NEURAL CONTROL OF BLOOD VOLUME

The proposal has two specific aims: 1) to determine the extent to which
baroreceptor denervation alters the renal response to volume expansion,
head-out water immersion, and selective atrial distension in the primate.
In addition, data will be obtained concerning the extent to which
baroreceptor denervation may produce a hypertensive state, and 2) to
determine if afferent neural activity from the kidney and liver can
appraise the central nervous system of the composition and volume of blood
which perfuses these organs. These proposals relate directly to
understanding better salt and water homeostasis in man. Standard
physiological methodology will be employed.