1,25-dihydroxy-16-ene-23-yne-vitamin d3 and prostate cancer cell proliferation in vivo

Gary G. Schwartz, Christopher C. Hill, Theresa A. Oeler, Michael J. Becich, Robert R. Bahnson

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

1,25-Dihydroxyvitamin D can inhibit the proliferation of prostate cancer cells, but its clinical use is limited by hypercalcemia. We examined the effects of a “noncalcemic” vitamin D analogue, 1,25-Dihydroxy-16-ene-23-yne-cholecalciferol (16-23-D3), on the proliferation of human prostate cancer cells in a mouse model. Twenty-four athymic nude mice were inoculated with human prostate carcinoma cells from the PC-3 cell line. Twelve mice (experimental group) received injections of 1.6 μg of 16-23-D3 on alternate days over a 22-day period. Twelve mice (control group) received sham injections. Tumor volumes, pathologic findings, and terminal serum calcium levels were compared between groups. The relative increase in tumor volume was significantly lower in the experimental than in the control group in the first interval following treatment (P < 0.01). Mean tumor volumes in the experimental group were approximately 15% smaller than in the control group. Serum calcium levels did not differ between groups. 16-23-D3 showed modest antiproliferative effects on prostate cancer cells in this model without evidence of drug-induced hypercalcemia. These findings support the concept that vitamin D analogues can inhibit the proliferation of human prostate cancer cells in vivo.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalUrology
Volume46
Issue number3
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of '1,25-dihydroxy-16-ene-23-yne-vitamin d<sub>3</sub> and prostate cancer cell proliferation in vivo'. Together they form a unique fingerprint.

  • Cite this