Abstract
18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been shown to reduce the self-administration of several drugs of abuse. Recently, this agent has also been shown to attenuate sucrose reward, decrease sucrose intake and prevent the development of sucrose-induced obesity in rats. The present experiments were designed to determine whether the latter effect was due to an 18-MC-induced conditioned taste aversion to sucrose. Both 18-MC (20. mg/ kg, i.p.) and control agent, lithium chloride (100. mg/kg, i.p.), reduced sucrose intake 24. h after association with sucrose; however, only lithium chloride reduced sucrose intake 72. h later. Consistent with previous data, 18-MC appears to have proactive effect for 24. h and it does not induce a conditioned taste aversion.
Original language | English (US) |
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Pages (from-to) | 247-250 |
Number of pages | 4 |
Journal | Pharmacology Biochemistry and Behavior |
Volume | 96 |
Issue number | 3 |
DOIs | |
State | Published - Sep 2010 |
Externally published | Yes |
Keywords
- Nicotinic receptors
- Obesity
- Sucrose intake
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience