Yuxiang Dong, PhD

  • 3259 Citations
  • 30 h-Index
1994 …2020

Research output per year

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Research Output

  • 3259 Citations
  • 30 h-Index
  • 76 Article
  • 5 Review article
  • 1 Comment/debate
  • 1 Short survey
Article

Activity of artemether and OZ78 against triclabendazole-resistant Fasciola hepatica

Keiser, J., Utzinger, J., Vennerstrom, J. L., Dong, Y., Brennan, G. & Fairweather, I., Dec 2007, In : Transactions of the Royal Society of Tropical Medicine and Hygiene. 101, 12, p. 1219-1222 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Activity of diimidazoline amides against African trypanosomiasis

Dong, Y., Wang, X., Cal, M., Kaiser, M. & Vennerstrom, J. L., Feb 1 2014, In : Bioorganic and Medicinal Chemistry Letters. 24, 3, p. 944-948 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

Activity of OZ78 analogues against Fasciola hepatica and Echinostoma caproni

Kirchhofer, C., Vargas, M., Braissant, O., Dong, Y., Wang, X., Vennerstrom, J. L. & Keiser, J., Apr 2011, In : Acta Tropica. 118, 1, p. 56-62 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes

Küster, T., Kriegel, N., Stadelmann, B., Wang, X., Dong, Y., Vennerstrom, J. L., Keiser, J. & Hemphill, A., Jan 2014, In : International Journal of Antimicrobial Agents. 43, 1, p. 40-46 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Padmanilayam, M., Scorneaux, B., Dong, Y., Chollet, J., Matile, H., Charman, S. A., Creek, D. J., Charman, W. N., Tomas, J. S., Scheurer, C., Wittlin, S., Brun, R. & Vennerstrom, J. L., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5542-5545 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Antiprotozoal Selectivity of Diimidazoline N-Phenylbenzamides

Wang, X., Dong, Y., Cal, M., Kaiser, M., Wittlin, S. & Vennerstrom, J. L., Jan 8 2016, In : ACS infectious diseases. 1, 3, p. 135-139 5 p.

Research output: Contribution to journalArticle

3 Scopus citations

A one-pot synthesis of unsymmetrical bis-styrylbenzenes

Flaherty, D. P., Dong, Y. & Vennerstrom, J. L., Nov 18 2009, In : Tetrahedron Letters. 50, 46, p. 6228-6230 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Aryl hydantoin Ro 13-3978, a broad-spectrum antischistosomal

Keiser, J., Panic, G., Vargas, M., Wang, C., Dong, Y., Gautam, N. & Vennerstrom, J. L., Nov 12 2014, In : Journal of Antimicrobial Chemotherapy. 70, 6, p. 1788-1797 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277

Zhou, L., Alker, A., Ruf, A., Wang, X., Chiu, F. C. K., Morizzi, J., Charman, S. A., Charman, W. N., Scheurer, C., Wittlin, S., Dong, Y., Hunziker, D. & Vennerstrom, J. L., Mar 1 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 5, p. 1555-1558 4 p.

Research output: Contribution to journalArticle

29 Scopus citations

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials

Perry, C. S., Charman, S. A., Prankerd, R. J., Chiu, F. C. K., Dong, Y., Vennerstrom, J. L. & Charman, W. N., Apr 2006, In : Journal of Pharmaceutical Sciences. 95, 4, p. 737-747 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Comparative antimalarial activities and ADME profiles of ozonides (1,2,4-trioxolanes) OZ277, OZ439, and their 1,2-dioxolane, 1,2,4-trioxane, and 1,2,4,5-tetraoxane isosteres

Wang, X., Dong, Y., Wittlin, S., Charman, S. A., Chiu, F. C. K., Chollet, J., Katneni, K., Mannila, J., Morizzi, J., Ryan, E., Scheurer, C., Steuten, J., Santo Tomas, J., Snyder, C. & Vennerstrom, J. L., Mar 28 2013, In : Journal of Medicinal Chemistry. 56, 6, p. 2547-2555 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Dong, Y., Creek, D., Chollet, J., Matile, H., Charman, S. A., Wittlin, S., Wood, J. K. & Vennerstrom, J. L., Aug 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 3033-3035 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

