Yuxiang Dong, PhD

  • 3214 Citations
  • 30 h-Index
1994 …2020

Research output per year

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Research Output

  • 3214 Citations
  • 30 h-Index
  • 76 Article
  • 5 Review article
  • 1 Comment/debate
  • 1 Short survey
2020

Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids

Wu, J., Wang, X., Chiu, F. C. K., Häberli, C., Shackleford, D. M., Ryan, E., Kamaraj, S., Bulbule, V. J., Wallick, A. I., Dong, Y., White, K. L., Davis, P. H., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3723-3736 14 p.

Research output: Contribution to journalArticle

Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67

Alshammari, A. M., Smith, D. D., Parriott, J., Stewart, J. P., Curran, S. M., McCulloh, R. J., Barry, P. A., Iyer, S. S., Palermo, N., Phillips, J. A., Dong, Y., Ronning, D. R., Vennerstrom, J. L., Sanderson, S. D. & Vetro, J. A., May 8 2020, In : ACS infectious diseases. 6, 5, p. 1169-1181 13 p.

Research output: Contribution to journalArticle

Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines

Leas, D. A., Dong, Y., Garrison, J. C., Wang, X., Ezell, E. L., Stack, D. E. & Vennerstrom, J. L., Feb 21 2020, In : Journal of Organic Chemistry. 85, 4, p. 2846-2853 8 p.

Research output: Contribution to journalArticle

2019

Design of Hedgehog pathway inhibitors for cancer treatment

Bariwal, J., Kumar, V., Dong, Y. & Mahato, R. I., May 2019, In : Medicinal Research Reviews. 39, 3, p. 1137-1204 68 p.

Research output: Contribution to journalReview article

6 Scopus citations

Polymeric micellar delivery of novel microtubule destabilizer and hedgehog signaling inhibitor for treating chemoresistant prostate cancer

Yang, R., Chen, H., Guo, D., Dong, Y., Miller, D. D., Li, W. & Mahato, R. I., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 864-875 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Stochastic Protein Alkylation by Antimalarial Peroxides

Jourdan, J., Walz, A., Matile, H., Schmidt, A., Wu, J., Wang, X., Dong, Y., Vennerstrom, J. L., Schmidt, R. S., Wittlin, S. & Mäser, P., Dec 13 2019, In : ACS infectious diseases. 5, 12, p. 2067-2075 9 p.

Research output: Contribution to journalArticle

2 Scopus citations

The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis

Kumar, V., Dong, Y., Kumar, V., Almawash, S. & Mahato, R. I., 2019, In : Theranostics. 9, 25, p. 7537-7555 19 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Formation of 2-Imino Benzo[e]-1,3-oxazin-4-ones from Reactions of Salicylic Acids and Anilines with HATU: Mechanistic and Synthetic Studies

Leas, D. A., Wu, J., Ezell, E. L., Garrison, J. C., Vennerstrom, J. L. & Dong, Y., Jan 31 2018, In : ACS Omega. 3, 1, p. 781-787 7 p.

Research output: Contribution to journalArticle

Progress in antischistosomal N,N′-diaryl urea SAR

Wu, J., Wang, C., Leas, D., Vargas, M., White, K. L., Shackleford, D. M., Chen, G., Sanford, A. G., Hemsley, R. M., Davis, P. H., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Feb 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 244-248 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

SAR of a new antischistosomal urea carboxylic acid

Wu, J., Wang, C., Häberli, C., White, K. L., Shackleford, D. M., Chen, G., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Dec 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 23-24, p. 3648-3651 4 p.

Research output: Contribution to journalArticle

1 Scopus citations

Synthesis of 2-Azaadamantan-6-one: A Missing Isomer

Wu, J., Leas, D. A., Dong, Y., Wang, X., Ezell, E. L., Stack, D. E. & Vennerstrom, J. L., Sep 30 2018, In : ACS Omega. 3, 9, p. 11362-11367 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2017

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Kumar, V., Chaudhary, A. K., Dong, Y., Zhong, H. A., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., Dec 1 2017, In : Scientific reports. 7, 1, 1665.

Research output: Contribution to journalArticle

14 Scopus citations

One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides

Leas, D. A., Dong, Y., Vennerstrom, J. L. & Stack, D. E., May 19 2017, In : Organic Letters. 19, 10, p. 2518-2521 4 p.

