Yazen Alnouti, PhD

  • 2417 Citations
  • 28 h-Index
20022020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 2417 Citations
  • 28 h-Index
  • 73 Article
  • 4 Review article
  • 1 Paper
Filter
Article
2 Scopus citations
1 Scopus citations

A long acting nanoformulated lamivudine ProTide

Smith, N., Bade, A. N., Soni, D., Gautam, N., Alnouti, Y., Herskovitz, J., Ibrahim, I. M., Wojtkiewicz, M. S., Dyavar Shetty, B. L., McMillan, J. E., Gendelman, H. E. & Edagwa, B., Dec 2019, In : Biomaterials. 223, 119476.

Research output: Contribution to journalArticle

6 Scopus citations

A major human oral lysophosphatidic acid species, LPA 18:1, regulates novel genes in human gingival fibroblasts

Cerutis, D. R., Weston, M. D., Alnouti, Y., Bathena, S. P., Nunn, M. E., Ogunleye, A. O., McVaney, T. P., Headen, K. V. & Miyamoto, T., May 1 2015, In : Journal of periodontology. 86, 5, p. 713-725 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Assessing the lymphoid tissue bioavailability of antiretrovirals in human primary lymphoid endothelial cells and in mice

Dyavar, S. R., Gautam, N., Podany, A. T., Winchester, L. C., Weinhold, J. A., Mykris, T. M., Campbell, K. M., Alnouti, Y. & Fletcher, C. V., Oct 1 2019, In : The Journal of antimicrobial chemotherapy. 74, 10, p. 2974-2978 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Autophagy facilitates macrophage depots of sustained-release nanoformulated antiretroviral drugs

Gnanadhas, D. P., Dash, P. K., Sillman, B., Bade, A. N., Lin, Z., Palandri, D. L., Gautam, N., Alnouti, Y., Gelbard, H. A., McMillan, J. M., Mosley, R. L., Edagwa, B. J., Gendelman, H. E. & Gorantla, S., Mar 1 2017, In : Journal of Clinical Investigation. 127, 3, p. 857-873 17 p.

Research output: Contribution to journalArticle

28 Scopus citations

A year-long extended release nanoformulated cabotegravir prodrug

Kulkarni, T. A., Bade, A. N., Sillman, B., Shetty, B. L. D., Wojtkiewicz, M. S., Gautam, N., Hilaire, J. R., Sravanam, S., Szlachetka, A., Lamberty, B. G., Morsey, B. M., Fox, H. S., Alnouti, Y., McMillan, J. E. M., Mosley, R. L., Meza, J., Domanico, P. L., Yue, T. Y., Moore, G., Edagwa, B. J. & 1 others, Gendelman, H. E., Aug 1 2020, In : Nature Materials. 19, 8, p. 910-920 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Buspirone, fexofenadine, and omeprazole: Quantification of probe drugs and their metabolites in human plasma

Gor, P., Alnouti, Y. & Reed, G. A., Jul 15 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 55, 5, p. 1127-1135 9 p.

Research output: Contribution to journalArticle

7 Scopus citations

Cisplatin-loaded core cross-linked micelles: Comparative pharmacokinetics, antitumor activity, and toxicity in mice

Oberoi, H. S., Nukolova, N. V., Laquer, F. C., Poluektova, L. Y., Huang, J., Alnouti, Y., Yokohira, M., Arnold, L. L., Kabanov, A. V., Cohen, S. M. & Bronich, T. K., 2012, In : International journal of nanomedicine. 7, p. 2557-2571 15 p.

Research output: Contribution to journalArticle

40 Scopus citations

Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection

Epstein, A. A., Narayanasamy, P., Dash, P. K., High, R., Bathena, S. P. R., Gorantla, S., Poluektova, L. Y., Alnouti, Y., Gendelman, H. E. & Boska, M. D., Dec 2013, In : Journal of Neuroimmune Pharmacology. 8, 5, p. 1224-1238 15 p.

Research output: Contribution to journalArticle

19 Scopus citations
15 Scopus citations

Creation of a long-acting nanoformulated 29,39-dideoxy-39-thiacytidine

Guo, D., Zhou, T., Araínga, M., Palandri, D., Gautam, N., Bronich, T., Alnouti, Y., McMillan, J., Edagwa, B. & Gendelman, H. E., Mar 1 2017, In : Journal of Acquired Immune Deficiency Syndromes. 74, 3, p. e75-e83

Research output: Contribution to journalArticle

28 Scopus citations

Creation of a long-acting nanoformulated dolutegravir

Sillman, B., Bade, A. N., Dash, P. K., Bhargavan, B., Kocher, T., Mathews, S., Su, H., Kanmogne, G. D., Poluektova, L. Y., Gorantla, S., McMillan, J., Gautam, N., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Dec 1 2018, In : Nature communications. 9, 1, 443.

