Project Details
Description
The hypothesis of this application is that differential O-glycosylation of MUC-1 mucin contributes to the detachment of cancer cells from a primary cancer and mediates attachment at metastatic sites. The hypothesis will be assessed by three specific aims. The first will identify various forms of the MUC-1 mucin that interact with the matrix protein. The second specific aim will characterize the oligosaccharide and protein structure of MUC-1 mucin that interact with matrix proteins. The third specific aim will characterize the MUC-1 mucins that interact in breast cancer with normal human lung endothelial cells.
Status | Active |
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Effective start/end date | 2/3/98 → … |
Funding
- National Institutes of Health: $12,766.00
ASJC
- Medicine(all)
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