Design, Synthesis and Biological Evaluation of novel Hedgehog Inhibitors for treating Pancreatic Cancer

Kumar, V., Chaudhary, A. K., Dong, Y., Zhong, H. A., Mondal, G., Lin, F., Kumar, V. & Mahato, R. I., Dec 1 2017, In : Scientific reports. 7, 1, 1665.

Research output: Contribution to journalArticle

15 Scopus citations
19 Scopus citations

Diozonides from coozonolyses of suitable O-methyl oximes and ketones

Griesbaum, K., Liu, X. & Dong, Y., Apr 14 1997, In : Tetrahedron. 53, 15, p. 5463-5470 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
90 Scopus citations

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

Dong, Y., Tang, Y., Chollet, J., Matile, H., Wittlin, S., Charman, S. A., Charman, W. N., Tomas, J. S., Scheurer, C., Snyder, C., Scorneaux, B., Bajpai, S., Alexander, S. A., Wang, X., Padmanilayam, M., Cheruku, S. R., Brun, R. & Vennerstrom, J. L., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6368-6382 15 p.

Research output: Contribution to journalArticle

58 Scopus citations

Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice

Xue, J., Wang, X., Dong, Y., Vennerstrom, J. L. & Xiao, S. H., Sep 1 2014, In : Parasitology research. 113, 9, p. 3259-3266 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

Keiser, J., Kirchhofer, C., Haschke, M., Huwyler, J., Dong, Y., Vennerstrom, J. L., Vanhoff, K., Kaminsky, R. & Malikides, N., Oct 29 2010, In : Veterinary Parasitology. 173, 3-4, p. 228-235 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

Formation of 2-Imino Benzo[e]-1,3-oxazin-4-ones from Reactions of Salicylic Acids and Anilines with HATU: Mechanistic and Synthetic Studies

Leas, D. A., Wu, J., Ezell, E. L., Garrison, J. C., Vennerstrom, J. L. & Dong, Y., Jan 31 2018, In : ACS Omega. 3, 1, p. 781-787 7 p.

Research output: Contribution to journalArticle

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe-Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., McIntosh, K., Padmanilayam, M., Santo Tomas, J., Scheurer, C., Scorneaux, B., Tang, Y., Urwyler, H., Wittlin, S. & Charman, W. H., Aug 19 2004, In : Nature. 430, 7002, p. 900-904 5 p.

Research output: Contribution to journalArticle

537 Scopus citations

Immune responses to methamphetamine by active immunization with peptide-based, molecular adjuvant-containing vaccines

Duryee, M. J., Bevins, R. A., Reichel, C. M., Murray, J. E., Dong, Y., Thiele, G. M. & Sanderson, S. D., May 14 2009, In : Vaccine. 27, 22, p. 2981-2988 8 p.

Research output: Contribution to journalArticle

51 Scopus citations

In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species

Xiao, S. H., Keiser, J., Chollet, J., Utzinger, J., Dong, Y., Endriss, Y., Vennerstrom, J. L. & Tanner, M., Apr 2007, In : Antimicrobial Agents and Chemotherapy. 51, 4, p. 1440-1445 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

In vivo activity of aryl ozonides against Schistosoma species

Keiser, J., Ingram, K., Vargas, M., Chollet, J., Wang, X., Dong, Y. & Vennerstrom, J. L., Feb 2012, In : Antimicrobial Agents and Chemotherapy. 56, 2, p. 1090-1092 3 p.

