• Keefe, Douglas H (PI)
  • Rubel, Edwin (PI)
  • Kuhl, Patricia K. (PI)
  • Folsom, Richard C. (PI)
  • Burns, Edward M. (PI)
  • Werner, Lynne A. (PI)

    Project: Research project

    Project Details


    The long term goals of this program project on Hearing Development are
    to understand the normal ontogeny of human hearing and the biological
    mechanisms underlying the occurrence of hearing disorders during
    development. the first steps toward achieving these goals are a more
    thorough understanding of the time course of hearing development in
    normal human infants, an understanding of structure-function
    relationships underlying auditory system ontogeny, and animal studies
    investigating the cellular mechanisms responsible for normal and abnormal
    development. toward these ends we have proposed seven interrelated
    research projects, all of which focus on development of hearing and the
    influence of experience on the auditory system. six of the projects
    investigate hearing, perceptual development, and language development in
    human infants, while one is concerned with the cellular mechanisms
    regulating development of central nervous system auditory neurons. A variety of techniques will be used to derive converging information on
    auditory development in human infants. For example, behavioral studies
    (Werner), physiological experiments (Folsom, Werner) and acoustical
    measurements of external, middle, and inner ear (Keefe, Folsom, Burns)
    will all address developmental changes in sensitivity, frequency
    selectivity, and temporal coding. Each of these studies provides
    important information for understanding the development of language
    processing and production, which will be directly investigated by Kuhl
    and Stoel-Gammon, who will also investigate cross-language comparisons
    to learn about the roles of experience in language production and
    perception. In addition the application of physiological, behavioral,
    and acoustical methods to hearing disabled children with Down's syndrome
    will be assessed. At a more cellular level we will continue
    investigating interactions between peripheral dysfunction and central
    nervous system development using morphological, immunohistochemical, and
    biochemical methods (Rubel). This entire research program is built on the philosophy that a number of
    well-equipped laboratories headed by senior investigators in close
    communication can use complimentary approaches and share resources to
    significantly advance our understanding of hearing development.
    Effective start/end date7/1/886/30/99


    • National Institutes of Health


    • Medicine(all)
    • Neuroscience(all)


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