Abstract
A number of 3-alkoxy-1,2-dioxolanes exhibit promising levels of antimalarial activity against Plasmodium falciparum. A new route to the 1,2-dioxolane core is reported based on tandem peroxidation/cyclization of enones.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 316-319 |
| Number of pages | 4 |
| Journal | ACS Medicinal Chemistry Letters |
| Volume | 2 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 14 2011 |
Keywords
- 3-alkoxy-1,2-dioxolane
- Malaria
- dioxolane
- peroxide
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Schiaffo, C. E., Rottman, M., Wittlin, S., & Dussault, P. H. (2011). 3-alkoxy-1,2-dioxolanes: Synthesis and evaluation as potential antimalarial agents. ACS Medicinal Chemistry Letters, 2(4), 316-319. https://doi.org/10.1021/ml100308d