Yuxiang Dong, PhD

  • 3231 Citations
  • 30 h-Index
1994 …2020

Research output per year

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Research Output

  • 3231 Citations
  • 30 h-Index
  • 76 Article
  • 5 Review article
  • 1 Comment/debate
  • 1 Short survey
1994

Natural-Abundance Oxygen-17 NMR Spectra of Ozonides

Hock, F., Ball, V., Dong, Y., Gutsche, S. H., Hilss, M., Schlindwein, K. & Griesbaum, K., 1994, In : Journal of Magnetic Resonance, Series A. 111, 2, p. 150-154 5 p.

Research output: Contribution to journalArticle

18 Scopus citations
1995

Ozonolyses of O‐methyloximes in the presence of acid derivatives: A new access to substituted ozonides

Griesbaum, K., Övez, B., Huh, T. S. & Dong, Y., Jul 24 1995, In : Liebigs Annalen. 1995, 8, p. 1571-1574 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
1997

Diozonides from coozonolyses of suitable O-methyl oximes and ketones

Griesbaum, K., Liu, X. & Dong, Y., Apr 14 1997, In : Tetrahedron. 53, 15, p. 5463-5470 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
2 Scopus citations

Ozonolyses of Acetylenes: Trapping of α-Oxo Carbonyl Oxides by Carbonyl Compounds and Stabilization of α-Oxo Ozonides by Derivatizations

Griesbaum, K., Dong, Y. & McCullough, K. J., 1997, In : Journal of Organic Chemistry. 62, 18, p. 6129-6136 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ozonolyses of acetylenes revisited

Griesbaum, K. & Dong, Y., 1997, In : Advanced Synthesis and Catalysis. 339, 6, p. 575-577 3 p.

Research output: Contribution to journalArticle

Ozonolyses of acetylenes revisited

Griesbaum, K. & Dong, Y., 1997, In : Journal fur Praktische Chemie - Chemiker - Zeitung. 339, 6, p. 575-577 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Short path syntheses of α-diozonides by sequential ozonolyses of acetylenes and O-methyl oximes

Dong, Y., Griesbaum, K. & McCullough, K. J., Jun 7 1997, In : Journal of the Chemical Society - Perkin Transactions 1. 11, p. 1601-1604 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1999
86 Scopus citations
2000

Methyl-substituted dispiro-1,2,4,5-tetraoxanes: Correlations of structural studies with antimalarial activity

McCullough, K. J., Wood, J. K., Bhattacharjee, A. K., Dong, Y., Kyle, D. E., Milhous, W. K. & Vennerstrom, J. L., Mar 23 2000, In : Journal of Medicinal Chemistry. 43, 6, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

59 Scopus citations

Synthesis and antimalarial activity of sixteen dispiro- 1,2,4,5-tetraoxanes: Alkyl-substituted 7,8,15,16- tetraoxadispiro[5.2.5.2]hexadecanes

Vennerstrom, J. L., Dong, Y., Andersen, S. L., Ager, A. L., Fu, H. N., Miller, R. E., Wesche, D. L., Kyle, D. E., Gerena, L., Walters, S. M., Wood, J. K., Edwards, G., Holme, A. D., McLean, W. G. & Milhous, W. K., Jul 13 2000, In : Journal of Medicinal Chemistry. 43, 14, p. 2753-2758 6 p.

Research output: Contribution to journalArticle

77 Scopus citations
2001
19 Scopus citations

Peroxidic antimalarials

Dong, Y. & Vennerstrom, J. L., 2001, In : Expert Opinion on Therapeutic Patents. 11, 11, p. 1753-1760 8 p.

Research output: Contribution to journalReview article

11 Scopus citations
2002

Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes.

Dong, Y., Apr 2002, In : Mini reviews in medicinal chemistry. 2, 2, p. 113-123 11 p.

Research output: Contribution to journalReview article

61 Scopus citations
2003

Mechanisms of in situ activation of peroxidic antimalarials

Dong, Y. & Vennerstrom, J. L., 2003, In : Redox Report. 8, 5, p. 284-288 5 p.

Research output: Contribution to journalReview article

19 Scopus citations
2004

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe-Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., McIntosh, K., Padmanilayam, M., Santo Tomas, J., Scheurer, C., Scorneaux, B., Tang, Y., Urwyler, H., Wittlin, S. & Charman, W. H., Aug 19 2004, In : Nature. 430, 7002, p. 900-904 5 p.

