Yuxiang Dong, PhD

  • 3259 Citations
  • 30 h-Index
1994 …2020

Research output per year

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Research Output

  • 3259 Citations
  • 30 h-Index
  • 77 Article
  • 5 Review article
  • 1 Comment/debate
  • 1 Short survey
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Article

Short report: Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978

Wang, C., Zhao, Q., Min, J., Muniyan, S., Vargas, M., Wang, X., Dong, Y., Guy, R. K., Lin, M. F., Keiser, J. & Vennerstrom, J. L., Jun 2014, In : American Journal of Tropical Medicine and Hygiene. 90, 6, p. 1156-1158 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Single-step conjugation of bioactive peptides to proteins via a self-contained succinimidyl bis-arylhydrazone

Phillips, J. A., Morgan, E. L., Dong, Y., Cole, G. T., McMahan, C., Hung, C. Y. & Sanderson, S. D., Oct 21 2009, In : Bioconjugate Chemistry. 20, 10, p. 1950-1957 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

Small molecule mimics of DFTamP1, a database designed anti-Staphylococcal peptide

Dong, Y., Lushnikova, T., Golla, R. M., Wang, X. & Wang, G., 2017, In : Bioorganic and Medicinal Chemistry. 25, 3, p. 864-869 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity

Wang, X., Creek, D. J., Schiaffo, C. E., Dong, Y., Chollet, J., Scheurer, C., Wittlin, S., Charman, S. A., Dussault, P. H., Wood, J. K. & Vennerstrom, J. L., Aug 15 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4542-4545 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Spiro and dispiro-1,2,4-trioxolanes as antimalarial peroxides: Charting a workable structure-activity relationship using simple prototypes

Dong, Y., Chollet, J., Matile, H., Charman, S. A., Chiu, F. C. K., Charman, W. N., Scorneaux, B., Urwyler, H., Santo Tomas, J., Scheurer, C., Snyder, C., Dorn, A., Wang, X., Karle, J. M., Tang, Y., Wittlin, S., Brun, R. & Vennerstrom, J. L., Jul 28 2005, In : Journal of Medicinal Chemistry. 48, 15, p. 4953-4961 9 p.

Research output: Contribution to journalArticle

95 Scopus citations

Spiro- and dispiro-1,2-dioxolanes: Contribution of iron(II)-mediated one-electron vs two-electron reduction to the activity of antimalarial peroxides

Wang, X., Dong, Y., Wittlin, S., Creek, D., Chollet, J., Charman, S. A., Tomas, J. S., Scheurer, C., Snyder, C. & Vennerstrom, J. L., Nov 15 2007, In : Journal of Medicinal Chemistry. 50, 23, p. 5840-5847 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Stochastic Protein Alkylation by Antimalarial Peroxides

Jourdan, J., Walz, A., Matile, H., Schmidt, A., Wu, J., Wang, X., Dong, Y., Vennerstrom, J. L., Schmidt, R. S., Wittlin, S. & Mäser, P., Dec 13 2019, In : ACS infectious diseases. 5, 12, p. 2067-2075 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Structure-activity relationship of an ozonide carboxylic acid (oz78) against fasciola hepatica

Zhao, Q., Vargas, M., Dong, Y., Zhou, L., Wang, X., Sriraghavan, K., Keiser, J. & Vennerstrom, J. L., May 27 2010, In : Journal of Medicinal Chemistry. 53, 10, p. 4223-4233 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Structure-Activity Relationship of Antischistosomal Ozonide Carboxylic Acids

Wu, J., Wang, X., Chiu, F. C. K., Häberli, C., Shackleford, D. M., Ryan, E., Kamaraj, S., Bulbule, V. J., Wallick, A. I., Dong, Y., White, K. L., Davis, P. H., Charman, S. A., Keiser, J. & Vennerstrom, J. L., Apr 9 2020, In : Journal of Medicinal Chemistry. 63, 7, p. 3723-3736 14 p.

Research output: Contribution to journalArticle

Structure-Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)

Dong, Y., Wang, X., Kamaraj, S., Bulbule, V. J., Chiu, F. C. K., Chollet, J., Dhanasekaran, M., Hein, C. D., Papastogiannidis, P., Morizzi, J., Shackleford, D. M., Barker, H., Ryan, E., Scheurer, C., Tang, Y., Zhao, Q., Zhou, L., White, K. L., Urwyler, H., Charman, W. N. & 4 others, Matile, H., Wittlin, S., Charman, S. A. & Vennerstrom, J. L., Apr 13 2017, In : Journal of Medicinal Chemistry. 60, 7, p. 2654-2668 15 p.

Research output: Contribution to journalArticle

23 Scopus citations

Synthesis and antimalarial activity of sixteen dispiro- 1,2,4,5-tetraoxanes: Alkyl-substituted 7,8,15,16- tetraoxadispiro[5.2.5.2]hexadecanes

Vennerstrom, J. L., Dong, Y., Andersen, S. L., Ager, A. L., Fu, H. N., Miller, R. E., Wesche, D. L., Kyle, D. E., Gerena, L., Walters, S. M., Wood, J. K., Edwards, G., Holme, A. D., McLean, W. G. & Milhous, W. K., Jul 13 2000, In : Journal of Medicinal Chemistry. 43, 14, p. 2753-2758 6 p.

