3-alkoxy-1,2-dioxolanes: Synthesis and evaluation as potential antimalarial agents

Charles E. Schiaffo, Matthias Rottman, Sergio Wittlin, Patrick H. Dussault

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


A number of 3-alkoxy-1,2-dioxolanes exhibit promising levels of antimalarial activity against Plasmodium falciparum. A new route to the 1,2-dioxolane core is reported based on tandem peroxidation/cyclization of enones.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalACS Medicinal Chemistry Letters
Issue number4
StatePublished - Apr 14 2011


  • 3-alkoxy-1,2-dioxolane
  • Malaria
  • dioxolane
  • peroxide

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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