18-Methoxycoronaridine, a potential anti-obesity agent, does not produce a conditioned taste aversion in rats

Olga D. Taraschenko, Isabelle M. Maisonneuve, Stanley D. Glick

Research output: Contribution to journalArticle

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Abstract

18-Methoxycoronaridine (18-MC), a selective antagonist of α3β4 nicotinic receptors, has been shown to reduce the self-administration of several drugs of abuse. Recently, this agent has also been shown to attenuate sucrose reward, decrease sucrose intake and prevent the development of sucrose-induced obesity in rats. The present experiments were designed to determine whether the latter effect was due to an 18-MC-induced conditioned taste aversion to sucrose. Both 18-MC (20. mg/ kg, i.p.) and control agent, lithium chloride (100. mg/kg, i.p.), reduced sucrose intake 24. h after association with sucrose; however, only lithium chloride reduced sucrose intake 72. h later. Consistent with previous data, 18-MC appears to have proactive effect for 24. h and it does not induce a conditioned taste aversion.

Original languageEnglish (US)
Pages (from-to)247-250
Number of pages4
JournalPharmacology Biochemistry and Behavior
Volume96
Issue number3
DOIs
StatePublished - Sep 1 2010

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Keywords

  • Nicotinic receptors
  • Obesity
  • Sucrose intake

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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