Research output: Contribution to journalArticle

77 Scopus citations
6 Scopus citations

Synthesis of 2-Azaadamantan-6-one: A Missing Isomer

Wu, J., Leas, D. A., Dong, Y., Wang, X., Ezell, E. L., Stack, D. E. & Vennerstrom, J. L., Sep 30 2018, In : ACS Omega. 3, 9, p. 11362-11367 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
68 Scopus citations

Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria

Charman, S. A., Arbe-Barnes, S., Bathurst, I. C., Brund, R., Campbell, M., Charman, W. N., Chiu, F. C. K., Chollet, J., Craft, J. C., Creek, D. J., Don, Y., Matile, H., Maurer, M., Morizzi, J., Nguyen, T., Papastogiannidis, P., Scheurer, C., Shackleford, D. M., Sriraghavan, K., Stingelin, L. & 7 others, Tang, Y., Urwyler, H., Wang, X., White, K. L., Wittlin, S., Zhou, L. & Vennerstrom, J. L., Mar 15 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 11, p. 4400-4405 6 p.

Research output: Contribution to journalArticle

260 Scopus citations

Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67

Alshammari, A. M., Smith, D. D., Parriott, J., Stewart, J. P., Curran, S. M., McCulloh, R. J., Barry, P. A., Iyer, S. S., Palermo, N., Phillips, J. A., Dong, Y., Ronning, D. R., Vennerstrom, J. L., Sanderson, S. D. & Vetro, J. A., May 8 2020, In : ACS infectious diseases. 6, 5, p. 1169-1181 13 p.

Research output: Contribution to journalArticle

Tetrasubstituted pyrazinones derived from the reaction of praziquantel with N-bromosuccinimide

Zhao, Q., Wang, C., Ezell, E. L., Dong, Y. & Vennerstrom, J. L., Aug 6 2014, In : Tetrahedron Letters. 55, 32, p. 4463-4465 3 p.

Research output: Contribution to journalArticle

2 Scopus citations

The activity of dispiro peroxides against Fasciola hepatica

Wang, X., Zhao, Q., Vargas, M., Dong, Y., Sriraghavan, K., Keiser, J. & Vennerstrom, J. L., Sep 15 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 18, p. 5320-5323 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

The comparative antimalarial properties of weak base and neutral synthetic ozonides

Tang, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Morizzi, J., Johnson, L. M., Tomas, J. S., Scheurer, C., Snyder, C., Zhou, L., Dong, Y., Charman, W. N., Matile, H., Urwyler, H., Dorn, A. & Vennerstrom, J. L., Jan 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 2, p. 563-566 4 p.

Research output: Contribution to journalArticle

11 Scopus citations

The reaction of carbonyldiimidazole with alcohols to form carbamates and N-alkylimidazoles

Tang, Y., Dong, Y. & Vennerstrom, J. L., Oct 18 2004, In : Synthesis. 15, p. 2540-2544 5 p.

Research output: Contribution to journalArticle

20 Scopus citations

The structure - Activity relationship of the antimalarial ozonide arterolane (OZ277)

Dong, Y., Wittlin, S., Sriraghavan, K., Chollet, J., Charman, S. A., Charman, W. N., Scheurer, C., Urwyler, H., Tomas, J. S., Snyder, C., Creek, D. J., Morizzi, J., Koltun, M., Matile, H., Wang, X., Padmanilayam, M., Tang, Y., Dorn, A., Brun, R. & Vennerstrom, J. L., 2010, In : Journal of Medicinal Chemistry. 53, 1, p. 481-491 11 p.

Research output: Contribution to journalArticle

77 Scopus citations

The structure and antimalarial activity of dispiro-1,2,4,5-tetraoxanes derived from (+)-dihydrocarvone

Dong, Y., McCullough, K. J., Wittlin, S., Chollet, J. & Vennerstrom, J. L., Nov 15 2010, In : Bioorganic and Medicinal Chemistry Letters. 20, 22, p. 6359-6361 3 p.

Research output: Contribution to journalArticle

20 Scopus citations

The synthetic peroxide OZ78 is effective against Echinostoma caproni and Fasciola hepatica

Keiser, J., Utzinger, J., Tanner, M., Dong, Y. & Vennerstrom, J. L., Dec 2006, In : Journal of Antimicrobial Chemotherapy. 58, 6, p. 1193-1197 5 p.

Research output: Contribution to journalArticle

56 Scopus citations

The use of micelles to deliver potential hedgehog pathway inhibitor for the treatment of liver fibrosis

Kumar, V., Dong, Y., Kumar, V., Almawash, S. & Mahato, R. I., 2019, In : Theranostics. 9, 25, p. 7537-7555 19 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

Coulter, D. W., McGuire, T. R., Sharp, J. G., McIntyre, E. M., Dong, Y., Wang, X., Gray, S., Alexander, G. R., Chatuverdi, N. K., Joshi, S. S., Chen, X. & Vennerstrom, J. L., Nov 8 2016, In : BMC cancer. 16, 1, 867.

Research output: Contribution to journalArticle

Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines

Leas, D. A., Dong, Y., Garrison, J. C., Wang, X., Ezell, E. L., Stack, D. E. & Vennerstrom, J. L., Feb 21 2020, In : Journal of Organic Chemistry. 85, 4, p. 2846-2853 8 p.

Research output: Contribution to journalArticle

Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Tang, Y., Dong, Y., Wittlin, S., Charman, S. A., Chollet, J., Chiu, F. C. K., Charman, W. N., Matile, H., Urwyler, H., Dorn, A., Bajpai, S., Wang, X., Padmanilayam, M., Karle, J. M., Brun, R. & Vennerstrom, J. L., Mar 1 2007, In : Bioorganic and Medicinal Chemistry Letters. 17, 5, p. 1260-1265 6 p.

Research output: Contribution to journalArticle

53 Scopus citations