Research output: Contribution to journalArticle

38 Scopus citations

Creation of a long-acting rilpivirine prodrug nanoformulation

Hilaire, J. R., Bade, A. N., Sillman, B., Gautam, N., Herskovitz, J., Dyavar Shetty, B. L., Wojtkiewicz, M. S., Szlachetka, A., Lamberty, B. G., Sravanam, S., Fox, H. S., Alnouti, Y., Dash, P. K., McMillan, J. E. M., Edagwa, B. J. & Gendelman, H. E., Oct 2019, In : Journal of Controlled Release. 311-312, p. 201-211 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles

Zhou, T., Su, H., Dash, P., Lin, Z., Dyavar Shetty, B. L., Kocher, T., Szlachetka, A., Lamberty, B., Fox, H. S., Poluektova, L., Gorantla, S., McMillan, J. E., Gautam, N., Mosley, R. L., Alnouti, Y., Edagwa, B. & Gendelman, H. E., Jan 2018, In : Biomaterials. 151, p. 53-65 13 p.

Research output: Contribution to journalArticle

39 Scopus citations
29 Scopus citations

Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma

Alnouti, Y., Srinivasan, K., Waddell, D., Bi, H., Kavetskaia, O. & Gusev, A. I., Jul 8 2005, In : Journal of Chromatography A. 1080, 2, p. 99-106 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

Development and characterization of a long-acting nanoformulated abacavir prodrug

Singh, D., McMillan, J. E., Hilaire, J., Gautam, N., Palandri, D., Alnouti, Y., Gendelman, H. E. & Edagwa, B., Aug 2016, In : Nanomedicine. 11, 15, p. 1913-1927 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

Sharma, S., Kozek, K. A., Abney, K. K., Kumar, S., Gautam, N., Alnouti, Y., David Weaver, C. & Hopkins, C. R., Mar 15 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 6, p. 791-796 6 p.

Research output: Contribution to journalArticle

Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in frozen human plasma

Bowden, J. A., Heckert, A., Ulmer, C. Z., Jones, C. M., Koelmel, J. P., Abdullah, L., Ahonen, L., Alnouti, Y., Armando, A. M., Asara, J. M., Bamba, T., Barr, J. R., Bergquist, J., Borchers, C. H., Brandsma, J., Breitkopf, S. B., Cajka, T., Cazenave-Gassiot, A., Checa, A., Cinel, M. A. & 74 others, Colas, R. A., Cremers, S., Dennis, E. A., Evans, J. E., Fauland, A., Fiehn, O., Gardner, M. S., Garrett, T. J., Gotlinger, K. H., Han, J., Huang, Y., Neo, A. H., Hyötyläinen, T., Izumi, Y., Jiang, H., Jiang, H., Jiang, J., Kachman, M., Kiyonami, R., Klavins, K., Klose, C., Köfeler, H. C., Kolmert, J., Koal, T., Koster, G., Kuklenyik, Z., Kurland, I. J., Leadley, M., Lin, K., Maddipati, K. R., McDougall, D., Meikle, P. J., Mellett, N. A., Monnin, C., Moseley, M. A., Nandakumar, R., Oresic, M., Patterson, R., Peake, D., Pierce, J. S., Post, M., Postle, A. D., Pugh, R., Qiu, Y., Quehenberger, O., Ramrup, P., Rees, J., Rembiesa, B., Reynaud, D., Roth, M. R., Sales, S., Schuhmann, K., Schwartzman, M. L., Serhan, C. N., Shevchenko, A., Somerville, S. E., St John-Williams, L., Surma, M. A., Takeda, H., Thakare, R., Thompson, J. W., Torta, F., Triebl, A., Trötzmüller, M., Ubhayasekera, S. J. K., Vuckovic, D., Weir, J. M., Welti, R., Wenk, M. R., Wheelock, C. E., Yao, L., Yuan, M., Zhao, X. H. & Zhou, S., 2017, In : Journal of Lipid Research. 58, 12, p. 2275-2288 14 p.

Research output: Contribution to journalArticle

116 Scopus citations

Head-to-head comparative pharmacokinetic and biodistribution (PK/BD) study of two dexamethasone prodrug nanomedicines on lupus-prone NZB/WF1 mice

Wei, X., Zhao, G., Wang, X., Gautam, N., Jia, Z., Zhao, Z., Kong, D., Zhang, F., Kumar, S., Sun, Y., Chen, N., Wang, X., Yang, L., Ren, R., Thiele, G. M., Bronich, T. K., O'Dell, J. R., Alnouti, Y. & Wang, D., Oct 2020, In : Nanomedicine: Nanotechnology, Biology, and Medicine. 29, 102266.

Research output: Contribution to journalArticle

Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders

Coiro, P., Padmashri, R., Suresh, A., Spartz, E., Pendyala, G. N., Chou, S., Jung, Y., Meays, B., Roy, S., Gautam, N., Alnouti, Y., Li, M. & Dunaevsky-Hutt, A., Nov 1 2015, In : Brain, Behavior, and Immunity. 50, p. 249-258 10 p.

Research output: Contribution to journalArticle

29 Scopus citations

Increased glycine-amidated hyocholic acid correlates to improved early weight loss after sleeve gastrectomy

Kindel, T. L., Krause, C., Helm, M. C., McBride, C. L., Oleynikov, D., Thakare, R., Alamoudi, J., Kothari, V., Alnouti, Y. & Kohli, R., Feb 1 2018, In : Surgical endoscopy. 32, 2, p. 805-812 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
26 Scopus citations

Irreversible binding of an anticancer compound (BI-94) to plasma proteins

Gautam, N., Thakare, R., Rana, S., Natarajan, A. & Alnouti, Y., Oct 3 2015, In : Xenobiotica. 45, 10, p. 858-873 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1)

Huang, J., Bathena, S. P., Tong, J., Roth, M., Hagenbuch, B. & Alnouti, Y., Mar 2010, In : Xenobiotica. 40, 3, p. 184-194 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

KVA-D-88, a Novel Preferable Phosphodiesterase 4B Inhibitor, Decreases Cocaine-Mediated Reward Properties in Vivo

Burkovetskaya, M. E., Liu, Q., Vadukoot, A. K., Gautam, N., Alnouti, Y., Kumar, S., Miczek, K., Buch, S., Hopkins, C. R. & Guo, M., Aug 5 2020, In : ACS Chemical Neuroscience. 11, 15, p. 2231-2242 12 p.

Research output: Contribution to journalArticle

Leveraging of rifampicin-dosed cynomolgus monkeys to identify bile acid 3-O-sulfate conjugates as potential novel biomarkers for organic anion-transporting polypeptidess

Thakare, R., Gao, H., Kosa, R. E., Bi, Y. A., Varma, M. V. S., Cerny, M. A., Sharma, R., Kuhn, M., Huang, B., Liu, Y., Yu, A., Walker, G. S., Niosi, M., Tremaine, L., Alnouti, Y. & Rodrigues, A. D., Jul 2017, In : Drug Metabolism and Disposition. 45, 7, p. 721-733 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice

Dash, P. K., Gendelman, H. E., Roy, U., Balkundi, S., Alnouti, Y., Mosley, R. L., Gelbard, H. A., McMillan, J., Gorantla, S. & Poluektova, L. Y., Nov 13 2012, In : AIDS. 26, 17, p. 2135-2144 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Mechanisms of gender-specific regulation of mouse sulfotransferases (Sults)

Alnouti, Y. & Klaassen, C. D., Mar 2011, In : Xenobiotica. 41, 3, p. 187-197 11 p.

Research output: Contribution to journalArticle

36 Scopus citations
31 Scopus citations

Method for internal standard introduction for quantitative analysis using on-line solid-phase extraction LC-MS/MS

Alnouti, Y., Li, M., Kavetskaia, O., Bi, H., Hop, C. E. C. A. & Gusev, A. I., Feb 15 2006, In : Analytical chemistry. 78, 4, p. 1331-1336 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

Hartmann, P., Hochrath, K., Horvath, A., Chen, P., Seebauer, C. T., Llorente, C., Wang, L., Alnouti, Y., Fouts, D. E., Stärkel, P., Loomba, R., Coulter, S., Liddle, C., Yu, R. T., Ling, L., Rossi, S. J., DePaoli, A. M., Downes, M., Evans, R. M., Brenner, D. A. & 1 others, Schnabl, B., Jun 2018, In : Hepatology. 67, 6, p. 2150-2166 17 p.

Research output: Contribution to journalArticle

54 Scopus citations
42 Scopus citations

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

Wang, L., Hartmann, P., Haimerl, M., Bathena, S. P., Sjöwall, C., Almer, S., Alnouti, Y., Hofmann, A. F. & Schnabl, B., Jun 2014, In : Journal of Hepatology. 60, 6, p. 1259-1267 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Novel fluorinated pyrrolomycins as potent anti-staphylococcal biofilm agents: Design, synthesis, pharmacokinetics and antibacterial activities

Yang, Z., Liu, Y., Ahn, J., Qiao, Z., Endres, J. L., Gautam, N., Huang, Y., Li, J., Zheng, J. C., Alnouti, Y., Bayles, K. W. & Li, R., 2016, In : European Journal of Medicinal Chemistry. 124, p. 129-137 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals

Zhou, T., Lin, Z., Puligujja, P., Palandri, DI., Hilaire, J., Araínga, M., Smith, N., Gautam, N., McMillan, J., Alnouti, Y., Liu, X., Edagwa, B. & Gendelman, H. E., Apr 2018, In : Nanomedicine. 13, 8, p. 871-885 15 p.

