, S. K., Arnst, J. L., Lele, S. M., Alnouti, Y., Hollingsworth, M. A. & Natarajan, A., Apr 15 2013, In : Clinical Cancer Research. 19, 8, p. 2025-2035 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

The profile of bile acids and their sulfate metabolites in human urine and serum

Bathena, S. P. R., Mukherjee, S., Olivera, M. & Alnouti, Y., Dec 30 2013, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 942-943, p. 53-62 10 p.

Research output: Contribution to journalArticle

56 Scopus citations
2014

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

Wang, L., Hartmann, P., Haimerl, M., Bathena, S. P., Sjöwall, C., Almer, S., Alnouti, Y., Hofmann, A. F. & Schnabl, B., Jun 2014, In : Journal of Hepatology. 60, 6, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Pharmacokinetics, biodistribution, and toxicity of folic acid-coated antiretroviral nanoformulations

Gautam, N., Puligujja, P., Balkundi, S., Thakare, R., Liu, X. M., Fox, H. S., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., Dec 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7510-7519 10 p.

Research output: Contribution to journalArticle

15 Scopus citations
2015

A major human oral lysophosphatidic acid species, LPA 18:1, regulates novel genes in human gingival fibroblasts

Cerutis, D. R., Weston, M. D., Alnouti, Y., Bathena, S. P., Nunn, M. E., Ogunleye, A. O., McVaney, T. P., Headen, K. V. & Miyamoto, T., May 1 2015, In : Journal of periodontology. 86, 5, p. 713-725 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

Coiro, P., Padmashri, R., Suresh, A., Spartz, E., Pendyala, G. N., Chou, S., Jung, Y., Meays, B., Roy, S., Gautam, N., Alnouti, Y., Li, M. & Dunaevsky-Hutt, A., Nov 1 2015, In : Brain, Behavior, and Immunity. 50, p. 249-258 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

Gautam, N., Thakare, R., Rana, S., Natarajan, A. & Alnouti, Y., Oct 3 2015, In : Xenobiotica. 45, 10, p. 858-873 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Urinary bile acids as biomarkers for liver diseases I. stability of the baseline profile in healthy subjects

Bathena, S. P. R., Thakare, R., Gautam, N., Mukherjee, S., Olivera, M., Meza, J. & Alnouti, Y., Feb 1 2015, In : Toxicological Sciences. 143, 2, p. 296-307 12 p., kfu227.

Research output: Contribution to journalArticle

25 Scopus citations

Urinary bile acids as biomarkers for liver diseases II. signature profiles in patients

Bathena, S. P. R., Thakare, R., Gautam, N., Mukherjee, S., Olivera, M., Meza, J. & Alnouti, Y., Feb 1 2015, In : Toxicological Sciences. 143, 2, p. 308-318 11 p., kfu228.

Research output: Contribution to journalArticle

19 Scopus citations
2016

Development and characterization of a long-acting nanoformulated abacavir prodrug

Singh, D., McMillan, J. E., Hilaire, J., Gautam, N., Palandri, D., Alnouti, Y., Gendelman, H. E. & Edagwa, B., Aug 2016, In : Nanomedicine. 11, 15, p. 1913-1927 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities

Yang, Z., Liu, Y., Ahn, J., Qiao, Z., Endres, J. L., Gautam, N., Huang, Y., Li, J., Zheng, J. C., Alnouti, Y., Bayles, K. W. & Li, R., 2016, In : European Journal of Medicinal Chemistry. 124, p. 129-137 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
2017
2 Scopus citations

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

Gnanadhas, D. P., Dash, P. K., Sillman, B., Bade, A. N., Lin, Z., Palandri, D. L., Gautam, N., Alnouti, Y., Gelbard, H. A., McMillan, J. M., Mosley, R. L., Edagwa, B. J., Gendelman, H. E. & Gorantla, S., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 857-873 17 p.

Research output: Contribution to journalArticle

28 Scopus citations

Creation of a long-acting nanoformulated 29,39-dideoxy-39-thiacytidine

Guo, D., Zhou, T., Araínga, M., Palandri, D., Gautam, N., Bronich, T., Alnouti, Y., McMillan, J., Edagwa, B. & Gendelman, H. E., Mar 1 2017, In : Journal of Acquired Immune Deficiency Syndromes. 74, 3, p. e75-e83

Research output: Contribution to journalArticle

28 Scopus citations

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in frozen human plasma

Bowden, J. A., Heckert, A., Ulmer, C. Z., Jones, C. M., Koelmel, J. P., Abdullah, L., Ahonen, L., Alnouti, Y., Armando, A. M., Asara, J. M., Bamba, T., Barr, J. R., Bergquist, J., Borchers, C. H., Brandsma, J., Breitkopf, S. B., Cajka, T., Cazenave-Gassiot, A., Checa, A., Cinel, M. A. & 74 others, Colas, R. A., Cremers, S., Dennis, E. A., Evans, J. E., Fauland, A., Fiehn, O., Gardner, M. S., Garrett, T. J., Gotlinger, K. H., Han, J., Huang, Y., Neo, A. H., Hyötyläinen, T., Izumi, Y., Jiang, H., Jiang, H., Jiang, J., Kachman, M., Kiyonami, R., Klavins, K., Klose, C., Köfeler, H. C., Kolmert, J., Koal, T., Koster, G., Kuklenyik, Z., Kurland, I. J., Leadley, M., Lin, K., Maddipati, K. R., McDougall, D., Meikle, P. J., Mellett, N. A., Monnin, C., Moseley, M. A., Nandakumar, R., Oresic, M., Patterson, R., Peake, D., Pierce, J. S., Post, M., Postle, A. D., Pugh, R., Qiu, Y., Quehenberger, O., Ramrup, P., Rees, J., Rembiesa, B., Reynaud, D., Roth, M. R., Sales, S., Schuhmann, K., Schwartzman, M. L., Serhan, C. N., Shevchenko, A., Somerville, S. E., St John-Williams, L., Surma, M. A., Takeda, H., Thakare, R., Thompson, J. W., Torta, F., Triebl, A., Trötzmüller, M., Ubhayasekera, S. J. K., Vuckovic, D., Weir, J. M., Welti, R., Wenk, M. R., Wheelock, C. E., Yao, L., Yuan, M., Zhao, X. H. & Zhou, S., 2017, In : Journal of Lipid Research. 58, 12, p. 2275-2288 14 p.

Research output: Contribution to journalArticle

116 Scopus citations

Leveraging of rifampicin-dosed cynomolgus monkeys to identify bile acid 3-O-sulfate conjugates as potential novel biomarkers for organic anion-transporting polypeptidess

Thakare, R., Gao, H., Kosa, R. E., Bi, Y. A., Varma, M. V. S., Cerny, M. A., Sharma, R., Kuhn, M., Huang, B., Liu, Y., Yu, A., Walker, G. S., Niosi, M., Tremaine, L., Alnouti, Y. & Rodrigues, A. D., Jul 2017, In : Drug Metabolism and Disposition. 45, 7, p. 721-733 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Wei, X., Li, F., Zhao, G., Chhonker, Y. S., Averill, C., Galdamez, J., Purdue, P. E., Wang, X., Fehringer, E. V., Garvin, K. L., Goldring, S. R., Alnouti, Y. & Wang, D., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

12 Scopus citations
2018

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., McMillan, J., Gautam, N., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Dec 1 2018, In : Nature communications. 9, 1, 443.

Research output: Contribution to journalArticle

38 Scopus citations