@article{3e68da374aa74c9a9ab1eb5829889a65,
title = "α-Vinyllysine and α-vinylarginine are time-dependent inhibitors of their cognate decarboxylases",
abstract = "(±)-α-Vinyllysine and (±)-α-vinylarginine display time-dependent inhibition of L-lysine decarboxylase from B. cadaveris, and L-arginine decarboxylase from E. coli, respectively. A complete Kitz-Wilson analysis has been performed using a modification of the Palcic continuous UV assay for decarboxylase activity.",
author = "Berkowitz, {David B.} and Jahng, {Wan Jin} and Pedersen, {Michelle L.}",
note = "Funding Information: Summary Using our procedure for the formal a-vinylation of a-amino acids, (±)-a-vinylarginine and (±)-a-vinyllysine were synthesized. A modifcafion of the continuous UV assay for dccarboxylascs reported by Palcic was used to conveniently perform a Kitz-Wilson kinetic analysis for time-dependent inhibition with these a-branched amino acids. Indeed, both compounds display pseudo-first order time-dependent inhibition of their respective amino acid dccarboxylascs, with (±)-a-vinyllysine displaying a KI that compares favorably with Kin. Acknowledgment. Financial support from the National Institutes of Health (CA 62034) is gratefully acknowledged. This research was facilitated by grants for shared instrumentation (NMR and GC/MS) from the NIH (SIG 1-$10-RR06301) and the NSF (CHE-93000831), respectively.",
year = "1996",
month = sep,
day = "17",
doi = "10.1016/0960-894X(96)00366-6",
language = "English (US)",
volume = "6",
pages = "2151--2156",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "18",
}