Research output: Contribution to journalArticle

12 Scopus citations
49 Scopus citations

Pharmacokinetic and Biodistribution Studies of HPMA Copolymer Conjugates in an Aseptic Implant Loosening Mouse Model

Wei, X., Li, F., Zhao, G., Chhonker, Y. S., Averill, C., Galdamez, J., Purdue, P. E., Wang, X., Fehringer, E. V., Garvin, K. L., Goldring, S. R., Alnouti, Y. & Wang, D., May 1 2017, In : Molecular Pharmaceutics. 14, 5, p. 1418-1428 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Pharmacokinetic and biodistribution studies of N -(2-hydroxypropyl) methacrylamide copolymer-dexamethasone conjugates in adjuvant-induced arthritis rat model

Quan, L. D., Yuan, F., Liu, X. M., Huang, J. G., Alnouti, Y. & Wang, D., Aug 2 2010, In : Molecular Pharmaceutics. 7, 4, p. 1041-1049 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

Pharmacokinetics, biodistribution, and toxicity of folic acid-coated antiretroviral nanoformulations

Gautam, N., Puligujja, P., Balkundi, S., Thakare, R., Liu, X. M., Fox, H. S., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., Dec 1 2014, In : Antimicrobial Agents and Chemotherapy. 58, 12, p. 7510-7519 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Pharmacokinetics, protein binding and metabolism of a quinoxaline urea analog as an NF-κB inhibitor in mice and rats by LC-MS/MS

Gautam, N., Bathena, S. P. R., Chen, Q., Natarajan, A. & Alnouti, Y., Jul 2013, In : Biomedical Chromatography. 27, 7, p. 900-909 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Pharmacokinetics of a long-acting nanoformulated dolutegravir prodrug in rhesus macaques

McMillan, J. E., Szlachetka, A., Slack, L., Sillman, B., Lamberty, B., Morsey, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., Gendelman, H. E. & Fox, H. S., Jan 2018, In : Antimicrobial Agents and Chemotherapy. 62, 1, e01316-17.

Research output: Contribution to journalArticle

16 Scopus citations

Pharmacokinetic testing of a first-generation cabotegravir prodrug in rhesus macaques

McMillan, J., Szlachetka, A., Zhou, T., Morsey, B., Lamberty, B., Callen, S., Gautam, N., Alnouti, Y., Edagwa, B., Gendelman, H. E. & Fox, H. S., Mar 1 2019, In : AIDS. 33, 3, p. 585-588 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Praziquantel analogs with activity against juvenile Schistosoma mansoni

Dong, Y., Chollet, J., Vargas, M., Mansour, N. R., Bickle, Q., Alnouti, Y., Huang, J., Keiser, J. & Vennerstrom, J. L., Apr 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 8, p. 2481-2484 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Preclinical pharmacokinetics and tissue distribution of long-acting nanoformulated antiretroviral therapy

Gautam, N., Roy, U., Balkundi, S., Puligujja, P., Guo, D., Smith, N., Liu, X. M., Lamberty, B., Morsey, B., Fox, H. S., McMillan, J. E., Gendelman, H. E. & Alnouti, Y., Jul 2013, In : Antimicrobial Agents and Chemotherapy. 57, 7, p. 3110-3120 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

ProTide generated long-acting abacavir nanoformulations

Lin, Z., Gautam, N., Alnouti, Y., McMillan, J., Bade, A. N., Gendelman, H. E. & Edagwa, B., 2018, In : Chemical Communications. 54, 60, p. 8371-8374 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.

Flynn, C. A., Alnouti, Y. & Reed, G. A., Aug 30 2011, In : Rapid communications in mass spectrometry : RCM. 25, 16, p. 2361-2366 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Quantitative determination of lysophosphatidic acids (LPAs) in human saliva and gingival crevicular fluid (GCF) by LC-MS/MS

Bathena, S. P., Huang, J., Nunn, M. E., Miyamoto, T., Parrish, L. C., Lang, M. S., McVaney, T. P., Toews, M. L., Cerutis, D. R. & Alnouti, Y., Sep 10 2011, In : Journal of Pharmaceutical and Biomedical Analysis. 56, 2, p. 402-407 6 p.

Research output: Contribution to journalArticle

17 Scopus citations
168 Scopus citations