β-blockade in adriamycin-induced cardiomyopathy

Arshia Noori, Joann Lindenfeld, Eugene Wolfel, Debbie Ferguson, Michael R. Bristow, Brian D. Lowes

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

β-Blockade consistently improves myocardial systolic function in patients with both nonischemic and ischemic cardiomyopathy. The effects of β-blockade on Adriamycin-induced cardiomyopathy (ACM), however, are unknown. We retrospectively evaluated the effects of β-blockade on patients with ACM by using a case-controlled design. The control group consisted of 16 consecutively chosen age- and sex-matched patients with idiopathic dilated cardiomyopathy (IDC) who were treated with β-blockers. Patients with ACM had a baseline mean left ventricular ejection fraction (LVEF) of 28%, which improved to 41% (P = .041) after treatment with β-blockers. The control group had a baseline mean LVEF of 26%, which improved to 32% (P = .015) after treatment. The mean duration of β-blocker therapy in the Adriamycin and control groups was 8 and 9 months, respectively. The degree of improvement between the 2 groups was not significantly different. β-Blockers have a beneficial effect on cardiac function in patients with ACM, which is at least comparable with other forms of heart failure with systolic dysfunction.

Original languageEnglish (US)
Pages (from-to)115-119
Number of pages5
JournalJournal of Cardiac Failure
Volume6
Issue number2
DOIs
StatePublished - Jun 2000
Externally publishedYes

Keywords

  • Adriamycin
  • Cardiomyopathy
  • β-blockade

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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