Research output: Contribution to journalArticle

17 Scopus citations

Semipinacol and protoadamantane-adamantane rearrangements of 5,6-dibromoadamantan-2-one and -2-ol

Wang, X., Dong, Y., Ezell, E. L., Garrison, J. C., Wood, J. K., Hagen, J. P. & Vennerstrom, J. L., 2017, In : Tetrahedron. 73, 20, p. 2972-2976 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide

Dong, Y., Lushnikova, T., Golla, R. M., Wang, X. & Wang, G., 2017, In : Bioorganic and Medicinal Chemistry. 25, 3, p. 864-869 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

Dong, Y., Wang, X., Kamaraj, S., Bulbule, V. J., Chiu, F. C. K., Chollet, J., Dhanasekaran, M., Hein, C. D., Papastogiannidis, P., Morizzi, J., Shackleford, D. M., Barker, H., Ryan, E., Scheurer, C., Tang, Y., Zhao, Q., Zhou, L., White, K. L., Urwyler, H., Charman, W. N. & 4 others, Matile, H., Wittlin, S., Charman, S. A. & Vennerstrom, J. L., Apr 13 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2654-2668 15 p.

Research output: Contribution to journalArticle

21 Scopus citations
2016

Antiprotozoal Selectivity of Diimidazoline N-Phenylbenzamides

Wang, X., Dong, Y., Cal, M., Kaiser, M., Wittlin, S. & Vennerstrom, J. L., Jan 8 2016, In : ACS infectious diseases. 1, 3, p. 135-139 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel)

Jourdan, J., Matile, H., Reift, E., Biehlmaier, O., Dong, Y., Wang, X., Mäser, P., Vennerstrom, J. L. & Wittlin, S., Jan 8 2016, In : ACS infectious diseases. 2, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

Wang, C., Zhao, Q., Vargas, M., Jones, J. O., White, K. L., Shackleford, D. M., Chen, G., Saunders, J., Ng, A. C. F., Chiu, F. C. K., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Dec 8 2016, In : Journal of Medicinal Chemistry. 59, 23, p. 10705-10718 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Coulter, D. W., McGuire, T. R., Sharp, J. G., McIntyre, E. M., Dong, Y., Wang, X., Gray, S., Alexander, G. R., Chatuverdi, N. K., Joshi, S. S., Chen, X. & Vennerstrom, J. L., Nov 8 2016, In : BMC cancer. 16, 1, 867.

Research output: Contribution to journalArticle

2015
14 Scopus citations
6 Scopus citations
2014

Activity of diimidazoline amides against African trypanosomiasis

Dong, Y., Wang, X., Cal, M., Kaiser, M. & Vennerstrom, J. L., Feb 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 3, p. 944-948 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes

Küster, T., Kriegel, N., Stadelmann, B., Wang, X., Dong, Y., Vennerstrom, J. L., Keiser, J. & Hemphill, A., Jan 2014, In : International Journal of Antimicrobial Agents. 43, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal

Keiser, J., Panic, G., Vargas, M., Wang, C., Dong, Y., Gautam, N. & Vennerstrom, J. L., Nov 12 2014, In : Journal of Antimicrobial Chemotherapy. 70, 6, p. 1788-1797 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice

Xue, J., Wang, X., Dong, Y., Vennerstrom, J. L. & Xiao, S. H., Sep 1 2014, In : Parasitology research. 113, 9, p. 3259-3266 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Short report: Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978

Wang, C., Zhao, Q., Min, J., Muniyan, S., Vargas, M., Wang, X., Dong, Y., Guy, R. K., Lin, M. F., Keiser, J. & Vennerstrom, J. L., Jun 2014, In : American Journal of Tropical Medicine and Hygiene. 90, 6, p. 1156-1158 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Tetrasubstituted pyrazinones derived from the reaction of praziquantel with N-bromosuccinimide

Zhao, Q., Wang, C., Ezell, E. L., Dong, Y. & Vennerstrom, J. L., Aug 6 2014, In : Tetrahedron Letters. 55, 32, p. 4463-4465 3 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres

Wang, X., Dong, Y., Wittlin, S., Charman, S. A., Chiu, F. C. K., Chollet, J., Katneni, K., Mannila, J., Morizzi, J., Ryan, E., Scheurer, C., Steuten, J., Santo Tomas, J., Snyder, C. & Vennerstrom, J. L., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2547-2555 9 p.

Research output: Contribution to journalArticle

51 Scopus citations
2012

In vivo activity of aryl ozonides against Schistosoma species

Keiser, J., Ingram, K., Vargas, M., Chollet, J., Wang, X., Dong, Y. & Vennerstrom, J. L., Feb 2012, In : Antimicrobial Agents and Chemotherapy. 56, 2, p. 1090-1092 3 p.

Research output: Contribution to journalArticle

47 Scopus citations

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

Sabbah, D. A., Simms, N. A., Wang, W., Dong, Y., Ezell, E. L., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Dec 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 24, p. 7175-7183 9 p.

