• Neely, Stephen T (PI)

    Project: Research project

    Project Details


    DESCRIPTION: (Adapted from the Applicant's Abstract.) The goal of the
    proposed research is to improve our basic understanding of the peripheral
    auditory system through mathematical analysis and computer simulation of
    cochlear mechanics. In recent years, models of cochlear mechanics with
    active elements helped to motivate physiologic research on outer hair cell
    motility. The motility of outer hair cells and their influence on cochlear
    mechanics remains a topic of considerable interest among physiologists. The present proposal will continue research on active and nonlinear models
    of cochlear mechanics. The emphasis will be on (1) establishing a physical
    basis for active elements in the cochlea which are essential for achieving
    sharp tuning and high sensitivity, (2) deriving an explicit representation
    for functional nonlinearity in the cochlea which serves to compress the
    large dynamic range of inputs to the ear into a smaller dynamic range of
    inputs to the auditory nerve, (3) simulating the intensity dependent travel
    time of acoustic transients typical of the human cochlea and (4) providing
    a framework for understanding independent measures of cochlear function
    such as otoacoustic emission and the auditory brainstem response in normal,
    impaired, and developing cochleas. Specific objectives are (1) to learn
    more about the influence of outer hair cells on cochlear mechanics, (2) to
    account for the decrease observed in latency with increasing intensity both
    in auditory brainstem responses and in otoacoustic emissions over a wide
    range of tone burst frequencies, (3) to simulate the influence of external
    tones on spontaneous acoustic emissions, (4) to simulate normal and
    abnormal growth of loudness observed in ears with and without functioning
    outer hair cells, and (5) to derive algorithms for frequency analysis of
    acoustic signals which will produce results similar to cochlear frequency
    analysis and provide an alternative to traditional Fourier frequency
    Effective start/end date4/1/853/31/95


    • National Institutes of Health: $71,417.00
    • National Institutes of Health: $77,082.00


    • Medicine(all)
    • Neuroscience(all)


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