Research output: Contribution to journalArticle

533 Scopus citations
67 Scopus citations

Synthetic peroxides as antimalarizals

Tang, Y., Dong, Y. & Vennerstrom, J. L., Jul 2004, In : Medicinal Research Reviews. 24, 4, p. 425-448 24 p.

Research output: Contribution to journalReview article

226 Scopus citations

The reaction of carbonyldiimidazole with alcohols to form carbamates and N-alkylimidazoles

Tang, Y., Dong, Y. & Vennerstrom, J. L., Oct 18 2004, In : Synthesis. 15, p. 2540-2544 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2005
90 Scopus citations

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes

Dong, Y., Chollet, J., Matile, H., Charman, S. A., Chiu, F. C. K., Charman, W. N., Scorneaux, B., Urwyler, H., Santo Tomas, J., Scheurer, C., Snyder, C., Dorn, A., Wang, X., Karle, J. M., Tang, Y., Wittlin, S., Brun, R. & Vennerstrom, J. L., Jul 28 2005, In : Journal of Medicinal Chemistry. 48, 15, p. 4953-4961 9 p.

Research output: Contribution to journalArticle

95 Scopus citations
2006

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Padmanilayam, M., Scorneaux, B., Dong, Y., Chollet, J., Matile, H., Charman, S. A., Creek, D. J., Charman, W. N., Tomas, J. S., Scheurer, C., Wittlin, S., Brun, R. & Vennerstrom, J. L., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5542-5545 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials

Perry, C. S., Charman, S. A., Prankerd, R. J., Chiu, F. C. K., Dong, Y., Vennerstrom, J. L. & Charman, W. N., Apr 2006, In : Journal of Pharmaceutical Sciences. 95, 4, p. 737-747 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

Dong, Y., Tang, Y., Chollet, J., Matile, H., Wittlin, S., Charman, S. A., Charman, W. N., Tomas, J. S., Scheurer, C., Snyder, C., Scorneaux, B., Bajpai, S., Alexander, S. A., Wang, X., Padmanilayam, M., Cheruku, S. R., Brun, R. & Vennerstrom, J. L., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6368-6382 15 p.

Research output: Contribution to journalArticle

58 Scopus citations

The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica

Keiser, J., Utzinger, J., Tanner, M., Dong, Y. & Vennerstrom, J. L., Dec 2006, In : Journal of Antimicrobial Chemotherapy. 58, 6, p. 1193-1197 5 p.

Research output: Contribution to journalArticle

56 Scopus citations
2007

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica

Keiser, J., Utzinger, J., Vennerstrom, J. L., Dong, Y., Brennan, G. & Fairweather, I., Dec 2007, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 101, 12, p. 1219-1222 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Dong, Y., Creek, D., Chollet, J., Matile, H., Charman, S. A., Wittlin, S., Wood, J. K. & Vennerstrom, J. L., Aug 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 3033-3035 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species

Xiao, S. H., Keiser, J., Chollet, J., Utzinger, J., Dong, Y., Endriss, Y., Vennerstrom, J. L. & Tanner, M., Apr 2007, In : Antimicrobial Agents and Chemotherapy. 51, 4, p. 1440-1445 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., McCullough, K. J., Dong, Y., Vennerstrom, J. L. & Charman, S. A., Nov 2007, In : Journal of Pharmaceutical Sciences. 96, 11, p. 2945-2956 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Kaiser, M., Wittlin, S., Nehrbass-Stuedli, A., Dong, Y., Wang, X., Hemphill, A., Matile, H., Brun, R. & Vennerstrom, J. L., Aug 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 2991-2993 3 p.

Research output: Contribution to journalArticle

63 Scopus citations

Polyfluorinated bis-styrylbenzene β-amyloid plaque binding ligands

Flaherty, D. P., Walsh, S. M., Kiyota, T., Dong, Y., Ikezu, T. & Vennerstrom, J. L., Oct 20 2007, In : Journal of Medicinal Chemistry. 50, 20, p. 4986-4992 7 p.

Research output: Contribution to journalArticle

53 Scopus citations

Spiro- and dispiro-1,2-dioxolanes: Contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides

Wang, X., Dong, Y., Wittlin, S., Creek, D., Chollet, J., Charman, S. A., Tomas, J. S., Scheurer, C., Snyder, C. & Vennerstrom, J. L., Nov 15 2007, In : Journal of Medicinal Chemistry. 50, 23, p. 5840-5847 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Tang, Y., Dong, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Charman, W. N., Matile, H., Urwyler, H., Dorn, A., Bajpai, S., Wang, X., Padmanilayam, M., Karle, J. M., Brun, R. & Vennerstrom, J. L., Mar 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
2008

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F. C. K., Morizzi, J., Charman, S. A., Charman, W. N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D. & Vennerstrom, J. L., Mar 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1555-1558 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., Dong, Y., Vennerstrom, J. L. & Charman, S. A., Apr 2008, In : Antimicrobial Agents and Chemotherapy. 52, 4, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

80 Scopus citations
2009

A one-pot synthesis of unsymmetrical bis-styrylbenzenes

Flaherty, D. P., Dong, Y. & Vennerstrom, J. L., Nov 18 2009, In : Tetrahedron Letters. 50, 46, p. 6228-6230 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines

Duryee, M. J., Bevins, R. A., Reichel, C. M., Murray, J. E., Dong, Y., Thiele, G. M. & Sanderson, S. D., May 14 2009, In : Vaccine. 27, 22, p. 2981-2988 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

Single-step conjugation of bioactive peptides to proteins via a self-contained succinimidyl bis-arylhydrazone

Phillips, J. A., Morgan, E. L., Dong, Y., Cole, G. T., McMahan, C., Hung, C. Y. & Sanderson, S. D., Oct 21 2009, In : Bioconjugate Chemistry. 20, 10, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity

Wang, X., Creek, D. J., Schiaffo, C. E., Dong, Y., Chollet, J., Scheurer, C., Wittlin, S., Charman, S. A., Dussault, P. H., Wood, J. K. & Vennerstrom, J. L., Aug 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4542-4545 4 p.

Research output: Contribution to journalArticle

21 Scopus citations
2010

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

Keiser, J., Kirchhofer, C., Haschke, M., Huwyler, J., Dong, Y., Vennerstrom, J. L., Vanhoff, K., Kaminsky, R. & Malikides, N., Oct 29 2010, In : Veterinary Parasitology. 173, 3-4, p. 228-235 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

Nuss, J. E., Dong, Y., Wanner, L. M., Ruthel, G., Wipf, P., Gussio, R., Vennerstrom, J. L., Bavari, S. & Burnett, J. C., Oct 14 2010, In : ACS Medicinal Chemistry Letters. 1, 7, p. 301-305 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers

Flaherty, D. P., Kiyota, T., Dong, Y., Ikezu, T. & Vennerstrom, J. L., Nov 25 2010, In : Journal of Medicinal Chemistry. 53, 22, p. 7992-7999 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Praziquantel analogs with activity against juvenile Schistosoma mansoni

Dong, Y., Chollet, J., Vargas, M., Mansour, N. R., Bickle, Q., Alnouti, Y., Huang, J., Keiser, J. & Vennerstrom, J. L., Apr 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 8, p. 2481-2484 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals

Fügi, M. A., Wittlin, S., Dong, Y. & Vennerstrom, J. L., Mar 2010, In : Antimicrobial Agents and Chemotherapy. 54, 3, p. 1042-1046 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Structure-activity relationship of an ozonide carboxylic acid (oz78) against fasciola hepatica

Zhao, Q., Vargas, M., Dong, Y., Zhou, L., Wang, X., Sriraghavan, K., Keiser, J. & Vennerstrom, J. L., May 27 2010, In : Journal of Medicinal Chemistry. 53, 10, p. 4223-4233 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L. M., Tomas, J. S., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J. L., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563-566 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

The structure - Activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Tomas, J. S., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J. L., 2010, In : Journal of Medicinal Chemistry. 53, 1, p. 481-491 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone

Dong, Y., McCullough, K. J., Wittlin, S., Chollet, J. & Vennerstrom, J. L., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6359-6361 3 p.

Research output: Contribution to journalArticle

20 Scopus citations
2011

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni

Kirchhofer, C., Vargas, M., Braissant, O., Dong, Y., Wang, X., Vennerstrom, J. L. & Keiser, J., Apr 2011, In : Acta Tropica. 118, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

30 Scopus citations