Yuxiang Dong, PhD

  • 3259 Citations
  • 30 h-Index
1994 …2020

Research output per year

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Research Output

  • 3259 Citations
  • 30 h-Index
  • 76 Article
  • 5 Review article
  • 1 Comment/debate
  • 1 Short survey
2007

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Dong, Y., Creek, D., Chollet, J., Matile, H., Charman, S. A., Wittlin, S., Wood, J. K. & Vennerstrom, J. L., Aug 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 3033-3035 3 p.

Research output: Contribution to journalArticle

14 Scopus citations

In vitro and in vivo activities of synthetic trioxolanes against major human schistosome species

Xiao, S. H., Keiser, J., Chollet, J., Utzinger, J., Dong, Y., Endriss, Y., Vennerstrom, J. L. & Tanner, M., Apr 2007, In : Antimicrobial Agents and Chemotherapy. 51, 4, p. 1440-1445 6 p.

Research output: Contribution to journalArticle

135 Scopus citations

Iron-mediated degradation kinetics of substituted dispiro-1,2,4-trioxolane antimalarials

Creek, D. J., Charman, W. N., Chiu, F. C. K., Prankerd, R. J., McCullough, K. J., Dong, Y., Vennerstrom, J. L. & Charman, S. A., Nov 2007, In : Journal of Pharmaceutical Sciences. 96, 11, p. 2945-2956 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)

Kaiser, M., Wittlin, S., Nehrbass-Stuedli, A., Dong, Y., Wang, X., Hemphill, A., Matile, H., Brun, R. & Vennerstrom, J. L., Aug 2007, In : Antimicrobial Agents and Chemotherapy. 51, 8, p. 2991-2993 3 p.

Research output: Contribution to journalArticle

64 Scopus citations

Polyfluorinated bis-styrylbenzene β-amyloid plaque binding ligands

Flaherty, D. P., Walsh, S. M., Kiyota, T., Dong, Y., Ikezu, T. & Vennerstrom, J. L., Oct 20 2007, In : Journal of Medicinal Chemistry. 50, 20, p. 4986-4992 7 p.

Research output: Contribution to journalArticle

54 Scopus citations

Spiro- and dispiro-1,2-dioxolanes: Contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides

Wang, X., Dong, Y., Wittlin, S., Creek, D., Chollet, J., Charman, S. A., Tomas, J. S., Scheurer, C., Snyder, C. & Vennerstrom, J. L., Nov 15 2007, In : Journal of Medicinal Chemistry. 50, 23, p. 5840-5847 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Tang, Y., Dong, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Charman, W. N., Matile, H., Urwyler, H., Dorn, A., Bajpai, S., Wang, X., Padmanilayam, M., Karle, J. M., Brun, R. & Vennerstrom, J. L., Mar 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

53 Scopus citations
2006

Antimalarial activity of N-alkyl amine, carboxamide, sulfonamide, and urea derivatives of a dispiro-1,2,4-trioxolane piperidine

Padmanilayam, M., Scorneaux, B., Dong, Y., Chollet, J., Matile, H., Charman, S. A., Creek, D. J., Charman, W. N., Tomas, J. S., Scheurer, C., Wittlin, S., Brun, R. & Vennerstrom, J. L., Nov 1 2006, In : Bioorganic and Medicinal Chemistry Letters. 16, 21, p. 5542-5545 4 p.

Research output: Contribution to journalArticle

47 Scopus citations

Chemical kinetics and aqueous degradation pathways of a new class of synthetic ozonide antimalarials

Perry, C. S., Charman, S. A., Prankerd, R. J., Chiu, F. C. K., Dong, Y., Vennerstrom, J. L. & Charman, W. N., Apr 2006, In : Journal of Pharmaceutical Sciences. 95, 4, p. 737-747 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Effect of functional group polarity on the antimalarial activity of spiro and dispiro-1,2,4-trioxolanes

Dong, Y., Tang, Y., Chollet, J., Matile, H., Wittlin, S., Charman, S. A., Charman, W. N., Tomas, J. S., Scheurer, C., Snyder, C., Scorneaux, B., Bajpai, S., Alexander, S. A., Wang, X., Padmanilayam, M., Cheruku, S. R., Brun, R. & Vennerstrom, J. L., Sep 15 2006, In : Bioorganic and Medicinal Chemistry. 14, 18, p. 6368-6382 15 p.

Research output: Contribution to journalArticle

58 Scopus citations

The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica

Keiser, J., Utzinger, J., Tanner, M., Dong, Y. & Vennerstrom, J. L., Dec 2006, In : Journal of Antimicrobial Chemotherapy. 58, 6, p. 1193-1197 5 p.

Research output: Contribution to journalArticle

56 Scopus citations
2005
90 Scopus citations

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes

Dong, Y., Chollet, J., Matile, H., Charman, S. A., Chiu, F. C. K., Charman, W. N., Scorneaux, B., Urwyler, H., Santo Tomas, J., Scheurer, C., Snyder, C., Dorn, A., Wang, X., Karle, J. M., Tang, Y., Wittlin, S., Brun, R. & Vennerstrom, J. L., Jul 28 2005, In : Journal of Medicinal Chemistry. 48, 15, p. 4953-4961 9 p.

