1,2,4-Trioxepanes: Redox-cleavable protection for carbonyl groups

Aqeel Ahmed, Patrick H. Dussault

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

(Chemical Equation Presented) 1,2,4-trioxepanes, readily prepared and easily handled derivatives of aldehydes and ketones, are stable to a variety of synthetic conditions and yet easily deblocked with Zn/HOAc or Mg/MeOH to regenerate the parent carbonyl. Trioxepanes may provide an alternative to 1,3-dithianes for acid-stable protection of carbonyl groups.

Original languageEnglish (US)
Pages (from-to)3609-3611
Number of pages3
JournalOrganic Letters
Volume6
Issue number20
DOIs
StatePublished - Sep 30 2004

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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