Research output: Contribution to journalArticle

47 Scopus citations

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., McCullough, K. J., Dong, Y., Vennerstrom, J. L. & Charman, S. A., Nov 2007, In : Journal of Pharmaceutical Sciences. 96, 11, p. 2945-2956 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Methyl-substituted dispiro-1,2,4,5-tetraoxanes: Correlations of structural studies with antimalarial activity

McCullough, K. J., Wood, J. K., Bhattacharjee, A. K., Dong, Y., Kyle, D. E., Milhous, W. K. & Vennerstrom, J. L., Mar 23 2000, In : Journal of Medicinal Chemistry. 43, 6, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel)

Jourdan, J., Matile, H., Reift, E., Biehlmaier, O., Dong, Y., Wang, X., Mäser, P., Vennerstrom, J. L. & Wittlin, S., Jan 8 2016, In : ACS infectious diseases. 2, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

17 Scopus citations

Natural-Abundance Oxygen-17 NMR Spectra of Ozonides

Hock, F., Ball, V., Dong, Y., Gutsche, S. H., Hilss, M., Schlindwein, K. & Griesbaum, K., 1994, In : Journal of Magnetic Resonance, Series A. 111, 2, p. 150-154 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

N-Phenyl-4-hydroxy-2-quinolone-3-carboxamides as selective inhibitors of mutant H1047R phosphoinositide-3-kinase (PI3Kα)

Sabbah, D. A., Simms, N. A., Wang, W., Dong, Y., Ezell, E. L., Brattain, M. G., Vennerstrom, J. L. & Zhong, H. A., Dec 15 2012, In : Bioorganic and Medicinal Chemistry. 20, 24, p. 7175-7183 9 p.

Research output: Contribution to journalArticle

24 Scopus citations

One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides

Leas, D. A., Dong, Y., Vennerstrom, J. L. & Stack, D. E., May 19 2017, In : Organic Letters. 19, 10, p. 2518-2521 4 p.

Research output: Contribution to journalArticle

19 Scopus citations
2 Scopus citations

Ozonolyses of Acetylenes: Trapping of α-Oxo Carbonyl Oxides by Carbonyl Compounds and Stabilization of α-Oxo Ozonides by Derivatizations

Griesbaum, K., Dong, Y. & McCullough, K. J., 1997, In : Journal of Organic Chemistry. 62, 18, p. 6129-6136 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ozonolyses of acetylenes revisited

Griesbaum, K. & Dong, Y., 1997, In : Advanced Synthesis and Catalysis. 339, 6, p. 575-577 3 p.

Research output: Contribution to journalArticle

Ozonolyses of acetylenes revisited

Griesbaum, K. & Dong, Y., 1997, In : Journal fur Praktische Chemie - Chemiker - Zeitung. 339, 6, p. 575-577 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Ozonolyses of O‐methyloximes in the presence of acid derivatives: A new access to substituted ozonides

Griesbaum, K., Övez, B., Huh, T. S. & Dong, Y., Jul 24 1995, In : Liebigs Annalen. 1995, 8, p. 1571-1574 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
14 Scopus citations

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Kaiser, M., Wittlin, S., Nehrbass-Stuedli, A., Dong, Y., Wang, X., Hemphill, A., Matile, H., Brun, R. & Vennerstrom, J. L., Aug 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 2991-2993 3 p.

Research output: Contribution to journalArticle

64 Scopus citations

Pharmacophore refinement guides the design of nanomolar-range botulinum neurotoxin serotype a light chain inhibitors

Nuss, J. E., Dong, Y., Wanner, L. M., Ruthel, G., Wipf, P., Gussio, R., Vennerstrom, J. L., Bavari, S. & Burnett, J. C., Oct 14 2010, In : ACS Medicinal Chemistry Letters. 1, 7, p. 301-305 5 p.

Research output: Contribution to journalArticle

14 Scopus citations

Phenolic bis-styrylbenzenes as β-amyloid binding ligands and free radical scavengers

Flaherty, D. P., Kiyota, T., Dong, Y., Ikezu, T. & Vennerstrom, J. L., Nov 25 2010, In : Journal of Medicinal Chemistry. 53, 22, p. 7992-7999 8 p.

