Project Details
Description
This research application of the Washington University Mass Spectrometry
Resource plans: 1) To continue to provide a wide range of low resolution GCMS, and high
resolution mass spectrometry services to biomedical investigators who
request this assistance. 2) To continue to provide expert technical assistance, analytical services,
and interpretive advice on high precision GCMS selected ion monitoring
quantitation of substrate content and stable isotope enrichment in
physiological samples. 3) To provide isotope ratio mass spectrometry (IRMS) services for precise
measurement of hydrogen, carbon, nitrogen, and oxygen isotopes in end
products of endogenous substrate metabolism occurring as a result of stable
isotope tracer experiments in man. 4) To provide GC/Combusion/IRMS analyses of the highly diluted carbon
isotopic enrichment values occurring in human precursor-product tracer
studies to facilitate application of these studies to clinical research
problems of biomedical importance. 5) To provide LCMS, CF-FAB and SCF-MS services for biochemical substrates
not amenable to GCMS analysis. 6) To provide fast atom bombardment and plasma desorption ionization mass
spectrometry for analysis of biopolymers of high molecular weight. 7) To make these facilities available for use by qualified investigators at
the loca, regional, national and international levels.
Resource plans: 1) To continue to provide a wide range of low resolution GCMS, and high
resolution mass spectrometry services to biomedical investigators who
request this assistance. 2) To continue to provide expert technical assistance, analytical services,
and interpretive advice on high precision GCMS selected ion monitoring
quantitation of substrate content and stable isotope enrichment in
physiological samples. 3) To provide isotope ratio mass spectrometry (IRMS) services for precise
measurement of hydrogen, carbon, nitrogen, and oxygen isotopes in end
products of endogenous substrate metabolism occurring as a result of stable
isotope tracer experiments in man. 4) To provide GC/Combusion/IRMS analyses of the highly diluted carbon
isotopic enrichment values occurring in human precursor-product tracer
studies to facilitate application of these studies to clinical research
problems of biomedical importance. 5) To provide LCMS, CF-FAB and SCF-MS services for biochemical substrates
not amenable to GCMS analysis. 6) To provide fast atom bombardment and plasma desorption ionization mass
spectrometry for analysis of biopolymers of high molecular weight. 7) To make these facilities available for use by qualified investigators at
the loca, regional, national and international levels.
Status | Finished |
---|---|
Effective start/end date | 6/1/75 → 12/31/14 |
Funding
- National Institutes of Health
ASJC
- Medicine(all)
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