Research output: Contribution to journalArticle

95 Scopus citations
2004

Identification of an antimalarial synthetic trioxolane drug development candidate

Vennerstrom, J. L., Arbe-Barnes, S., Brun, R., Charman, S. A., Chiu, F. C. K., Chollet, J., Dong, Y., Dorn, A., Hunziker, D., Matile, H., McIntosh, K., Padmanilayam, M., Santo Tomas, J., Scheurer, C., Scorneaux, B., Tang, Y., Urwyler, H., Wittlin, S. & Charman, W. H., Aug 19 2004, In : Nature. 430, 7002, p. 900-904 5 p.

Research output: Contribution to journalArticle

537 Scopus citations
68 Scopus citations

Synthetic peroxides as antimalarizals

Tang, Y., Dong, Y. & Vennerstrom, J. L., Jul 2004, In : Medicinal Research Reviews. 24, 4, p. 425-448 24 p.

Research output: Contribution to journalReview article

226 Scopus citations

The reaction of carbonyldiimidazole with alcohols to form carbamates and N-alkylimidazoles

Tang, Y., Dong, Y. & Vennerstrom, J. L., Oct 18 2004, In : Synthesis. 15, p. 2540-2544 5 p.

Research output: Contribution to journalArticle

20 Scopus citations
2003

Mechanisms of in situ activation of peroxidic antimalarials

Dong, Y. & Vennerstrom, J. L., 2003, In : Redox Report. 8, 5, p. 284-288 5 p.

Research output: Contribution to journalReview article

19 Scopus citations
2002

Synthesis and antimalarial activity of 1,2,4,5-tetraoxanes.

Dong, Y., Apr 2002, In : Mini reviews in medicinal chemistry. 2, 2, p. 113-123 11 p.

Research output: Contribution to journalReview article

61 Scopus citations
2001
19 Scopus citations

Peroxidic antimalarials

Dong, Y. & Vennerstrom, J. L., 2001, In : Expert Opinion on Therapeutic Patents. 11, 11, p. 1753-1760 8 p.

Research output: Contribution to journalReview article

11 Scopus citations
2000

Methyl-substituted dispiro-1,2,4,5-tetraoxanes: Correlations of structural studies with antimalarial activity

McCullough, K. J., Wood, J. K., Bhattacharjee, A. K., Dong, Y., Kyle, D. E., Milhous, W. K. & Vennerstrom, J. L., Mar 23 2000, In : Journal of Medicinal Chemistry. 43, 6, p. 1246-1249 4 p.

Research output: Contribution to journalArticle

60 Scopus citations

Synthesis and antimalarial activity of sixteen dispiro- 1,2,4,5-tetraoxanes: Alkyl-substituted 7,8,15,16- tetraoxadispiro[5.2.5.2]hexadecanes

Vennerstrom, J. L., Dong, Y., Andersen, S. L., Ager, A. L., Fu, H. N., Miller, R. E., Wesche, D. L., Kyle, D. E., Gerena, L., Walters, S. M., Wood, J. K., Edwards, G., Holme, A. D., McLean, W. G. & Milhous, W. K., Jul 13 2000, In : Journal of Medicinal Chemistry. 43, 14, p. 2753-2758 6 p.

Research output: Contribution to journalArticle

77 Scopus citations
1999
87 Scopus citations
1997

Diozonides from coozonolyses of suitable O-methyl oximes and ketones

Griesbaum, K., Liu, X. & Dong, Y., Apr 14 1997, In : Tetrahedron. 53, 15, p. 5463-5470 8 p.

Research output: Contribution to journalArticle

13 Scopus citations
2 Scopus citations

Ozonolyses of Acetylenes: Trapping of α-Oxo Carbonyl Oxides by Carbonyl Compounds and Stabilization of α-Oxo Ozonides by Derivatizations

Griesbaum, K., Dong, Y. & McCullough, K. J., 1997, In : Journal of Organic Chemistry. 62, 18, p. 6129-6136 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

Ozonolyses of acetylenes revisited

Griesbaum, K. & Dong, Y., 1997, In : Advanced Synthesis and Catalysis. 339, 6, p. 575-577 3 p.

Research output: Contribution to journalArticle

Ozonolyses of acetylenes revisited

Griesbaum, K. & Dong, Y., 1997, In : Journal fur Praktische Chemie - Chemiker - Zeitung. 339, 6, p. 575-577 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Short path syntheses of α-diozonides by sequential ozonolyses of acetylenes and O-methyl oximes

Dong, Y., Griesbaum, K. & McCullough, K. J., Jun 7 1997, In : Journal of the Chemical Society - Perkin Transactions 1. 11, p. 1601-1604 4 p.

Research output: Contribution to journalArticle

5 Scopus citations
1995

Ozonolyses of O‐methyloximes in the presence of acid derivatives: A new access to substituted ozonides

Griesbaum, K., Övez, B., Huh, T. S. & Dong, Y., Jul 24 1995, In : Liebigs Annalen. 1995, 8, p. 1571-1574 4 p.

Research output: Contribution to journalArticle

25 Scopus citations
1994

Natural-Abundance Oxygen-17 NMR Spectra of Ozonides

Hock, F., Ball, V., Dong, Y., Gutsche, S. H., Hilss, M., Schlindwein, K. & Griesbaum, K., 1994, In : Journal of Magnetic Resonance, Series A. 111, 2, p. 150-154 5 p.

Research output: Contribution to journalArticle

18 Scopus citations