α-Vinyllysine and α-vinylarginine are time-dependent inhibitors of their cognate decarboxylases

David B. Berkowitz, Wan Jin Jahng, Michelle L. Pedersen

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

(±)-α-Vinyllysine and (±)-α-vinylarginine display time-dependent inhibition of L-lysine decarboxylase from B. cadaveris, and L-arginine decarboxylase from E. coli, respectively. A complete Kitz-Wilson analysis has been performed using a modification of the Palcic continuous UV assay for decarboxylase activity.

Original languageEnglish (US)
Pages (from-to)2151-2156
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume6
Issue number18
DOIs
StatePublished - Sep 17 1996

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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