δ-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development

Jyothi Arikkath, I. Feng Peng, Gie Ng Yu, Inbal Israely, Xin Liu, Erik M. Ullian, Louis F. Reichardt

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

The maintenance of spine and synapse number during development is critical for neuronal circuit formation and function. Here we show that δ-catenin, a component of the cadherin-catenin cell adhesion complex, regulates spine and synapse morphogenesis during development. Genetic ablation or acute knockdown of δ-catenin leads to increases in spine and synapse density, accompanied by a decrease in tetrodotoxin induced spine plasticity. Our results indicate that δ-catenin may mediate conversion of activity-dependent signals to morphological spine plasticity. The functional role of δ-catenin in regulating spine density does not require binding to cadherins, but does require interactions with PDZ domain-containing proteins. We propose that the perturbations in spine and synaptic structure and function observed after depletion of δ-catenin during development may contribute to functional alterations in neural circuitry, the cognitive deficits observed in mutant mice, and the mental retardation pathology of Cri-du-chat syndrome.

Original languageEnglish (US)
Pages (from-to)5435-5442
Number of pages8
JournalJournal of Neuroscience
Volume29
Issue number17
DOIs
StatePublished - Apr 29 2009

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'δ-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development'. Together they form a unique fingerprint.

  • Cite this

    Arikkath, J., Peng, I. F., Yu, G. N., Israely, I., Liu, X., Ullian, E. M., & Reichardt, L. F. (2009). δ-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development. Journal of Neuroscience, 29(17), 5435-5442. https://doi.org/10.1523/JNEUROSCI.0835-09.2009