27. Prefrontal systems underlying spontaneous and directed strategic processing during verbal learning

C. R. Savage, T. Deckersbach, S. Heckers, A. D. Wagner, D. L. Schacter, S. L. Rauch

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Prefrontal cortex supports strategic memory processes, including the ability to use semantic organizational strategies in novel or ambiguous learning situations. We used PET and a verbal learning paradigm to evaluate neural systems supporting spontaneous and directed use of semantic organizational strategies. There were three encoding conditions (Spontaneous, Di-rected, Unrelated) and behavioral measures of semantic clustering. In graded PET contrasts (D > S > U), two activations were found in left inferior prefrontal cortex (IPFC) and left dorsolateral prefrontal cortex (DLPFC). Covariate analyses indicated that blood flow in orbitofrontal cortex (OFC) was strongly correlated with spontaneous use of semantic clustering strategies during free recall. Findings indicate that OFC plays an important, and previously unappreciated, role in strategic memory by supporting early mobilization of behavioral strategies in novel or ambiguous situations.

Original languageEnglish (US)
Pages (from-to)116-120
Number of pages5
JournalBrain and Cognition
Volume47
Issue number1-2
StatePublished - 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)
  • Cognitive Neuroscience

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