3-alkoxy-1,2-dioxolanes: Synthesis and evaluation as potential antimalarial agents

Charles E. Schiaffo; Matthias Rottman; Sergio Wittlin; Patrick H. Dussault

doi:10.1021/ml100308d

3-alkoxy-1,2-dioxolanes: Synthesis and evaluation as potential antimalarial agents

Charles E. Schiaffo, Matthias Rottman, Sergio Wittlin, Patrick H. Dussault

Chemistry

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A number of 3-alkoxy-1,2-dioxolanes exhibit promising levels of antimalarial activity against Plasmodium falciparum. A new route to the 1,2-dioxolane core is reported based on tandem peroxidation/cyclization of enones.

Original language	English (US)
Pages (from-to)	316-319
Number of pages	4
Journal	ACS Medicinal Chemistry Letters
Volume	2
Issue number	4
DOIs	https://doi.org/10.1021/ml100308d
State	Published - Apr 14 2011

Keywords

3-alkoxy-1,2-dioxolane
Malaria
dioxolane
peroxide

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1021/ml100308d

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abstract = "A number of 3-alkoxy-1,2-dioxolanes exhibit promising levels of antimalarial activity against Plasmodium falciparum. A new route to the 1,2-dioxolane core is reported based on tandem peroxidation/cyclization of enones.",

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