2019 Clinical Update in Liver Transplantation

Cale A. Kassel, Bradley A. Fremming, Brittany A. Brown, Nicholas W. Markin

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Liver transplantation continues be the standard for treatment of end-stage liver disease, and even with recent advances in organ preservation, the anesthetic management continues to require understanding of multiple organ systems beyond the liver. Multiple factors contribute to hemodynamic changes after reperfusion of the liver graft that anesthesiologists should be aware of before unclamping. Concomitant renal dysfunction in end-stage liver disease is not uncommon, and preparation for continuous renal replacement therapy may need to be considered in certain cases. Cardiac evaluation of liver transplantation patients with an emphasis on arrhythmias, including atrial fibrillation, can help prevent both intraoperative and postoperative complications detrimental to the patient and graft. Finally, combined liver and thoracic organ transplantations may be indicated for certain disease processes that affect multiple organs. These cases require an understanding of the surgical technique and acknowledgment that some goals of the procedures may be in direct opposition to each other.

Original languageEnglish (US)
Pages (from-to)1495-1502
Number of pages8
JournalJournal of Cardiothoracic and Vascular Anesthesia
Issue number5
StatePublished - May 2021


  • atrial fibrillation
  • heart-liver transplantation
  • liver transplantation
  • lung-liver transplantation
  • postreperfusion syndrome
  • renal replacement therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Anesthesiology and Pain Medicine


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