Research output: Contribution to journalArticle

27 Scopus citations

Polyfluorinated bis-styrylbenzene β-amyloid plaque binding ligands

Flaherty, D. P., Walsh, S. M., Kiyota, T., Dong, Y., Ikezu, T. & Vennerstrom, J. L., Oct 20 2007, In : Journal of Medicinal Chemistry. 50, 20, p. 4986-4992 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Polymeric micellar delivery of novel microtubule destabilizer and hedgehog signaling inhibitor for treating chemoresistant prostate cancer

Yang, R., Chen, H., Guo, D., Dong, Y., Miller, D. D., Li, W. & Mahato, R. I., 2019, In : Journal of Pharmacology and Experimental Therapeutics. 370, 3, p. 864-875 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Praziquantel analogs with activity against juvenile Schistosoma mansoni

Dong, Y., Chollet, J., Vargas, M., Mansour, N. R., Bickle, Q., Alnouti, Y., Huang, J., Keiser, J. & Vennerstrom, J. L., Apr 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 8, p. 2481-2484 4 p.

Research output: Contribution to journalArticle

44 Scopus citations

Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals

Fügi, M. A., Wittlin, S., Dong, Y. & Vennerstrom, J. L., Mar 2010, In : Antimicrobial Agents and Chemotherapy. 54, 3, p. 1042-1046 5 p.

Research output: Contribution to journalArticle

42 Scopus citations

Progress in antischistosomal N,N′-diaryl urea SAR

Wu, J., Wang, C., Leas, D., Vargas, M., White, K. L., Shackleford, D. M., Chen, G., Sanford, A. G., Hemsley, R. M., Davis, P. H., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Feb 1 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 3, p. 244-248 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Relationship between antimalarial activity and heme alkylation for spiro- and dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., Dong, Y., Vennerstrom, J. L. & Charman, S. A., Apr 2008, In : Antimicrobial Agents and Chemotherapy. 52, 4, p. 1291-1296 6 p.

Research output: Contribution to journalArticle

80 Scopus citations

Revisiting the SAR of the Antischistosomal Aryl Hydantoin (Ro 13-3978)

Wang, C., Zhao, Q., Vargas, M., Jones, J. O., White, K. L., Shackleford, D. M., Chen, G., Saunders, J., Ng, A. C. F., Chiu, F. C. K., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Dec 8 2016, In : Journal of Medicinal Chemistry. 59, 23, p. 10705-10718 14 p.

Research output: Contribution to journalArticle

12 Scopus citations

SAR of a new antischistosomal urea carboxylic acid

Wu, J., Wang, C., Häberli, C., White, K. L., Shackleford, D. M., Chen, G., Dong, Y., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Dec 15 2018, In : Bioorganic and Medicinal Chemistry Letters. 28, 23-24, p. 3648-3651 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Semipinacol and protoadamantane-adamantane rearrangements of 5,6-dibromoadamantan-2-one and -2-ol

Wang, X., Dong, Y., Ezell, E. L., Garrison, J. C., Wood, J. K., Hagen, J. P. & Vennerstrom, J. L., 2017, In : Tetrahedron. 73, 20, p. 2972-2976 5 p.

Research output: Contribution to journalArticle

1 Scopus citations

Short path syntheses of α-diozonides by sequential ozonolyses of acetylenes and O-methyl oximes

Dong, Y., Griesbaum, K. & McCullough, K. J., Jun 7 1997, In : Journal of the Chemical Society - Perkin Transactions 1. 11, p. 1601-1604 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Short report: Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978

Wang, C., Zhao, Q., Min, J., Muniyan, S., Vargas, M., Wang, X., Dong, Y., Guy, R. K., Lin, M. F., Keiser, J. & Vennerstrom, J. L., Jun 2014, In : American Journal of Tropical Medicine and Hygiene. 90, 6, p. 1156-1158 3 p.

Research output: Contribution to journalArticle

5 Scopus citations