Research output: Contribution to journalArticle

24 Scopus citations
2011

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni

Kirchhofer, C., Vargas, M., Braissant, O., Dong, Y., Wang, X., Vennerstrom, J. L. & Keiser, J., Apr 2011, In : Acta Tropica. 118, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Charman, S. A., Arbe-Barnes, S., Bathurst, I. C., Brund, R., Campbell, M., Charman, W. N., Chiu, F. C. K., Chollet, J., Craft, J. C., Creek, D. J., Don, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D. M., Sriraghavan, K., Stingelin, L. & 7 others, Tang, Y., Urwyler, H., Wang, X., White, K. L., Wittlin, S., Zhou, L. & Vennerstrom, J. L., Mar 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4400-4405 6 p.

Research output: Contribution to journalArticle

254 Scopus citations

The activity of dispiro peroxides against Fasciola hepatica

Wang, X., Zhao, Q., Vargas, M., Dong, Y., Sriraghavan, K., Keiser, J. & Vennerstrom, J. L., Sep 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 18, p. 5320-5323 4 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

Keiser, J., Kirchhofer, C., Haschke, M., Huwyler, J., Dong, Y., Vennerstrom, J. L., Vanhoff, K., Kaminsky, R. & Malikides, N., Oct 29 2010, In : Veterinary Parasitology. 173, 3-4, p. 228-235 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

Nuss, J. E., Dong, Y., Wanner, L. M., Ruthel, G., Wipf, P., Gussio, R., Vennerstrom, J. L., Bavari, S. & Burnett, J. C., Oct 14 2010, In : ACS Medicinal Chemistry Letters. 1, 7, p. 301-305 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers

Flaherty, D. P., Kiyota, T., Dong, Y., Ikezu, T. & Vennerstrom, J. L., Nov 25 2010, In : Journal of Medicinal Chemistry. 53, 22, p. 7992-7999 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Praziquantel analogs with activity against juvenile Schistosoma mansoni

Dong, Y., Chollet, J., Vargas, M., Mansour, N. R., Bickle, Q., Alnouti, Y., Huang, J., Keiser, J. & Vennerstrom, J. L., Apr 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 8, p. 2481-2484 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals

Fügi, M. A., Wittlin, S., Dong, Y. & Vennerstrom, J. L., Mar 2010, In : Antimicrobial Agents and Chemotherapy. 54, 3, p. 1042-1046 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Structure-activity relationship of an ozonide carboxylic acid (oz78) against fasciola hepatica

Zhao, Q., Vargas, M., Dong, Y., Zhou, L., Wang, X., Sriraghavan, K., Keiser, J. & Vennerstrom, J. L., May 27 2010, In : Journal of Medicinal Chemistry. 53, 10, p. 4223-4233 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L. M., Tomas, J. S., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J. L., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563-566 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

The structure - Activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Tomas, J. S., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J. L., 2010, In : Journal of Medicinal Chemistry. 53, 1, p. 481-491 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone

Dong, Y., McCullough, K. J., Wittlin, S., Chollet, J. & Vennerstrom, J. L., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6359-6361 3 p.

Research output: Contribution to journalArticle

20 Scopus citations
2009

A one-pot synthesis of unsymmetrical bis-styrylbenzenes

Flaherty, D. P., Dong, Y. & Vennerstrom, J. L., Nov 18 2009, In : Tetrahedron Letters. 50, 46, p. 6228-6230 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines

Duryee, M. J., Bevins, R. A., Reichel, C. M., Murray, J. E., Dong, Y., Thiele, G. M. & Sanderson, S. D., May 14 2009, In : Vaccine. 27, 22, p. 2981-2988 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Single-step conjugation of bioactive peptides to proteins via a self-contained succinimidyl bis-arylhydrazone

Phillips, J. A., Morgan, E. L., Dong, Y., Cole, G. T., McMahan, C., Hung, C. Y. & Sanderson, S. D., Oct 21 2009, In : Bioconjugate Chemistry. 20, 10, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity

Wang, X., Creek, D. J., Schiaffo, C. E., Dong, Y., Chollet, J., Scheurer, C., Wittlin, S., Charman, S. A., Dussault, P. H., Wood, J. K. & Vennerstrom, J. L., Aug 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4542-4545 4 p.

Research output: Contribution to journalArticle

21 Scopus citations
2008

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F. C. K., Morizzi, J., Charman, S. A., Charman, W. N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D. & Vennerstrom, J. L., Mar 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1555-1558 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., Dong, Y., Vennerstrom, J. L. & Charman, S. A., Apr 2008, In : Antimicrobial Agents and Chemotherapy. 52, 4, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

79 Scopus citations
2007

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica

Keiser, J., Utzinger, J., Vennerstrom, J. L., Dong, Y., Brennan, G. & Fairweather, I., Dec 2007, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 101, 12, p. 1219-1222 4 p.

Research output: Contribution to journalArticle

47 Scopus citations